Articles tagged with Chemical Biology
Scientists have developed a new method for synthesizing complex carbohydrates, enabling researchers to study their function in cellular processes and diseases. The method, reported in Nature Chemistry, allows for rapid and controlled synthesis of oligosaccharides, paving the way for the creation of libraries of carbohydrate molecules.
Researchers at Idaho National Laboratory are testing lasers to scrub surfaces clean of sulfur mustard gas and VX, a nerve agent. The tests have proved successful on complex, porous surfaces like concrete.
Matthew Lux, a Virginia Tech Ph.D. student, has been awarded a US Department of Defense SMART scholarship to explore opportunities in synthetic biology for defense applications. His research involves developing intelligent sensors and countermeasures using calibrated genetic parts.
Researchers create powerful new tool for calculating Casimir forces, allowing repulsion in microelectromechanical systems. This breakthrough could significantly reduce the failure rate of existing MEMS devices and enable affordable, new technologies.
Researchers found that each junco has a unique and recognizable odor profile stable over two weeks, distinguishable from other individuals. The study's findings suggest that smell could play a role in reproductive isolation and the origin of new bird species.
A new multifunctional polymer material can rapidly neutralize both biological and chemical toxins, including bacteria, viruses, and nerve agents. The material has been shown to be effective in restoring enzyme activity after exposure to toxins.
Researchers have discovered over 30 species of invertebrates and 100 single-celled organisms at the East Stoke Fen nature reserve. The findings highlight the importance of protecting 'cryptic biodiversity', which helps natural ecosystems recover from environmental change.
Researchers from Berkeley Lab are measuring gas dispersion in Boston's subway system as part of a DHS study. The data will help develop next-generation biological and chemical agent detector systems, as well as inform planning for fires and other emergencies.
Scientists at Harvard University have introduced kinks into arrow-straight nanowires, creating zigzagging 2-D and 3-D structures with enhanced electrical properties. These new nanostructures enable the integration of active devices, fostering potential breakthroughs in biomedicine and electronics.
Researchers at Oregon State University and institutions have developed a new plasmonic nanorod metamaterial for medical, biological and chemical sensors. The device is up to 10 times more sensitive than existing technology and can detect various substances with high precision.
A small molecule called DAz-2 helps identify over 190 proteins involved in diverse biological processes affected by reactive oxygen species (ROS). The tool will aid in understanding chronic oxidative stress and its role in diseases.
A new probe identifies over 190 proteins that undergo oxidation due to ROS, offering insights into disease processes and potential targets for treatments. The discovery may lead to strategies for fighting diseases involving excessive oxidation reactions.
Researchers found that skylark neighbours share similar dialects in their songs, allowing them to identify and reprimand threatening intruders. This complex communication system enables the birds to maintain social cohesion and defend their territories against potential threats.
The National Cancer Institute has named Emory University's Chemical Biology Discovery Center as part of an 11-member national consortium aiming to develop innovative targeted cancer therapies. The consortium will focus on unmet medical needs, including drugs with significant clinical promise.
Burnham will partner with NCI and private-sector companies to translate basic research into new cancer treatments. The consortium aims to accelerate the development of innovative therapeutics for high-risk areas of cancer biology.
A new computer program called Scaffold Hunter helps researchers identify potential active agents for cancer and malaria treatment by navigating the vast ocean of molecules. The program generates maps of chemically-related structures and links them to biological activity, identifying promising candidates.
Researchers describe a mathematical model that helps fine-tune artificial biomolecular switches, shedding light on their evolution and potential applications in detecting chemicals and disease markers.
A study by US-based researchers found that great white sharks use highly focused hunting methods, comparable to those of serial criminals. The research used geographic profiling techniques to analyze shark attack data and located the anchor point for younger sharks.
Researchers at University of Georgia have developed a method to grow molecular wire brushes that conduct electrical charges, a crucial step in developing biological fuel cells. The technique, called 'grafting from,' allows for the creation of ultra-thin films with controlled polymer architecture.
A team of UC San Diego-led researchers made the first-ever direct detection of biological particles within ice clouds. Analysis revealed that half were mineral dust and about a third contained nitrogen, phosphorus, and carbon, the signature elements of biological matter.
The US Department of Energy has funded a research center at Lawrence Berkeley National Laboratory to study carbon storage underground. The Center aims to develop new technologies to sequester CO2 and manage fluid dynamics, chemical interactions, and biological reactions in the subsurface.
