Articles tagged with Estrogen
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A study published in PLOS Medicine found that certain reproductive events, such as shorter estrogen exposure, may be associated with increased dementia risk in women. However, the association between the number of children and dementia risk was similar for women and men, suggesting social and behavioral factors may play a role.
Researchers found that female mice produce more of the FPR2 protein, which helps prevent NAFLD, and that estrogen mediates its production. This discovery highlights the need for sex-balanced animal experiments and could lead to novel treatments and gender-based therapies for NASH
Researchers at Clemson University have identified a genetic variation associated with congenital idiopathic megaesophagus (CIM) in German shepherd dogs, which is often fatal if left untreated. A genetic test using melanin-concentrating hormone receptor 2 and dog's sex can predict the risk of CIM with 75% accuracy.
A study found that arterial stiffness increases with age, but hormonal fluctuations also play a role. Women's hormone levels, particularly estradiol and follicle-stimulating hormone, were associated with stiffer arteries, while older women had stiffer vessels regardless of hormone status.
A study of over 200,500 women found an increased risk of death in younger pre-menopausal women when ovaries and fallopian tubes were removed during surgery. In contrast, the procedure is safer for older post-menopausal women, whose ovaries have already stopped producing estrogen.
A new study suggests that greater cumulative estrogen exposure in life may counter the brain-shrinking effect of menopause. Women with longer reproductive years, more children, and hormone therapy showed increased gray matter volume in certain brain areas. This protective effect may help reduce Alzheimer's risk in women.
Researchers have identified a novel estrogen compound that provides benefits similar to hormone replacement therapy but without the risk factors associated with it. The compound has been shown to reduce excess lipid deposition in the liver and prevent the progression of fibrosis, which can lead to liver failure and metabolic problems.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
A new study found that women whose menstrual cycle length increased two years before menopause had better vascular health than those with stable cycles. Changes in cycle length may predict cardiovascular disease risk, allowing clinicians to recommend preventive strategies.
Research shows that estrogen replacement during menopause reduces the risk of bone fractures, diabetes, and cancer, but increases stroke, blood clots, and breast/ovarian cancer risk. The quality of systematic reviews on MHT is mixed, with some findings inconclusive.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
Researchers at Duke University Medical Center identified a mechanism where breast cancer cells use cholesterol to develop tolerance to stress, allowing them to resist ferroptosis and proliferate. This finding highlights the importance of lowering cholesterol in preventing cancer progression and offers new approaches for treatment.
Lobular breast cancer patients often experience recurrence or metastasis despite hormonal therapies. CU Cancer Center researcher Matthew Sikora is studying the role of MDC1 in this subtype, finding it linked to estrogen receptor activity and potentially a novel target for treatment.
A new study identifies hundreds of chemicals that may increase breast cancer risk by stimulating hormone production. The chemicals include pesticides and ingredients in personal care products.
Researchers have identified stearic acid and ornithine as indicators of coronary microvascular disease (CMD), a condition that damages blood vessels and causes decreased blood flow to the heart muscle. The study suggests that estrogen may also play a role in CMD development, particularly in postmenopausal women.
A study published in JAMA found that the age at natural menopause has increased in US women over the past 60 years, with a corresponding increase in reproductive life span. The research suggests that longer reproductive life spans may be associated with better metabolic health outcomes due to prolonged estrogen exposure.
Researchers at Rensselaer Polytechnic Institute have developed a polymerized estrogen biomaterial that shows promise as a treatment for spinal cord injuries. The study found enhanced neuroprotection in preclinical mouse models with implanted polymerized estrogen, suggesting a potential therapeutic approach.
Researchers at Texas A&M University discovered that cytisine reduces dopamine neuron loss in females, providing potential evidence for treating Parkinson's disease. The protective effect of cytisinex occurred only in female animal models, and combining it with estrogen produced a stronger effect.
A new study found that estrogen deficiency during menopause leads to altered microRNA signalling in skeletal muscle, potentially activating cell death pathways and resulting in muscle wasting. The study suggests resistance training may be beneficial for maintaining muscle mass and power in middle-aged women.
A daily oral combination therapy has been found to be reliable, safe and effective for long-term treatment of uterine fibroids. The therapy, which combines relugolix with small doses of estrogen and synthetic progesterone, led to dramatic improvements in fibroid-related measures such as volume of menstrual blood loss and pain.
