Articles tagged with Estrogen
New research reveals that fetal BPA exposure alters the uterine epigenome, affecting almost 1,000 genes regulated by estrogen. This changes lead to an increased risk of estrogen-related diseases such as infertility and breast cancer in offspring.
Research suggests a 'two-hit' process links estrogen withdrawal to menstrual migraine. Women with migraine experience a faster rate of estrogen decline than those without, which may make them vulnerable to migraine triggers like stress and sleep deprivation.
A Northwestern University study found that a class of drugs inhibiting estrogen production can quickly and effectively suppress brain seizures. The effect was profound and clear, suggesting a new approach to treating seizures by shutting down the brain's production of estrogen when a seizure first begins.
Researchers discovered a new factor in seizure escalation: estrogen synthesis in the brain. Aromatase inhibitors showed promise in suppressing seizures without negative side effects, promising a novel therapeutic approach.
Researchers have identified cellular pathways in skin pigment cells activated by estrogen and progesterone, leading to either skin darkening or lightening. The discovery could lead to the development of new products changing skin tone without harmful chemicals.
A new study links gut bacteria to post-menopausal bone loss, showing probiotics can prevent this condition by attenuating inflammation. Treatment with probiotics also reduced bone loss in normal mice, highlighting therapeutic potential for probiotics in osteoporosis prevention.
A review paper suggests that estrobolome disparities could help develop microbiome-based biomarkers for mitigating certain cancers. The gut bacterial genes capable of metabolizing estrogens play a crucial role in shaping systemic estrogen levels.
A new study found that estrogen replacement therapy improves verbal memory and cognitive flexibility in young female athletes with amenorrhea. The study showed significant improvements in both immediate recall of words and ability to switch between tasks, even when controlling for age and pre-treatment test scores.
A Swedish population study found that estrogen-only therapy carries a lower risk of blood clots than combined estrogen-progestogen therapy. Transdermal estrogen and vaginal estrogen also show no significantly increased risk of blood clots.
Researchers found that women who take the birth control pill are less likely to suffer serious knee injuries compared to those who do not use hormonal contraception. Women between 15-19 years old with ACL injuries were 22% less likely to be taking birth control pills.
Researchers discovered that estrogen-producing glial cells play a role in controlling inflammation in the injured zebra finch brain. The process happens within hours and could lead to new therapies for human brain injuries such as stroke, Alzheimer's disease, and Parkinson's disease.
EPFL scientists have developed an animal model for estrogen receptor-positive breast cancer that faithfully captures the disease. The new model has been tested on human breast tissue in a pre-clinical context, providing crucial factors such as hormone action and molecular responses to therapies.
Researchers investigate if estrogen plays a role in sex differences in hypertension among young, obese women. High levels of aldosterone, triggered by leptin in obesity, contribute to cardiovascular problems.
Researchers investigate sex differences in hypertension mechanisms and explore potential therapeutic strategies for premenopausal women. Studies suggest that obesity leads to increased aldosterone levels, contributing to cardiovascular problems.
Researchers found that dairy farm waste treated with an advanced anaerobic digestion system still contained high levels of estrogens and antibiotics, which can harm wildlife and contribute to antibiotic resistance. The study highlights the need for improved treatment techniques to remove these chemicals from waste.
Researchers found that estrogens selectively calm hyperactive behavior in zebrafish with a genetic mutation linked to autism. The study suggests estrogens may target specific brain pathways affected in ASD, which could lead to new treatments for the condition.
A recent study by Johns Hopkins Bloomberg School of Public Health suggests that estrogen may offer additional benefits to hormone replacement therapy or infertility treatment. The research found that estrogen dramatically reduced the amount of flu virus that replicated in infected cells from women, but not from men.
In a phase III trial, DHEA showed significant improvements in vaginal discomfort after menopause, reducing pain with sex by 0.36 points and improving vaginal dryness by 0.27 points compared to a placebo. The treatment also led to increased superficial cells and decreased parabasal cells, indicating improved vaginal health.
A new study by University of Guelph researchers found that adding estrogen to female mouse brains boosts short-term learning, likely through a 'use-it-or-lose-it' process. The team discovered that brain cells grow more synapses on branches of neurons when exposed to estrogen.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism suggests that high testosterone levels may increase the risk of developing uterine fibroids in midlife women. Women with both high testosterone and estrogen levels faced a greater risk of developing fibroids.
A study published in JNCI Journal of the National Cancer Institute found that continuous joint use of estrogen and progestin reduces the risk of endometrial cancer by 35% in postmenopausal women. The study analyzed data from 16,608 women aged 50-79 with normal uteri, who were randomly assigned to daily estrogen plus progestin or placebo.
