Articles tagged with Estrogen
Research published in JNeurosci suggests that estrogen may protect movement neurons from Parkinson's disease, with brain-selective estrogen treatment reducing alpha-synuclein breakdown and severe symptoms in male mice. Female mice also showed less severe symptoms at a later age, indicating potential benefits of estrogen-based treatments.
Researchers at UMN Medical School found that estrogen deficiency leads to a 30-60% drop in muscle stem cells and severe difficulty reproducing new muscle after injury. Estrogen replacement therapy may help maintain muscle health, but risks cancer due to its effects on tissues.
A study found that women's immune response to the flu vaccine is stronger than men's, but declines with age, especially in women. Researchers discovered that estrogen levels boost female immunity, while testosterone has a weaker effect on male responses.
Researchers at MUSC found that older men with scleroderma have higher estrogen levels than postmenopausal women, which is linked to more severe disease and heart involvement. This discovery provides evidence for the role of estrogen in scleroderma and may lead to new therapeutic approaches.
Researchers discovered subtle changes in female hearts during perimenopause, indicating stress at this early stage. Estrogen-mimicking drugs can still be beneficial for protecting hearts, but timing is crucial to maximize effectiveness.
A large observational study found that oral contraceptives were most protective in young women aged 15-19 years, reducing the risk of reconstructive surgery by 63%. The study suggests that taking oral contraceptives may suppress hormonal surges during the menstrual cycle, leading to a lower rate of injury.
Researchers have discovered a correlation between estrogen byproducts and survival rates for women with breast cancer, with higher levels of the "good" metabolite associated with reduced mortality. The study suggests that measuring these byproducts may help predict prognosis after breast cancer diagnosis.
Researchers found a connection between estrogen and protein Sema3A in maintaining bone health. As women lose estrogen with age, Sema3A levels drop, leading to osteocytes dying and bones losing support structure.
Researchers found that estrogen affects astrocytes, which produce growth factors promoting brain metastasis. Anti-estrogen therapy may prevent brain metastasis in women with triple-negative breast cancer.
Neurons in both males and females produce estrogen, which is essential for synaptic plasticity and memory. Research shows that mice lacking estrogen have impaired spatial reference memory and recognition memory.
A Texas A&M-led study reveals that estrogen can decrease insulin resistance and glucose production, reducing Type 2 diabetes incidences. The study highlights the importance of estrogen receptor signaling and Foxo1-mediated gluconeogenesis in regulating glucose homeostasis.
A Rutgers study found that hormone concentrations in early fetal development are significantly affected by maternal age, body mass index, and race. Older mothers, heavier women, and those of African descent had distinct hormone profiles, with potential implications for future health risks such as breast and ovarian cancer.
Researcher Jenny Robinson studies estrogen's potential to protect menisci and regenerate damaged tissue, aiming to develop targeted therapies. The goal is to create an off-the-shelf material that could be implanted into the knee to promote repair and inhibit further degeneration.
Researchers found that aromatase inhibitors suppress estrogen synthesis, but paradoxically increase estrogen levels in the brain, leading to memory and thermal regulation deficits. The study calls for new therapies to prevent breast cancer recurrence while minimizing side effects.
Researchers found that female mice with Alzheimer's-like pathology spent more time in stages with high estrogen levels than control mice, associated with impaired learning and memory. Beta-amyloid production also increased during these stages, highlighting the importance of female biology in nervous system disorders.
A study published in Proceedings of the National Academy of Sciences found that age-related increases in estrogen levels can weaken abdominal walls and cause inguinal hernias. The researchers discovered that a hormone inhibitor could strengthen muscles and prevent hernias, offering potential treatment for at-risk patients.
Research suggests that women's reproductive health, hormones, and mental health play a crucial role in maintaining telomere length and slowing the aging process. Dr. Elissa Epel's presentation highlights the importance of estrogen's protective effects on telomeres and heart disease.
A new study found that exercise minimizes changes in muscle mass, bone density, and belly fat when estrogen levels drop, but does not protect against metabolic changes. Researchers discovered that while exercise reduces the risk of osteoporosis, it does not affect resting metabolic rate or energy balance in women with menopause.
A new study suggests that low estrogen levels during menopause may contribute to increased anxiety and minor memory problems. The research, conducted on female rats without ovaries, found a link between estrogen deficiency and anxiety-like behavior.
A study published in Frontiers in Molecular Biosciences suggests that sex hormones, particularly estrogen, play a key role in migraine occurrence in women. The research found that estrogen levels sensitize cells around the trigeminal nerve to stimuli, making it easier to trigger a migraine attack.