A new imaging test can reliably distinguish breast cancer patients who are unlikely to benefit from hormone therapy. The test measures estrogen receptor functionality, and a PET scan detects increased progesterone receptors in response to estrogen stimulation.
Researchers found that oral hormone therapy alters the metabolome of postmenopausal women, with estrogen-alone therapy providing a protective effect against cardiovascular disease. The study also identified metabolites associated with increased CHD risk in combination therapy.
Females in this primate species mature faster after a new male arrives, with some maturing earlier than expected. The researchers observed that these females were previously suppressed from maturing due to their fathers' presence.
Researchers found that some PFASs mimic estrogen's ability to activate transcription, while others inhibit expression, but block natural hormone activity when present. A computational model predicted that PFASs bind to distinct sites on the receptor surface, potentially blocking estrogen's action
A University of Cincinnati biologist found that even small concentrations of estrogen in water can lead to a gender ratio imbalance and smaller fish populations. The study used least killifish, which have live young, and found that exposure to estrogen resulted in more females than males.
Researchers found that a modified bentonite complex can remove 17α-ethinylestradiol and other pharmaceutical organic micropollutants from wastewater environments. The study demonstrates an effective and cost-efficient method for removing synthetic estrogen from bodies of water.
Researchers found that estrogen receptor beta is essential for female skeletal muscle growth and regeneration, promoting muscle stem cell proliferation and inhibiting cell death. In contrast, male mice lacking the ERβ gene did not show impaired muscle regenerative capacity, suggesting a gender-specific mechanism.
Fetal estrogens, such as estetrol and estriol, show promising characteristics in reducing hot flashes and improving cardiovascular health. They may also provide added benefits that have yet to be fully explored, making them a promising new approach to hormone therapy.
A Northwestern University study has identified the specific regions of brain tissue where a key gene named aromatase regulates male sexual behavior in mice. Aromatase converts testosterone to estrogen, driving male sexual activity. The discovery could lead to new treatments for disorders of low and compulsive sexual desire.
When brain oxygen is low, neurons produce estrogen that activates astrocytes to increase cell signaling, release neuroprotective factors, and clear neurotoxins. Astrocyte activation is critical for brain protection, and researchers have found that neuron-derived estrogen is essential for this process.
A PET brain imaging study found that low aromatase levels in the amygdala are associated with higher BMI and lower self-control. The results suggest a novel method for characterizing estrogen's role in obesity and impairments in self-regulation.
A PET imaging study found that low aromatase enzyme activity in the brain's amygdala is associated with higher BMI and lower self-control. Estrogen production in the amygdala may regulate feeding behavior, influencing BMI.
A review of preclinical data suggests estrogen lowers ACE2 levels, which may explain why women experience milder symptoms. Higher ACE2 levels in men could account for worse outcomes.
A study by Tufts University researchers found that estrogen can have a disruptive effect on glucose metabolism in females, but not males, when a specific protein is absent. The study identified a key protein in the brain that mediates these effects and provides insight into the differences between men and women in their risk of diabetes.
A large study of middle-aged women found that physical activity helps slow the decline in muscle mass during menopausal transition. The research, conducted by the University of Jyväskylä, measured muscle size in perimenopausal and postmenopausal states.
A recent study published in the Journal of Neuroscience found that high estrogen levels may increase feelings of reward in response to alcohol in female mice. The research suggests that treatment for alcohol use disorder may be more effective if sex differences are considered.
Research suggests fluctuating estrogen levels make alcohol more rewarding to female mice, potentially increasing susceptibility to alcohol use disorders. Activating estrogen receptors increases dopamine release and binge drinking behavior in female mice.
Research suggests that low levels of sex hormone-binding globulin (SHBG) may be associated with an increased risk of ischemic stroke in postmenopausal women. The study, which examined data from over 13,000 women, found that those with the lowest SHBG levels were 51% more likely to have had a stroke.
A study found that individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies. However, a small molecule inhibitor increased the response of individual alleles to hormone, establishing a previously unrecognized mode of regulation at the single cell level.
A new study has found that spaying dogs reduces their risk of developing mammary tumors, but may increase the risk of more aggressive cancers. Higher serum estrogen levels in spayed animals with mammary tumors were associated with longer times to metastasis and improved survival times.
Researchers at Rensselaer Polytechnic Institute have developed a biomaterial that polymerizes estrogen to protect and potentially regenerate nervous system cells damaged by spinal cord injuries. The slow-releasing biomaterial targets injured tissue, reducing further damage and promoting regeneration.
