Articles tagged with Estrogen
A new study finds that estrogen-only therapy does not increase the risk of breast cancer in postmenopausal women, contradicting previous findings. In contrast, hormone therapy combining estrogen and progestin was linked to a 26% higher risk of breast cancer.
Women taking estrogen had fewer breast cancer tumors, but the difference was not statistically significant. Participants also underwent more mammograms and biopsies, which may be related to changes in breast tissue.
A study analyzing data from the Women's Health Initiative found that postmenopausal hormone therapy may increase the risk of developing venous thromboembolism, particularly in women with higher physical activity levels and lower HDL cholesterol. The risk was significantly increased for deep vein thrombosis, but not for pulmonary embolism.
A study of 23,191 black women found a significant association between hormone use and breast cancer risk, with the longest cumulative exposure increasing the risk. The strongest association was seen in leaner women, who may be more susceptible to the effects of estrogen due to fat tissue producing this hormone.
A study published by Mayo Clinic researchers found that surgical ovary removal elevates the risk of dementia in younger women, possibly due to insufficient estrogen. Women who underwent the surgery at a younger age may be more susceptible to cognitive decline, highlighting the need for ongoing hormone replacement therapy.
Research identifies three estrogen-related gene variants associated with an increased risk of Parkinson's disease in women. The study found that these genetic variations affect 10-20% of the female population and could be used to predict disease risk using a simple blood test.
Researchers at the University of Texas at Austin have discovered a link between estrogen, progesterone, and allergic responses in women. High levels of IgE antibodies against these hormones are associated with symptoms such as premenstrual asthma, menstrual migraines, and fibromyalgia.
Researchers have identified certain metabolites that can trigger breast and prostate cancer, paving the way for early detection and prevention. The study's findings suggest a novel approach to cancer prevention by eliminating these initiating steps.
Researchers found that more growth hormone is produced in females than males and in adults, with the hormone responding to estrogen. The study has implications for menopausal women using estrogen replacement therapy and athletes taking growth hormone and anabolic steroids.
Researchers at Ohio State University identified seven partner proteins that interact with estrogen to activate or suppress genes in breast cancer cells. The study suggests that c-MYC is one of these activating partner proteins, which could lead to new drug targets and improved treatment options for hormone-resistant tumors.
A study found that high doses of soy isoflavones can block the effects of estrogen in postmenopausal women, potentially reducing breast cancer risk. Women with higher estrogen levels may benefit from a diet rich in soy isoflavones.
A study by CU-Boulder researchers found that male mice with hypertrophic cardiomyopathy developed enlarged hearts and heart failure on a soy diet, but not female mice. The team hypothesized that plant-based estrogens in the soy diet triggered biochemical reactions leading to programmed cell death in the heart.
A study of 183 women with inactive or stable lupus found that taking oral contraceptives had no statistically significant difference in the occurrence of flares compared to those taking a placebo. Mild-to-moderate flares and disease complications were also similar between the two groups over a 12-month follow-up.
A laboratory study demonstrates that breast cancer cells die when re-introduced to estrogen after becoming resistant to tamoxifen and other estrogen inhibition drugs. This finding has important clinical implications for long-term therapy with aromatase inhibitors, suggesting a new strategy for treating treatment-resistant breast cancer.
Estradiol induces apoptosis by activating the intrinsic apoptotic pathway, which controls protein expression and mitochondrial function. The study found complete tumor regression in mice with estradiol-treated breast cancer cells, suggesting a potential strategy for aromatase inhibitor resistance.
Research in monkeys shows that stress in younger years can lead to reduced estrogen levels and increased risk of heart disease later in life. Perimenopause is a critical time for cardiovascular health, and starting hormone therapy earlier may be more effective than waiting until menopause.
Researchers found that BPA can mimic estrogen's actions in developing neurons, leading to potential harm to the brain. The study suggests that even low concentrations of BPA may be hazardous, as they are comparable to human fetal exposures and water supply levels.
A study found that estrogen levels affect brain memory areas, enabling females to adapt to complex environments and enhance reproductive success. The researchers suggest this adaptation facilitates tasks such as mate selection and finding food and shelter.
Researchers found no link between high soy consumption and increased uterine cancer risk in postmenopausal women. The studies suggest that dietary soy may even offer a protective effect against endometrial cancer, contradicting previous concerns about its safety.
Researchers found that estrogen depletion exacerbates diastolic dysfunction and increases blood pressure in rats fed a high salt diet. The study suggests that estrogen may protect against hypertension and renal damage caused by excess salt intake.
