Articles tagged with Estrogen
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Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
A team of researchers found little evidence to support the notion that roles were assigned specifically to each sex during the Paleolithic era. Women's physiology and anatomy revealed they were physically capable of hunting, with advantages in endurance activities.
Researchers investigated the role of estrogen receptor beta-positive neurons in the medial amygdala, a region involved in social information processing. They found that MeA-ERβ+ neurons exhibit different roles for receptivity-based and sex-based preferences.
Researchers at the Francis Crick Institute found that pregnancy hormones oestrogen and progesterone act on a small population of neurons in the brain to switch on parental behaviour. This adaptation results in stronger and more selective responses to pups, enabling mothers to care for their young.
Researchers at Caltech developed a wearable sensor that detects estradiol levels in sweat, allowing for real-time monitoring of female hormones. The sensor can track changing estradiol levels throughout the reproductive cycle, providing valuable insights for fertility and hormone replacement therapy.
A new study published in Neurology suggests that a longer reproductive lifespan may be associated with a lower risk of cerebral small vessel disease. Researchers analyzed data from 9,000 postmenopausal female participants and found that those with higher lifetime hormone exposure had smaller white matter hyperintensity volumes.
UTHSC researchers are studying the role of balanced sex hormones in DNA repair in human melanocytes to determine if hormonal imbalances contribute to melanoma risk. The study aims to find novel prevention methods to decrease melanoma cases and potentially save lives.
Researchers found that African American women with ER-positive breast cancer have decreased levels of amino acids and increased levels of fatty acids compared to non-Hispanic white women. This study may help explain the higher mortality rates in African American women with the disease, suggesting potential new screening strategies.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
Scientists have created iron oxide nanoparticles called 'smart rust' that can remove a range of contaminants from water, including oil, nano- and microplastics, and estrogen hormones. The particles are magnetic and can be easily removed with a magnet, making them a promising tool for improving water treatment.
Research identifies key molecular signatures and pathways contributing to skeletal muscle strength loss in females with estrogen deficiency. The study found parallel patterns of inhibition and activation across various signaling pathways, including AMPK and calcium signaling.
A new study by researchers at Dartmouth Cancer Center shows that a combination of estrogen and PARP inhibitors can effectively treat advanced ER+ breast cancer by damaging cancer cells and preventing DNA repair. The treatment strategy has been shown to be effective regardless of BRCA1 or BRCA2 genetic mutations.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
Researchers aim to understand how estrogen levels and menopausal status interact with memory-related brain function and behavioral outcomes in women aged 35-80. The study could help identify physiological factors underlying sex differences in Alzheimer's incidence and improve early disease detection and preventive therapies.
A new study published in Hypertension found that oral estrogen hormone therapy may increase the risk of high blood pressure in women, while transdermal and vaginal formulations appeared to have a lower impact. The research involved over 112,000 women aged 45 years and older who took estrogen-only hormone therapy.
Researchers at Nagoya University have found that ATP, an energy 'currency' within cells, acts as a neurotransmitter in the brain and causes mammalian ovulation. Administering ATP to rats induced the LH surge leading to ovulation, suggesting a potential new treatment for infertility.
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
A first-of-its-kind study has estimated that transgender women taking estrogen are at a higher risk for prostate cancer, with 14 cases per 10,000 people. The study found disparities in diagnosis rates among different racial groups.
A comprehensive review reveals that postmenopausal dyspareunia is a common condition with various causes, including lack of estrogen, cancer treatments, and musculoskeletal problems. Effective treatments are available, such as lubricants, vaginal estrogen, and fractional CO2 laser treatments.
A new computational model suggests that reducing hormone doses in contraceptives could effectively suppress ovulation. The model found that hormone doses could be lowered by up to 92% in estrogen-only contraceptives and 43% in progesterone-only contraceptives, while still preventing ovulation.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
Researchers at the Mayo Clinic found that surgical removal of both ovaries in women under 43 increases their risk of developing Parkinson's disease and parkinsonism. The study used health record data from the Rochester Epidemiology Project to analyze over 2,750 women who underwent bilateral oophorectomy.
A new study published in PLOS Medicine found a similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk. The analysis of almost 10,000 women under 50 years old showed a 20-30% relative increase in breast cancer risk associated with both types of contraceptives.
Researchers from Linköping University found that estrogen impairs the function of a specific ion channel, Kv7.1/KCNE1, which is associated with long QT syndrome and arrhythmia. This suggests that estrogen may be a risk factor for certain types of heart rhythm disturbances in women with hereditary mutations.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
A new study found that low estrogen levels are paired with higher calcitonin gene-related peptide (CGRP) levels in female participants with migraine. Researchers collected blood and tear fluid samples from three groups of women with episodic migraine to determine CGRP concentrations, revealing significant fluctuations during menstruation.
Research at Charité – Universitätsmedizin Berlin identifies a possible explanation for migraine frequency during menstruation: higher levels of CGRP, a neurotransmitter that triggers migraines. The study found significant differences in CGRP concentrations between women with migraines and those without, suggesting a hormonal link.
A University of Jyväskylä study found that estrogen deficiency affects systemic signaling in response to exercise. Exercise typically induces changes in micro-RNA molecules, but estrogen levels impact this process in postmenopausal women.
