Researchers developed a chemotherapy gel that slowly releases doxorubicin to kill remaining cancer cells, eradicating tumors in mice. The treatment also reduces breast deformity by filling dimples and indentations after surgery.
Researchers discover the structure of the WRN exonuclease domain, revealing its role in repairing DNA damage and maintaining genomic integrity. The study sheds light on the mechanisms underlying Werner's syndrome, a rare inherited disease that accelerates aging.
The University of Utah is working on a bionic arm that can move naturally in response to thoughts and allow users to feel sensations, with the goal of restoring the capability of amputees. Researchers will develop a peripheral nerve interface device that relays signals from nerves to the artificial limb.
A study found that both alcoholism and chronic smoking alter gene expression in the human prefrontal cortex, which is responsible for decision-making, fear, and emotion. This suggests a common underlying mechanism for addiction and may lead to therapeutic solutions or pharmaceuticals.
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a mutation in the ACVR1 gene, leading to an armament of bone that locks movement impossible. The discovery provides a highly specific target for future drug development and holds promise for altering symptoms and the disease itself.
Researchers found that groups of three, four, and five members perform better than the best individual on complex problems requiring verbal, quantitative, or logical conceptual skills. This suggests that group work may be beneficial for students in school and for scientific research teams.
A study by the Veterans Affairs Medical Center found that individuals with a family history of alcoholism who exhibit behavioral disinhibition are at higher risk of developing alcoholism. This group shows working-memory deficits and an attraction to reward-taking challenges.
A study by Harvard Medical School researchers identifies specific neurons in the orbitofrontal cortex that assign values to different goods. This discovery sheds light on choice deficit disorders such as eating disorders and compulsive gambling.
Scientists found that certain artificial sweeteners like sodium saccharin and acesulfame-K paradoxically inhibit sweetness at high concentrations. When rinsed with water, the sweetness returns, revealing potential applications in medicine and food industry.
Researchers have found cancer cells suppress entire chromosome bands through epigenetic changes, silencing genes that prevent tumor growth. The discovery could lead to new treatments targeting DNA demethylation.
Research suggests that prenatal alcohol exposure can lead to long-lasting alterations in the ability to synchronize circadian rhythms with environmental cues. This can result in behavioral problems, such as sleep disorders, attention issues, and mood regulation difficulties. The study's findings have implications for understanding the ...
Researchers at Joslin Diabetes Center found that beta cells can develop and grow normally even when both insulin and IGF-I receptors are missing. This discovery suggests the presence of independent growth factors and pathways necessary for beta cell development, which may lead to new treatments for people with diabetes.
A polyvalent inhibitor has been developed that recognizes multiple sites on the anthrax toxin molecular structure, making it four orders of magnitude more potent. The inhibitor was tested in rats and protected them from anthrax toxin, showing promise as a potential therapeutic for anthrax exposure.
Researchers identified an intrinsic pathway involving PTEN that regulates stem cell transitions between quiescence and activity. Disrupting PTEN leads to increased active cycling and loss of quiescent stem cells, hindering long-term maintenance.
A new potential vaccine against deadly leishmaniasis has been developed by a research group led by Peter H. Seeberger, combining a virosome delivery system with a synthetic carbohydrate antigen. This innovative approach aims to overcome the limitations of existing vaccines and provide a strong protective action against the disease.
A team of researchers is examining how genetics interact with exposure to secondhand smoke in the development of cardiovascular disease. They will investigate 585 children aged 15-20 who have a parent or grandparent with hypertension or heart disease, looking for signs of cellular damage and increased cardiovascular risk.
Researchers have developed a new technique called biochemical suppression to identify protein targets for small molecule inhibitors. This method allows for rapid identification of multiple components of complex biological systems, such as cancer cell spread.
Researchers developed a new method to analyze the MHC of the human genome, enabling the study of complex diseases and transplanted organs. The method may also be useful in studying other gene complexes with variability.
Researchers have identified a new protein called PlyPH that can kill anthrax bacteria by bursting their cell walls. This protein has a wide pH range and is highly specific to anthrax bacteria, making it an attractive option for environmental decontamination and treatment.
The Khaled bin Sultan Living Oceans Foundation is conducting a pioneering study on the Farasan Islands Marine Protected Area off the coast of Saudi Arabia. The research will assess the effects of ecotourism, pollution, over-fishing, climate change, dredging, and development on coral reefs.
