Articles tagged with Neurotrophin Signaling
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
Researchers discovered the p75NTR receptor plays a key role in glioma invasion, with expression sufficient to induce aggressive tumor growth. This finding highlights a previously unknown function of the receptor and suggests it may be a novel therapeutic target.
Researchers at the University of Pennsylvania School of Medicine have shown that neurotrophin signaling is essential for maintaining normal synapse health. The study used a novel gene therapy technique to block neurotrophin activity and demonstrated the disassembly of synapses in adult mice, highlighting the potential therapeutic benef...