Researchers developed a technique to restore P2P privacy by hiding user-intended downloading behavior in a cloud of random downloads. This approach disrupts classification and provides users with 'plausible deniability,' making it difficult for eavesdroppers to accurately identify groups of users with similar download behavior.
James Crivello, a prominent polymer researcher at Rensselaer Polytechnic Institute, has been awarded the Herman F. Mark Senior Scholar Award by the ACS. His groundbreaking research on novel polymers and innovative applications in energy conservation, coating, and composites has earned him this prestigious recognition.
Researchers at Penn State have discovered a way to control the geometry and stability of self-assembled monolayers using different carboranethiol isomers. The new SAMs show exceptional properties, including selective capture of biomolecules and high-quality patterning.
A new study by NYU Professor Mitchell Moss suggests that the Robert T. Stafford Act is out of date and requires revision to provide rapid financial assistance after a catastrophe. The act's failure to recognize 21st-century threats and its lack of distinction between rural and urban disasters are major concerns.
Researchers found three factors governing circadian clock resetting: Cryptochrome, Jetlag, and Timeless. These proteins fine-tune light responses on a molecular level, ensuring the bodyclock stays synchronized with its environment.
Researchers developed a novel x-ray technique to observe molecular motion in real time, allowing better understanding of structural evolution during chemical reactions. This discovery has promising prospects for applications in magnetic data storage, solar energy, and biology.
Researchers at Monell Chemical Senses Center found that an individual's underlying odor signature persists regardless of diet, providing a potential method for identifying individuals. This discovery could lead to the development of electronic sensors for early disease detection and diagnosis.
A new antibody strategy has been developed to target gastric hormone ghrelin, which is linked to weight gain and fat storage. The study found that the antibody increased metabolic rate in fasting mice and suppressed feeding after 24-hour food deprivation.
Researchers at NIST discovered gold nanostars exhibit superior optical qualities for SERS, outperforming nanorods and nanospheres for enhanced signal detection. The team created gold nanostars using surface alterations and demonstrated their ability to amplify molecular signatures.
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded $25 million in grants to develop new diagnostics and treatments for radiation exposure. Researchers will focus on improving the diagnosis and treatment of individuals exposed to radiation, as well as investigating the effects of radiation combined injuries.
Researchers at the Salk Institute discovered that only a few mutations in an enzyme can shift the output of plant compounds, allowing them to adapt to changing environments. This finding has implications for developing environmentally friendly fungicides and pesticides, as well as new flavors and fragrances.
Research by Queen Mary University of London scientists found that some bat species' echolocation genes are similar to those of fruit bats, indicating possible independent evolution of the trait. This suggests that echolocation may not be a single evolutionary event but rather an example of convergent evolution.
The Broad Institute will develop molecular tools to probe human biology and disease using small molecules. The six-year NIH grant supports high-throughput screening of molecular libraries to identify compounds with interesting biological functions.
Researchers will investigate fundamental mechanisms of SERS and develop high-performance substrates using optical antennas, laser nanostructuring, and theoretical chemistry. The goal is to improve the technology's practical use in detecting materials, including chemical and biological agents.
NIST researchers have discovered that a single layer of molecular 'salve' can significantly reduce surface stress, which is crucial for applications like chemical and biological sensors. The 'salve' reduces stress by allowing atoms to adopt the molecules into their family, resulting in a more stable and tension-free surface.
The US Department of Homeland Security has developed a wearable hood for emergency escape with 15-minute chemical protection. The EH-15 mask provides protection against chemicals and biologics, has a three-year shelf life, and highly efficient particulate filters.
Researchers at NIST have developed a new imaging system that detects naturally occurring terahertz radiation with high sensitivity and resolution. The technology enables rapid identification of chemical hazards and may aid in early tumor detection.
Scientists at Argonne National Laboratory have developed techniques to create accurate movies of molecular movements, allowing for the direct observation of complex molecule motions in solution. This breakthrough enables researchers to test the accuracy of computer simulations and gain insights into molecular structure and behavior.
Scott A. Strobel has made seminal contributions to the understanding of RNA structure and function, revealing its catalytic role through various disciplines. He will give the award lecture at the American Society of Biochemistry and Molecular Biology annual meeting.
Researchers at the University of Texas at Austin have discovered a new method to control fluid particle motion in tiny channels. By arranging particles in layers aligned with channel boundaries, they can promote faster particle transport and improve the efficiency of micro- and nano-scale technologies.
