Articles tagged with Ip3 Signaling
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Researchers have discovered that ascidians measure time to adulthood by accumulating cyclic adenosine monophosphate (cAMP), ensuring a reliable timing of metamorphosis. The study's findings provide insights into time-measurement mechanisms in other organisms and may aid in aquaculture and marine biofouling control.
Researchers discovered that 15-deoxy-prostamide-J2 induces ER stress-mediated apoptosis selectively in tumor cells, reducing melanoma growth. The molecule activates PERK, IP3R, and the mitochondrial permeability transition pore, leading to cell death.
Scientists discovered how mutations in the IP3R1 protein contribute to degenerative movements disorders like spinocerebellar ataxias. By disrupting calcium release, these mutations impair motor control and lead to cerebellum dysfunction.
Ca2+ plays a crucial role in arteriolar function by triggering vasodilation through endothelial cells. The magnitude of these signals depends on IP3 receptors.
The study provides detailed insights into the function of IP3R, a molecular train station controlling cell functions. The new crystal structure reveals how IP3 signals trigger the opening of the Ca2+ channel, shedding light on long-range communication mechanisms.
A rare genetic disorder called anhidrosis has been linked to a mutation in the ITPR2 gene, which controls calcium release in sweat glands. The study, led by Katsuhiko Mikoshiba and Niklas Dahl, found that a single nucleotide change in the DNA code impairs sweat production, leading to hyperthermia risk.
A study published in PNAS reveals that a protein cross-linking enzyme interacts with a cell receptor to lock it in a closed state, reducing neuron signaling in neurodegenerative diseases like Huntington's and Alzheimer's. The mechanism may provide insight into the development of new drug therapies for these conditions.
Research published in Nature reveals how IP3 receptors cluster to broadcast chemical messages, enabling better understanding of disease mechanisms and potential drug targets. The discovery fills a crucial gap in knowledge about the molecule's role in human health and its potential as a treatment for various conditions.
Researchers at University of Toronto and Princess Margaret Hospital have discovered the key mechanism behind IP3 molecule's role in setting calcium levels within cells. This finding holds promise for developing novel treatments against epilepsy by regulating calcium waves.
Researchers discovered a link between plant hormone auxin and stress response, mediated by the BIG protein. The study also found that IP3 acts as a second messenger in plant cell signaling.
Scientists have identified enzymes called kinases that add phosphates to inositol, triggering the export of messenger RNA from the cell nucleus. The discovery provides insight into a previously unknown signaling pathway and its role in regulating gene expression.