Researchers discovered that low doses of azithromycin can halt and reverse lung function decline in the majority of lung transplant patients with BOS, offering a new hope for treatment.
Researchers find that stressed cells introduce errors in DNA repair, but only in specific locations and times, which can increase the chances of beneficial mutations. This process may accelerate the evolution of complex protein machines.
Scientists have made significant progress in predicting protein structures using computers. The Rosetta program uses a two-step process to generate energy calculations and select the lowest energy shape as prediction. This approach has achieved almost atomic resolution in structure prediction for about one-third of small proteins.
Researchers have discovered how defensins and mannan-binding lectin can prevent viruses from entering cells. Defensins block the influenza virus entry into cells by preventing membrane fusion, while mannan-binding lectin works in a similar way. These findings may lead to new strategies for preventing viral diseases.
A study by Georgia Tech researchers found the number of Category 4 and 5 hurricanes worldwide has nearly doubled over 35 years, despite a decrease in total hurricanes. Global sea surface temperatures have increased, driving this shift.
Researchers discovered that sponges are the most important inhabitants of underwater caves on coral reefs, filling over 60% of cavities. They filter massive quantities of planktonic particles, facilitating growth and conversion of organic to inorganic nutrients.
Research suggests climate change will lead to decreased air quality in Texas and the western U.S., while the Midwest is predicted to receive more rain, which could help reduce ozone levels. Satellite data also reveals the temperature of Earth's ring current, with plasma ion temperatures consistent with in situ measurements.
Acidic water from the Ijen Crater Lake in East Java poses a significant threat to both human health and local ecosystems, with high levels of aluminum and fluoride found in river water and groundwater. Researchers suggest channelling acidic water into the sea as a possible solution to mitigate this issue.
Scientists used satellite imagery to estimate that at least 23% of the Mississippi River's freshwater discharge traveled into the Gulf of Mexico, around Florida Keys, and into the Atlantic Ocean. The study combined MODIS data with ship observations to track the dark water plume's journey, reaching as far as the Georgia coast.
Purdue researchers led by Jorge H. Rodriguez are developing computational tools to simulate and predict biochemical reactions using quantum physics. This technique could help select the best potential new drug compounds and expand knowledge of life's fundamental processes.
A new study suggests that scintigraphy using radioactive isotope (99mTc-DPD) can help distinguish between hereditary and acquired forms of cardiac amyloidosis, two conditions with different treatment options. The test shows promise in reducing misdiagnosis and improving patient outcomes.
A study by University of Michigan Health System researchers found that students who applied self-applied acupressure treatments to stimulation points on their legs, feet, hands and heads showed a statistically significant reduction in sleepiness compared to those who only relaxed. This discovery could have implications for improving al...
Researchers at Duke University developed a computer model to study the effect of adsorbed gas on quasicrystal alloys, which could lead to improved low-friction properties for machine parts. The model suggests ways to control the transition from quasicrystalline to crystalline structures, preserving the alloy's high lubricity.
Researchers have identified Notch1 and Jagged1 as markers indicating a patient's probable prognosis for aggressive breast cancer. The study suggests that targeting the Notch signalling pathway may improve treatment outcomes for patients.
Researchers develop a computational model that accurately predicts cell behavior, revealing intricate protein interactions and improving cancer treatment design. The model has practical applications in developing targeted therapies that don't weaken patients' immune systems.
A new treatment approach blocks memory for places associated with cocaine use by inactivating the ERK protein, suggesting a potential strategy for developing addiction therapies. The research provides novel insights into brain mechanisms underlying relapse and shows long-lasting effects.
The workshop explored the government's use of commercial data for homeland security, raising important privacy concerns. Stevens' Wright discussed her work on PORTIA project, which addresses handling of sensitive information in a networked world and provides cryptographically strong methods for maintaining data privately.
Researchers at the University of Pennsylvania School of Medicine have developed a cancer vaccine that uses the bacterium Listeria monocytogenes to boost an immune response against breast tumor-associated antigens. The vaccine was tested in mice with established breast tumors, resulting in complete tumor eradication after 100 days.
Researchers found that abused children exhibited prolonged attention to angry voices and didn't break focus even after the argument ended. This reaction may be linked to their brain's ongoing attempt to cope with past trauma, making them more prone to interpersonal problems.
