Articles tagged with Bacterial Signaling
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Researchers at UC San Diego create an inducible quorum sensing system that allows for precise control of single and multiple bacterial populations, regulated by p-coumaric acid. This new genetic circuit enables better control over tasks such as drug delivery and bioproduction.
A signaling molecule, c-di-GMP, initiates a clock-like mechanism in bacteria that determines individual reproduction. The molecule activates enzymes called kinases, which prepare the cell for division under favorable living conditions.
Scientists have developed a self-propelled chemical trap to corner and destroy pathogens in body fluids, reducing the need for antibiotics. The device uses a magnesium metal engine propelled by hydrogen bubbles, trapping bacteria with an acid-soluble polymer cage that releases a toxin to kill them.
Scientists have transferred genes into bacteria to convert nitrogen from the air into a natural fertilizer, reducing the need for man-made fertilizers. This research could increase crop production and alleviate environmental impacts, particularly in underdeveloped countries.
Researchers have discovered that Pseudomonas aeruginosa bacteria send out warning signals when attacked by antibiotics or viruses, allowing them to survive and potentially evade treatment. This communication mechanism may hold the key to developing new treatments and improving existing ones.
Researchers from Boston University School of Medicine have discovered that lung resident memory T (TRM) cells recruit neutrophils to protect the lungs against future bacterial infections. This study has implications for preventing and treating pneumonia, potentially leading to improved treatment options and personalized medicine.
Researchers identified the molecular signals that activate MAIT cells during Salmonella or Legionella infections. They found that IL-23 is key to expanding MAIT cell numbers and attacking the infection.
A world first study reveals how gut bacteria influence blood sugar levels by communicating with cells producing serotonin in the host body. The microbiome worsens metabolism by driving up serotonin levels, leading to significant metabolic problems.
Scientists have developed a new metabolic engineering technique that enables cells within microbial consortia to regulate their own composition through autonomous cell-to-cell communication. The approach utilizes the universal QS signal AI-2, allowing for tunable growth rates and improved coordination among subpopulations.
A new study reveals that serotonin and certain antidepressants can significantly impact the gut's microbiota, a crucial system of 100 trillion microorganisms. The research identifies Turicibacter sanguinis as a key bacterium responding to serotonin levels, which can influence its growth and presence in the gut.
Research reveals that diet can alter the effectiveness of metformin, a type-2 diabetes drug, by influencing gut bacteria. The study found that specific nutrients can either enhance or suppress these effects, highlighting the importance of dietary guidance for improved treatment outcomes.
Researchers at Aarhus University have discovered a key player in legume-rhizobial symbiosis, enabling the transfer of biological nitrogen fixation to non-legume crops. This breakthrough could help smallholder farmers increase crop yields without relying on fertilizers.
A new study by the Francis Crick Institute found that antibiotics can wipe out early flu resistance and leave the lung vulnerable to viral infections. Gut bacteria help maintain a first line of defense in the lining of the lung, but antibiotics can destroy this defense.
Researchers developed a bacterial memory circuit that can detect and report disease signals in the gut, enabling non-invasive diagnosis. The system uses E. coli bacteria with synthetic trigger elements to identify potential biosensors, showing promise for long-term digestive health monitoring and treatment.
Researchers at Osaka University developed a graphene-based biosensor to detect stomach-cancer causing bacteria using microfluidics. The sensor can detect tiny concentrations of bacteria in under 30 minutes, paving the way for faster diagnoses and improved healthcare outcomes.
Scientists at the University of Warwick have developed a new technology that can detect live bacteria in minutes using bioelectrical signals. This breakthrough could lead to faster diagnosis and treatment of infections, including antibiotic-resistant threats.
University of Minnesota researchers have identified a novel circuit in the cell membrane that signals changes to bacterial surface adhesive proteins. This intramembrane signaling system appears to provide a 'fail-safe' mechanism to edit surface proteins and enable bacteria to adhere and colonize different body surfaces.
Researchers discovered that certain bacteria use viruses to identify and kill rival bacteria for resources. The discovery has implications for synthetic biology and medicine, where understanding bacterial competition could lead to breakthroughs in treating infectious diseases.
Scientists at Hokkaido University discovered a compound in cycad roots that triggers the transformation of Nostoc bacteria into motile hormogonia. This process enables the bacteria to provide nitrogen to host plants, potentially leading to more efficient and fertilizer-dependent agricultural production.
Scientists at the University of Groningen have created a light-controlled switch that can be used to inhibit or stimulate bacterial communication. The molecule was tested on Pseudomonas aeruginosa and showed a strong response to light, inducing quorum sensing signals.
