Estrogen

UT Arlington study links estrogen loss to heart risk

AI-driven wearable patches help identify undetected hormone disruption in unexplained infertility

The 28th European Congress of Endocrinology (ECE) starts tomorrow

Scientists offer new explanation for the rise in heart disease risk after menopause

A study published in Cells suggests that declining estrogen levels alter epigenetics, which may explain the rise in heart disease risk after menopause. The researchers identify a potential link between estrogen loss and changes in cardiovascular health.

World Hormone Day 2026

The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.

Testosterone level not a given sign of well-being

A higher testosterone level does not always indicate well-being in men, according to a study at the University of Gothenburg. Muscle health and inflammation are linked to testosterone levels, but symptoms like fatigue and depression have weaker connections.

How estrogen helps protect women from high blood pressure

Researchers from the University of Waterloo have identified the key factor behind estrogen's protective effects against high blood pressure, finding vasodilation to be the crucial mechanism. This discovery holds promise for more effective treatment options for women after menopause, when estrogen levels naturally decline.

Could finger length provide vital clue to understanding human brain evolution?

A study of 225 newborns found that high prenatal oestrogen levels, indicated by long index fingers, are associated with large head circumference and increased brain size in boys. This could provide evidence for the positive influence of prenatal oestrogen on human brain evolution

Female athlete health, well-being focus of updated report

A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.

The way our cells respond to oestrogen, the main female sex hormone, depends on how DNA is ‘supercoiled’

New research reveals that DNA's physical property of supercoiling is crucial for cells to respond to oestrogens. The study found that enzymes called topoisomerases regulate DNA coiling and activate target genes.

Do hormones explain why women experience more gut pain?

Estrogen activates previously unknown pathways in the colon, triggering pain and increasing sensitivity to certain foods. This explains why women are more likely to suffer from IBS and provides potential new ways to treat the condition.

Synthetic stress hormone dexamethasone could reduce breast cancer metastases

Researchers discovered that synthetic stress hormone dexamethasone can combat therapy-resistant breast cancer metastases in mice trials. The drug activates the glucocorticoid receptor, suppressing estrogen receptor production and slowing tumor growth. Further studies are needed to confirm these findings in patients with breast cancer.

European Society of Endocrinology leads global call to raise awareness of hormone health on World Hormone Day 2026

The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.

Microplastics hit male arteries hard

A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.

Teeth of babies of stressed mothers come out earlier, suggests study

Research shows that infants of stressed mothers have an earlier and faster tooth eruption, with more teeth by six months of age. Cortisol levels during late pregnancy are associated with this accelerated process.

Study sheds new light on how hormones influence decision-making and learning

A recent study published in Nature Neuroscience has made significant breakthroughs in understanding how hormones like estrogen impact brain function, particularly in learning and decision-making. The research found that estrogen boosts dopamine activity, leading to enhanced learning capabilities and a potential connection to neuropsych...

Women better protected against early neurodegeneration in Parkinson's disease

A large international study reveals that women with a precursor condition to Parkinson's disease exhibit significantly less brain atrophy compared to men. The research suggests that estrogens may play a crucial role in protecting the brain from neurodegeneration.

Breast cancer discovery could help prevent recurrence

Biologists at Cold Spring Harbor Laboratory have made a significant discovery that could lead to better patient outcomes for ER+ breast cancer patients. Inhibiting the BPTF protein in mice can slow cancer metastasis and restore tumors' susceptibility to hormone therapy, offering new hope for treating resistant forms of the disease.

New EndoCompass Research Roadmap calls for coordinated investment to tackle Europe’s hormone health challenge

The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.

A keto diet might benefit females more than males, a new UT Health San Antonio study suggests

A keto diet may have different effects on males and females, with estrogen found to promote protection against adverse effects such as cellular senescence. The study found that male mice on a keto diet showed increased markers of oxidative stress and cellular senescence, but these effects were reversed by estrogen treatment.

Vaginal estrogen tablets may be safe for postmenopausal women who have had a stroke

A new study found that using vaginal estrogen tablets was not associated with an increased risk of recurrent ischemic stroke among postmenopausal women. The study examined prescription data from over 34,000 women and discovered no increased risk of stroke in this high-risk population.

Normal hormone levels trigger severe depression in some women; researcher discovers mechanism

Dr. David Rubinow's research reveals that susceptible women respond differently to normal hormonal fluctuations, leading to breakthrough treatment approaches and FDA-approved medication for postpartum depression. His work validates the experiences of millions of women whose hormone-related mood symptoms were previously misunderstood.