A recent study suggests that elevated levels of the enzyme APOBEC3B drive tamoxifen resistance in estrogen receptor-positive breast cancer. Higher APOBEC3B levels were associated with shorter progression-free survival times.
A study published in Menopause journal found that over half of women after menopause experience vulvovaginal symptoms, affecting lifestyle and sex life. Nearly a third haven't seen a gynecologist in two years, while most aren't receiving standard treatment for genitourinary syndrome of menopause.
A new study found that local estrogens, such as vaginal tablets, may be more effective than cream in treating genitourinary symptoms of menopause. Women who took tablets were more likely to adhere to treatment guidelines and show improved results.
A Yale study reveals that suburban ponds experience a gender revolution due to elevated levels of estrogen in shrubbery and lawn areas. The research shows that female frogs outnumber males, likely caused by endocrine disruption from phytoestrogens produced by plants commonly found in lawns.
A new study demonstrates postmenopausal women's willingness to use vaginal estrogen (VE) to alleviate painful intercourse and vaginal dryness, with benefits comparable to or exceeding systemic hormone therapy. The study suggests that VE may be a viable solution for certain urogenital problems in menopausal women.
Research reveals that low concentrations of 5α-dihydrotestosterone can induce complete or incomplete sex reversal in female Pelophylax nigromaculatus frogs. Environmental androgenic endocrine disrupting chemicals pose a threat to aquatic ecosystems, highlighting the need for increased regulation.
Researcher Laura Vandenberg is studying the role of BPS, an estrogen-mimicking chemical found in plastics and food packaging, on breast cancer risk. Exposure to these chemicals in the womb may increase breast cancer risk decades later.
A recent study has found that estrogen receptors are almost entirely absent in cervical cancer tumors, but still present in the tumor microenvironment. This finding highlights a critical communication between the microenvironment and tumor cells, allowing the tumor to thrive despite its inability to respond to estrogen.
The Endocrine Society recommends improving the accuracy of estrogen testing methods for better patient care and research, particularly for hormone-related cancers and chronic conditions. The panel advises standardization of measurements through programs like CDC's.
New research by Dr. Liisa Galea suggests that previous motherhood permanently alters the brain's response to hormone therapy, with estradiol-based HT showing beneficial effects and estrone-based HT having detrimental effects on cognition and dementia risk in women.
Aromatase, an enzyme converting testosterone to estrogen, plays a significant role in the healthy and injured brain. In healthy brains, it helps neurons produce estrogen, maintaining cognitive function. After injury, aromatase expression shifts to astrocytes, aiding their support of stressed neurons and promoting recovery.
Analysis of two Women's Health Initiative clinical trials reveals a pattern of changing influences on breast cancer incidence over time, with estrogen plus progestin use linked to increased risk and estrogen alone showing reduced risk. The study suggests that ongoing influences after stopping hormone therapy require recalibration of br...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that pesticide exposure contributes to heightened cardiovascular disease risk and inflammation in premenopausal women. The research suggests that endocrine-disrupting chemicals like DDT can aggravate complications of obesity, including...
The study of over 160,000 postmenopausal women revealed no significant link between lung cancer risk and reproductive history or hormone therapy. However, some subgroups showed reduced risks for specific types of lung cancer, emphasizing the need for further research into complex relationships.
Lactating women are more likely to experience vaginal dryness and discomfort on sexual intercourse due to low estrogen levels. The study suggests that physicians should be aware of this issue and provide appropriate treatment, such as vaginal estrogen cream.
A study by Harvard Medical School found that higher testosterone levels and lower estrogen levels in men worsen cardiovascular risk factors such as insulin resistance and muscle fat. This discovery may help explain why men have a higher risk of heart disease compared to premenopausal women.
A large study of 2,000 Australian women aged 40-65 found that 42% of those between 60-65 years old experienced hot flashes, while 62% continued to experience sexual symptoms. The study highlights the need for better treatment options for these women, many of whom are not receiving adequate care.
A survey shows that postmenopausal women with VVA report improved satisfaction with VagiCap, a vaginal estrogen treatment. The study found that 63% of women on TX-004HR VagiCap reported an improved quality of life after just two weeks of therapy.
Research suggests that spraying treated wastewater on land can diminish water pollution by filtering out endocrine-disrupting compounds, which can harm fish populations. Soils with more organic carbon accumulate higher levels of these compounds, but some break down instead.
Research by UC San Francisco scientists reveals that estrogen-producing neurons play a crucial role in regulating aggression in mice, affecting both male and female behavior. The study found that eliminating these neurons slowed response times to threats and reduced aggression in males, while females showed similar changes in maternal ...