Researchers from Helmholtz Munich used optoacoustic imaging with purple bacteria to detect macrophages in tumors, providing insights into their activity and role in cancer development. This breakthrough enables novel non-invasive technologies for diagnosis and treatment.
Scientists have developed a microscopy method that directly observes bacterial filaments, revealing a new mechanism by which bacteria interact with surfaces. The study shows that type IV pili movements are coordinated through sequential control of pilus extension and retraction, enabling efficient movement across surfaces.
Researchers at the Advanced Science Research Center discovered a unique protein sensing and signaling process in bacteria Erythrobacter litoralis that responds to blue light. This finding could help develop new drugs targeting related signaling processes in pathogenic bacteria.
Researchers at University of Basel discover how Pseudomonas aeruginosa attaches to tissue within seconds and spreads using motile spreaders and virulent stickers. The bacterium exploits a simple business model: settle, grow, expand.
Scientists at Linköping University create a new type of living electrode by embedding Shewanella oneidensis bacteria into conducting polymers, resulting in a significant increase in electron flow and current output. The technology has potential applications in environmental sensors and bioelectronics.
Researchers from ITMO University developed nanocontainers that can translate light signals into metabolic changes in bacteria, opening a new way to control bacterial growth. The containers are made of titanium dioxide nanoparticles coated with silver and polymers, and can be used for controlled drug delivery.
The Konstanz research team developed a technique to measure enzyme inhibition in living cells, which allows for the discovery of inhibitors targeting quinolone biosynthesis. Inhibiting this process disrupts bacterial communication and prevents toxin production, blocking infectious properties.
Researchers at the University of Delaware will study clostridium bacteria for biofuel production, aiming to create sustainable energy from renewable resources. The project seeks to demonstrate that using multiple complementary microorganisms can improve process yields and create valuable chemicals.
Researchers propose a simple chemical reaction network that yields power-law statistics with tunable exponents. This suggests bacteria can naturally generate power-law distributions in flagellar rotation intervals, making them more capable in solving searching tasks.
A study by Carnegie Mellon University researchers reveals that bacteria have retained the same 'password' for sporulation since its evolution 2.7 billion years ago. The discovery challenges traditional theories on evolution and highlights the persistence of ancient signaling networks in these organisms.
Researchers developed a modified Nurr1 protein that can enter cells from the outside, showing promise in treating Parkinson's disease. The protein increased tyrosine hydroxylase production, a key enzyme in dopamine synthesis, and protected against neurotoxin-induced cell death.
Researchers create a genetic signal-transmission system allowing E. coli and Salmonella Typhimurium bacteria to communicate in the mouse gut, enabling a potential 'synthetic microbiome' with engineered bacteria species. This breakthrough could lead to optimized human health through coordinated bacterial functions.
Scientists at the University of Leicester have identified a protein that allows bacteria to detect amino acids in their surroundings, regulating their metabolism and sensing nutrient availability. This discovery could lead to new insights into how bacteria function and inform the development of drugs and antibiotics.
Researchers at the University of California San Diego discovered that bacterial communities employ percolation theory to effectively communicate over long distances. This strategy allows cells to signal each other and maintain a balanced community by regulating growth and resource distribution.
A new study shows that innate immune pathways in the intestine fine-tune body metabolism to diet and conditions in response to
Scientists have developed a new method to study pattern formation in living systems by engineering bacteria to exhibit stochastic Turing patterns. These random patterns can be stabilized by noise, providing a potential explanation for the emergence of complex structures in biological organisms.
Researchers have developed a probiotic intervention that suppresses Vibrio cholerae colonization in the intestinal tract and detects its presence through stool sampling. The approach leverages Lactococcus lactis to create an inhospitable environment for V. cholerae and incorporates synthetic gene circuits to sense secreted signals from...
A recent study by a multi-institutional team identifies new linkages between quorum sensing activity and sugar metabolism in the gut, using AI-2 as an autoinducer secreted by various species of bacteria.
MIT researchers have developed an ingestible sensor equipped with genetically engineered bacteria that can diagnose bleeding in the stomach or other gastrointestinal problems. The sensor, powered by ultra-low-power electronics, can detect biological signals in near real-time and transmit data to a smartphone.
Researchers have developed an ingestible sensor that can detect disease-driving molecules in the gut, providing real-time data to doctors. The device, called Ingestible Micro-Bio-Electronic Device (IMBED), uses bacteria engineered to sense biomolecules, which activate when target molecules diffuse across a semipermeable membrane.
