Articles tagged with Estrogen
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Researchers have identified a molecular mechanism underlying the harmful effects of DES on male testis development and function. Neonatal exposure to DES leads to reduced fertility in mice, with NR0B2 deficiency protecting against these effects.
A combination of estrogen and a selective estrogen receptor modulator (SERM) may relieve menopause symptoms and lower breast cancer risk without the progestin side effects. Researchers treated breast and endometrial cell lines with the hormone mix, finding that it blocked cell growth and prevented proliferation.
A study at UCSF has identified networks of nerve cells controlled by estrogen that influence male territorial behavior, challenging the view of single gender-related behaviors.
A new study in mice reveals that early estrogen exposure 'masculinizes' the brain circuitry, leading to aggressive and territorial behaviors typically observed in males. The researchers found that female mice exposed to estrogen as pups exhibit similar behaviors, suggesting a critical role for estrogen in shaping masculine behavior.
New research from Purdue University raises concerns about estrogen supplements claiming to improve bone health in postmenopausal women. While some plant-derived isoflavones show modest effects, many supplements lack efficacy or are less effective than current treatments for osteoporosis.
A recent study found that low-dose estrogen treatment can stop disease progression in patients with metastatic breast cancer, with 87% of those without PET flare reactions showing no response. The treatment was also well-tolerated, with fewer severe side effects compared to high doses.
Researchers found high concentrations of phytoestrogens, hormone-mimicking compounds, in the wastewater discharged from eight industrial sites. Phytoestrogens can be removed through standard treatment, but levels may still harm fish at certain thresholds.
Researchers discovered that uterine stromal cells increase estrogen production through the enzyme aromatase, supporting decidualization and blood vessel growth. Progesterone supplementation is necessary for successful pregnancy, highlighting the benefits of local estrogen production.
Researchers found that estrogen suppresses p53 after stroke, preventing cell death and reducing damage. The study used female rats treated with estrogen versus placebo to induce global cerebral ischemia, a common type of ischemic stroke.
Research highlights the gender disparities in stroke risks, with males outnumbering females by two to one, while women's outcomes worsen with age. Women also face disadvantages in stroke treatment, including lower response rates to tissue plasminogen activator.
A recent study has identified a 'feed-forward' pathway that links estrogen receptors in the uterus to increased local estrogen levels and promotes cell growth. This pathway may be targeted in drug therapies for endometriosis and uterine cancer.
A new study found that estrogen action through GPR30 promotes breast tumor cell survival, rather than growth, and activates integrin α5β1 to create a provisional extracellular matrix. This suggests that targeting GPR30 may be an important step in controlling ER-positive breast cancer.
Researchers from the University of Chicago discovered a 'yin-yang' effect between estrogen and retinoic acid on gene expression in breast cancer cells. This balanced control can lead to new ways of preventing and treating breast cancer, including more precise diagnoses and novel anti-cancer drugs.
Research suggests that estrogens acting through their receptors affect the dopamine transporter, which may explain trends in timing of women's susceptibility to these diseases. Estrogen levels vary significantly at different life stages, and women are more likely to experience neurological disease onset or exacerbation during these times.
Bisphenol A (BPA) exposure may be associated with abnormal activity in female rat and mouse hearts, potentially leading to improper heartbeat control. Researchers found estrogen receptors play a key role in this effect, which could have significant implications for women's heart health.
Exposure to low-dose BPA and estrogen increases arrhythmias in female rats and mice, a new study found. The results suggest a possible risk for female heart health due to increased levels of estrogens in the body and exposure to environmental estrogen BPA.
Research by USGS scientists links estrogen exposure to reduced immune response in largemouth bass, potentially making them more vulnerable to diseases. The study reveals that estrogen blocks production of hepcidin, a hormone that regulates iron and has antimicrobial properties.
A study published in JAMA found that men with systolic chronic heart failure who have low or high levels of estradiol have an increased risk of death compared to those with moderate levels. The study, conducted on 501 men, showed that both low and high concentrations of circulating estradiol are significant predictors of a poor prognosis.
A recent study found that women have a more powerful innate immune system than men due to the presence of estrogen. Estrogen blocks an enzyme called Caspase-12, which prevents the inflammatory process, making women more resistant to infection.
A new study by Penn State professor Donna Korzick explores the link between estrogen deficiency and increased risk of heart disease in women. Researchers hope to identify proteins that respond to low-estrogen environments, which could lead to new treatments for heart disease.
