Articles tagged with Estrogen
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Researchers used X-ray crystallography to visualize how brominated flame retardants bind to proteins like estrogens, potentially disrupting the body's natural hormones. The study sheds light on the effects of flame retardants on human health and provides insights for developing safer alternatives.
A Yale University study reveals that nearly 50,000 unnecessary deaths among women aged 50-69 with hysterectomies could have been avoided if they used estrogen-only therapy instead of combined hormone therapy. The decline in estrogen usage was linked to the 2002 WHI study's findings on women with a uterus, but not those without one.
Researchers identified a young woman with an estrogen receptor-α mutation that blocks the hormone's action, resulting in high estrogen levels and reproductive issues. The study found that the woman had significantly elevated estrogen levels compared to normal ranges, despite having no effect from estrogen.
Researchers at University at Buffalo found that estrogen protects female stress resilience, but damages male working memory. The study, published in Molecular Psychiatry, suggests that estrogen hormone produced in the brain may be responsible for this difference.
A new study by University of Illinois Chicago researcher Gail Prins found that early exposure to BPA in the developing prostate increases the risk of later prostate cancer. Prostate stem cells become sensitized to estrogen through BPA exposure, making them more susceptible to cancer development.
A new study finds that estrogen replacement therapy decreases anxiety symptoms in girls with anorexia nervosa, which may help prevent relapse. The treatment also appears to prevent worsening attitudes toward body image and food.
A global survey found that treatment with vaginal estrogen improved sex lives for postmenopausal women, reducing pain and increasing satisfaction. The study also showed a positive impact on self-esteem and relationships.
Researchers at UC Irvine have discovered a new mechanism by which estrogen suppresses lipid synthesis in the liver, revealing potential new approaches for treating certain liver diseases. The study found that estrogen acts on cell membrane-based receptors to inhibit lipid synthesis, changing long-held views in the field.
Researchers found that estrogen and interleukin-6 collude to cause immune cell misconduct and fuel autoimmune liver damage. Female mice with intact ovaries developed worse liver damage than those without ovaries, suggesting a key role for estrogen in the condition.
Researchers at UC Santa Barbara have found two hormonal signals that predict sexual motivation in young women. Estrogen levels surge two days before the increase in sexual desire, while progesterone levels drop during the luteal phase, leading to a decrease in sexual motivation.
A study published in the Journal of the National Cancer Institute found that estrogen plus progestin use is associated with an increased risk of breast cancer incidence. However, survival after diagnosis did not differ between users and non-users, suggesting higher mortality rates among hormone therapy users.
A study by University of Texas Medical Branch at Galveston researchers found that combining low doses of multiple xenoestrogens can have a dramatically greater effect on hormone signaling than any one compound alone. The combination of bisphenol A, bisphenol S and nonylphenol was found to gang up on estradiol and thwart its response.
Women who undergo surgical menopause experience a two-fold increase in cognitive decline and dementia due to premature estrogen loss. Research suggests that this leads to increased sensitivity to stressors and abnormal protein production, which can contribute to Alzheimer's disease. Follow-up studies are needed to confirm the findings.
Research reveals that estrogen deficiency after menopause leads to increased fat storage in the abdomen, associated with a higher risk of health issues. Post-menopausal women experience changes in cellular processes, leading to more fat being stored overall, which can be a target for future medical advances.
Researchers from Scripps Research Institute have identified a class of compounds that can modify cell signaling activity, including anti-inflammatory effects, which could lead to innovative treatments for breast cancer. The study focuses on compounds interacting with the estrogen receptor-α, a key target in breast cancer treatment.
Post-menopausal women who received estrogen-only medication reported significantly lower joint pain frequencies compared to those receiving a placebo. The study found modest but sustained relief from joint pain in these women.
Researchers found that estrogen alone significantly reduced joint pain in women who had undergone a hysterectomy, with 74% of those taking estrogen experiencing no pain after three years compared to 80% of those taking a placebo. The Women's Health Initiative trial showed modest but significant differences between the two groups.
High estrogen levels during IVF pregnancy increase the risk of small birth weight and preeclampsia. Freezing embryos for later transfer when hormone levels were lower reduced the incidence of these complications in a small study.
A recent analysis of almost 150 BPA studies shows that human exposure levels are likely too low for estrogenic effects. The study found that blood concentrations of BPA are many times lower than those causing toxicity in animals, suggesting that animal studies may not accurately reflect the human BPA experience.
A study of 20 cohort studies found that high fruit and vegetable intake was associated with a lower risk of estrogen receptor-negative (ER-) breast cancer. The results suggest that increasing vegetable consumption may help lower ER- breast cancer risk, which accounts for only 15-20% of breast cancers.