Scientists at UT Arlington have developed a new method for detecting trace amounts of estrogen in small samples, improving research into cancer and other diseases. The new method is sensitive enough to detect estrogens at levels as low as 10 parts per trillion, making it applicable to human health, medicine, and environmental analysis.
Researchers found that estrogen enhances an enzyme driving life-threatening allergic reactions in female mice, leading to more severe and longer-lasting reactions. Blocking estrogen or reducing eNOS activity eliminated the gender disparity, suggesting a potential role for estrogen in allergic reactions.
A team of researchers has identified a chemical compound called indazole chloride that can decrease the effects of multiple sclerosis. Ind-Cl works by inhibiting selective inflammation and remyelinating axons, restoring neuronal function and potentially reducing MS progression.
Researchers discovered that estrogen-producing glial cells play a crucial role in controlling inflammation within hours of brain injury, potentially leading to new therapies. This rapid response could help preserve vital brain function and hasten recovery from brain injuries such as stroke.
A pilot study found that S-equol supplements improved vaginal epithelium and reduced vaginal atrophy in postmenopausal Japanese women. The supplement showed a positive trend to superiority compared to the placebo group without significant abnormalities in vaginal cells or hormone levels.
Researchers found that estrogen pre-activates the unfolded-protein response (UPR), a pathway that prepares cells to divide and grow. UPR activation is linked to cell proliferation and poor survival in estrogen-receptor-positive breast cancer, making it a potential prognostic marker.
Research suggests that lactation may reduce the risk of estrogen receptor-negative and triple-negative breast cancers in African American women. Parous women had a higher chance of developing these aggressive subtypes if they never breastfed, particularly those with four or more births.
A study published by The Endocrine Society found that diverse gut bacteria are associated with a favorable ratio of estrogen metabolites, which may reduce the risk of breast cancer. Researchers analyzed fecal and urine samples from 60 postmenopausal women and discovered a relationship between bacterial diversity and estrogen levels.
A study published in JCI Journals suggests that estrogen replacement therapy can suppress binge-eating behaviors in mice. The effect required the presence of estrogen receptors in serotonin neurons, and direct delivery of an estrogen conjugate also reduced binge eating in these animals.
Researchers at Baylor College of Medicine developed an estrogen-based compound that inhibits binge-like eating behavior in female mice. The study found that the compound, GLP-1-estrogen, works by delivering estrogen to specific brain regions where serotonin neurons are present, reducing binge eating.
The new term GSM describes the complex genital, sexual, and urinary symptoms women experience after menopause. By standardizing a physical examination tool, healthcare providers can diagnose and treat these conditions more accurately and effectively.
Researchers are investigating whether brain estrogens enhance learning and memory in young birds and adults, with the goal of developing targeted treatments for cognitive disorders. Studies will use drugs to manipulate estrogen levels and electrophysiology to assess memory consolidation.
Researchers at UCI have discovered a new role for estrogen receptors on the surface of cells, which collaborate with nuclear receptors to regulate organ development and function. The study has significant implications for understanding estrogen's role in diseases such as cancer, cardiovascular disease, and bone disease.
Researchers validated microbial translocation hypothesis in SIV-infected pigtail macaques, finding that sevelamer treatment reduced systemic LPS and activated peripheral CD4+ T cells. Sevelamer also lowered viral titers and coagulation biomarkers, suggesting a potential therapeutic strategy for HIV.
Researchers found sildenafil's benefits for female mice modeling human heart failure varied with estrogen levels, but were generally ineffective. In contrast, male mice showed improved cardiac health due to sildenafil's effects on cGMP pathways independent of estrogen.
A clinical study of 158 patients with relapsing remitting multiple sclerosis (RRMS) found that combining Copaxone with estriol improved symptom reduction by 12 months, but the effect waned over time. The results suggest a potential benefit to supplementing Copaxone therapy with estrogen.
A new study from the Women's Health Initiative found no link between low vitamin D levels and menopause symptoms, including hot flashes, night sweats, and sleep disturbances. The study analyzed data from 530 women participating in the calcium and vitamin D WHI trial.
A recent study found that female hormone therapy, particularly estrogen plus progesterone, significantly improved survival among women with non-small cell lung cancer. The combination of hormone therapy and long-term use showed the most notable improvements in median survival time.
Developing heart valves in zebrafish embryos may be vulnerable to environmental endocrine disruptors, which can mimic estrogen and lead to abnormalities. The study uses genetically modified zebrafish to detect and identify the mechanisms of action of these chemicals.