A study by University of Illinois researchers found that estrogen reduces levels of a crucial nuclear receptor corepressor, N-CoR, leading to increased breast cancer cell growth. The anti-estrogen drug tamoxifen can facilitate recovery of N-CoR, suggesting potential therapeutic implications for its use.
Recent evidence suggests a link between estrogen deprivation and joint pain, particularly in women undergoing hormone therapy for breast cancer. Studies have shown that aromatase inhibitors and other estrogen-depleting treatments can increase the risk of musculoskeletal symptoms, including joint pain.
A study by UC Irvine researchers discovered that estrogen has a protective effect on the mitochondria in vascular cells, increasing energy production efficiency and reducing oxidative stress. This finding suggests that estrogen may be beneficial for women's cardiovascular health, particularly after menopause.
Researchers aim to investigate whether starting hormone therapy early can prevent atherosclerosis and heart attacks. The KEEPS trial, led by Yale University, seeks healthy women aged 42-58 for a double-blind study exploring the effects of early menopausal hormone therapy.
Researchers found that estrogen triggers molecular activity blocking cardiac hypertrophy, a common cause of heart enlargement and heart failure. The study suggests that estrogen supplements may prevent cardiac hypertrophy in postmenopausal women, continuing a debate on the hormone's role in limiting cardiovascular disease.
Researchers investigate estrogen and estrogen-like drugs' ability to protect brain cells after a stroke. Preliminary data suggest that these substances can help traumatized cells survive and encourage stem cell maturation into new brain cells.
A study of 8,405 women found that moderate or severe vasomotor symptoms were reported by 21.2% of former hormone therapy users, compared to 4.8% of placebo group respondents. Lifestyle and medical strategies may help manage symptoms after discontinuing hormone therapy.
Researchers found that the drop in estrogen levels during menopause is linked to increased cortisol levels and abdominal fat. Estrogen replacement therapy may help prevent this rise in cortisol and delay or prevent weight issues.
Researchers at University of Minnesota have made a groundbreaking discovery on how estrogen affects the brain, revealing distinct differences between females and males. The study suggests that estrogen activation of glutamate receptors could explain various non-reproductive behaviors, such as female motor control and pain sensation.
A study of pregnant women with psoriasis found that 55% experienced improvement in symptoms, while 65% reported worsening. High estrogen levels were correlated with improvement, whereas progesterone levels did not show a correlation.
Researchers found that exposure to BPA and BBP altered gene expression in mammary tissues of young rats, increasing protein production with age. The study suggests these estrogens could contribute to breast cancer development.
A study published by Mayo Clinic researchers found that removing the ovaries elevates the risk of Parkinson's disease and parkinsonism in women. The study, which analyzed data from over 2,500 women, suggested that a reduction in estrogen levels after ovary removal may contribute to this increased risk.
Research found low doses of BPA in female rats inhibit estrogen-induced synaptic connections, affecting hippocampal development and memory. High concentrations of BPA have been reported in pregnant women's blood, potentially impacting human hippocampal development and long-term effects on children's learning ability.
Scientists have discovered that elevated estrogen levels can reduce the severity of asthma by preventing abnormal airway constriction. Selective estrogen receptor modifiers (SERMs) also showed similar effects, suggesting a new molecular target for asthma therapy.
Scientists have discovered that an estrogen receptor, ERβ, plays a crucial role in regulating defeminization, a process by which males lose female-like behavior. The study found that neonatal males are exposed to estrogen produced by their testes, leading to changes in gene expression and neural architecture.
A large clinical trial found that menopausal hormone therapy increased the incidence of urinary incontinence, particularly stress UI, and worsened its characteristics among symptomatic women. The study suggests that MHT should be reevaluated as a treatment option for UI.
Researchers at Medical College of Georgia have found changes in blood vessel chemistry that may explain how estrogen increases the risk of heart disease in older women. Estrogen targets nitric oxide synthase, producing a powerful age-promoting oxygen-free radical instead of making nitric oxide.
New studies suggest that blocking estrogen may be essential to slowing the spread of lung cancer. Researchers found that a combination therapy targeting both estrogen and epidermal growth factor receptors resulted in a 59% tumor volume decrease.
Researchers found a genetic variant of the CYP1A1 gene associated with lower estrogen levels, higher bone resorption markers, and lower bone density in hip bones. This variant may serve as an important genetic marker for identifying women at high risk of osteoporosis.