Researchers at Scripps Research Institute have discovered the mechanism behind the bright blue glow of fluorescent monoclonal antibodies, which could lead to the development of novel biosensors. The study found that a specific charge recombination between an electron hole and stilbene creates this effect.
A team of chemists led by Chad Mirkin aims to mimic nature's finely controlled chemical processes to develop materials and devices with high sensitivity and selectivity. The researchers will focus on creating supramolecular structures for environmental remediation, power generation, and detection systems.
A team of chemists at the University of Georgia has proposed a mechanism for how adenine, a key component of DNA, might be formed from five cyanide molecules under terrestrial conditions. The research suggests that simple molecules can combine chemically to form the building blocks of life, offering a new answer to an unsolved puzzle.
Scientists at UC San Diego's Scripps Institution of Oceanography have developed a new method to create natural antibacterial molecules using enzyme ingredients. This breakthrough process allows for the synthesis of complex molecules in a relatively simple mixing process, paving the way for cheaper and more sustainable 'green' chemistry.
Researchers have created a biological detergent that can be turned on and off depending on its application, offering potential solutions for improving laundry efficiency and reducing irritation in eye care products. The 'switchable' detergent has broad applications across various industries, including personal care and oil extraction.
New discoveries in ACS Chemical Biology highlight the potential for snail toxins to lead to new drugs, as well as strategies to minimize the side effects of COX inhibitors. The journal also explores how sex hormones activate cell signaling pathways, and helper peptides influence calcium channel opening.
Biologics may be a valuable treatment option for inflammatory bowel disease (IBD), offering new hope for patients. However, gastroenterologists must carefully weigh the potential benefits against significant side effects and costs. Research is ongoing to better understand the role of biologics in IBD treatment.
The FDA's Nanotechnology Task Force report highlights the challenges of regulating nanotechnology across various product categories. With over 500 manufacturer-identified nanotechnology consumer products being sold annually, the agency must ensure the safety of novel products before they enter the market.
Researchers at the University of Illinois Chicago created a theoretical blueprint for assembling a nanoscale propeller with molecule-sized blades. The propeller's efficiency in pumping liquids is highly sensitive to its chemical and biological composition, finding that hydrophobic blades pump more water while hydrophilic blades become ...
Recent studies from ACS Chemical Biology reveal new insights into how cells die when chemicals bind to DNA, fast ways to create novel molecules, thyroid hormone regulation, and the regulation of attaching proteins to membranes. The journal provides a platform for exploring cellular function from both chemical and biological perspectives.
A new report from NIST and EPA offers building owners retrofit options to improve safety against airborne chemical and biological hazards. The report evaluates 14 alternative techniques, including filtration and air cleaning systems, and provides a life-cycle cost analysis tool.
Researchers have discovered a tool for rapid drug discovery by combining molecular fragments, allowing for more specific targeting of cancer cells. Additionally, two new peptides enable the labeling of proteins, enabling further study and modification.
A new study reveals how a fungus uses its circadian clock to control carotenoid production, protecting against sun damage. The discovery may also shed light on the regulation of human sleep cycles.
Researchers at the University of Buffalo have developed a device that can rapidly detect infectious viruses in biological samples. The innovation uses nanoparticles to transport viral particles to specific locations, allowing for quick detection and paving the way for an 'on-the-spot' virus detector.
Kansas State University researchers are developing robots to search for weapons of mass destruction and improvised bombs, using intelligent sensor networks and autonomous capabilities. The robot teams will be able to adapt to changing environments and team goals.
The journal ACS Chemical Biology explores recent discoveries in cellular function, including the inhibition of new blood vessel formation using an antifungal drug. Nanoparticles are also shown to enhance the delivery of short interfering RNAs to cells, potentially aiding clinical applications.
Researchers at Johns Hopkins have discovered that zinc pyrithione, an active ingredient in dandruff shampoos, can calm overexcited nerve cells, potentially treating seizures. The compound works by allowing more potassium flow through defective channels, restoring normal nerve cell activity.
Researchers from Virginia Tech, University of Pennsylvania, and Drexel University aim to create high-performance membranes and electroactive devices using ionic liquids. The project seeks to integrate ILs into various applications, such as fuel cell membranes, micro sensors, and smart clothes.
The journal reveals how changing protein charges enables cell membrane passage and introduces an enzyme's role in synthesizing antibiotics against resistant bacteria. Additionally, researchers develop artificial methods to induce keratinocytes' differentiation, providing insight into diseases like psoriasis and basal cell carcinoma.