Articles tagged with Chemical Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have successfully created bacteria that can produce an unnatural amino acid, para-nitro-L-phenylalanine (pN-Phe), which has potential applications in vaccine development. The discovery was made using genetic code expansion methods and metabolic engineering techniques.
Researchers develop a new method for fixing carbon dioxide using formic acid, which can replace conventional chemical manufacturing processes with carbon-neutral biological methods. The process produces formaldehyde, a non-toxic substance that can be fed into metabolic pathways to create valuable substances.
Scientists have developed a gene-editing technique that allows them to easily engineer specific cancer-linked mutations into mouse models. This new method, based on CRISPR genome-editing technology, enables researchers to explore many unknown mutations and develop new drugs targeting those mutations.
Scientists at Duke University found electric fields within biological condensates, which could change the way researchers think about biological chemistry. The discovery suggests that these structures may have played a crucial role in the first life on Earth, providing energy for essential reactions.
Scripps Research scientists develop a new strategy to identify small molecules that can alter protein function, offering a promising path for discovering targeted cancer drugs. By comparing how mirror image versions of small molecules impact clusters of proteins, they identified potential new drug targets such as MY-1B and EV-96.
A new discovery by researchers at the University of Warwick has found a simple material that can prevent bacterial viruses from contaminating laboratories and microbial factories. This breakthrough aims to develop next-generation industrial biotechnologies and remove a bottleneck in fundamental research.
Origin-of-life chemists suggest glyoxylate reaction scenario could have yielded simple sugars without drawbacks of formaldehyde-based reactions. The researchers aim to demonstrate this hypothesis in the laboratory and explore potential commercial applications.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
A team of researchers has discovered that chromium(III) supplementation can regulate glucose metabolism in type 2 diabetic mice by targeting ATP synthase activity. This process improves mitochondrial deformation caused by high glucose levels and boosts glucose metabolism.
Researchers at Cold Spring Harbor Laboratory have created a method to safely synthesize the cancer-fighting molecule JA, which has shown promise in treating triple-negative breast cancer. The team found that JA inhibits metabolic activity in cancer cells, starves them of energy and building blocks, leading to cell death.
Researchers at UC San Francisco have created the first molecular-level picture of how an odor molecule activates a human odorant receptor, opening doors to creating novel smells. This achievement paves the way for new insights into biological processes, including fragrances and food science.
Researchers at the University of Nebraska-Lincoln have discovered that the orientation of a single amino acid in peptides can direct activation to specific neurons, influencing communication among brain cells. This finding has far-reaching implications for understanding and regulating signaling processes in the brain.
A new device developed by quantum engineers can measure the spins in materials with high precision, breaking the current record of thousands of spins. This breakthrough enables researchers to study systems that were previously inaccessible, such as microscopic samples and two-dimensional materials.
Scientists studied F1-ATPase function in bacteria to clarify the angle of rotation during ATP hydrolysis. The study revealed three sets of short and long dwells associated with different intervals per revolution, resolving a long-term debate over the ATP-cleavage shaft angle.
Scientists at St. Jude Children's Research Hospital demonstrate a framework to develop solutions to evade detoxification networks in drug development, potentially reducing side effects. By altering the structure of a small molecule, they found a way to stretch out binding regions, making it energetically unfavorable for drugs to bind a...
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
A Keck School of Medicine study found exposure to PFAS, known as 'forever chemicals,' disrupts key biological processes in children and young adults, increasing risk of diseases such as developmental disorders, cardiovascular disease, and cancer. The study highlights the importance of regulating PFAS as a class of chemicals.
The team developed a technology to globally assess Fe-S cluster binding in an entire proteome without laborious protein purification or radioisotopes. The study found differential sensitivity of iron-sulfur clusters to iron limitation and pathway impairment, prioritizing iron-sulfur cluster delivery in E. coli.
Researchers at Nagoya University have identified 2,6-dihalopurines as a new class of stomatal opening inhibitors, potentially involving LRX3-5 and RALF peptide. This discovery may lead to the development of new agrochemicals and chemical biology research applications.