A study published in Nature found that caspase-12 deficient mice are resistant to peritonitis and septic shock, clearing pathogenic bacteria more efficiently. The absence of caspase-12 reduces pro-inflammatory cytokine production, increasing vulnerability to bacterial infection and septic mortality.
The study found that 34% of children living in FEMA-subsidized community settings have at least one diagnosed chronic medical condition, with high rates of asthma and behavioral problems. The survey also revealed difficulties in accessing mental health services, with nearly half of caregivers scoring at levels consistent with clinicall...
A large-scale phase IV trial found FOSRENOL significantly reduced daily tablet burden and improved patient satisfaction, while maintaining mean serum phosphorus control. Higher initial doses of FOSRENOL more rapidly controlled hyperphosphatemia without increasing adverse events.
A recent study suggests that TV viewing is associated with an increase in calorie intake in children, particularly for unhealthy foods advertised on screen. The research found that each additional hour of TV viewing resulted in a total energy increase of 167 calories, mostly due to increased consumption of sugar-sweetened beverages.
The study found a triple interaction between CD44, hyaluronan, and LARG that initiates two molecular pathways causing tumor cell growth and migration. The complex can be used as a marker for potentially aggressive head-neck tumors and may lead to new therapeutic strategies targeting the PDZ domain of LARG.
Research at Vanderbilt University Medical Center found that cholesterol attachment to the developmental protein Sonic hedgehog controls finger and toe development in mice. Without cholesterol, mice developed extra digits and malformed toes.
Geologists drilled nearly five months to recover samples of hard rock called gabbro from intact ocean crust, offering insights into fast-spreading oceanic crust formation. The discovery sheds light on the origin of oceanic crust and its composition.
Researchers found that larger social networks are associated with reduced cognitive impairment in people with Alzheimer's disease pathology. The study suggests that healthy interactions with friends and family can have a positive impact on disease prevention.
A recent study challenges metabolic ecology models, which failed to explain tropical forest structure and dynamics. Instead, researchers found that environmental conditions and species traits play a crucial role in shaping these ecosystems.
Researchers have developed a new hybrid virus that can target tumors systemically to deliver an imaging or therapeutic gene, allowing for the monitoring of drug effectiveness at the molecular level. This breakthrough could lead to improved diagnosis, monitoring, and treatment of human cancers.
Deferasirox proved equally as effective as deferoxamine in reducing iron overload levels in patients with beta-thalassemia. The new drug was well-tolerated, with common side effects including skin rash and gastrointestinal issues.
A new study examining 911 babies treated with either letrozole or clomiphene citrate found no statistically significant difference in major and minor malformations or chromosomal abnormalities between the two groups. The findings confirm concerns about a link between letrozole and birth defects are unfounded.
Researchers successfully mapped the regulatory circuitry of human embryonic stem cells using microarray technology. The study reveals that Polycomb group proteins play a crucial role in repressing genes essential for later development, leading to uncontrolled growth when these genes are lost.
For the first time, researchers have tracked cellulose fiber formation in real-time, providing evidence of a functional connection between cellulose synthase and microtubules. This breakthrough discovery has significant implications for designing energy-rich biofuel crops and improved fiber crops.
A team of scientists has successfully drilled into a fossil magma chamber beneath the Pacific Ocean's crust, providing valuable insights into how new ocean crust is formed. The discovery confirms theories about the relationship between seismic velocity and crustal rock composition.
A study by McGill University researchers found that people who expect to smoke soon are more susceptible to visual cues, leading to increased cravings. The study suggests that stress or disruptions to the prefrontal cortex can also trigger relapse, shedding light on nicotine addiction treatment.
A study analyzing NINDS-supported clinical trials found a 4600% return on investment and estimated benefits of over $50 billion. The studies improved health outcomes and saved lives, with some trials showing benefits of over $6 billion.
Scientists have discovered that agrin controls nerve cell excitability by regulating sodium pump activity in the brain, potentially leading to new treatments for epilepsy. Agrin also regulates potassium levels in heart tissue, raising the possibility of its use in treating congestive heart failure.
Data from the National Health Interview Survey show a significant link between obesity and increasing diabetes incidence. Lifestyle interventions, including moderate weight loss and exercise, can prevent or delay diabetes onset in high-risk adults.
Researchers found a synergistic combination of a low-dose CD3 antibody and proinsulin peptide to reverse recent-onset type 1 diabetes in mice, promoting pancreatic beta cell regeneration. This approach may hold great potential for the treatment of individuals with recent-onset type 1 diabetes.