Researchers found that bacterial signals play a crucial role in developing pre-leukemic myeloproliferation, a precursor condition to leukemia, in mice with TET2 mutations. The study suggests that targeted treatments could reverse the disease by blocking aberrant IL-6 signals.
Researchers found that bacteria in Pseudomonas aeruginosa colonies produce dual signal responses to antibiotic tobramycin, including a localized and community-wide response. This communication may enable the bacteria to develop tolerance to some antibiotics.
A new study in mice suggests that a weakened gut barrier may contribute to autoimmune disease. Researchers found that certain bacteria, such as <i>Enterococcus gallinarum</i>, can leak out of the intestines and trigger an autoimmune response similar to what's seen in lupus.
Scientists have developed an innovative process to detect TB bacteria using a fluorogenic trehalose analog, called DMN-trehalose. This new stain only illuminates inside living TB bacteria, making diagnosis more accurate and quick. The innovation aims to simplify the traditional smear microscopy process.
Researchers at UIC have identified a small molecule that promotes quorum sensing in Streptococci, stabilizing chemical signals between cells. This discovery may lead to new ways to manipulate bacterial activity and suppress virulence, potentially aiding in the fight against antibiotic-resistant infections.
Researchers at Aarhus University have determined a fundamental mechanism by which staphylococci bacteria handle stress when exposed to antibiotics. The discovery reveals that bacteria produce an enzyme capable of modifying DNA building blocks into signal molecules, allowing them to survive antibiotic treatment.
Researchers at the Babraham Institute have discovered that good bacteria in the gut can control gene expression by producing short chain fatty acids, which increase crotonylations and affect gene activity. This process may help prevent cancer and fight infections, highlighting the importance of a healthy diet and gut bacteria.
MIT engineers have devised a 3D printing technique that uses live bacteria cells to create interactive structures. The team printed a 'living tattoo' with branches that light up in response to different chemical stimuli, demonstrating the potential for wearable sensors and interactive displays.
Researchers have successfully interfaced individual bacteria with a computer to build a hybrid bio-digital circuit. This setup allows for the simulation of complex biological systems, enabling the 'debugging' of such systems like complex computer codes.
Researchers discovered bacteria possess a 'sense of touch' enabling them to recognize surfaces and induce adhesive production in response to mechanical stimulation. This mechanism helps pathogens colonize host cells, making it crucial for understanding infectious diseases.
Researchers at KU Leuven have identified specific ion channels in airway cells that recognize lipopolysaccharide molecules from bacteria, triggering a rapid response mechanism against infections. This early defence mechanism is essential for combating bacterial invasion and could lead to the development of more effective treatments.
Researchers have identified a key protein, MgtE, that plays a crucial role in signaling bacteria to form clusters, or biofilms, in the lungs of cystic fibrosis patients. The study reveals how fluctuations in magnesium levels influence MgtE activity, providing new insights into the development of chronic pneumonia.
Researchers at John Innes Centre developed an advanced analysis method to study bacterial signalling, enabling a comprehensive 'signalling map' for the key protein Hfq. This approach integrates data from multiple experiments, increasing our capacity to understand plant and human diseases.
Researchers at Houston Methodist have discovered a critical target for developing a potential Group A Streptococcus vaccine or antibiotic. By blocking the production of streptococcal pyrogenic exotoxin B (SpeB), they hope to reduce disease severity and prevent necrotizing fasciitis, also known as flesh-eating disease.
Researchers found that cilia play an active role in filtering bacteria by creating a vortical flow field, and shorter cilia mix the local flow to enhance chemical screening. Cilia are essential for selective recruitment of symbiotic bacteria, as their dysfunction can lead to pulmonary conditions and infertility.
A team of scientists has identified all the genes required for Methylobacterium extorquens to live on methanol. The bacterium can use either larger carbon molecules or methanol from plants as a nutrient, depending on availability.
A new study reveals that manipulating bacterial communication can help the body defeat an infection without causing drug-resistant strains. By targeting the dormancy-signal molecule, researchers hope to develop molecules that can disrupt specific bacteria's language, reducing resistance development.
A new study by CU Boulder researchers found that individual bacteria cells can feel their external environment through electrical signals, similar to vertebrates. This discovery could advance fundamental bacteria research and aid in developing drugs for infectious diseases.
Dr. Warren Ruder is developing microparticles carrying engineered bacteria known as 'smart biomaterials' to reprogram mammalian cell signaling and influence disease outcomes. His goal is to use these hybrid biomaterials to better understand how cell signaling works and affect many diseases.
The CRISPR-Cas system has discovered a new mechanism to defend against viral invaders by producing a signaling molecule that activates an anti-viral enzyme. This discovery reveals similarities between bacterial and human immune systems.