Researchers developed a new method for measuring indoor air quality using transgenic nematode strains that produce fluorescence when exposed to harmful pollutants. The amount of fluorescence can be measured and used to detect various impurities in the air, including fungal samples, surfactants, and volatile compounds.
A research team led by Professor Xiang David LI has developed a novel chemical tool called photo-ANA to investigate bacterial interactions with the host in real-time. This approach enables scientists to comprehensively profile host–bacteria protein interactions during infection, revealing known and newly discovered interactions.
Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.
A new electrochemical sensor has been developed to detect dopamine levels in biological fluids, potentially leading to earlier disease detection for conditions like Parkinson's disease and depression. The method uses carbon quantum dots and ionic liquids, offering a quick and sensitive test.
Researchers identified hundreds of microorganisms associated with plant roots and soil, showing potential for developing biological substitutes for phosphorus-based fertilizers. The discovery highlights the importance of microbial communities in supplying essential nutrients like nitrogen.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers have discovered that ancient crocodilian hemoglobin required 21 interconnected mutations to develop its hyper-efficient oxygen-binding properties. This complexity, not found in other vertebrates, enabled crocodilians to exploit their onboard oxygen stores for extended periods underwater.
Researchers at Kyoto University have discovered a vital role of two proteins, ABCA1 and Aster-A, in maintaining the asymmetric distribution of cholesterol within cells. This process allows for selective control over substances entering and leaving cells.
Researchers have created a chemical compound, Pillar[6]MaxQ (P6AS), which can counteract the effects of fentanyl and methamphetamine in lab experiments. The compound works as a molecular container, binding to drugs and reversing their biological properties.
Researchers from Japan have developed an RNA interference method using antisense oligonucleotides to correct a genetic defect in Fukuyama Muscular Dystrophy. This approach has shown promise in treating patients with the disease, which is characterized by generalized muscle weakness and intellectual disability.
Researchers at Johns Hopkins Medicine discovered that regulating the electrical charge on the inner side of the cell membrane can activate pathways responsible for cell movement. This finding has potential implications for understanding cancer cell migration and immune cell function.
Researchers at Scripps Research have developed a general synthesis method for 1,2,3,5-tetrazines, a family of compounds with great promise for making new pharmaceuticals and chemical products. The new method is more efficient than previous approaches, requiring just five reaction steps to produce myriad versions of these compounds.
Researchers modeled how genetic changes affecting protein synthesis speed can lead to misfolding and altered activity levels in proteins. This finding suggests the importance of kinetics alongside sequence for determining protein structure and function, with potential implications for fields such as biopharmaceutics and medicine.
Researchers developed an integrated approach to accelerate drug discovery by combining complex datasets from two screening platforms and next-generation metabolomics analysis. The new framework identified known compounds, confirmed mechanisms of action, and discovered novel compounds with unique biological signatures.
Through its Integrated Pest Management program, WVU Extension educates growers on safe techniques, including barriers, insect traps, and predatory insects. The goal is to reduce pesticide use and promote environmentally friendly practices.
Researchers at Texas A&M University engineered DARPins to block the interaction between the COVID-19 virus and host cells, significantly reducing disease progression. The nasal sprays showed effectiveness against various variants, including omicron, and could provide a lower-cost therapeutic option for those at high risk.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
Researchers used quantum chemical calculations to study DNA replication and found that enzyme helicase speeds up the process, stabilizing mutated forms of DNA. This discovery sheds new light on the role of quantum effects in genetic mutations.
Researchers at Princeton University have identified a multi-step biosynthetic pathway that transforms a biologically inert peptide into structurally complex antibiotics, called enteropeptins. Enteropeptins exhibit narrow-spectrum activity and inhibit the growth of specific bacteria, such as Enterococcus.
MU researchers, including Jay J. Thelen and Dong Xu, are exploring genetic modification to increase seed oil production in camelina and pennycress for biofuel use in the aviation industry. The team aims to create a sustainable 'green energy' source as an alternative to petroleum-based fossil fuels.