Researchers used neodymium isotopes in tiny fish teeth to date the Drake Passage opening and confirm it was earlier than previously thought, potentially contributing to Antarctica's cooling. The circumpolar current isolated the continent from warm waters, leading to upwelling of cold water and growth of algae that consumed carbon dioxide.
A recent study documents six new frog species found in Laos over a two-year period, showcasing the country's remarkable biodiversity. Conservationists are concerned about the combined loss of forest cover and over-exploitation of species threatening much of Laos' wildlife.
Researchers found that blood tests T-SPOT.TB and QuantiFERON-TB Gold show good diagnostic agreement with the skin test, but have higher specificity. This suggests they could increase diagnostic sensitivity in testing for latent TB infection. However, results differ between blood tests, especially in immunosuppressed patients and young ...
Researchers used ancient and modern DNA to study the decline of Ctenomys sociabilis, a colonial tuco-tuco species. The analysis suggests that population bottlenecks and environmental changes led to the loss of genetic diversity, but also hints at the evolution of social behavior.
Researchers develop a combination therapy that reverses recent-onset type 1 diabetes in mice by inducing regulatory T cells to shield insulin-producing cells from autoimmune destruction. The therapy, which combines an oral and intranasal treatment, shows greater efficacy than individual treatments alone.
HHMI's Janelia Farm Research Campus aims to promote high-risk, high-reward research by providing internal funding and a flexible environment. The campus will feature small research groups, active bench scientists, and excellent support facilities.
Despite global recommendations, many women are not following daily folic acid guidelines to reduce neural tube defects. Countries should intensify national campaigns to increase knowledge and use of supplements among women.
Researchers using ERS-2's radar altimetry and InSAR found anomalies in ice-sheet surface elevation, suggesting large floods of water from deep within the ice may have generated huge floods that reached the ocean. The discovery raises concerns about ancient life in subglacial lakes.
A study of over 39,000 women found that hormone therapy reduced the risk of heart attacks by 32% for those starting treatment in their 50s. However, the risk increased in older women within the first year of treatment before it decreased after two years.
Researchers find that high FSH levels are necessary for bone loss in postmenopausal women, suggesting an alternative approach to prevent osteoporosis. The study reveals a direct link between pituitary-derived hormones and bone remodeling, revising the understanding of pituitary hormone physiology.
Scientists at the University of Rochester Medical Center have found a mechanism to modify the effects of major drug class, potentially leading to better control of pain relief, inflammation, and heart disease. The new drugs aim to influence related signaling on the inside of cells, rather than on the outside.
Researchers at La Jolla Institute for Immunology have made a major finding on a potential cure for type 1 diabetes by combining two therapies, producing better efficacy and longer-lasting results in preclinical trials. The combination therapy is being planned to begin human clinical trials later this year.
A study found that young people prefer vinyl due to its visual appeal and the physical interaction required. This resistance against the music industry's attempts to define what's popular is a liberating experience for these teens.
A comprehensive mineral history of Mars reveals that conditions became increasingly dry and acidic around 3.5 billion years ago, making it an unlikely place for life to thrive. The study identifies clay-rich rocks and soil as potential targets for future lander missions.
The study found that the three-dimensional structure of SOCS3 enables the design of selective inhibitors, which may extend the activity of G-CSF in restoring white blood cells. Additionally, an engineered version of SOCS3 with improved stability and repressive functions shows potential for treating inflammatory diseases.
Researchers at the Broad Institute found an unusual molecular structure near developmental genes that enables embryonic stem cells to maintain their unique plasticity. This 'bivalent domain' acts as a kind of gene gatekeeper, controlling the expression of crucial genes in early development.
Rice University is leading an international team in building a cylindrical bank of over 23,000 particle detectors for the Solenoidal Tracker at RHIC. The collaboration, valued at $7 million, demonstrates robust scientific cooperation between US and Chinese institutions.
The Salk Institute researchers created a cell-free system to study the insertion of nuclear pore complexes into the nuclear membrane. Using advanced imaging tools, they observed the formation of nuclear membranes and pores within an hour.
A Cornell University study reveals that galaxies in the early universe tend to cluster near large clumps of dark matter. The research uses data from the Spitzer Wide-area InfraRed Extragalactic survey and confirms that ultraluminous infrared galaxies are precursors to galaxy clusters.
A new study by University of Florida researchers found that bullying among overweight children is linked to lower rates of physical activity and depression. The study suggests that positive support from family and friends can help mitigate the negative effects of bullying on exercise habits.