Articles tagged with Estrogen
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A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
New research reveals that DNA's physical property of supercoiling is crucial for cells to respond to oestrogens. The study found that enzymes called topoisomerases regulate DNA coiling and activate target genes.
Estrogen activates previously unknown pathways in the colon, triggering pain and increasing sensitivity to certain foods. This explains why women are more likely to suffer from IBS and provides potential new ways to treat the condition.
Researchers discovered that synthetic stress hormone dexamethasone can combat therapy-resistant breast cancer metastases in mice trials. The drug activates the glucocorticoid receptor, suppressing estrogen receptor production and slowing tumor growth. Further studies are needed to confirm these findings in patients with breast cancer.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
Research shows that infants of stressed mothers have an earlier and faster tooth eruption, with more teeth by six months of age. Cortisol levels during late pregnancy are associated with this accelerated process.
A recent study published in Nature Neuroscience has made significant breakthroughs in understanding how hormones like estrogen impact brain function, particularly in learning and decision-making. The research found that estrogen boosts dopamine activity, leading to enhanced learning capabilities and a potential connection to neuropsych...
A large international study reveals that women with a precursor condition to Parkinson's disease exhibit significantly less brain atrophy compared to men. The research suggests that estrogens may play a crucial role in protecting the brain from neurodegeneration.
Biologists at Cold Spring Harbor Laboratory have made a significant discovery that could lead to better patient outcomes for ER+ breast cancer patients. Inhibiting the BPTF protein in mice can slow cancer metastasis and restore tumors' susceptibility to hormone therapy, offering new hope for treating resistant forms of the disease.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A keto diet may have different effects on males and females, with estrogen found to promote protection against adverse effects such as cellular senescence. The study found that male mice on a keto diet showed increased markers of oxidative stress and cellular senescence, but these effects were reversed by estrogen treatment.
A new study found that using vaginal estrogen tablets was not associated with an increased risk of recurrent ischemic stroke among postmenopausal women. The study examined prescription data from over 34,000 women and discovered no increased risk of stroke in this high-risk population.
Dr. David Rubinow's research reveals that susceptible women respond differently to normal hormonal fluctuations, leading to breakthrough treatment approaches and FDA-approved medication for postpartum depression. His work validates the experiences of millions of women whose hormone-related mood symptoms were previously misunderstood.
Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.
A new hypothesis suggests that prenatal sex steroid hormones and placental function played a crucial role in shaping the human brain and its cognitive traits. This may have led to increased brain size and reduced competition among males, allowing for the emergence of large social groups.
A new study suggests that women who spend more time in their reproductive phase may experience slower brain aging. Estradiol, the most potent form of estrogen during this period, may help protect the brain from age-related decline. However, further research is needed to fully understand the relationship between estradiol and brain health.
The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.
Researchers discovered neuroestrogen's role in regulating food intake and hunger. Neuroestrogen enhances the brain's responsiveness to leptin, a hormone that helps regulate hunger.
A recent study found that women are more metabolically efficient under extreme conditions, closing the performance gap with men. Women's greater fat mass may contribute to this advantage, enabling them to complete longer distances without burning out.
A new analysis found that oral hormone therapy can lower levels of lipoprotein(a), a genetic risk factor associated with higher risk of heart attack and stroke. Hormone therapy also improved biomarkers of cardiovascular health, including cholesterol levels.
Researchers investigated the therapeutic mechanisms of ursolic acid on metabolic dysfunction-associated steatotic liver disease. Ursolic acid was found to reduce inflammation by modulating estrogen conversion via HSD17B14, a crucial enzyme regulating estrogen balance.
A cohort study found that women with screen-detected estrogen receptor–positive or human epidermal growth factor receptor 2–negative breast cancer who underwent prior screening had an earlier stage of diagnosis and lower breast cancer mortality compared to those who did not undergo prior screening.
A study published in Nature Metabolism reveals a novel mechanism connecting prolactin, estrogen, the brain, and metabolic adaptations during lactation. Hormonal changes during lactation lead to increased hunger and reduced fat-burning, which are sustained by a specific area of brain cells called ERα neurons.
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
A study found that women who underwent bilateral oophorectomy were more likely to develop heart failure later in life. The researchers suggest that early menopause may be a contributing factor to this increased risk, and recommend closer cardiovascular monitoring for women contemplating the procedure.
A new rat study by researchers at Washington University School of Medicine suggests that biological differences in males and females may contribute to the gender disparity in opioid misuse. Female rats with chronic pain showed no increase in opioid intake, whereas male rats increased their fentanyl consumption over time.
New research found that neuroestrogens produced in the brain help suppress appetite, as confirmed by experiments where aromatase expression was restored specifically in the brain. This suggests a link between neuroestrogen levels and body weight regulation.
A recent study found that estrogen can partially restore progesterone levels and improve ovarian health in Mcoln1−/− mice, a model for human mucolipidosis type IV. The research also showed that hormone therapies including estrogen improved luteal cell morphology and lysosomal function.
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
A preclinical study led by Weill Cornell Medicine scientists found that estrogen surges promote binge drinking in females, causing them to 'pregame' and consume large quantities of alcohol. The study identifies a neural circuit in the brain where estrogen increases activity, leading to enhanced binge drinking behavior.