Experimental studies reveal a strong interplay between liganded and non-liganded transcriptional activations of ERs. Natural estrogens can restore DNA surveillance in tumor cells via harmonized transactivation of AF1 and AF2 domains.
Researchers found that estrogen receptor modulators increase the effectiveness of HIV latency reversal therapies. Exposure to estrogen limits the emergence of HIV from latency, suggesting a potential factor in future eradication therapies.
A new study found increased levels of estrogen in men with migraine, as well as symptoms of lower testosterone. Testosterone levels did increase before a migraine in some participants, and symptoms of relative testosterone deficiency were more frequent and severe in men with migraine.
Researchers found that estrogen therapy changes microbial composition and activity in the gut, affecting how estrogens are metabolized. Probiotics may be used to manipulate the gut biome to improve estrogen-replacement therapy's benefits without increasing cancer risks.
Research reveals estrogen receptor alpha influences T cell activation, proliferation and survival in autoimmune diseases, including MS, RA, and SLE. Regulatory T cells play a crucial role in preventing autoimmune diseases, and the study identifies potential targets for novel treatments.
Researchers from INRS published a study demonstrating the potential effects of neonicotinoids on human health by disrupting hormonal systems. The study found an increase in aromatase expression and changes in its pattern similar to those observed in certain breast cancers.
Researchers are investigating the impact of antioxidant vitamins C and E, alpha lipoic acid, resveratrol, and Sirt1 on blood vessel health in premenopausal women with type 1 diabetes. Early evidence suggests that treatment may restore protection against cardiovascular disease.
A six-year study of 24 transgender men treated with testosterone therapy found no rise in estrogen levels and a later stabilization within normal ranges. The results support the safety of testosterone therapy for transgender men without additional risks to female reproductive tissues.
A new study published by The Endocrine Society found that estrogen replacement therapy can improve drive for thinness, body dissatisfaction, and uncontrolled eating in female athletes with exercise-induced menstrual irregularities. Female athletes with irregular periods reported more disordered eating behavior than those with regular p...
Researchers found that estrogens from treated wastewater persist in vernal pools for weeks, transforming into more potent compounds and impacting sensitive aquatic habitats. The study suggests inadequate water treatment practices may be contributing to this issue.
Research found that women with estrogen receptor-negative breast cancer had an increased risk of preterm birth and low birth weight compared to those with other types. The study also showed a lower birth rate among breast cancer survivors, with only about 8% having children by 10 years after diagnosis.
Researchers discovered that a hormone therapy combination of conjugated estrogens and bazedoxifene improves metabolism, prevents weight gain, and reduces inflammation in the liver. The treatment also showed no increased risk of reproductive cancer.
Researchers at University of Wisconsin-Madison discover estrogen produced in brain is necessary for ovulation in monkeys, potentially revealing cause of infertility problems and pointing to new methods of birth control. The discovery challenges traditional understanding of hormonal cascade leading to egg release from ovaries.
The USPSTF has updated its recommendation statement on the use of hormone therapy in postmenopausal women, citing uncertain evidence on whether menopause increases the risk of chronic conditions. The organization recommends against combined estrogen and progestin hormone therapy or estrogen alone for primary prevention.
Researchers discovered a novel mechanism of estrogen action on heart physiology, revealing that xenoestrogens can influence cardiac function by regulating thyroid hormone production. This study highlights the potential risks of environmental estrogens on human health.
Chronic preconception exposure to genistein affected pregnancy rates in mice, resulting in prolonged labor, smaller litters, and higher pup mortality. The study found that high doses of genistein may boost fertility rates but also have adverse effects on reproductive outcomes.
Researchers found that neurons in the brain's 'reward center' fired more rapidly in response to alcohol when estrogen levels were high. This increased sensitivity may play a role in the development of addiction in women, particularly during certain stages of their menstrual cycle.
A new study confirms vaginal estrogen is effective in managing sexual and urinary problems of menopause without increasing risk of serious health issues like heart disease and cancer. The WHI data review also clears the use of vaginal estrogen for genitourinary syndrome of menopause.
Researchers found that menopause triggers metabolic changes in the brain, increasing the risk of Alzheimer's disease. The study used PET imaging to measure glucose metabolism in the brains of 43 healthy women aged 40-60, revealing lower levels of glucose metabolism in post-menopausal women.
Clomid's development and impact on assisted reproduction are celebrated in a new paper at Brown University. The drug has helped millions of people conceive, making it one of the globe's essential medicines.
