Articles tagged with Estrogen
Scientists at Fox Chase Cancer Center discovered a link between estrogen and tobacco smoke, suggesting that new therapies targeting estrogen metabolism may help prevent or treat lung cancer. Estrogen metabolites increase in the lungs of mice exposed to tobacco smoke, promoting cell growth and damage.
A new study by Georgetown Lombardi Comprehensive Cancer Center finds that using a c-Src inhibitor like PP2 in combination with estrogen may cancel out the benefits of estrogen therapy. Instead, a c-Src inhibitor alone may offer an alternative treatment option for breast cancer patients whose tumors no longer respond to tamoxifen or aro...
Researchers at Fox Chase Cancer Center have identified two proteins that could restore treatment sensitivity to hormone-resistant breast cancer cells. These proteins may help develop a new therapy combining estrogen and interferon-alpha, offering more treatment options for patients with resistant disease.
A new study suggests that estrogen reduces the activity of a protective lipid pathway, leading to slower wound healing in women. The research provides new clues for treating inflammatory diseases such as dry eye disease and scleroderma.
Researchers at the University of Cincinnati found evidence that BPA can alter the structure of the uterus, leading to increased susceptibility to pyometra, a potentially deadly infection. In animal models, exposure to BPA induced immune cell numbers in the uteri, which were five-fold higher than control animals.
A recent study published in the Journal of The National Cancer Institute suggests that estrogen alone may reduce breast cancer risk, whereas estrogen plus progestin can increase it. The findings are based on data from two randomized clinical trials conducted as part of the Women's Health Initiative.
A recent review of large prospective cohort studies and WHI trials found that estrogen plus progestin increases breast cancer risk, while estrogen alone decreases risk in women with a previous hysterectomy. The study proposes that mammography screening differences may explain the observed effects.
A new study published in The Lancet Oncology found that estrogen-only form of menopausal hormone therapy continues to protect women from breast cancer, with a 23% reduced incidence and 63% lower mortality rate compared to placebo. The research followed over 7,500 women for nearly 12 years.
A study found that boosting male garter snake estrogen levels causes them to secrete the same pheromones as females, attracting multiple males. The research confirms estrogen's powerful role in biology and has implications for environmental impact.
A new NIH study found that moderate caffeine intake is associated with higher estrogen levels in Asian women and lower estrogen levels in white women. Caffeine consumption from caffeinated soda or green tea also linked to elevated estrogen levels in all ethnic groups, but without affecting ovulation.
Research suggests that estrogen can improve mood in women, particularly during the premenstrual phase. Studies have shown a significant increase in activity in brain areas related to emotional processing premenstrually, and estrogen has been linked to reduced symptoms of depression and anxiety in postmenopausal women.
Mice genetically engineered to lack Foxa genes show reversed gender-related incidence of liver cancer, highlighting the protective role of estrogens against liver cancer. The study suggests that genetic markers called SNPs within Foxa binding sites may contribute to increased liver cancer risk in women.
Research in songbirds reveals glial cells and synapses can produce estrogen, a hormone linked to neurodegenerative diseases. This discovery could provide new insights into the prevention and treatment of conditions like Alzheimer's and Parkinson's.
A recent study found that women taking combination estrogen and progestin menopausal hormone therapy are at a greater risk of developing breast cancer if they experience new onset breast tenderness. In contrast, women on estrogen alone without breast tenderness did not have an increased risk of breast cancer.
Researchers at USC's Keck School of Medicine discovered how estrogen activates genes in breast-cancer cells through a protein called TIP60, which recognizes methylation signals in chromatin. This finding builds upon previous work and has broader implications for gene regulation and potentially global significance.
A UT Southwestern study found that estrogen acts on two hypothalamic neural centers to regulate hunger and energy expenditure in female mice, keeping their body weight in check. This discovery has potential implications for postmenopausal women, who may benefit from targeted hormonal replacement therapies.
Researchers have identified estrogen receptors in specific brain areas that influence metabolism, weight gain, and fertility. Deleting these receptors from mice resulted in significant weight gain and metabolic changes.
Researchers at UCLA found that estrogen treatment can reverse the progression of pulmonary hypertension to heart failure and restore lung and ventricle structure and function. The study suggests that even short-term estrogen therapy may suffice to reverse the disease, offering new potential therapeutic applications for human patients.
A study published in Food and Chemical Toxicology found that a soy-based natural S-equol supplement did not increase the risk of estrogen-sensitive breast cancer. The supplement, SE5-OH containing Natural S-equol, was previously shown to reduce menopause symptoms in postmenopausal women.
