Cornell University researchers discovered how chronic stress intensifies the adrenaline response by controlling the structure of donut-shaped protein channels on adrenal cells. This 'molecular memory' can be influenced by lifestyle factors, paving the way for gene therapy and potential treatments for hypertension and heart attacks.
Researchers discovered a molecular pathway that leads to heart enlargement and found a way to block it using immunosuppressant drugs. The study used mice whose progression from cardiac hypertrophy mirrored humans', finding that activated calcineurin is sufficient to induce cardiac hypertrophy.
UCSF researchers have identified a protein essential for forming concentrated urine in mice, which has potential implications for treating fluid retention diseases such as congestive heart failure and cirrhosis. The study shows that inhibiting the water channel with drugs could effectively treat these conditions.
Researchers developed a new technique using combinatorial chemistry to screen thousands of catalysts simultaneously, reducing time by fractions. The method enables potential improvements in fuel emission controls, solar energy harvesting, drug preparation, and converting natural resources into useful products.