Membrane-initiated estrogen receptor α (mERα) in specific cell types found crucial for bone strength

Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.

Placenta and hormone levels in the womb may have been key driver in human evolution, say researchers

A new hypothesis suggests that prenatal sex steroid hormones and placental function played a crucial role in shaping the human brain and its cognitive traits. This may have led to increased brain size and reduced competition among males, allowing for the emergence of large social groups.

New study links longer reproductive years to healthier brain aging in women

A new study suggests that women who spend more time in their reproductive phase may experience slower brain aging. Estradiol, the most potent form of estrogen during this period, may help protect the brain from age-related decline. However, further research is needed to fully understand the relationship between estradiol and brain health.

Manuel Heitor to share perspectives on the future of research in Europe at launch of EndoCompass

The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.

Neuroestrogen: The brain’s secret weapon against hunger

Researchers discovered neuroestrogen's role in regulating food intake and hunger. Neuroestrogen enhances the brain's responsiveness to leptin, a hormone that helps regulate hunger.

Interview opportunity: Women are overtaking men in the most extreme sports events

A recent study found that women are more metabolically efficient under extreme conditions, closing the performance gap with men. Women's greater fat mass may contribute to this advantage, enabling them to complete longer distances without burning out.

Can hormone therapy improve heart health in menopausal women?

A new analysis found that oral hormone therapy can lower levels of lipoprotein(a), a genetic risk factor associated with higher risk of heart attack and stroke. Hormone therapy also improved biomarkers of cardiovascular health, including cholesterol levels.

Ursolic acid modulates estrogen conversion to relieve inflammation in metabolic dysfunction-associated steatotic liver disease via HSD17B14

Researchers investigated the therapeutic mechanisms of ursolic acid on metabolic dysfunction-associated steatotic liver disease. Ursolic acid was found to reduce inflammation by modulating estrogen conversion via HSD17B14, a crucial enzyme regulating estrogen balance.

Screening history, stage at diagnosis, and mortality in screen-detected breast cancer

A cohort study found that women with screen-detected estrogen receptor–positive or human epidermal growth factor receptor 2–negative breast cancer who underwent prior screening had an earlier stage of diagnosis and lower breast cancer mortality compared to those who did not undergo prior screening.

How mothers adapt to the metabolic demands of nursing

A study published in Nature Metabolism reveals a novel mechanism connecting prolactin, estrogen, the brain, and metabolic adaptations during lactation. Hormonal changes during lactation lead to increased hunger and reduced fat-burning, which are sustained by a specific area of brain cells called ERα neurons.

Estrogen and progesterone stimulate the body to make opioids

Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.

Ovary removal increases heart failure risk

A study found that women who underwent bilateral oophorectomy were more likely to develop heart failure later in life. The researchers suggest that early menopause may be a contributing factor to this increased risk, and recommend closer cardiovascular monitoring for women contemplating the procedure.

Female sex hormone protects against opioid misuse, rat study finds

A new rat study by researchers at Washington University School of Medicine suggests that biological differences in males and females may contribute to the gender disparity in opioid misuse. Female rats with chronic pain showed no increase in opioid intake, whereas male rats increased their fentanyl consumption over time.

Does the brain produce estrogen to control appetite?

New research found that neuroestrogens produced in the brain help suppress appetite, as confirmed by experiments where aromatase expression was restored specifically in the brain. This suggests a link between neuroestrogen levels and body weight regulation.

Estrogen partially restores progesterone production and ovarian health in mice with lysosomal storage disorder

A recent study found that estrogen can partially restore progesterone levels and improve ovarian health in Mcoln1−/− mice, a model for human mucolipidosis type IV. The research also showed that hormone therapies including estrogen improved luteal cell morphology and lysosomal function.

Drug reverses groin hernias in male mice without surgery, shows promise in humans

Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.

Epigenetic aging and DNA-methylation as tumor markers for breast cancer

A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.

Preclinical study finds surges in estrogen promote binge drinking in females

A preclinical study led by Weill Cornell Medicine scientists found that estrogen surges promote binge drinking in females, causing them to 'pregame' and consume large quantities of alcohol. The study identifies a neural circuit in the brain where estrogen increases activity, leading to enhanced binge drinking behavior.

Save the date: European Society of Endocrinology (ESE) and ESE Foundation announce inaugural World Hormone Day

The European Society of Endocrinology (ESE) and ESE Foundation will host the first-ever World Hormone Day on April 24, 2025. The campaign aims to raise public awareness of good hormone health and improve national political engagement for better prevention, diagnosis, and treatment of endocrine disease.