A new study published in Neurology found that higher lifetime estrogen exposure is associated with a lower risk of stroke in postmenopausal women. The study, which involved 122,939 female participants, showed that those with longer reproductive life spans had a 5% lower risk of all types of stroke.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
Researchers discovered a modified form of an inflammatory immune protein called complement C3 that is present at higher levels in women's brains with Alzheimer's compared to men's. This finding may explain why women are more likely to develop the disease, as estrogen levels drop during menopause and lose their brain-protective effects.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
A new study identifies anti-Müllerian hormone (AMH) as a key factor in regulating cholesterol levels during the menopause transition. High AMH levels are associated with lower HDL-C, or good cholesterol, which may indicate cardiovascular risk despite its traditionally protective effects.
Researchers identified a strong association between beneficial bacteria and estrogen hormone therapy in postmenopausal women. The study found that estrogen may play a role in reducing susceptibility to recurrent UTIs by promoting the growth of good bacteria such as Lactobacilli in the bladder. Conversely, women with recurrent UTIs had ...
Researchers at Cedars-Sinai found that estrogen can prevent symptoms of delirium in mice with urinary tract infections, reducing IL-6 levels in the blood and protecting neurons. The study suggests estrogen may be a tool to mitigate delirium, particularly in older women with UTIs.
A study using a mouse model found that over-expression of the Esr1 gene increased the risk of developing estrogen receptor-positive breast cancer in older women. Giving anti-hormonal drugs to mice with Esr1 over-expression lowered or reversed this risk.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A study found widespread occurrence of microplastics in Monterey Bay water and in the digestive tracts of anchovies and common murres. The researchers discovered that almost a quarter of the examined murres had particles exhibiting estrogenic activity, potentially disrupting hormone functions.
A new preclinical study discovered the underlying cause of gender differences in immunotherapy-associated myocarditis and identified potential treatment strategies. Hormone therapies targeting the endocrine-cardiac-immune pathway may reduce this risk without affecting treatment efficacy.
A study of obese women on the 'warrior diet' found no significant change in sex-binding globulin hormone levels but a moderate drop in dehydroepiandrosterone (DHEA) levels, linked to reduced breast cancer risk. Women also experienced weight loss and improved insulin resistance.
A study found that nicotine from a single cigarette reduces estrogen production in women's brains, which may explain their greater resistance to quitting smoking. The effect was observed in the thalamus, part of the limbic system involved in behavioral responses.
A new study found that traumatic experiences are associated with lower concentrations of estrogens estrone and estradiol in postmenopausal women. The relationship between trauma and hormones depends on sleep duration, with women experiencing low levels of estrogens who get less than 6 hours of sleep per night
A Rutgers study finds CBD improves glucose disposal, burns energy, and enhances bone density in estrogen-deficient mice. The compound also reduces inflammation and boosts beneficial gut bacteria.
Recent evidence suggests hormone therapy at menopause does not significantly increase the risk of invasive breast cancer. However, estrogen combined with progesterone increases breast cancer risk for women with an intact uterus. Menopause experts offer reassurance to women and their healthcare providers about the safety of hormone ther...
A large study of over 296,000 patients found that being overweight was negatively associated with dementia in women, while underweight was positively linked to an increased risk of dementia in men. The results suggest that moderate weight gain may be beneficial for cognitive health in older women.
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
A $3.1 million grant will enable researchers to collaborate on a prospective study investigating early signs of heart vessel damage in young, pre-menopausal breast cancer survivors. The CROWN study aims to identify biomarkers that correlate with cardiovascular risk and develop strategies to lower the risk of irreversible heart disease.
A study published in PLOS ONE found an association between reduced estrogen and progesterone levels and increased risk of snoring and obstructive sleep apnea in postmenopausal women. Low estrogen levels were linked to a 19% decreased odds of snoring, while low progesterone levels were associated with a 9% decrease.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
A University of Jyväskylä study found that menopausal women's ability to use fat as an energy source is not impaired by estrogen levels or menopause. Women who burned more fat during exercise had higher fitness and physical activity levels, while those with better glucose tolerance did not necessarily burn more fat.
Research led by Texas A&M AgriLife scientist Shaodong Guo found that estrogen protects female mice from cardiomyopathy and death, reversing the effects of insulin resistance. The study suggests that estrogen replacement therapy may be a feasible treatment option for diabetic cardiomyopathy.
Researchers at West Virginia University are studying the mechanisms behind Alzheimer's disease and PTSD, using animal models to investigate how stressful events affect brain cells. They aim to understand the role of estrogen and high-cholesterol diet in developing the disease.
The study examines how estrogen regulates the brain's bioenergetic system, which affects glucose transport and metabolism. Researchers aim to understand changes in this system during menopause and its potential link to age-associated neurodegenerative diseases like Alzheimer's disease.
A new study found that hormone replacement therapy within six months of COVID-19 diagnosis was associated with a 78% reduction in all-cause mortality in women. This suggests estrogen may offer protective effects against COVID-19 severity, explaining the lower hospitalization and death rates among women compared to men.
Researchers found that hormone fluctuations, particularly estrogen, shape brain development and behavior. Estrogen influences the growth of brain regions, leading to permanent changes in neural circuitry.
Patients with lower levels of sex hormones are more likely to undergo surgery for rotator cuff tears, according to a study published in The Journal of Bone & Joint Surgery. Estrogen deficiency was associated with a 48% higher incidence of rotator cuff repair in women, while testosterone deficiency was linked to an 89% higher rate in men.
A study published in PLOS Medicine found that certain reproductive events, such as shorter estrogen exposure, may be associated with increased dementia risk in women. However, the association between the number of children and dementia risk was similar for women and men, suggesting social and behavioral factors may play a role.