Articles tagged with Estrogen
A recent study published in JAMA found that transgender women on hormone therapy have drastically lower PSA levels, which may lead to delayed diagnosis and treatment of prostate cancer. The researchers analyzed Veterans Health Administration records and recommended caution when interpreting PSA values in transgender women.
Researchers found that women who had their ovaries removed before menopause experience reduced white matter integrity in multiple brain regions. This reduction may contribute to an increased risk of cognitive decline and dementia later in life.
A new brain imaging study led by Weill Cornell Medicine researchers found that estrogen receptors in the brain increase with age during menopause, affecting cognitive and mood symptoms. The study pioneers PET imaging as a tool to track estrogen activity in the brain, revealing potential predictors of common menopause-related issues.
Research highlights socioecologic factors contributing to racial disparities in breast cancer prognostic scores, emphasizing the impact of structural racism on health outcomes. Additional research is needed to better understand the influence of social determinants on breast cancer biology among disadvantaged communities.
A study shows post-menopausal women experience a steep rise in heart problems due to reduced estrogen levels, accelerating plaque buildup and cardiovascular risk. Researchers highlight the importance of recognizing early warning signs and increasing screening for coronary artery calcium.
Dr. Rhonda Voskuhl's groundbreaking research has shed light on the mechanisms underlying sex differences in MS, highlighting a gene on female sex chromosomes that promotes inflammation and brain-protective effects of estrogen. Her work may lead to new treatment approaches for MS.
A new study suggests that anxiety and depression in younger women may accelerate the development of cardiovascular risk factors, putting them at nearly par with men of the same age. The researchers found that these mental health conditions were associated with a much higher relative risk among young women than seen in other groups.
Researchers discovered a feedback loop involving estrogen that may explain why women become more dependent on nicotine. Estrogen-induced proteins called olfactomedins could be targeted with therapies to help control nicotine consumption.
A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.
Researchers at the University of Adelaide have discovered a new approach to defeating breast cancer by stimulating the androgen receptor. The study found that enobosarm was effective against estrogen receptor-positive breast cancer, which is the most common form of the disease.
A recent study by researchers at the University of Texas at Arlington found that women are more susceptible to cocaine addiction than men due to fluctuations in sex hormones. The study discovered that the female sex hormone estradiol enhances the rewarding effects of cocaine, leading to increased sensitivity among females.
Scientists have discovered a way to predict breast cancer risk based on specific chemical traits, identifying over 900 chemicals that could contribute to the disease. These chemicals are commonly found in consumer products, food, and workplaces, and can alter hormones or damage DNA.
Researchers investigated role of estrogen receptors in lateral septum regulating social anxiety in male mice, finding that ERβ plays a crucial role in neural circuitry. Knockdown effects on ERβ gene expression showed increased social anxiety, highlighting its importance in social situations.
Scientists in Brazil have developed a method to obtain a substance similar to estrogen from soy isoflavones, which may help alleviate menopause symptoms. The researchers extracted equol from soybean oil production residue and found it to be more bioavailable than glycosylated forms.
A recent study published in Lancet Oncology has found that measuring blood hormone levels can identify post-menopausal women who are most likely to benefit from anastrozole, a medication used to prevent breast cancer. The study suggests that inexpensive blood tests could be used to personalize preventive therapy for these women.
A study of 152 male gym enthusiasts found a significant lack of awareness about the risks of gym lifestyle on fertility. High levels of estrogen from protein supplements were linked to fertility issues, prompting a call for men to educate themselves about supplementation.
Recent studies by Cara Ocobock and Sarah Lacy found that prehistoric women engaged in hunting, with their female anatomy providing advantages such as endurance and fat metabolism. The research corrects the historical erasure of women from the narrative of human evolution.
Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
A team of researchers found little evidence to support the notion that roles were assigned specifically to each sex during the Paleolithic era. Women's physiology and anatomy revealed they were physically capable of hunting, with advantages in endurance activities.
Researchers investigated the role of estrogen receptor beta-positive neurons in the medial amygdala, a region involved in social information processing. They found that MeA-ERβ+ neurons exhibit different roles for receptivity-based and sex-based preferences.
Researchers at the Francis Crick Institute found that pregnancy hormones oestrogen and progesterone act on a small population of neurons in the brain to switch on parental behaviour. This adaptation results in stronger and more selective responses to pups, enabling mothers to care for their young.
Researchers at Caltech developed a wearable sensor that detects estradiol levels in sweat, allowing for real-time monitoring of female hormones. The sensor can track changing estradiol levels throughout the reproductive cycle, providing valuable insights for fertility and hormone replacement therapy.
A new study published in Neurology suggests that a longer reproductive lifespan may be associated with a lower risk of cerebral small vessel disease. Researchers analyzed data from 9,000 postmenopausal female participants and found that those with higher lifetime hormone exposure had smaller white matter hyperintensity volumes.
UTHSC researchers are studying the role of balanced sex hormones in DNA repair in human melanocytes to determine if hormonal imbalances contribute to melanoma risk. The study aims to find novel prevention methods to decrease melanoma cases and potentially save lives.
Researchers found that African American women with ER-positive breast cancer have decreased levels of amino acids and increased levels of fatty acids compared to non-Hispanic white women. This study may help explain the higher mortality rates in African American women with the disease, suggesting potential new screening strategies.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
Scientists have created iron oxide nanoparticles called 'smart rust' that can remove a range of contaminants from water, including oil, nano- and microplastics, and estrogen hormones. The particles are magnetic and can be easily removed with a magnet, making them a promising tool for improving water treatment.