A large observational study found that combined oral contraceptives are associated with an increased risk of systemic lupus erythematosus (SLE), particularly among women who started using them recently. The study suggests a possible dose-response effect of estrogen on SLE onset.
A new study published in Menopause: The Journal of the North American Menopause Society found that transdermal estrogen delivery may not increase the risk of blood clots in postmenopausal women, unlike oral delivery. The study suggests that transdermal HT delivery may be a safer alternative for some women.
A study by Wagner and Oehlmann analyzed mineral waters for estrogenic chemicals, detecting contamination in 60% of samples. Plastic bottle water showed higher levels than glass-bottled water, with more embryos developing in New Zealand mud snails exposed to plastic bottles.
A study published by the American Academy of Neurology found that people with osteoporosis are three times more likely to experience vertigo than those without. Researchers discovered a strong link between low bone density and an increased risk of inner ear disorders, which can cause dizziness.
Researchers found that estrogen activates genes encoding nitric oxide synthases, leading to enhanced lung function and reduced ventilation support needs. Estrogen also prevented low blood pressure and closed the ductus arteriosus, a shunt that connects the pulmonary artery to the aorta.
A study from the Women's Health Initiative found that postmenopausal women who stopped taking combined estrogen plus progestin experienced a marked decline in breast cancer risk. The researchers also discovered that continued use of the hormone therapy after five years doubles subsequent breast cancer risk each year.
Primary ovarian insufficiency is a menopause-like condition affecting girls and young women, characterized by loss of menstrual periods, infertility, and hot flashes. A comprehensive plan provides recommendations for diagnosis and treatment, including hormone replacement therapy and counseling.
A new study confirms that estrogen and progesterone increase the risk of breast cancer more than estrogen alone. The study suggests a two-year safe period for hormone replacement therapy.
Key epigenetic abnormalities in endometriosis have been identified, including the presence of aromatase, which produces excessive estrogen in affected tissue. Aromatase inhibitors are now being tested for treatment options.
Dr. Debashis Ghosh's groundbreaking work has determined the three-dimensional structure of aromatase, a key enzyme in estrogen production. This breakthrough opens doors to customized, comprehensive medical treatment for breast cancer patients.
A diet rich in fruits, vegetables, and fiber has been shown to reduce the risk of recurrence in early-stage breast cancer survivors who do not experience hot flashes. This subgroup of patients typically faces higher recurrence rates and lower survival rates compared to those with hot flashes.
A secondary analysis of a large clinical trial found that a diet high in fruits, vegetables, and fiber reduces the risk of breast cancer recurrence by approximately 31 percent in women without hot flashes. Women with estrogen receptor-positive cancers often receive hormone therapy to combat circulating estrogen levels.
A study found that estrogen therapy can stop the growth of tumors or cause them to shrink in about a third of women with metastatic breast cancer that has developed resistance to standard estrogen-lowering therapy. The high-dose regimen had significant side effects, while the low-dose regimen was well tolerated.
Research articles explore impact of endocrine-disrupting chemicals on aquatic vertebrates and humans. Studies reveal mechanisms behind reproductive abnormalities and ecological risks associated with environmental contaminants.
Researchers discovered that past oral contraceptive use can reduce estrogen levels for years after treatment is stopped, potentially leading to a reduced risk of ovarian and uterine cancers. The study used cynomolgus monkeys and found significant reductions in estrogen metabolites three years after surgical menopause.
A study found that genistein, a soy-based dietary supplement, can negate the effectiveness of aromatase inhibitors used to treat post-menopausal breast cancer. The researchers observed a dose-dependent reduction in treatment efficacy, leading to tumor growth.
Researchers found that hormone levels alter the brain's response to social cues, affecting preferences for male voices and behavior. The study suggests a possible neural basis for changes in human social decision-making across the menstrual cycle.
A study by Université de Montréal researchers found that Montreal's water treatment plants dump up to 90 times the critical amount of estrogen products into the river. The presence of these hormones can disrupt the endocrine system of fish and decrease their fertility, threatening aquatic ecosystems.
A new study led by the University of Leicester found that men's sex hormones, particularly estradiol and estrone, are associated with increased cardiovascular risk factors such as high total cholesterol and LDL-cholesterol. This suggests that natural endogenous estrogens may play a role in increasing heart disease risk in men.
Researchers investigated estrogen's action in the brain, finding that it protects neurons and enables learning and memory throughout life. Estrogen receptors are present in both men and women, and a protein called PELP-1 enables rapid hormone action.