New study finds neurobiological evidence of peripartum depression in women, distinguishing it from major depressive disorder

Researchers have identified structural grey matter differences in the brains of women with a history of peripartum depression compared to those without. The study found that hormone fluctuations during pregnancy and childbirth may be key to understanding this condition.

Hormone therapy affects the metabolic health of transgender individuals

Long-term hormone therapy in transgender individuals leads to significant changes in body composition and risk factors for cardiovascular disease. Transgender men experience increased muscle volume and abdominal fat, while women's muscle mass decreases, according to a new study published in the Journal of Internal Medicine.

Short-term menopausal hormone therapy has no long-term cognitive impact

Researchers found that short-term MHT did not cause long-term cognitive decline in women in early postmenopause. The KEEPS Continuation Study suggests that timing is crucial for the safety of MHT.

Molecular insights into differences in color and shape of male and female chicken feathers

The study reveals hormone-dependent molecular mechanisms that cause sexual dimorphism in chicken feathers, including the role of thyroid hormone activation/inactivation system. The findings also shed light on the cultural significance of chickens in Japanese society and its impact on promoting social cohesion.

How estrogen’s millisecond-fast action happens

Researchers at Baylor College of Medicine discovered estrogen's fast actions are mediated by the coupling of ER-alpha with ion channel protein Clic1, controlling chloride ion flux and enabling rapid neuronal responses. This finding sheds light on estrogen's role in regulating various physiological processes.

Hot flash drug shows significant, rapid benefits in pivotal clinical trials

A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.

Breakthrough addresses sex-related weight gain and disease

Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.

Hormone therapy for breast cancer linked with lower dementia risk

A new study published in JAMA Network Open found that hormone modulating therapy (HMT) used to treat breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias. The protective effect of HMT decreased with age, particularly for women over 80.

Scientists discover a new hormone that can build strong bones

Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.

Scientists create first mouse model with complete, functional human immune system

Researchers have developed a humanized mouse model with a fully functional human immune system, enabling the study of immunotherapy development, disease modeling, and vaccine development. The new model, called TruHuX, mounts specific antibody responses and can develop full-fledged systemic lupus autoimmunity.

Prostate cancer test is missing early disease in transgender women

A recent study published in JAMA found that transgender women on hormone therapy have drastically lower PSA levels, which may lead to delayed diagnosis and treatment of prostate cancer. The researchers analyzed Veterans Health Administration records and recommended caution when interpreting PSA values in transgender women.

Scans show brain's estrogen activity changes during menopause

A new brain imaging study led by Weill Cornell Medicine researchers found that estrogen receptors in the brain increase with age during menopause, affecting cognitive and mood symptoms. The study pioneers PET imaging as a tool to track estrogen activity in the brain, revealing potential predictors of common menopause-related issues.

Removal of ovaries before menopause associated with reduced white matter integrity in brain

Researchers found that women who had their ovaries removed before menopause experience reduced white matter integrity in multiple brain regions. This reduction may contribute to an increased risk of cognitive decline and dementia later in life.

Socioecologic factors and racial differences in breast cancer prognostic scores

Research highlights socioecologic factors contributing to racial disparities in breast cancer prognostic scores, emphasizing the impact of structural racism on health outcomes. Additional research is needed to better understand the influence of social determinants on breast cancer biology among disadvantaged communities.

Heart health declines rapidly after menopause

A study shows post-menopausal women experience a steep rise in heart problems due to reduced estrogen levels, accelerating plaque buildup and cardiovascular risk. Researchers highlight the importance of recognizing early warning signs and increasing screening for coronary artery calcium.

Noted UCLA neurologist Dr. Rhonda Voskuhl wins 2024 John Dystel Prize for multiple sclerosis research

Dr. Rhonda Voskuhl's groundbreaking research has shed light on the mechanisms underlying sex differences in MS, highlighting a gene on female sex chromosomes that promotes inflammation and brain-protective effects of estrogen. Her work may lead to new treatment approaches for MS.

For younger women, mental health now may predict heart health later

A new study suggests that anxiety and depression in younger women may accelerate the development of cardiovascular risk factors, putting them at nearly par with men of the same age. The researchers found that these mental health conditions were associated with a much higher relative risk among young women than seen in other groups.

Study suggests that estrogen may drive nicotine addiction in women

Researchers discovered a feedback loop involving estrogen that may explain why women become more dependent on nicotine. Estrogen-induced proteins called olfactomedins could be targeted with therapies to help control nicotine consumption.

New screening tool saving lives: Metamor team developing tool to catch cancer earlier

A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.