Researchers found a 2.5 times higher prevalence of HFI in modern female participants compared to historic skulls, with average age of onset dropping drastically. Hormonal imbalance, lifestyle factors, and fertility habits may contribute to the condition.
A UCLA study reveals that the loss of a critical protein regulating estrogen and immune activity can lead to metabolic syndrome, characterized by Type 2 diabetes, atherosclerosis, and cancer. The research found that this protein's absence promotes increased fat accumulation, inflammation, and glucose intolerance in female mice.
Biologists found that male and female digit proportions are determined by the balance of sex hormones during early embryonic development. The study provides a genetic explanation for links between finger proportions and traits such as sperm counts, aggression, and health problems like autism and breast cancer.
A recent study found that postmenopausal women who smoke have higher androgen and estrogen levels than non-smoking women. Smoking cessation appears to reverse this effect, suggesting a potential mechanism by which tobacco smoke influences chronic disease risk through hormonal mechanisms.
Researchers at Georgetown University Medical Center found that overproduction of aromatase in breast tissue is more dangerous than excess estrogen receptors. Aromatase inhibitors may prove to be a more potent choice for cancer prevention in postmenopausal women.
A randomized controlled trial found that soy isoflavone tablets did not prevent bone loss or reduce menopausal symptoms in women, contradicting previous hopes for an alternative to estrogen therapy. The study involved 248 women with low bone density and followed them for two years.
Researchers found that prolonged estrogen deprivation in aging rats reduces brain receptors for the hormone and its ability to prevent strokes. Early estrogen replacement therapy can forestall this damage. The study's results suggest a critical window for estrogen therapy, either right before or right after menopause.
Scientists identify two genetic sequences that control how a breast cancer gene responds to estrogen, leading to tamoxifen resistance. The discovery may help guide the search for new therapeutic targets in breast cancer.
A recent study from MIT shows that estrogen dramatically lowers the rates of stomach cancer in male mice treated with the bacterium Helicobacter pylori. The researchers found that estrogen interferes with the recruitment and activity of immune cells, promoting inflammation and ultimately leading to gastritis and cancer.
A new study found a significant correlation between high BMI and decreased aromatase availability in the brains of overweight subjects. This suggests that low estrogen levels may lead to reduced control over appetite and food intake, resulting in weight gain.
Girls with anorexia nervosa saw significant increases in bone density at the spine and hip after receiving physiological estrogen therapy, according to a new study. However, they still had lower bone density than healthy-weight controls.
Chronic estrogen exposure has been linked to an increase in superoxide, a compound that causes stress in the body, leading to hypertension. Resveratrol has been shown to reverse this effect, suggesting a potential therapeutic avenue for female patients using hormone replacement therapy.
The European Menopause and Andropause Society (EMAS) has published a position statement on managing menopausal women with a personal or family history of venous thromboembolism. The statement recommends transdermal estrogen as a first-choice option for overweight/obese women requiring hormone therapy, while micronized progesterone and ...
A UT Southwestern researcher has identified the most comprehensive measurement to date of estrogen's effect on breast cancer cells, showing that estrogen regulates a strikingly large percentage of all RNA molecules in a rapid and transient manner. This finding could lead to new therapeutic applications and provide a model for understan...
A clinical study suggests that a specific combination of nutritional ingredients, including indole-3 carbinol and vitamin D, may increase the mean urinary concentration of 2-OHE in pre- and post-menopausal women by 110% and 88%, respectively. The supplement was well-tolerated with no adverse side effects.
A new study suggests that the soy-based compound Natural S-equol does not increase the risk of estrogen-sensitive breast cancer. Supplements containing SE5-OH have reduced menopause symptoms in postmenopausal women, and the study's findings enhance our understanding of Natural S-equol's safety profile.
A new study published in the New England Journal of Medicine found that treating girls with Turner syndrome with low doses of estrogen and growth hormone significantly increased their adult height. The treatment also showed modest synergy between growth hormone and low-dose estrogen in promoting growth.
A decades-long study demonstrates that low doses of estrogen combined with growth hormone in prepubescent girls with Turner syndrome has a synergistic effect on growth, increasing their height and improving cognitive functioning. The treatment also shows benefits for psychosocial development.
Higher levels of perfluorocarbons associated with increased odds of experiencing menopause in women between 42 and 64 years old. Women with high PFCs also had lower estradiol concentrations.
A new ACS podcast analysis concludes that birth control pills account for less than 1% of estrogens found in US drinking water. The main source of estrogen is instead from natural sources like animal waste and industrial production.
Researchers found that blue-green algae may produce an estrogen-like compound, disrupting reproductive hormones and affecting fish, plants, and human health. Exposure to the algal cells induced a response consistent with estrogen exposure in larval fish.
