Translation Regulation
Articles tagged with Translation Regulation
FOXG1: a SISSA study reveals the dual role of key neurodevelopmental gene
A new study finds that the FOXG1 gene has a dual function in regulating RNA transcription and translation, essential for proper brain development. The discovery raises questions about the evolution of this complex mechanism and its potential role in neuroplasticity.
WVU researchers putting CBD to the test from behind the wheel
Researchers will examine cognitive and psychomotor functions to compare effects of CBD on driving performance between men and women. The five-year study aims to provide a comprehensive understanding of the substance's influence.
Global experts help nanomedicines DELIVER on healthcare promise
A new framework from a global team of scientists aims to overcome translational hurdles in nanomedicine development. The DELIVER guidelines provide early-stage recommendations for maximizing clinical translation and enabling the successful development of new nanomedicine treatments.
New discovery shows how cells defend themselves during stressful situations
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
Stress granules control Alzheimer's gene transcripts and neuronal proteostasis
Researchers identified mRNAs and long non-coding RNAs targeted by stress granule proteins, which accumulate AD-associated gene transcripts in these structures. SGs may play a key role in regulating AD development through the impairment of protein neurohomeostasis.
A ribosomal traffic jam that breaks the heart
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
A key mechanism that controls human heart development discovered
A specialized mRNA translation circuit controlled by protein RBPMS determines the competence for heart formation in human embryonic development. The study provides a better understanding of human cardiac development and reveals potential molecular targets for therapeutic interventions.
“Snapshots” of translation could help us investigate cellular proteins
A team of scientists from Tokyo Institute of Technology developed PETEOS to capture 'snapshots' of translation in the cell. The non-labeling methodology enriches and rapidly captures pep-tRNAs, enabling analyses that current methods cannot, with potential applications to any organism.
WVU receives NIH funding to dissect the mechanism of retinal degeneration
Researchers at WVU are studying the Musashi proteins to understand their role in retinal degeneration and develop a universal therapy. By investigating protein translation and gene suppression, they hope to identify potential pathways to boost protein production and slow vision loss.
Regulation of protein homeostasis by cardiac glycosides
Researchers discovered periplocin, a potent inhibitor of the IRE1-XBP1 axis, which suppresses the unfolded protein response (UPR). Cardiac glycosides, commonly used for cardiac insufficiency therapy, also exhibited similar UPR-suppressing effects.
Highly sensitive and effective tool measures how your cells grow and divide
The study reveals dynamic changes of poly(A) tails in eggs and embryos, furthering understanding of how the fabric of life is shaped. The improved sequencing tool mTAIL-seq allows for enhanced sequencing depth to measure poly(A) tail length at a genomic scale.