Articles tagged with Electrophysiology
Researchers at OIST developed a method to recreate connections between neurons from two different brain areas in a dish, allowing for the study of brain function and potential treatments for neurological disorders. The breakthrough used neurons from embryos of mice and created a working corticostriatal network.
Researchers at SISSA have developed a novel method to analyze the structure of biological proteins immersed in their physiological context. This technique allows for excellent spatial resolution and study of molecules in their natural environment, providing new insights into the opening/closing mechanism of major ion channels. The stud...
Researchers have developed transparent graphene microelectrodes that enable real-time observation of neural circuits in epilepsy and other neurological disorders. This technology provides high spatial and temporal resolution, allowing for detailed analysis of seizure patterns and brain electrical activity.
Researchers from UK institutions released a treasure trove of data on the developing retina, pushing the boundaries of neuroscience publishing. The dataset includes 366 recordings from 12 studies and is made available in a standardized and interoperable manner, allowing for reproducibility and further analysis.
Researchers developed tissue-engineered nerves using acellular nerve allografts and bone marrow mesenchymal stem cells to repair long-segment sciatic nerve defects. The study showed improved hind limb motor function and similar conduction velocities to autologous nerve grafting.
A study by UPV/EHU researchers has characterised the functioning of a protein responsible for cell membrane splitting, making it possible to see the basic mechanisms of cell life from a fresh perspective. The methodology developed will allow various neuromuscular disorders to be diagnosed.
Researchers at UCLA successfully treated two patients with severe ventricular arrhythmias using a minimally invasive technique normally employed in treating brain aneurysms. The coil embolization procedure helped stop the electrical storms and eliminate the blood supply to the affected area, allowing the heart to return to normal rhythm.
Researchers developed a noninvasive stimulation protocol to temporarily improve hand function in people with spinal cord injuries. The treatment, paired with transcranial magnetic stimulation and electrical stimulation, successfully enhanced spinal cord transmission and voluntary motor output, leading to greater manual dexterity.
Researchers at Michigan Medicine have developed a safer method for steadying abnormal heart rhythms, using photodynamic therapy to target specific cells causing the arrhythmia. This cell-specific approach aims to decrease unwanted cell injury and inflammation, paving the way for more effective therapies.
The CHA2DS2-VASc score has been validated in different populations, identifying very low risk patients who do not need antithrombotic therapy. New oral anticoagulants have a greater net clinical benefit compared to warfarin when both bleeding and stroke risks are high.
The European Society of Cardiology and the European Heart Rhythm Association will hold a joint Congress annually from 2014 to 2017, featuring four main topics: electrophysiology, devices, non-invasive EP, and basic science. The agreement aims to improve scientific collaboration and quality among cardiac electrophysiology communities.
Dr. Samuel Young receives grant to develop critical technology for researching potential therapies targeting LRRK2, a key Parkinson's-related gene. The technology aims to overcome challenges in expressing the gene using commonly used neuroscience research tools.
Researchers at Columbia Engineering and the University of Pennsylvania have created a new integrated circuit design that enables faster single-molecule measurements, including DNA sequencing. This breakthrough could lead to cheaper and more accurate diagnostic tests for diseases, as well as insights into inherited traits.
Research by Université de Montrêl neuropsychologist Dave Ellemberg shows that adolescents are more sensitive to the effects of a sport-related concussion than adults or children. The study found that a first concussion can result in six months to a year of neurophysiological side effects for adolescents, adults, and children alike.
Researchers report using simultaneous techniques to reduce radiation exposure during cardiac testing, with results showing a 75-85% decrease in patient risk. The new high-definition CT scan method offers improved safety for patients concerned about radiation exposure.
A recent study published in Circulation: Arrhythmia & Electrophysiology found that laser lead extraction is as safe in people aged 80 or older as it is in younger patients. The study, which analyzed 506 patients, found no significant differences in infection rates, complications, or other health outcomes between the two groups.
A protocol developed by Johns Hopkins cardiologists has enabled patients with implanted cardiac devices to safely undergo MRI scans. With appropriate precautions and careful patient monitoring, the risk of device malfunction is very low.
A new protocol significantly reduced radiation exposure in children undergoing electrophysiology procedures, with a 22% reduction in X-ray machine time and 52% reduction in dose entering the skin. The protocol also showed a 51% reduction in median effective dose, correlating to decreased lifetime cancer risk.
A study reports on UCLA's experience with new techniques combining catheter ablation with minimally invasive surgical methods to access hard-to-reach areas of the heart. These procedures significantly improved accuracy in applying ablation therapy, offering more treatment options for high-risk patients.
A new study reveals that some classes of interneurons may underlie distinct brain disorders, such as epilepsy and autism. The research suggests that precise dysfunction in specific circuits can lead to these disorders, shedding light on potential future treatments.
Researchers found that particulate air pollution from PM2.5 exposure can affect heart electrophysiology up to six hours after inhalation, leading to increased risk of cardiovascular disease. Elevated PM2.5 levels may trigger acute cardiac events and contribute to chronic heart disease.
Researchers at Harvard University developed an all-optical technique to measure how neurons excite or inhibit each other. The study successfully mapped the interplay of four neurons, revealing that multiple neurons can influence their neighbors' activity.