Research identifies key molecular signatures and pathways contributing to skeletal muscle strength loss in females with estrogen deficiency. The study found parallel patterns of inhibition and activation across various signaling pathways, including AMPK and calcium signaling.
A new study by researchers at Dartmouth Cancer Center shows that a combination of estrogen and PARP inhibitors can effectively treat advanced ER+ breast cancer by damaging cancer cells and preventing DNA repair. The treatment strategy has been shown to be effective regardless of BRCA1 or BRCA2 genetic mutations.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
Researchers aim to understand how estrogen levels and menopausal status interact with memory-related brain function and behavioral outcomes in women aged 35-80. The study could help identify physiological factors underlying sex differences in Alzheimer's incidence and improve early disease detection and preventive therapies.
A new study published in Hypertension found that oral estrogen hormone therapy may increase the risk of high blood pressure in women, while transdermal and vaginal formulations appeared to have a lower impact. The research involved over 112,000 women aged 45 years and older who took estrogen-only hormone therapy.
Researchers at Nagoya University have found that ATP, an energy 'currency' within cells, acts as a neurotransmitter in the brain and causes mammalian ovulation. Administering ATP to rats induced the LH surge leading to ovulation, suggesting a potential new treatment for infertility.
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
A first-of-its-kind study has estimated that transgender women taking estrogen are at a higher risk for prostate cancer, with 14 cases per 10,000 people. The study found disparities in diagnosis rates among different racial groups.
A comprehensive review reveals that postmenopausal dyspareunia is a common condition with various causes, including lack of estrogen, cancer treatments, and musculoskeletal problems. Effective treatments are available, such as lubricants, vaginal estrogen, and fractional CO2 laser treatments.
A new computational model suggests that reducing hormone doses in contraceptives could effectively suppress ovulation. The model found that hormone doses could be lowered by up to 92% in estrogen-only contraceptives and 43% in progesterone-only contraceptives, while still preventing ovulation.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
Researchers at the Mayo Clinic found that surgical removal of both ovaries in women under 43 increases their risk of developing Parkinson's disease and parkinsonism. The study used health record data from the Rochester Epidemiology Project to analyze over 2,750 women who underwent bilateral oophorectomy.
A new study published in PLOS Medicine found a similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk. The analysis of almost 10,000 women under 50 years old showed a 20-30% relative increase in breast cancer risk associated with both types of contraceptives.
Researchers from Linköping University found that estrogen impairs the function of a specific ion channel, Kv7.1/KCNE1, which is associated with long QT syndrome and arrhythmia. This suggests that estrogen may be a risk factor for certain types of heart rhythm disturbances in women with hereditary mutations.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
Research at Charité – Universitätsmedizin Berlin identifies a possible explanation for migraine frequency during menstruation: higher levels of CGRP, a neurotransmitter that triggers migraines. The study found significant differences in CGRP concentrations between women with migraines and those without, suggesting a hormonal link.
A new study found that low estrogen levels are paired with higher calcitonin gene-related peptide (CGRP) levels in female participants with migraine. Researchers collected blood and tear fluid samples from three groups of women with episodic migraine to determine CGRP concentrations, revealing significant fluctuations during menstruation.
A University of Jyväskylä study found that estrogen deficiency affects systemic signaling in response to exercise. Exercise typically induces changes in micro-RNA molecules, but estrogen levels impact this process in postmenopausal women.
A new study published in Neurology found that higher lifetime estrogen exposure is associated with a lower risk of stroke in postmenopausal women. The study, which involved 122,939 female participants, showed that those with longer reproductive life spans had a 5% lower risk of all types of stroke.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
Researchers discovered a modified form of an inflammatory immune protein called complement C3 that is present at higher levels in women's brains with Alzheimer's compared to men's. This finding may explain why women are more likely to develop the disease, as estrogen levels drop during menopause and lose their brain-protective effects.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
Researchers identified a strong association between beneficial bacteria and estrogen hormone therapy in postmenopausal women. The study found that estrogen may play a role in reducing susceptibility to recurrent UTIs by promoting the growth of good bacteria such as Lactobacilli in the bladder. Conversely, women with recurrent UTIs had ...
A new study identifies anti-Müllerian hormone (AMH) as a key factor in regulating cholesterol levels during the menopause transition. High AMH levels are associated with lower HDL-C, or good cholesterol, which may indicate cardiovascular risk despite its traditionally protective effects.
Researchers at Cedars-Sinai found that estrogen can prevent symptoms of delirium in mice with urinary tract infections, reducing IL-6 levels in the blood and protecting neurons. The study suggests estrogen may be a tool to mitigate delirium, particularly in older women with UTIs.
A study using a mouse model found that over-expression of the Esr1 gene increased the risk of developing estrogen receptor-positive breast cancer in older women. Giving anti-hormonal drugs to mice with Esr1 over-expression lowered or reversed this risk.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A study found widespread occurrence of microplastics in Monterey Bay water and in the digestive tracts of anchovies and common murres. The researchers discovered that almost a quarter of the examined murres had particles exhibiting estrogenic activity, potentially disrupting hormone functions.
A new preclinical study discovered the underlying cause of gender differences in immunotherapy-associated myocarditis and identified potential treatment strategies. Hormone therapies targeting the endocrine-cardiac-immune pathway may reduce this risk without affecting treatment efficacy.
A study of obese women on the 'warrior diet' found no significant change in sex-binding globulin hormone levels but a moderate drop in dehydroepiandrosterone (DHEA) levels, linked to reduced breast cancer risk. Women also experienced weight loss and improved insulin resistance.