Researchers found higher uropathogenic E. coli reservoirs in post-menopausal women's bladders compared to pre-menopause, which can lead to UTIs. Estrogen supplementation reduced these reservoirs dramatically, highlighting a potential new approach to prevent or treat UTIs in this population.
Researchers found that estrogen levels can affect infection susceptibility, bladder health and the inflammatory response to infection in mice with simulated menopause. Boosting estrogen levels may get a second look as an approach for reducing urinary tract infections in menopausal women.
A recent study by University of Texas Medical Branch researchers found that BPA substitute BPS disrupts cellular responses to estrogen, changing patterns of cell growth and death and hormone release. The study showed that low levels of BPS exposure can have similar effects as BPA, posing a concern for human health.
A new hormone therapy combining conventional estrogen with a bone-protective SERM-like drug has shown promise in reducing menopausal symptoms and osteoporosis risk without increasing breast cancer risk. The treatment approach, termed TSEC, was tested in postmenopausal nonhuman primates over a 20-month period.
A team of researchers has identified KNDy neurons as a likely control switch of hot flushes, suggesting that hormonal changes in menopause trigger vasodilation and increased body temperature. The discovery provides a crucial step towards developing more effective treatments for hot flushes.
Researchers at Indiana University found a way to combine two hormones into a single molecule, producing more effective weight loss with fewer side effects. The hormone combination targets the hypothalamus and pancreas, reducing the risk of cancer and stroke.
Researchers have engineered natural gut peptides to carry small steroids, improving insulin secretion, blood glucose, and body weight in mice. The study's findings suggest a potential breakthrough in treating type 2 diabetes and metabolic syndrome, with minimal risk of estrogen-related side effects.
The US Preventive Services Task Force recommends against the use of estrogen and progestin for chronic disease prevention in postmenopausal women. Hormone replacement therapies may reduce fracture risk but increase risk for stroke, thromboembolic events, and urinary incontinence. The recommendations aim to balance benefits with risks.
A study led by Kaiser Permanente found that drospirenone-containing birth control pills increase the risk of arterial thrombotic events and venous thromboembolic events. The study suggests that these drugs should be used cautiously for women seeking hormonal contraception, with alternatives available to minimize risks.
Researchers at UC San Diego School of Medicine found that BPA's metabolite MBP interacts more strongly with estrogen receptors than BPA itself, posing a greater health threat. This discovery could lead to the development of new drugs targeting excessive estrogen activity linked to diseases.
Researchers at UC Davis discovered that early-life diet and metabolic changes can stimulate breast growth and increase the risk of breast cancer, independent of estrogen levels. The study used mice with a diet supplemented with CLA to mimic metabolic syndrome, which was found to increase mammary duct growth and tumor formation.
The European Menopause and Andropause Society published a clinical guide on low-dose vaginal estrogens for postmenopausal vaginal atrophy, finding them effective in managing symptoms. The guide recommends annual review due to the chronic nature of vaginal atrophy.
Researchers found that maternal exposure to high-fat diets and excess estrogens during pregnancy increases breast cancer risk in daughters, granddaughters, and even great-granddaughters. The study suggests that biological alterations caused by maternal diet affect the offspring's breast tissue and make it more sensitive to carcinogens.
Researchers identified 12 genetic markers associated with sex hormone-binding globulin (SHBG) levels, which regulate testosterone and estrogen in the bloodstream. The study found that SHBG levels are influenced by multiple factors, including genes related to liver function, metabolism, and type 2 diabetes.
A new study found that long-term treatment with estrogen and MPA increased levels of a protein marker for synapses in the prefrontal cortex of aged rats. This contradicts previous research on human hormone therapy, which linked hormone replacement to an increased risk of stroke and dementia.
A study using pregnant mice found that BPA exposure changes the way genes respond to estrogen in adulthood, potentially explaining increased incidence of estrogen-related disorders. This can lead to conditions like uterine fibroids and endometriosis.
Research reveals that environmental estrogens, such as BPA and genistein, activate estrogen receptors in the heart valves of zebrafish embryos. This finding suggests that these compounds may have a critical role in early developmental stages, potentially leading to deleterious effects.
Researchers found that estrogens convert from one form to another in anoxic conditions, stalling biodegradation and complicating detection. The study reveals a reverse transformation process, where estrone reverts to alpha- and beta-estradiols, inhibiting further degradation.
The American College of Physicians Task Force recommends updating hormone therapy guidelines due to significant adverse events. Exercise and vitamin D supplementation are effective at reducing falls, but multifactorial risk assessment is not recommended for all elderly patients.
A possible link between benzophenone sunscreens and endometriosis has been identified by researchers. High levels of 2,4OH-BP were associated with an increased risk of endometriosis diagnosis in a study of 625 women.
