Articles tagged with Bacterial Signaling
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Researchers found that certain bacteria can trigger the virulence of plant pathogens by eavesdropping on signals from other species. This discovery could lead to new strategies for preventing crop diseases.
Researchers have proposed a universal mechanism for the 'sense of smell' in bacteria, involving two-component systems and molecular machines. The study revealed how proteins transmit signals through cell membranes, potentially leading to new antibiotics and treatments for biofilms.
A team of researchers has discovered an inflammatory signaling platform that cells use to defend against Salmonella infections, which may lead to the development of new antibiotic treatments. The study found that protein chains relay pro-inflammatory signals to trigger degradation of bacteria and restrict their proliferation.
Researchers at McMaster University have identified post-biotics, by-products of bacteria, that lower blood glucose and allow insulin to work better. This discovery could lead to new therapies for obesity-related diabetes, as more than half of Canadians are overweight or obese.
Researchers identify detailed structure of protein complex used by bacteria to detect environmental changes and adapt to them. This discovery sheds light on how bacteria develop resistance to antibiotics.
Researchers at Rice University engineered bacteria capable of sensing colitis in mice, detecting elevated thiosulfate levels and finding a potential biomarker for human colitis. The breakthrough could lead to orally ingestible bacteria for monitoring gut health and disease.
Modified bacteria successfully infiltrated tumors and activated the immune system to eliminate malignant cells. In a mouse model of human colon cancer, the combination of Salmonella and FlaB shrunk tumors and prolonged survival.
Researchers at UC San Diego discovered that bacteria in biofilm communities can send long-range electrical signals to recruit new members from different species. This discovery reveals a human-like trait in bacteria, showing that they can exert dynamic control over distant cells through electrical signaling.
Researchers at University of Illinois Chicago are studying bacterial chemical signals to manipulate sickness-causing microorganisms into a nonhostile state. By understanding the molecular mechanisms of these signals, scientists aim to develop new alternatives to antibiotics that fight bacterial infections.
Scientists used worms to decipher how bacterial signals from the microbiome influence the host, shedding light on diseases such as type 2 diabetes and obesity. The study found that specific bacterial genes modify worm physiology, serving as a model to study the gut microbiome in mammals.
Researchers have developed a method to control genetically altered bacteria to release medicines to tumors or the gut, using temperature regulation. This technology has applications in novel therapeutics for cancer and other diseases.
A computational model helps biologists predict minimal mutations for efficient reprogramming of signaling proteins, expanding the landscape for two-component systems in bacteria. The model connects interaction specificity and promiscuity, enabling researchers to design novel interactions.
Researchers at Duke University have successfully delivered bacterial genes to human cells, enhancing electrical signaling and making cells more excitable. The technique could one day be used to treat cardiac arrhythmia, restore electrical functions to scarred tissues, or improve conductivity in genetic diseases.
A new device can rapidly identify harmful bacteria and determine its susceptibility to antibiotics in a matter of minutes. The device uses nano-scale technology to detect bacteria in extremely small fluid samples, offering a potential solution to the growing problem of drug-resistant strains.
A trio of researchers identified the agr1 gene locus controlling toxin production in C. difficile bacteria, suggesting a new approach to treat the life-threatening infection. The study found that jamming the signaling communication system can stop toxin production, providing hope for non-antibiotic therapy.
Researchers at Indiana University School of Medicine found that the body's immune response system malfunctions during severe bacterial infections, leading to permanent damage to blood-producing cells. This discovery provides a new target for protecting the immune system during major infections.
A new group of cells has been discovered in the human colon that can wash away invading bacteria, potentially preventing inflammatory bowel disease. These sentinel cells detect bacteria and trigger a rapid chain reaction of mucus production to push out the invaders.
Researchers found that chronic high fat diet disturbs neural messages in rats by shifting gut bacteria populations. Manipulating the gut microbiome can reverse this effect, leading to less overeating and weight gain. Additionally, specific foods like blueberries may also target and improve the microbiota composition.
Researchers at Boston Children's Hospital have discovered a new potential avenue for controlling severe bacterial infections and sepsis. The study reveals that a protein fragment called gasdermin-D-NT can kill both bacteria and infected cells, offering a defense against antibiotic-resistant infections.
Washington State University researchers created a simple sensor that can detect and amplify the signal of E. coli 0157:H7, a harmful pathogen causing severe diarrhea and kidney damage. The biosensor uses a nanoflower particle with organic and inorganic components to recognize and amplify the bacteria's signal.
