Articles tagged with Cell Death Pathways
Scientists have identified a new enzyme pathway that leads to nerve cell death outside of the cells, which can be targeted by new drugs. This discovery could lead to novel treatments for stroke and several neurodegenerative diseases.
A team of researchers has identified the entire series of proteins that relay a message of survival from a neuron to a glial cell in the fruit fly Drosophila melanogaster, shedding light on how cells 'know' whether to survive or perish. This discovery may lead to novel treatments for diseases such as Alzheimer's and cancer.
Research suggests that Alzheimer's disease may be caused by defects in a protein's role as an attachment point for a molecular motor that transports packets of protein within nerve cells. The study found that the missing protein, APP, and other proteins stay mainly in the cell body when it is absent, stalling normal cargo transport.
Researchers found that malignant melanomas often lose the protein Apaf-1, leading to resistance to chemotherapy drug adriamycin. Restoring Apaf-1 in melanoma cells rescues their ability to kill themselves in response to adriamycin.
Cystic fibrosis patients' lungs are infected primarily with bacterial biofilms, which are resistant to antibiotic treatment and cause damage to the lungs. A new test developed by University of Iowa researchers shows that Pseudomonas aeruginosa produces signaling molecules indicative of a biofilm state.
Researchers have discovered that normal prions may fine-tune neuronal functions at the cellular level through a signaling pathway. This discovery could provide new insights into how brain-degenerating diseases occur and potentially lead to treatments.
Researchers discovered how a new anticancer drug inhibits a runaway protein switch that causes chronic myelogenous leukemia by exploiting alterations in the shape of the protein. This precise control could give pharmaceutical companies and basic researchers new tools for manipulating cell growth and signaling pathways.
Researchers at UNC Health Care have identified a new way to halt herpes simplex virus reproduction by targeting its molecular tracks. The study found that inhibiting JNK protein kinase reduces viral yield in cells by up to 70%.
Researchers found Yersinia pestis uses a protein called YopJ to cut off cellular communication, disrupting immune response and killing the host. Understanding this mechanism could have important implications in medicine, particularly for cancer and immune-related diseases.
University of Rochester scientists use the herpes virus to modify brain cells, making them more resistant to death after a stroke. The study aims to provide a new way to save patients from years of disability caused by strokes.
Researchers at UT Southwestern Medical Center have converted dendritic cells into cells that deliver death signals, potentially preventing and treating inflammatory diseases. This technology could lead to the prevention and treatment of inflammatory diseases such as rheumatoid arthritis.
Scientists at Harvard Medical School have discovered that a member of the MAP kinase family, ERK, may act as a molecular gatekeeper activating excitotoxic pathways. This finding could lead to new drug targets against stroke and other neurodegenerative diseases.
A new study in Nature reveals that floor plate development occurs earlier and is driven by factors other than the notochord. This challenges the classic model of neural cell patterning, which posits a central role for Sonic hedgehog signaling.
Researchers at Jefferson University have identified a crucial mechanism of the tumor-suppressor protein Fhit, which plays a significant role in preventing cancer development. By understanding how Fhit works, scientists may be able to find ways to interfere with cancer growth and potentially develop new treatments.
Researchers discovered a molecular pathway that leads to heart enlargement and found a way to block it using immunosuppressant drugs. The study used mice whose progression from cardiac hypertrophy mirrored humans', finding that activated calcineurin is sufficient to induce cardiac hypertrophy.
Researchers discovered a protein, Apaf-3, that signals apoptosis and is essential for life. The study's findings may lead to the development of more effective cancer treatments by activating the cell death pathway.
Researchers at Massachusetts General Hospital discovered that chemotherapy treatment with doxorubicin causes mouse oocytes to undergo apoptosis, or programmed cell death. The study sheds light on the mechanisms behind female infertility after chemotherapy, potentially leading to new ways of selectively targeting cancer cells.
Researchers found that Phyllopod and Sina proteins team up to target the Tramtrack protein for destruction, allowing cells to become neurons. This discovery sheds light on the nervous system and brain development, with potential applications in cancer research.
Researchers at Johns Hopkins University aim to extend the lifetime of biotech lab cells by stopping their suicidal impulses. By understanding the genetic path that leads to apoptosis, scientists can apply
Scientists have identified a key genetic pathway responsible for 90 percent of colon cancers, which could lead to the development of targeted therapies. The mutation of the APC gene disrupts normal cell regulation, causing uncontrolled growth and cancer.