Researchers discovered a molecule called KLF15 that controls estradiol's actions by inhibiting DNA synthesis. This finding raises the possibility of preventing or treating endometrial and breast cancer with KLF15.
Research suggests that brief prenatal exposure to plant estrogens may affect a woman's fertility as an adult. Exposure to estrogenic chemicals in the womb or during childhood has been shown to alter immune response genes and compromise oviduct support for preimplantation embryo development, leading to infertility.
A study led by Dr. Joshua Gatson reveals that estrone, an estrogen hormone, promotes brain-derived neurotrophic factor (BDNF) which supports cell survival after traumatic brain injury. The findings indicate a fresh avenue for future research on protective capabilities of estrogen hormones.
Scientists at Fox Chase Cancer Center discovered a link between estrogen and tobacco smoke, suggesting that new therapies targeting estrogen metabolism may help prevent or treat lung cancer. Estrogen metabolites increase in the lungs of mice exposed to tobacco smoke, promoting cell growth and damage.
A new study by Georgetown Lombardi Comprehensive Cancer Center finds that using a c-Src inhibitor like PP2 in combination with estrogen may cancel out the benefits of estrogen therapy. Instead, a c-Src inhibitor alone may offer an alternative treatment option for breast cancer patients whose tumors no longer respond to tamoxifen or aro...
Researchers at Fox Chase Cancer Center have identified two proteins that could restore treatment sensitivity to hormone-resistant breast cancer cells. These proteins may help develop a new therapy combining estrogen and interferon-alpha, offering more treatment options for patients with resistant disease.
A new study suggests that estrogen reduces the activity of a protective lipid pathway, leading to slower wound healing in women. The research provides new clues for treating inflammatory diseases such as dry eye disease and scleroderma.
Researchers at the University of Cincinnati found evidence that BPA can alter the structure of the uterus, leading to increased susceptibility to pyometra, a potentially deadly infection. In animal models, exposure to BPA induced immune cell numbers in the uteri, which were five-fold higher than control animals.
A recent study published in the Journal of The National Cancer Institute suggests that estrogen alone may reduce breast cancer risk, whereas estrogen plus progestin can increase it. The findings are based on data from two randomized clinical trials conducted as part of the Women's Health Initiative.
A recent review of large prospective cohort studies and WHI trials found that estrogen plus progestin increases breast cancer risk, while estrogen alone decreases risk in women with a previous hysterectomy. The study proposes that mammography screening differences may explain the observed effects.
A new study published in The Lancet Oncology found that estrogen-only form of menopausal hormone therapy continues to protect women from breast cancer, with a 23% reduced incidence and 63% lower mortality rate compared to placebo. The research followed over 7,500 women for nearly 12 years.
A study found that boosting male garter snake estrogen levels causes them to secrete the same pheromones as females, attracting multiple males. The research confirms estrogen's powerful role in biology and has implications for environmental impact.
A new NIH study found that moderate caffeine intake is associated with higher estrogen levels in Asian women and lower estrogen levels in white women. Caffeine consumption from caffeinated soda or green tea also linked to elevated estrogen levels in all ethnic groups, but without affecting ovulation.
Research suggests that estrogen can improve mood in women, particularly during the premenstrual phase. Studies have shown a significant increase in activity in brain areas related to emotional processing premenstrually, and estrogen has been linked to reduced symptoms of depression and anxiety in postmenopausal women.
Mice genetically engineered to lack Foxa genes show reversed gender-related incidence of liver cancer, highlighting the protective role of estrogens against liver cancer. The study suggests that genetic markers called SNPs within Foxa binding sites may contribute to increased liver cancer risk in women.
Research in songbirds reveals glial cells and synapses can produce estrogen, a hormone linked to neurodegenerative diseases. This discovery could provide new insights into the prevention and treatment of conditions like Alzheimer's and Parkinson's.
A recent study found that women taking combination estrogen and progestin menopausal hormone therapy are at a greater risk of developing breast cancer if they experience new onset breast tenderness. In contrast, women on estrogen alone without breast tenderness did not have an increased risk of breast cancer.
Researchers at USC's Keck School of Medicine discovered how estrogen activates genes in breast-cancer cells through a protein called TIP60, which recognizes methylation signals in chromatin. This finding builds upon previous work and has broader implications for gene regulation and potentially global significance.
A UT Southwestern study found that estrogen acts on two hypothalamic neural centers to regulate hunger and energy expenditure in female mice, keeping their body weight in check. This discovery has potential implications for postmenopausal women, who may benefit from targeted hormonal replacement therapies.
Researchers have identified estrogen receptors in specific brain areas that influence metabolism, weight gain, and fertility. Deleting these receptors from mice resulted in significant weight gain and metabolic changes.