Articles tagged with Translation Regulation
The study reveals how the encephalomyocarditis virus (EMCV) hijacks host ribosomes and translational factors to translate viral genes while blocking host gene translation. Targeting this mechanism could lead to new treatments for EMCV and similar viruses like poliovirus.
A study by IRB Barcelona researchers sheds light on the regulation of protein production in fatty liver cells, revealing a key role for CPEB4 in controlling gene expression. The findings provide new perspectives on the disease and its progression towards more severe forms.
A new study finds that the FOXG1 gene has a dual function in regulating RNA transcription and translation, essential for proper brain development. The discovery raises questions about the evolution of this complex mechanism and its potential role in neuroplasticity.
Researchers will examine cognitive and psychomotor functions to compare effects of CBD on driving performance between men and women. The five-year study aims to provide a comprehensive understanding of the substance's influence.
A new framework from a global team of scientists aims to overcome translational hurdles in nanomedicine development. The DELIVER guidelines provide early-stage recommendations for maximizing clinical translation and enabling the successful development of new nanomedicine treatments.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
Researchers identified mRNAs and long non-coding RNAs targeted by stress granule proteins, which accumulate AD-associated gene transcripts in these structures. SGs may play a key role in regulating AD development through the impairment of protein neurohomeostasis.
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
A specialized mRNA translation circuit controlled by protein RBPMS determines the competence for heart formation in human embryonic development. The study provides a better understanding of human cardiac development and reveals potential molecular targets for therapeutic interventions.
A team of scientists from Tokyo Institute of Technology developed PETEOS to capture 'snapshots' of translation in the cell. The non-labeling methodology enriches and rapidly captures pep-tRNAs, enabling analyses that current methods cannot, with potential applications to any organism.
Researchers at WVU are studying the Musashi proteins to understand their role in retinal degeneration and develop a universal therapy. By investigating protein translation and gene suppression, they hope to identify potential pathways to boost protein production and slow vision loss.
Researchers discovered periplocin, a potent inhibitor of the IRE1-XBP1 axis, which suppresses the unfolded protein response (UPR). Cardiac glycosides, commonly used for cardiac insufficiency therapy, also exhibited similar UPR-suppressing effects.
The study reveals dynamic changes of poly(A) tails in eggs and embryos, furthering understanding of how the fabric of life is shaped. The improved sequencing tool mTAIL-seq allows for enhanced sequencing depth to measure poly(A) tail length at a genomic scale.