Researchers have discovered that zearalenone, a widespread food estrogen, can pass through the placenta and affect fetal development. The study found that even low concentrations of zearalenone can have a significant impact on the unborn child's hormonal balance.
A single cholesterol-derived molecule, 27-hydroxycholesterol (27HC), has been found to increase body fat even without a high-fat diet. The molecule affects white adipose tissue and expands the capacity of existing fat cells.
Research published in JNeurosci suggests that estrogen may protect movement neurons from Parkinson's disease, with brain-selective estrogen treatment reducing alpha-synuclein breakdown and severe symptoms in male mice. Female mice also showed less severe symptoms at a later age, indicating potential benefits of estrogen-based treatments.
Researchers at UMN Medical School found that estrogen deficiency leads to a 30-60% drop in muscle stem cells and severe difficulty reproducing new muscle after injury. Estrogen replacement therapy may help maintain muscle health, but risks cancer due to its effects on tissues.
A study found that women's immune response to the flu vaccine is stronger than men's, but declines with age, especially in women. Researchers discovered that estrogen levels boost female immunity, while testosterone has a weaker effect on male responses.
Researchers at MUSC found that older men with scleroderma have higher estrogen levels than postmenopausal women, which is linked to more severe disease and heart involvement. This discovery provides evidence for the role of estrogen in scleroderma and may lead to new therapeutic approaches.
Researchers discovered subtle changes in female hearts during perimenopause, indicating stress at this early stage. Estrogen-mimicking drugs can still be beneficial for protecting hearts, but timing is crucial to maximize effectiveness.
A large observational study found that oral contraceptives were most protective in young women aged 15-19 years, reducing the risk of reconstructive surgery by 63%. The study suggests that taking oral contraceptives may suppress hormonal surges during the menstrual cycle, leading to a lower rate of injury.
Researchers have discovered a correlation between estrogen byproducts and survival rates for women with breast cancer, with higher levels of the "good" metabolite associated with reduced mortality. The study suggests that measuring these byproducts may help predict prognosis after breast cancer diagnosis.
Researchers found a connection between estrogen and protein Sema3A in maintaining bone health. As women lose estrogen with age, Sema3A levels drop, leading to osteocytes dying and bones losing support structure.
Researchers found that estrogen affects astrocytes, which produce growth factors promoting brain metastasis. Anti-estrogen therapy may prevent brain metastasis in women with triple-negative breast cancer.
Neurons in both males and females produce estrogen, which is essential for synaptic plasticity and memory. Research shows that mice lacking estrogen have impaired spatial reference memory and recognition memory.
A Texas A&M-led study reveals that estrogen can decrease insulin resistance and glucose production, reducing Type 2 diabetes incidences. The study highlights the importance of estrogen receptor signaling and Foxo1-mediated gluconeogenesis in regulating glucose homeostasis.
A Rutgers study found that hormone concentrations in early fetal development are significantly affected by maternal age, body mass index, and race. Older mothers, heavier women, and those of African descent had distinct hormone profiles, with potential implications for future health risks such as breast and ovarian cancer.
Researcher Jenny Robinson studies estrogen's potential to protect menisci and regenerate damaged tissue, aiming to develop targeted therapies. The goal is to create an off-the-shelf material that could be implanted into the knee to promote repair and inhibit further degeneration.
Researchers found that aromatase inhibitors suppress estrogen synthesis, but paradoxically increase estrogen levels in the brain, leading to memory and thermal regulation deficits. The study calls for new therapies to prevent breast cancer recurrence while minimizing side effects.
Researchers found that female mice with Alzheimer's-like pathology spent more time in stages with high estrogen levels than control mice, associated with impaired learning and memory. Beta-amyloid production also increased during these stages, highlighting the importance of female biology in nervous system disorders.
A study published in Proceedings of the National Academy of Sciences found that age-related increases in estrogen levels can weaken abdominal walls and cause inguinal hernias. The researchers discovered that a hormone inhibitor could strengthen muscles and prevent hernias, offering potential treatment for at-risk patients.
Research suggests that women's reproductive health, hormones, and mental health play a crucial role in maintaining telomere length and slowing the aging process. Dr. Elissa Epel's presentation highlights the importance of estrogen's protective effects on telomeres and heart disease.