The new lab will provide practical training in security and information assurance, preparing students to meet the challenges in protecting the nation's information infrastructure. The lab will increase the number of IT professionals educated and trained in theoretical and practical aspects of information assurance and security.
Researchers found that parents' warmth and positivity in interactions with their children in childhood are related to the children's self-regulation and adjustment in adolescence. Children of warm parents tend to exhibit fewer problem behaviors as they age.
Researchers are testing the Space Cycle, a human-powered centrifuge that generates artificial gravity, to prevent muscle loss and atrophy in astronauts. The device simulates various levels of gravity, from Earth to five times Earth's gravity, to assess its effectiveness in maintaining muscle mass and strength.
A study found that HIV-infected macrophages travel to the temporal lobe, causing inflammation and damaging memories. Researchers hope to develop drugs targeting these cells to prevent HIV-associated dementia.
A recent study found that long-term alcoholics are at a four-fold higher rate of postoperative infections, as well as increased length of need for mechanical ventilation and ICU treatment. The study suggests that pre- and perioperative immune-modulating treatments may help decrease infection rates in high-risk patients.
A study analyzing 13,000 Scottish individuals found that excluding deprivation from heart disease risk scoring can exacerbate social gradients in disease. The researchers call for guidelines to be adjusted to take account of deprivation, potentially saving thousands of lives.
OHSU neurologists offer reliable strategies for diagnosing and managing Parkinson's disease. The article highlights the importance of non-pharmacological therapies such as exercise, nutrition, and emotional health in addition to pharmacological care.
Researchers found abatacept to be effective in treating rheumatoid arthritis, improving at least 20% of patients' condition compared to placebo. The drug reduces immune system attack on joints, providing significant pain relief and improving functionality.
A recent study reveals that managed care drug cost-control strategies are failing due to flawed contracts and inadequate information sharing between HMOs and doctors. The survey found widespread dissatisfaction with the current approach, which relies on financial incentives to control prescribing practices. The researchers propose thre...
Dmir-1 is specifically expressed in muscle cells, regulating Twist and Mef2 transcription factors. Muscle integrity and identity are maintained by Dmir-1, ensuring non-muscle gene mRNAs remain inactive.
Researchers at Rice University have discovered a simple geometry where light behaves exactly as electrons do in these systems. This finding has the potential to create nanoscale antennae that convert light into broadband electrical signals, increasing data transmission capabilities by 1 million times.
A recent study published in the Journal of Applied Physiology found that visceral fat buildup is a major consequence of inactivity. The researchers discovered that increasing exercise amounts can significantly reduce visceral fat, while even moderate exercise can prevent accumulation and reverse it in some cases.
Results from two Phase II studies support the efficacy profile of sitagliptin, a novel DPP-IV inhibitor, improving glycaemic control in patients with type 2 diabetes. Treatment with sitagliptin resulted in no significant weight gain and a low risk of hypoglycaemia.
A study of 51 countries found that women outlive men due to higher murder rates among men and patriarchal societies. The wealth gap also contributes to male mortality, with GDP accounting for 13.6% of death rate variation among men.
The U.S. National Science Foundation has deployed small unmanned aircraft, including a fixed-wing plane and a miniature helicopter, to assist in the search and rescue efforts during hurricanes. These vehicles provided valuable information to emergency responders, helping them focus their efforts and avoid hazards.
A study found that fetal alcohol exposure can alter the dopamine system in monkeys, affecting cognition and behavior. The timing of exposure during gestation varies the impact, with early exposure blunting the system and later exposure leading to supersensitive receptors.
Researchers successfully disrupted cocaine memories to battle addiction, utilizing anti-sense DNA treatment that blocked gene activation. This approach may provide a powerful and novel method to diminish the impact of drug cues, thereby reducing relapse rates.
The University of Wisconsin-Madison's Tropical Cyclones group is using its specialized tools to help forecasters track Hurricane Ophelia. The tools provide critical information on the storm's trajectory and intensity, enabling more accurate forecasts and helping to save lives.
Researchers have discovered thousands of years-old plant remains exposed by the Quelccaya ice cap, suggesting that the region may not have been as warm as it is today in over 500 centuries. The findings are significant, as they provide a unique perspective on ancient climate change.
Researchers found that marital problems can lead to elevated blood pressure readings and increased stress levels, affecting both men and women. A study of 105 middle-age civil service workers in the London area found a strong link between poor marital relationships and serious health problems.