Scientists are studying zebra finches, a type of songbird, to understand how hormones like estrogen impact brain function and behavior. The research aims to uncover the role of synaptically produced estrogen in learning, memory, and neuroprotection.
A randomized, double-blind study involving 102 women with schizophrenia found that estrogen estradiol improved psychotic symptoms more effectively than antipsychotic medications alone. No significant difference was observed in negative symptoms, suggesting potential for longer-term treatment or alternative approaches.
Researchers at University of Illinois found that chronic exposure to estradiol decreases working memory and response inhibition in rats. This impairment is linked to altered brain activity in the prefrontal cortex, a region crucial for planning and decision-making.
Researchers at the University of Florida have discovered a way to improve thought processes in female mice by recharging a naturally occurring estrogen receptor in the brain. This breakthrough suggests that drugs can be developed to offset cognitive decline related to low estrogen levels, protecting against neurological diseases.
Researchers at the University of Missouri discovered significant changes in the brain's vascular system after menopause. The study advises extreme caution when using estrogen-based hormone therapies due to potential complications and adverse effects on vascular health.
Researchers have identified a new family of compounds that can effectively treat estrogen receptor-positive breast cancers resistant to tamoxifen. The compounds, including TPBM and related agents, work by inhibiting the growth of cancer cells stimulated by estrogen.
A new animal study suggests that estrogen treatment is not toxic per se, but its effects on the brain depend on an individual's reproductive age. In rats, estrogen therapy reduced brain damage when given before menopause, but increased it after, highlighting a narrow window of time for neuroprotective benefits.
A research study has found that a simple blood test can indicate whether post-menopausal hormone therapies increase the risk of a heart attack. Women with favorable cholesterol levels were not at increased risk of developing heart problems while taking hormones, whereas those with unfavorable cholesterol levels were at higher risk.
A study of 121,700 women found that postmenopausal hormone therapy is associated with a higher risk of stroke, even in younger women taking hormones near menopause. The risk was strongest for those taking larger doses and longer durations of hormone therapy.
A randomized controlled trial found that conjugated equine estrogen increased the risk of benign proliferative breast disease by more than two-fold. Women taking estrogen supplements had 155 cases of benign disease compared to 77 in the placebo group.
A new study in mice found that moderate and high doses of estrogen replacement therapy increased problems in the kidney and heart. The results suggest that ERT dosage may be an important determinant in a woman's overall health.
Researchers at Yale University found that exposure to DES alters HOXA10 gene expression, leading to uterine cancer and fertility problems in female offspring. Long-term effects of similar substances like BPA on reproductive health remain a concern.
A follow-up study of WHI participants found an increased risk of invasive breast cancer and other cancers in women taking estrogen plus progestin. The risk of heart disease, stroke, and blood clots decreased after the intervention was stopped.
A recent study found that post-menopausal women who stopped taking combined hormone therapy experienced an increased risk of all cancers, including lung cancer. The research, led by Rowan T. Chlebowski, confirms previous findings on the risks of hormone therapy.
Researchers have found that hormone replacement therapy does not significantly affect the risk of developing or exacerbating rheumatoid arthritis. The study analyzed data from over 27,000 postmenopausal women taking part in a clinical trial, revealing no notable differences between those on hormone replacement therapy and placebo groups.
A five-year grant aims to uncover the genetic mechanism behind increased sensitivity to estrogen due to low-dose BPA exposure, which may predispose men to prostate cancer later in life. The study will use human prostate-like structures and animal models to characterize dose-response and gene modifications.
Researchers found that miniscule amounts of synthetic estrogen in municipal wastewater can decimate wild fish populations living downstream, causing feminization and reproductive issues. Removing estrogen through wastewater treatment can reverse the adverse impact on wild fish populations, offering a glimmer of hope for recovery.
Researchers have found that 400 chemicals resist breaking down in the environment, affecting fish and wildlife, and potentially human health. The study also reveals pesticides can be more toxic when combined, threatening salmon populations and human health.
A 15-year study found women with low bone mineral density and a previous vertebral fracture had a higher risk of new vertebral fractures compared to those with normal bone density and no previous fracture. Women who experienced a new fracture were more likely to have a positive fracture history, weigh less, and report lower estrogen use.
Researchers found that despite strong contradictory evidence, favorable citations for vitamin E persisted in medical literature until 2005. For beta-carotene and estrogen, similar findings were observed, with a majority of citing articles remaining favorable even after contradicting evidence was published.