Researchers discovered that genetic mutations in certain genes can impair the immune-enhancing effects of beneficial bacteria, leading to reduced efficacy of probiotic therapies in treating Crohn's disease. The study suggests a new potential cause for the disorder and may lead to advances in personalized medicine.
Researchers at Georgia State University have discovered a critical role for CYLD in controlling the body's inflammatory response to pathogens. This finding could lead to the development of novel anti-inflammatory agents, as traditional treatments like steroids can cause serious side effects.
Bacteria sense their environment and change direction using a molecular machinery that relies on protein interactions and chemical signals. The new study reveals key insights into the chemosensory array, shedding light on how bacteria make decisions.
Researchers found that gut bacteria produce proteins that stimulate the release of satiety hormones and activate neurons that reduce appetite. This discovery suggests that gut microbiota play a role in controlling appetite and satiety.
Researchers at U of T discovered genetic mutations in Candida albicans that allow it to defend itself against neighboring bacteria. The fungus has evolved to ignore bacterial signals, potentially becoming a more significant threat to patients with weakened immune systems.
Researchers at UC San Diego found that bacteria use electrical signaling mechanisms similar to those in the human brain to communicate and resolve metabolic stress. This discovery suggests that bacterial biofilms may be connected to neurological disorders, such as migraines and seizures.
A University of Maryland-led team has discovered an enzyme that breaks the signaling pathway of biofilms, a complex web of fibers that protects bacteria from threats. This finding could lead to the development of new treatments to prevent biofilm-related complications and reduce hospital equipment failures.
Researchers have identified a protective mechanism used by beneficial bacteria to safeguard intestinal cells from stress and damage. By stimulating the Nrf2 pathway, these bacteria can help prevent weight loss and death after radiation exposure, as well as protect against toxic herbicides like paraquat.
In bacterial communities, resolving social conflict is key to survival. The discovery reveals that biofilms develop an 'emergent phenomenon' where individuals balance opposing needs through metabolic codependence. This strategy allows bacteria to coordinate activities, resolve internal conflicts and ensure the survival of the community.
Researchers discovered that a plant hormone, salicylic acid, acts as a 'bacterial bouncer' below ground, sculpting the microbiome surrounding a plant's roots. This finding suggests that salicylic acid is required to assemble a normal, commensal root microbiome.
Researchers at MIT have created sensors, memory switches, and circuits that can be encoded in the common human gut bacterium Bacteroides thetaiotaomicron. These basic computing elements will allow the bacteria to sense, memorize, and respond to signals in the gut.
A team of researchers has identified the first known exopolysaccharide receptor gene in plants, allowing them to distinguish between beneficial and harmful bacteria. This discovery has significant implications for agricultural research and medical science.
A new screen has identified key environmental signals that modulate bacterial behavior in Salmonella typhimurium, a food-poisoning bacterium. These signals trigger survival tactics and alter biofilm formation.
Researchers at University of Toronto designed a diagnostic chip to test for antibiotic-resistant bacteria in just one hour. The chip uses electrochemical detection to analyze the effects of antibiotics on bacteria, allowing doctors to quickly prescribe targeted treatments.
Researchers at Princeton University have revealed the structure and biosynthesis of streptide, a peptide involved in bacterial quorum sensing. The study used a combination of chemical and biological approaches to determine the structure of streptide and its mechanism of production.
A team of scientists at San Diego State University has identified a molecular process that allows bacteria to bypass the brain's defenses and cause meningitis. The discovery could lead to new treatments for this deadly disease by controlling the expression of a key protein involved in breaking down the blood-brain barrier.
Scientists have developed a method to analyze uranium isotopes to determine whether bacteria were active in forming sediments billions of years ago. This new approach gives researchers a unique tool to study microbial activity and environmental niches from the past.
Scientists deciphered bacterial communication mechanisms, revealing new ways bacteria regulate gene expression. Quorum sensing controls a variety of biologically relevant processes, and the study expands our understanding of regulation in Bacillus subtilis.
Researchers discovered a compound produced by Pseudomonas protegens that prevents Bacillus subtilis from forming biofilms at low concentrations, blocking spore formation as well. This finding may lead to creating healthy microbial soil communities and boosting agricultural yields.
A study published in Cell Reports reveals a potential strategy for promoting the right balance of gut microbes in antibiotic-treated mice by manipulating the autoinducer-2 (AI-2) chemical signal. The researchers found that high levels of AI-2 increased the expansion of Firmicutes phylum, leading to a healthy state of the gut microbiota.