Research by American University neuroscience Professor Colin Saldanha shows that estrogen synthesis in the brains of zebra finches can fight off neuroinflammation caused by infection. This finding reveals clues about the interplay between the body's neuroendocrine and immune systems.
Research reveals that estrogen hormones regulate gene expression through a multi-step process involving sequential recruitment of coactivators. The study, published in Molecular Cell, shows that the addition of specific coactivator CARM1 guides subsequent steps leading to gene activation.
A comprehensive review highlights the importance of lifestyle modifications and emerging approaches to manage menopausal symptoms after breast cancer. Non-pharmacologic therapies and several promising emerging agents show promise for symptom relief with reduced breast cancer risk.
A study from Hiroshima University found that the brain's estrogen levels are directly linked to DHA intake, which can prevent seizures. The research suggests that dietary sources of DHA may contribute to brain health and could lead to the development of new epilepsy treatments.
A new study by Penn State researchers finds that injecting manure into crop fields instead of spreading it on the surface significantly reduces estrogen loads in surface runoff. The method also showed reduced transport rates of total dissolved phosphorus and dissolved organic carbon.
A new study published in Menopause found that vaginal estrogen therapy does not increase the risk of cardiovascular disease, cancer, or other health issues in post-menopausal women. The research suggests that vaginal estrogen is a safe treatment for genitourinary symptoms associated with menopause.
Researchers at UCLA found that estrogen therapy's dose, not delivery method, affects risk and benefit for postmenopausal women. Higher doses of conjugated equine estrogen are associated with greater risk of heart disease and certain cancers, especially in obese women.
Researchers have discovered that adding estrogen to brain regions helps regulate weight and glucose levels in rats with induced menopause. The finding suggests that the medial amygdala is crucial for metabolic health, making it a potential target for treatment.
A new study from Uppsala University found that tea consumption in women leads to epigenetic changes in genes related to cancer and estrogen metabolism. However, coffee consumption was not associated with such changes.
Research reveals that fluctuations in estrogen can trigger atypical functioning in a key brain memory circuit in women with a common version of the gene, NIMH scientists have discovered. This finding may help explain individual differences in menstrual cycle and reproductive-related mental disorders linked to fluctuations in the hormone.
A study has identified hormones as the cause of inguinal hernias in older men, finding that increased estrogen action and decreased testosterone levels lead to muscle tissue weakness and scarring. The researchers propose using aromatase inhibitors as a potential treatment to prevent recurrence or even surgery.
Exposure to BPS multiplies breast cancer cells, exhibiting estrogen-mimicking behavior, and may cause breast cancer to become more aggressive. The study confirms BPS as a potent endocrine disruptor.
A new organ culture system developed by Tufts University researchers enables tests of BPA's direct effects on developing fetal mouse mammary tissue. BPA significantly increased tissue growth at environmentally relevant doses, while higher levels inhibited growth.
New research from Emory University School of Medicine found that estrogen modulates gene activity to protect against post-traumatic stress disorder (PTSD). Women with low estrogen levels during certain stages of their menstrual cycle may be more susceptible to PTSD, while high estrogen levels offer protection.
Researchers found that estrogen intensifies the brain's dopamine reward pathway, leading to increased pleasurable effects of cocaine. The study suggests using birth control pills or similar strategies to adjust the hormonal cycle as a possible addiction intervention.
A complex of genes regulating epigenetic mechanisms is linked to premenstrual dysphoric disorder (PMDD), a condition affecting 2-5% of women of reproductive age. Dysregulated expression of these genes suggests abnormal cellular response to sex hormones, which may hold hope for improved treatment.
Researchers at Scripps Florida Institute developed a novel approach for identifying how chemicals in the environment can produce infertility and promote breast cancer. The new method uses high-resolution imaging techniques to visualize the effects of estrogenic chemicals on cells.
Researchers found that women who had their last pregnancy at 35 or older scored higher on verbal memory and executive function tests. The study suggests that hormonal changes during menopause can have a positive impact on cognitive function if they occur later in life.
A study by University of Illinois researchers found that isoliquiritigenin, a licorice compound, disrupts steroid sex hormone production in the mouse ovary. This can lead to problems with reproduction and potentially impact fertility, estrogen levels for healthy brains and bones, and cardiovascular health.
Researchers found higher levels of estrogen in lung tissue of postmenopausal women with synchronous multiple lung adenocarcinoma (SMLA) compared to those with single tumor lung adenocarcinoma. The study suggests an association between estrogen and SMLA, potentially leading to gene therapy development.