Postmenopausal women receiving hormone replacement therapy with estrogen plus progestin are at increased risk of breast cancer due to the interaction between estrogen, progesterone, and amphiregulin. The discovery may lead to new treatment methods targeting hormone-dependent breast cancers.
Researchers at UNC Chapel Hill are conducting a clinical trial to determine if estrogen replacement therapy can help prevent depression and cardiovascular illness in women between 45-55. The study, funded by the NIH, aims to identify which women will benefit from estradiol treatment during perimenopause.
A study published at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium found that hormone replacement therapy (HRT) with estrogen alone can reduce breast cancer risk in certain women. The analysis of data from the Women's Health Initiative (WHI) trials showed a significantly reduced breast cancer incidence in subsets of wom...
Scientists analyzed studies on estrogen in drinking water and found most estrogens come from natural sources such as soy, dairy, and animal waste, not birth control pills. Researchers concluded that the pill accounts for less than 1% of estrogens in drinking water supplies.
A recent study by the University of Delaware found that pelletized manure and no-tillage treatments can significantly reduce estrogen concentrations in manure runoff. The study, published in the Journal of Environmental Quality, suggests that measuring all forms of estrogens is crucial to understanding their environmental impact.
Researchers at Northwestern University have found a way to mimic estrogen's effects on brain cells without increasing cancer risk. By activating an estrogen receptor, they increased the number of connections between brain cells, improving mental performance.
Researchers used PET scans to image aromatase, an enzyme responsible for estrogen production, in the human brain. The study found that aromatase is concentrated in unique regions, differing from animal studies.
Researchers at UC discover that rabbit food can effectively reduce estrogen levels in wastewater, with a potential impact on the environment and wildlife. The study found that the rabbit food reduced estrogen hormone levels by more than 80%, making it a promising alternative for treatment.
A study published in the JAMA Network found that hormone therapy use by postmenopausal women is associated with an increased incidence of invasive breast cancers, particularly those with positive lymph nodes. The study also showed a higher risk of deaths attributable to breast cancer among women who received combined hormone therapy.
African American women with higher vegetable intake have a lower risk of developing estrogen receptor-negative breast cancer. High cruciferous and carrot consumption may play a role in reducing breast cancer risk through their effects on estrogen metabolism and antioxidant properties.
A study published in Archives of Internal Medicine found that hormone therapy after menopause increases the risk of developing kidney stones by approximately 20 percent. The research calls into question the long-held belief that estrogen protects women from the disease, and clinicians need to consider the risks and benefits of hormone ...
Scientists from Scripps Research Institute uncovered new evidence challenging the current theory of ligand-protein interaction in modern drug design. The study found that ligands can adapt to changing protein structures, binding productively to both active and inactive forms.
A study by Concordia University researchers found that high estrogen levels are associated with an inability to pay attention and learn in female rodents. Human females experience similar difficulties during ovulation, suggesting a direct link between estrogen and cognitive function.
A team of researchers from the University of Illinois will investigate the health effects of botanical estrogens, including phytoestrogens from soy and other plants. The study aims to determine whether these compounds have beneficial or detrimental effects on human health.
A study by the University of Houston team suggests that higher exposure to estrogens may be connected to gallbladder cancer. The research found that eliminating estrogens prevents tumor development in a specific animal model, leading to potential new drugs and understanding individual risks.
A recent study published in JNCI Journal of the National Cancer Institute found that estrogen alone was not associated with increased lung cancer mortality among postmenopausal women. In contrast, combined hormone therapy showed a statistically significant increase in breast cancer incidence and a reduction in colorectal cancer.
A new study suggests that oral contraceptives and hormone replacement therapy may reduce the incidence of brain aneurysms in women. The study, conducted at Rush University Medical Center, found strong similarities between women with unruptured and ruptured aneurysms, including lower estrogen levels.
A large-scale study involving over 7,700 participants found a positive association between DNA polymorphisms related to estrogen production and breast cancer development. The research suggests that combining multiple genetic markers can estimate breast cancer risk and may lead to the development of new prevention and treatment strategies.
Researchers discovered an estrogen-dendrimer conjugate that selectively targets heart-protective pathways in mice, promoting cardiovascular protection without stimulating uterine enlargement or breast cancer growth. The findings pave the way for potential therapeutic interventions targeting non-nuclear estrogen receptors.
A new synthetic molecule targeting non-nuclear estrogen receptors may activate cardiovascular benefits of estrogen without increasing cancer risk. The study suggests this approach could be beneficial for women, particularly those with high cholesterol and diseased arteries.