Articles tagged with Estrogen
A study published in Neurology found that estrogen had no effect on improving memory and mental functions in postmenopausal women with mild to moderate Alzheimer's disease after a 12-week period. Researchers suggest further trials are needed to determine the effectiveness of estrogen in preventing or delaying the onset of Alzheimer's.
Researchers found that estrogen use reduced cognitive decline in women with e2 and e3 ApoE alleles, but not in those with e4 variants. Estrogen also showed protective effects on carotid wall thickening and atherosclerosis.
Researchers found greater numbers of estrogen receptors on lung cancer cells, suggesting a role for this hormone in enhancing tumor growth. Estrogen was shown to increase cell division and tumor growth in both cultured lung cancer cells and animal models.
A new study of 309 older women found that hormone replacement therapy (HRT) did not slow the progression of heart disease. HRT lowered cholesterol, but this benefit did not translate to a measurable impact on artery narrowing.
A high dose of estrogen administered soon after a stroke can prevent substantial brain damage in laboratory animals, with a 60% decrease in brain cell death. The study builds on observations that postmenopausal women who take estrogen replacement therapy are more likely to survive stroke.
A study led by MGH researchers found that androstenedione supplementation increases testosterone levels in healthy young men, with estrogen levels also rising at both 100 and 300mg doses. Long-term effects of androstenedione on hormone levels and athletic performance are unknown
Researchers found that supplemental estrogen prevented hypertension in 3-month-old female rats with healthy hearts, but not in 17-month-old rats who already had hypertension. The study suggests that estrogen supplementation may be beneficial for women nearing or going through perimenopause, where estrogen levels decline.
Scientists generate mutant mice with disrupted estrogen receptors, resulting in adult female ovaries transforming into male-like cells. This discovery advances our understanding of the action of estrogen and its role in human fertility and cancer.
Researchers found that estrogen can reduce the risk of developing cataracts by up to 77%, with estradiol and estrone showing particular promise. The study used rats with induced ovarian failure to test the effects of different estrogens on cataract development.
A new study suggests that estrogen supplementation in postmenopausal women may slow the progression of periodontal disease, protecting their teeth. The research found that estrogen deficiency and osteopenia/osteoporosis speed oral bone loss following menopause, leading to tooth loss.
Researchers found that methylation of estrogen receptor genes may be linked to atherosclerosis and increased risk of heart disease in women. The study suggests that a genetic shutdown may contribute to the perplexing results of hormone replacement therapy on heart disease.
Researchers found that genetic variation significantly impacts an individual's sensitivity to estrogen, challenging traditional laboratory-animal-based safety tests. The study suggests that genetic makeup should be considered when prescribing estrogen and related hormones for medical purposes.
Researchers found that tamoxifen causes the estrogen receptor to form a unique pocket that changes its response to the drug. New drugs targeting this pocket may offer hope to patients with breast cancer resistant to tamoxifen.
Researchers at Cedars-Sinai Medical Center are launching a clinical trial to assess the impact of isoflavones, found in clover and soybeans, on the human endometrium. The study aims to determine whether these plant compounds can counteract estrogen's proliferative effects and reduce the risk of endometrial cancer.
Biologists at Washington University in St. Louis have discovered that lower estrogen levels allow cytokines to bind to bone cell surfaces, leading to bone destruction. Estrogen replacement therapy may be able to prevent this by increasing decoy receptor proteins, which inhibit cytokine binding.
A study found that breast cancer patients experiencing estrogen deficiency during treatment are at a higher risk of developing depression. Eight women (38 percent) developed major depression, most in the first six months of treatment.
A study by Johns Hopkins Medicine found that combined hormone therapy of estrogen and androgen increased muscle mass and decreased fat in postmenopausal women. The therapy showed an average 2-4% reduction in body fat and a 4-6% increase in muscle mass.
Researchers found that extracts of these plant products bound to estrogen receptors, causing an estrogen-like response in rats. This could lead to reduced LH production, but also raises concerns about potential dangers for women with a history of breast or uterine cancer.
Estrogen therapy has been shown to alter brain activation patterns in postmenopausal women, increasing activation in areas associated with verbal memory and registration, similar to younger adults. The study used fMRI technology to observe changes in brain function while performing memory tasks.
Researchers found that estrogen activates neurotransmitter receptors, increasing neuronal activity and long-term potentiation, a process linked to memory and cognitive function. The study suggests estrogen may play a key role in delaying the onset of Alzheimer's disease.
Estrogen has been found to improve blood vessel function and provide protection against coronary artery disease in premenopausal women. The hormone works by causing endothelial cells to produce more nitric oxide, leading to increased blood flow and reduced risk of heart disease.
Research suggests that soy supplements may decrease breast and endometrial cell proliferation, potentially lowering cancer risk. However, individual differences in metabolism and response to estrogens limit the benefit.
Researchers have discovered the precise three-dimensional shape of the complex between tamoxifen and the estrogen receptor. This clarifies how estrogens turn on genes and shows precisely how tamoxifen blocks this process, setting the stage for intentional drug design with precise action.
