Articles tagged with Calcium Signaling
Researchers found that elevated calcium levels near amyloid plaques can disrupt neuronal function, leading to cellular degeneration. This study provides a new understanding of the connection between amyloid plaques and neurodegeneration in Alzheimer's disease.
Mutations in PS1 and PS2 proteins disrupt calcium ion flow, leading to increased amyloid beta production. The study identifies the inositol trisphosphate receptor as a potential target for new therapeutic options.
A study reveals a direct link between Alzheimer's disease-causing mutations and aberrant calcium signaling. The researchers found that this disrupted calcium release led to amyloid beta protein generation, a hallmark of the disease.
Researchers discovered a new mechanism in worm defecation that could be applicable to humans, involving pH signaling and potential therapeutic implications. The study found that positively charged hydrogen ions are used to send signals between cells, which may be involved in cell-to-cell communication.
Researchers at Washington University School of Medicine discovered a plant herbicide that disrupts Toxoplasma gondii's signaling pathway, reducing fatal infection risk in mice. Low doses of the herbicide prevent T. gondii from increasing its numbers and remaining dormant.
UC Riverside scientists warn that chemicals used to slow the spread of fires in consumer goods, such as televisions and sofas, can be found in high concentrations in human blood and breast milk. Long-term exposure to these chemicals may pose a health risk, particularly for infants and toddlers.
OHSU research reveals calcium ions modulate auditory nerve cells' recharging after bursting signals. High levels of calcium can be toxic, but regulating sodium pump activity conserves energy and prevents cell death.
A team of Canadian researchers discovered a distinct dopamine signalling complex in the brain, which may have a significant role in understanding and treating schizophrenia. This novel target involves two different types of dopamine receptors that only create brain signals when both are stimulated at the same time.
Researchers discovered that presenilins act as calcium channels, controlling the balance of calcium within cells. This finding may suggest a new avenue for treating Alzheimer's disease by restoring normal calcium levels. The study also highlights the potential for combination therapies targeting both amyloid and calcium signaling.
Researchers discovered that calcium fills a small structure in cells, forcing muscles to relax when full. This understanding can help doctors treat patients more accurately with the body's natural mechanisms.
Researchers have found that deliberate damage to sensory receptor cells in the inner ear can trigger a cascade of signals through ATP release, leading to the spread of calcium ions. This mechanism is activated by loud noise levels commonly experienced in nightclubs and when using personal headphones.
Researchers use high-speed imaging to track movement of calcium waves in cell signaling, identifying a sequence of amino acids (LTL) that controls the pathway. The findings have implications for treating autoimmune diseases such as arthritis and uveitis.
Researchers discovered a molecular switch that guides cell communication before a message reaches the nucleus, adding complexity to understanding cellular signals. This switch determines which signal - calcium or cAMP - will be used, leading to different responses in target proteins and potential therapies for serious disorders.
The LAT protein is essential for T-cell activation and a normal immune response. Mutations in the protein can lead to unbalanced signaling pathways, potentially causing autoimmune disorders.
Researchers found that estrogen production protects females from cardiac hypertrophy, but not males. By blocking estrogen receptors, female mice developed cardiac enlargement similar to males.