The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.
Researchers have identified structural grey matter differences in the brains of women with a history of peripartum depression compared to those without. The study found that hormone fluctuations during pregnancy and childbirth may be key to understanding this condition.
Long-term hormone therapy in transgender individuals leads to significant changes in body composition and risk factors for cardiovascular disease. Transgender men experience increased muscle volume and abdominal fat, while women's muscle mass decreases, according to a new study published in the Journal of Internal Medicine.
Researchers found that short-term MHT did not cause long-term cognitive decline in women in early postmenopause. The KEEPS Continuation Study suggests that timing is crucial for the safety of MHT.
The study reveals hormone-dependent molecular mechanisms that cause sexual dimorphism in chicken feathers, including the role of thyroid hormone activation/inactivation system. The findings also shed light on the cultural significance of chickens in Japanese society and its impact on promoting social cohesion.
Researchers at Baylor College of Medicine discovered estrogen's fast actions are mediated by the coupling of ER-alpha with ion channel protein Clic1, controlling chloride ion flux and enabling rapid neuronal responses. This finding sheds light on estrogen's role in regulating various physiological processes.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.
A new study published in JAMA Network Open found that hormone modulating therapy (HMT) used to treat breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias. The protective effect of HMT decreased with age, particularly for women over 80.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
Researchers have developed a humanized mouse model with a fully functional human immune system, enabling the study of immunotherapy development, disease modeling, and vaccine development. The new model, called TruHuX, mounts specific antibody responses and can develop full-fledged systemic lupus autoimmunity.
A recent study published in JAMA found that transgender women on hormone therapy have drastically lower PSA levels, which may lead to delayed diagnosis and treatment of prostate cancer. The researchers analyzed Veterans Health Administration records and recommended caution when interpreting PSA values in transgender women.
Researchers found that women who had their ovaries removed before menopause experience reduced white matter integrity in multiple brain regions. This reduction may contribute to an increased risk of cognitive decline and dementia later in life.
A new brain imaging study led by Weill Cornell Medicine researchers found that estrogen receptors in the brain increase with age during menopause, affecting cognitive and mood symptoms. The study pioneers PET imaging as a tool to track estrogen activity in the brain, revealing potential predictors of common menopause-related issues.
Research highlights socioecologic factors contributing to racial disparities in breast cancer prognostic scores, emphasizing the impact of structural racism on health outcomes. Additional research is needed to better understand the influence of social determinants on breast cancer biology among disadvantaged communities.
A study shows post-menopausal women experience a steep rise in heart problems due to reduced estrogen levels, accelerating plaque buildup and cardiovascular risk. Researchers highlight the importance of recognizing early warning signs and increasing screening for coronary artery calcium.
Dr. Rhonda Voskuhl's groundbreaking research has shed light on the mechanisms underlying sex differences in MS, highlighting a gene on female sex chromosomes that promotes inflammation and brain-protective effects of estrogen. Her work may lead to new treatment approaches for MS.
A new study suggests that anxiety and depression in younger women may accelerate the development of cardiovascular risk factors, putting them at nearly par with men of the same age. The researchers found that these mental health conditions were associated with a much higher relative risk among young women than seen in other groups.
Researchers discovered a feedback loop involving estrogen that may explain why women become more dependent on nicotine. Estrogen-induced proteins called olfactomedins could be targeted with therapies to help control nicotine consumption.
A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.
Researchers at the University of Adelaide have discovered a new approach to defeating breast cancer by stimulating the androgen receptor. The study found that enobosarm was effective against estrogen receptor-positive breast cancer, which is the most common form of the disease.
A recent study by researchers at the University of Texas at Arlington found that women are more susceptible to cocaine addiction than men due to fluctuations in sex hormones. The study discovered that the female sex hormone estradiol enhances the rewarding effects of cocaine, leading to increased sensitivity among females.
Scientists have discovered a way to predict breast cancer risk based on specific chemical traits, identifying over 900 chemicals that could contribute to the disease. These chemicals are commonly found in consumer products, food, and workplaces, and can alter hormones or damage DNA.
Researchers investigated role of estrogen receptors in lateral septum regulating social anxiety in male mice, finding that ERβ plays a crucial role in neural circuitry. Knockdown effects on ERβ gene expression showed increased social anxiety, highlighting its importance in social situations.
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
A recent study published in Lancet Oncology has found that measuring blood hormone levels can identify post-menopausal women who are most likely to benefit from anastrozole, a medication used to prevent breast cancer. The study suggests that inexpensive blood tests could be used to personalize preventive therapy for these women.
A study of 152 male gym enthusiasts found a significant lack of awareness about the risks of gym lifestyle on fertility. High levels of estrogen from protein supplements were linked to fertility issues, prompting a call for men to educate themselves about supplementation.
Recent studies by Cara Ocobock and Sarah Lacy found that prehistoric women engaged in hunting, with their female anatomy providing advantages such as endurance and fat metabolism. The research corrects the historical erasure of women from the narrative of human evolution.