Research found that physically abused children showed increased emotional arousal and focus on threat signs during a calm-anger-resolve conversation. They remained alert after the conflict resolved, suggesting anxiety about environmental aspects others may overlook.
A study by Newcastle University found that men who experience a downward social shift are four times more likely to suffer depression, whereas women in the same position show no significant difference. The researchers suggest that this disparity may be due to differences in how men and women derive self-esteem and fulfillment.
A study found that victimized children develop more negative self-perceptions and beliefs about their peers, leading to increased aggressive behavior. School programs can counteract these effects by teaching positive peer interactions and social competence.
Researchers analyzed data from 674 families with same-sex adolescent pairs to explore the connections between environmental factors and individual traits. The study found three key factors: overall adjustment, independence, and parental monitoring, which explained the complexity of family relationships.
The team's creation is the smallest robot that transduces force, is untethered, and engages in its own locomotion. It features two independent microactuators for forward motion and turning, powered by a grid of electrodes.
At-risk children benefit from high-quality instructional and emotional support, regardless of their mother's education level. High-quality classrooms reduce academic and social problems in early school years, supporting teacher quality reforms.
Researchers at MIT created electronic maps of cellphone use in Graz, Austria, tracking tens of thousands of people using anonymous data. The project showcases the dynamics of a city in real time, opening up new possibilities for urban studies and planning.
Astronomers detect unusual quasar with no visible host galaxy, sparking debate about its origin. The object's properties suggest a rare collision between galaxies, potentially illuminating the formation of massive black holes and their role in shaping the universe.
Researchers tracked children from kindergarten to fourth grade, finding that early parent-child relationships and warmth can reduce conduct problems. Effective monitoring practices are laid down in early elementary school years, making interventions during childhood crucial for adolescent outcomes.
Researchers found that college students accurately report their alcohol consumption, contradicting previous laboratory studies suggesting they underreport. This suggests that the drinking problem remains significant, but data collection methods may need to be reevaluated.
New research from Rice University suggests the immune system's mild inefficiency may lead to autoimmune diseases, as its mechanisms for developing antibodies could also attack healthy cells. Ancient neutrinos created in the early universe may provide evidence for or against string theory and quantum loop gravity.
The NMSU Physical Science Laboratory designed and fielded a countermeasure device in under three months to combat IEDs, providing increased survivability for warfighters. The signal-jamming equipment is being used by the US Army, Marines, and Navy Explosive Ordinance Disposal unit.
A new study found that horses with exercise-induced pulmonary hemorrhage (EIPH) trail the winner by an average of 14 feet after intense exercise. Horses with mild EIPH perform just as well as those without the disorder, but severe cases significantly hinder performance.
A new study reveals that SARS can infect brain tissue, causing severe central nervous system symptoms. The researchers found a high level of Mig, an immune system regulator, in the patient's bloodstream and brain, which may contribute to brain damage.
A study published in Alcoholism: Clinical & Experimental Research found that adolescents and young adults with AUDs have a smaller prefrontal cortex, which is associated with early-onset drinking. This may lead to difficulties in inhibiting urges, delaying gratification, and thinking clearly about the consequences of actions.
Scientists at NIST have successfully synchronized the signals emitted by multiple nanoscale oscillators, amplifying their output power and stabilizing their signal pattern. This breakthrough could lead to smaller, cheaper wireless communications components.
The Columbia battery, introduced in 1896, marked a significant step in transforming batteries from industrial products to consumer goods. Its technology served as the basis for all dry cell batteries for sixty years.
Researchers found that a nanoscale corrugated surface increases YBCO films' current-carrying capacity by over 30%. This suggests that some degree of substrate roughness might improve high-temperature superconductor performance.
Researchers have developed a new dating technique using radioactive carbon-14 in tooth enamel, which can accurately determine a person's age at the time of death within 1.6 years. This method can help forensic scientists identify victims of disasters like Hurricane Katrina and narrow down search efforts.
A University of Cincinnati team is interviewing Inupiaq elders to better understand and predict future environmental changes, combining western science with traditional knowledge. The research focuses on climate and environment on Alaska's North Slope, with unique findings on the impacts of global warming.
A study found suicide incidence in English and Welsh prisons from 1978–2003 was five times greater than the general male population of similar ages. Young offenders aged 15–17 years had an even higher risk, with a rate around 18 times that of the general population.