Researchers in The Netherlands found a positive trend in rheumatoid arthritis disease activity over the last decade, coinciding with more aggressive treatment strategies. The study showed that patients diagnosed with RA within the last ten years had less severe disease activity and a more favorable course of their disease.
K-State researchers are working on a new drug to treat cystic fibrosis by designing chloride-selective pores that can help ions travel across cell membranes. Their goal is to create a medication that works efficiently and effectively at low doses, improving the lives of those affected by the disease.
Researchers discover Chk1 protein plays natural defense against therapeutic damage in cancer cells, making treatment less effective. Combining chemotherapy agents with Chk1 inhibitors may increase efficacy and overcome clinical resistance.
Researchers found that dehydration reduces performance by 8% in temperate weather but has minimal effect in cold temperatures. A study also discovered glycerol as an effective hyperhydration agent to retain fluid in the body, which can be beneficial for prolonged outdoor exposure.
A study found that an abstinence-only sex education program increased teens' knowledge of HIV/STDs and their commitment to abstinence. However, it had mixed effects on sexual behavior, with no impact on the likelihood of having sex or using condoms. The program may reduce casual sex encounters among sexually active students.
Researchers are studying how insects recognize infection caused by microorganisms and the pathway of reactions that follow in their immune systems. The goal is to understand how to disrupt disease transmission by blood-feeding insects, such as mosquitoes.
Recent evidence suggests a link between estrogen deprivation and joint pain, particularly in women undergoing hormone therapy for breast cancer. Studies have shown that aromatase inhibitors and other estrogen-depleting treatments can increase the risk of musculoskeletal symptoms, including joint pain.
Researchers found that 97% of patients achieved control over ocular inflammation after one month of treatment with the new drug. Additionally, 82% were able to taper their dose of steroid prednisone without experiencing increased side effects.
Researchers found that high-dose vitamin E supplementation improved rat lifespan, cognitive function, and neuromuscular performance. The results show a significant correlation between vitamin E levels and mitochondrial function, supporting the free radical theory of aging.
Tropical forest landscapes are changing rapidly as old-growth forests become agricultural lands, degraded land is abandoned, and urbanization intensifies. Scientists are studying the dimensions and mechanisms of forest responses to rapid human-population increase and environmental changes.
Researchers have made a crucial breakthrough in understanding Rett Syndrome by identifying the specific genetic targets involved in the disease. The discovery of an A-T stretch required for MeCP2 binding provides a key clue to finding new target genes.
Researchers found that physical fitness reduces cardiovascular disease death risk by over 50% across all cholesterol levels. The study analyzed data from 19,125 men aged 20-79 and confirmed the effectiveness of revised guidelines for lowering bad cholesterol.
The FANTOM consortium's findings provide a major step towards identifying all protein building blocks, using multiple mechanisms to produce different forms of proteins in mammals. The research also explores the importance of non-coding RNA in development and evolution, revealing why complex organisms evolved beyond simple genes.