Articles tagged with Autocrine Signaling
A new University of Cincinnati study reveals that a signaling pathway in the brain helps maintain health and prevent inflammation and cognitive deficits. Microglia cells produce their own TGF-β ligand to regulate local states of inflammation.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
A new study from Tokyo Medical and Dental University sheds light on the neural stem cell niche's composition during development. Researchers found that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in maintaining NSPCs under hypoxic conditions, promoting lower rates of cell death and increased cell proliferation.
Researchers found that interleukin-2 promotes the development of two subsets of CD8 T cells, one producing IL-2 and the other not, with distinct fates. The IL-2-producing cells develop into immune memory cells with long-term protection, while the non-IL-2-producing cells gain effector traits but lose memory formation.
Researchers have identified an autocrine signaling system within single dendritic spines, leading to spine enlargement and activation of signaling molecules. The findings reveal a three-molecule model of structural plasticity, implicating the localized, coincident activation of Rac1, Cdc42, and RhoA proteins.