Research found that estrogen therapy significantly increases the risk of gallbladder disease and surgery in postmenopausal women, with CEE showing a 67% increased risk. The study also revealed higher risks for cholecystitis and cholelithiasis among estrogen users.
Researchers found that women experiencing menopause have reduced estrogen sensitivity in their brains, leading to increased hot flashes and night sweats. The study suggests that this insensitivity may contribute to menopause-related symptoms.
A study found that dental x-rays were as sensitive as questionnaires in identifying women with spinal osteoporosis. Dental x-rays can be used as a first step in determining which women need further BMD testing, especially for those with low response rates to questionnaires.
Research in female mice reveals estrogen's protective effects against atherosclerosis, highlighting potential risks of COX-2 inhibitors for premenopausal women. The study identifies prostacyclin as a key mediator of estrogen's benefits.
A nationwide study found that women taking osteoporosis medications had fewer bone abnormalities and less knee pain associated with osteoarthritis. The research suggests that these medications, primarily alendronate and estrogen, may offer protective benefits for the development of knee OA.
Researchers found that estrogen deficiency triggers the expression of interferon gamma, which stimulates T cell activation and TNF production. Estrogen treatment increases TGFb levels in bone marrow, leading to bone preservation.
Researchers examine how and why hormone therapy affects cognition, finding that treatment regimen influences memory performance. Continuous versus cyclical estrogen regimens show differing effects on cognitive function, with cyclical regimens leading to more errors in reference and working memory tests.
Research suggests reproductive hormones like estradiol affect the brain's growth and development, influencing cognitive functions such as learning and memory. Estradiol has complex interactions with these processes, differing between males and females, and may help explain gender differences in cognition and mental diseases.
A pilot study found that Cenestin reduced hot flashes and night sweats in post-menopausal women by 79% and improved overall sleep quality. The study also showed a significant reduction in galvanic skin responses, indicating better sweat gland activity.
A study by Yale University found that estrogen has no impact on memory in mice living in enriched environments, but improves spatial memory in those with standard conditions. The results suggest that estrogen benefits mice from un-stimulating environments more than those raised in stimulating ones.
A study of monkeys found that a high-soy diet did not alter menstrual cycle characteristics or ovarian hormone levels, suggesting that soy consumption may not affect fertility. The research confirms earlier findings that stress levels can impact ovarian function and fertility.
Researchers found that increasing dietary fiber intake leads to sharp drops in estrone and estradiol hormone levels. Higher fat intake paradoxically increased hormone levels, but dietary fiber remained a significant predictor of hormone levels when both were included.
Researchers found a sharp drop in estrone and estradiol hormone levels with increased dietary fiber intake. A higher intake of dietary fiber was also associated with lower hormone levels even when dietary fat was present.
A new study suggests that low-dose estrogen therapy may be as effective as traditional doses in reducing atherosclerosis and improving cardiovascular health. Monkeys treated with low-dose estrogen had 55% less atherosclerosis than those not receiving the therapy.
A study found that hormone therapy can limit heart muscle damage to 5% or cause permanent damage to 35%. Researchers are exploring how estrogen alone and other anti-inflammatory treatments may impact muscle damage. The study suggests different hormone therapies may have varying effects on postmenopausal women.
Two studies found that soy-based diets improved cholesterol levels and increased bone mass in monkeys, suggesting a potential benefit for premenopausal women. The research suggests that soy may provide a potent protection against cardiovascular disease and could help maintain bone health after menopause.
A recent study published in JAMA found that the use of estrogen plus progestin therapy was associated with an increased risk of venous thrombosis. The risk was higher among older and overweight postmenopausal women, as well as those with a genetic mutation for Factor V Leiden.
The Illinois initiative aims to examine the biological effects of isoflavones on various bodily systems, including breast, brain and adipose tissues. Researchers will investigate the mechanisms at work between isoflavones and estrogen receptors to ensure safety and effectiveness in dietary supplements.
Research finds that age-related testosterone depletion promotes Alzheimer's disease in men by protecting neurons from injury and reducing beta-amyloid protein levels. The study suggests that understanding the link between testosterone loss and Alzheimer's is crucial for identifying those at risk.
Researchers at OHSU-VAMC found that estrogen increases regulatory cells and FoxP3 protein, key for fighting autoimmune diseases like MS. The study provides a new mechanism for understanding how pregnancy reduces MS symptoms.
A new UCI study has identified a gene linked to breast cancer that can also suppress tumor growth by blocking estrogen and growth factor signals. The research provides further insight into how estrogen interacts with mutated BRCA1 genes to promote breast cancer development.