A survey of 1,469 women between 40-69 years old found that many are not getting enough counseling about estrogen-replacement therapy. Only 53% felt they made an informed decision about taking hormone replacement, highlighting the need for better education and guidance.
A clinical trial is underway to investigate whether estrogen can enhance the effects of drugs used to treat Parkinson's patients, who experience a 'roller coaster' effect from daily Levodopa use. The study aims to determine if hormone replacement therapy can improve the effectiveness and duration of Mirapex treatment.
The HERS study found that hormone replacement therapy did not prevent further heart attacks or death from coronary heart disease (CHD) in postmenopausal women with CHD, despite positive effects on lipoproteins. However, the treatment increased the risk of clots and lung embolism.
The first investigation of estrogen metabolism in prostate cancer will determine if differences exist between healthy men and those with the disease. The study aims to find potential new strategies to prevent this important disease.
A recent study found that soy phytoestrogens provided equivalent stroke-prevention benefits to standard Premarin therapy in postmenopausal monkeys. The treatment reduced internal carotid artery atherosclerosis by more than half, preventing the development of an 'atherogenic plasma lipid profile'.
A large-scale study shows that estrogen replacement therapy, with or without progestin, consistently and sustainably reduces plasma lipoprotein (a) concentrations, a high-risk factor for heart attacks and strokes. The results also confirm hormone therapy's broad-scale impact on cholesterol metabolism.
Researchers found that female African frogs use a rapid series of loud clicks to attract mates, triggering a reciprocal signaling system. This discovery contradicts traditional views on mating habits and highlights the role of hormones in regulating vocalization and courtship behavior.
A review of 20 published trials found that combining estrogen replacement with at least 1200 mg calcium daily preserves better bone health than using either treatment alone. This review suggests a combination therapy approach to managing osteoporosis in postmenopausal women.
A long-term study found that post-menopausal women who used estrogen replacement therapy performed better on visual memory tests than those who didn't receive treatment. The researchers also found that stable memory performance was maintained by some participants who began ERT during regular visits to the NIA.
Researchers at Northwestern University Medical School found that resveratrol in red wine is a form of estrogen with cardioprotective properties. Moderate consumption of red wine may reduce cardiovascular disease risk due to its resveratrol content, which activates estrogen receptors and increases HDL cholesterol.
Research reveals estrogen regulates fluid reabsorption in efferent ductules, essential for sperm maturation and normal fertility. The study found high concentrations of estrogen receptors in the male reproductive tract.
Researchers found that estrogen replacement therapy accelerated wound healing in elderly postmenopausal women, outperforming those not on hormone therapy. The study suggests that hormone replacement therapy may benefit chronic wounds in older patients.
University of Washington scientists investigate how estrogen replacement therapy protects against Alzheimer's disease by promoting neuron survival and protecting against toxic substances. They found that estrogen may activate an enzyme to increase the expression of neurotransmitter genes, facilitating learning and memory.
Researchers have identified a new compound, GW5638, that strengthens bones and improves cardiovascular health like natural estrogen, while stopping the growth of cancer in uterine cells. The compound's potential may replace tamoxifen as a treatment for breast cancer.
A study of 472 women found a significant link between estrogen use and reduced risk of Alzheimer's disease. The research suggests that estrogen may stimulate nerve cell growth, inhibit apolipoprotein E levels, and increase neurotransmitters like acetylcholine, potentially reducing the risk of AD.
A study by Johns Hopkins researchers reveals that long-term estrogen replacement therapy can increase blood flow to the heart and cause blood vessels to stay open wider and longer. This leads to a reduced risk of heart attack and improved coronary circulation.
A clinical trial is underway to study the effects of minocycline on postmenopausal women with osteoporosis. The drug has been shown to increase bone mineral density and improve bone strength in laboratory animals, suggesting a promising treatment for the disease.
A study in rats found that natural estrogen levels provide significant neuroprotection against stroke damage, sparing up to three times more brain tissue than male counterparts. Researchers are now investigating the optimal dose of estrogen for this effect and its potential as a brain-protective therapy.
Duke researchers found that aging female rats treated with estrogen had more connections in a brain area associated with memory formation than did similar untreated rats. The study suggests that replacing estrogens may alleviate minor memory losses sometimes associated with aging.
A new hormonal drug combination allows post-menopausal women to get the benefits of estrogen without experiencing menses-like bleeding. The therapy significantly increases bone mineral density and improves blood cholesterol levels.
Breast-cancer researchers at the University of Illinois have identified four critical amino acids in the binding of estrogen and anti-estrogen hormones to receptor proteins. This discovery may lead to the development of more tissue-selective therapies for breast cancer treatment, addressing resistance to current treatments like tamoxifen.
Researchers at Eli Lilly have discovered a new pathway through which estrogen affects various organs, including the bones and cardiovascular system. The study provides a potential explanation for how estrogen regulates body functions in different tissues.