Concurrent imaging of metabolic and electric signals in the heart reveals a dynamic relationship between multiple cardiac variables. The new dual-camera system allows for rapid setup, dichroic image separation, and high spatial resolution, enabling correlative multimodal cardiac imaging.
The European Heart Rhythm Association's (EHRA) White Book reveals significant disparities in arrhythmia treatment across Europe. The book highlights differences in guideline implementation, trained physicians, and implantation rates, with some countries having no reimbursement for ICD or pacemaker therapy.
A study found that patients implanted with ICDs by nonelectrophysiologist physicians had higher rates of complications and were less likely to receive CRT-D devices. Electrophysiologists performed safer procedures, suggesting differences in training, experience, and technique.
This article provides optimization strategies for polymerase chain reaction (PCR) and a method for loading individual cells with fluorescent probes via patch pipettes. The techniques are described in detail, including touchdown PCR and hot-start PCR, and their applications in neuroscience research.
A new study measures movements smaller than one-billionth of a meter in ion channels, revealing that the voltage sensor moves by only a small amount to allow ion flow. The findings challenge models that predicted large movements of protein segments, providing new insights into the complex process of generating electrical impulses.
The La Mente Bilingüe research team, led by Dr. Itziar Laka, investigates language acquisition and processing in bilingual brains. They use experimental methodologies to understand how languages are organized and processed, including analyzing word order and syntax, and exploring the effect of age on phonology, vocabulary, and grammar.
Patients with end-stage renal disease have a significantly shorter life expectancy after ICD implantation, highlighting the need for continued research on prevention and treatment strategies. The study calls into question the survival benefit of ICDs in patients with kidney disease who meet current implant indications.
A new imaging procedure using intracardiac echocardiography (ICE) provides real-time monitoring of the esophagus during ablation, reducing the risk of esophageal injury. The study involved 152 patients who underwent left atrial ablation for AF and found that ICE could detect lesions on the posterior wall of the heart's left atrium.
Researchers created frequency maps for most of the 11 auditory cortex fields (ACFs) and observed a periodic pattern of topographic preference for certain frequencies. The ACFs were divided into two groups, with three core fields reacting to individual frequencies in simple sounds like tones.
A study published by The Reis Group found that the survival rates of young competitive athletes experiencing sudden cardiac arrest are significantly lower than expected, even with proper CPR and defibrillation. The authors suggest that underlying heart conditions may be a major factor contributing to these poor outcomes.
A team of University of Michigan researchers used fMRI to capture the brain's instant response to costly mistakes. They found that the rostral anterior cingulate cortex (rACC) becomes more active when errors carry consequences, suggesting a key role in emotional responses and decision-making processes.
Temporary esophageal stenting is a new alternative to surgery for correcting esophageal perforations, which can occur during atrial fibrillation ablation procedures. This non-invasive method has been shown to be effective in healing the esophagus without surgery.
Researchers will investigate how brains perceive novelty and importance using a computational theory of surprise. The project combines experiments, modeling, and neurophysiological studies to develop a new understanding of how the brain codes for these concepts.
Researchers found that Carvedilol has anti-arrhythmic properties that can reduce cardiac death and atrial fibrillation. The study suggests an alternative to implantable cardiovertor defibrillators (ICDs) for managing patients at high risk of sudden cardiac death.
Researchers have developed a new approach to cardiac resynchronization therapy that uses a minimally invasive method to place pacing leads. The technique, which involves puncturing the heart's pericardium to insert the lead, shows promise in improving treatment outcomes for patients with heart failure.
A study published in Pacing and Clinical Electrophysiology journal confirms catheter ablation is safe for patients, with no significant damage to cardiac nerves. The procedure is now a standard therapy for various arrhythmias, including SVT, atrial fibrillation, and AV nodal re-entrant tachycardia.
The Multicenter UnSustained Tachycardia Trial found significant differences in characteristics, treatment, and outcome between men and women with coronary artery disease. Women were more likely to have experienced angina and had lower rates of atrial fibrillation than men.
A new study published in the Journal of Cardiovascular Electrophysiology suggests that rapid ventricular pacing is a key factor in developing heart failure. The research found that goats subjected to high atrial and ventricular rates developed end-stage CHF, while those with low ventricular rates remained healthy.
A new gene therapy technique has successfully treated irregular heart rhythms in pigs, using a 'painting' method to deliver the therapy. The technique, which uses a plastic, gel-like substance to contain the gene therapy, shows promise for treating atrial fibrillation, a common heart condition.
A new study published in the Journal of Cardiovascular Electrophysiology found radiofrequency ablation to be a safe and effective treatment for children with various forms of heart problems. The procedure showed high success rates, with over 98% of patients able to be cured, regardless of demographics or specific disorder location.
Researchers used 3D technology to map the electrical pathways in patients with atrial flutter, revealing additional abnormal circuits that could be missed by conventional methods. Radiofrequency heat energy was then used to destroy these tissues, curing the patients and improving treatment outcomes.
Researchers at Emory University have developed an innovative technique for biventricular resynchronization that minimizes risks and eliminates ionizing radiation. The new approach uses tiny incisions and specialized tools to connect leads to the heart, offering a safer and more efficient alternative to traditional methods.
Researchers at Penn find a cure for atrial fibrillation by targeting triggers in pulmonary veins, eliminating the need for pacemakers and medication. The new procedure has shown effectiveness and low complication rates, offering hope for patients with this serious condition.