Research finds that bacterial communication through autoinducer-2 can restore balance of gut microbiota after antibiotic treatment. The study suggests using bacteria's own language to control and exploit beneficial microbes in the human gut.
Researchers at the University of Maryland have developed chemical compounds that enhance conventional antibiotics' effectiveness and inhibit bacterial biofilms. The compounds block quorum sensing signals, preventing biofilm formation and alerting the immune system to their presence.
Researchers identify thiocillin as an antibiotic that activates biofilm formation in a way unrelated to its killing ability, suggesting that antibiotics may evolve to produce biofilms rather than kill other bacteria.
Researchers at the University of Colorado School of Medicine have discovered an RNA structure-based signal that bridges evolutionary divergence between bacteria and eukaryotes, enabling protein synthesis. This finding challenges long-held assumptions about the molecular signals initiating protein synthesis in these distinct life forms.
Researchers have identified a new bacterial communication pathway, dialkylresorcinol, that is widely distributed among pathogenic bacteria. This discovery offers a promising therapeutic target for new medicines, potentially reducing the risk of antibiotic resistance.
Scientists at ETH Zurich develop a method to produce pre-structured cellulose materials with three-dimensional micro-structures, enhancing biocompatibility. This leads to reduced inflammation and rejection reactions when using artificial implants.
Researchers at UNH are investigating how certain plants and bacteria communicate to form beneficial partnerships. Using next-generation sequencing tools, they aim to understand the chemical signals between Frankia bacteria and actinorhizal plants.
A new study reveals that naturally occurring carbon monoxide is essential for the macrophages' surveillance plan, detecting the presence of bacteria and instigating an attack. CO also boosts the immune response to enhance clearance of bacteria and resolution of SIRS.
New research reveals that plants use mechanical stimulation to respond to beneficial fungi and bacteria, enabling mutual exchanges of signals. This mechanism is essential for the symbiotic relationships between plants and mycorrhizal fungi, as well as legumes with rhizobia.
A study published in the Journal of Clinical Investigation found that engineered bacteria can prevent weight gain in mice by producing a compound called NAPE, which signals the brain to stop eating. Mice fed high-fat food with NAPE-producing bacteria exhibited limited weight gain and associated symptoms.
A new method using SlipChip technology allows researchers to target and grow specific, previously uncultured microbes from the human gut. By isolating individual bacterial species, scientists can better understand their roles in human health and potentially identify beneficial or harmful microbes.
Researchers found that bioelectrical signals from distant cells can control tumor formation, with a common fatty acid produced by bacteria playing a key role. This discovery opens up possibilities for preventing, detecting, and treating cancer.
Rice University synthetic biologist Jeff Tabor is working on a three-year project to engineer probiotic bacteria that can detect disease signals in the gut and prevent diseases such as obesity and depression. The goal is to create an edible probiotic bacterium that can help protect sailors and marines from these health issues.
Researchers at the University of Missouri identified a molecular signal that invites bacterial attack in plants. This discovery could lead to natural defenses against harmful bacteria in food-producing plants.
A study found that certain plant acids invite bacterial infection by focusing the attackers on a specific target. This molecular signal can be used to protect plants and potentially lead to new biofuels and human health applications.
Researchers discovered that Pseudomonas aeruginosa bacteria use combinatorial communication to achieve an effect different from the sum of individual signals, a method previously thought to be unique to humans and some primates. This finding has serious implications for our understanding of language origins.
Freiburg researchers identify LRP1 as a key molecule that regulates the intake of toxic bacteria like Clostridium perfringens. This finding opens up new avenues for developing agents against clostridia and may lead to breakthroughs in treating diseases caused by these pathogens.
Researchers discovered that bacteria use indole to communicate and plan ahead for lean periods, leading to new ways to combat dangerous bacteria. The study could help scientists find new ways to control MRSA and other harmful bacteria.
A new strain of E. coli bacteria has been engineered to detect and record environmental signals in the mouse gut, remembering what it 'saw' for up to a week. The approach, which uses a genetic switch from a virus, could lead to a radically new screening tool for human gut health and living diagnostics.
Researchers discovered how gut bacteria produce an enzyme that modifies signaling in cells lining the gut and breaks down phytate, a crucial nutrient. The enzyme is packaged in outer membrane vesicles (OMVs) which allow for cross-kingdom communication with human cells, influencing calcium signaling and potentially improving health.