Researchers at Nagoya University identified the pheromone PGE2 involved in puffer fish spawning behavior, which is synchronized with the lunar cycle. The study found that applying PGE2 to puffer fish triggers their characteristic writhing motion during spawning.
Researchers have engineered a microbe to break down and upcycle mixed plastics into building blocks for next-generation materials. The process converts deconstructed plastic waste into polyhydroxyalkanoates or beta-ketoadipate, ideal for applications such as automotive parts.
New research by Frank Schroeder's team reveals two parallel biosynthetic pathways for serotonin production in C. elegans, challenging the long-held assumption that serotonin is made and quickly broken down. The findings suggest new therapeutic targets for treating anxiety, depression, and eating disorders.
Researchers have made a breakthrough in plastics recycling by developing a technology that can convert mixed plastics into biodegradable products, reducing the need for costly separations. The process uses chemical oxidation and biological processes to break down plastics into smaller building blocks that can be consumed by microorgani...
Researchers at Tokyo Institute of Technology have developed a novel method for detecting protein phosphorylation using phosphate's electrical signature. The technique boasts 95% accuracy and 91% specificity, offering new avenues for clinical diagnosis and pharmaceutical applications.
A new drug, NMT5, has shown promising results in blocking SARS-CoV-2 infection in animals. The drug coats the virus with chemicals that temporarily alter the human ACE2 receptor, preventing it from infecting cells. In cell culture experiments, the Omicron variant of SARS-CoV-2 was prevented from attaching to human ACE2 receptors by 95%.
Using biofertilizer on 80% of their planted area, Brazilian soybean growers enjoy environmental and economic benefits by employing the microbiome instead of chemical fertilizers. The use of biofertilizer saves farmers huge amounts of money, with costs significantly lower than chemical fertilizer.
A new study by Grant Brown and Braeden Donaldson found that juvenile convict cichlids exposed to high-risk alarm cues have brains 16% larger compared to low-risk groups, with noticeable increases in olfactory and optic bulbs. The brains revert to normal size after removal of the alarm cues.
Researchers discover that male spotted lanternflies are strongly attracted to the smell of honeydew produced by male conspecifics, emitting specific sex-attractant profiles. This finding may lead to the development of new pest management tools to reduce the population and spread of this invasive species.
A joint research team from Korea and Japan developed site-specific organelle fluorescent thermometers that visualize temperature changes in almost all typical organelles. The new thermometers, called Thermo Greens (TGs), provide quantitative images of heat generation at different organelles, offering insights into cellular processes.
Researchers from the Institute of Physical Chemistry, Polish Academy of Sciences, have developed a novel polymer-based solution that enables easy delivery of large molecules to cells. By applying hypertonic solutions, they can induce osmotic stress and relax the cell membrane, allowing for precise control over molecule transfer.
A new DNA-based fluorescence technique using single-molecule electron-transfer kinetics can identify point mutations in mRNA, facilitating the diagnosis of gliomas and potentially treating the disease. This breakthrough may lead to real-time cancer diagnostics during surgical biopsies, reducing the need for multiple surgeries.
Researchers found a strong association between ultra-processed food consumption and adverse mental health symptoms, including depression, anxiety, and mentally unhealthy days. The study suggests that the high sugar, salt, and saturated fat content of ultra-processed foods may contribute to these negative effects.
Researchers developed a label-free Raman spectroscopy approach with enhanced sensitivity and speed, allowing for non-invasive imaging of biological samples. The new CARS microscopy system can acquire microscopic images and identify biomolecules with unprecedented resolution and speed.
Researchers at Karolinska Institutet have developed a method to create a three-dimensional gel from spider silk proteins that can be designed to deliver functional proteins. The gel has the potential to revolutionize regenerative medicine, enabling controlled drug release and tissue engineering applications.
The workshop will discuss recent advances, perspectives, and applications of medical cannabis and cannabinoids. Researchers will explore their chemistry, pharmacology, analysis, influence on mitochondria, and potential use as anticancer agents.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at Ohio State University have developed an artificial protein that could provide new insights into chemical evolution on early Earth. The protein, inspired by a key enzyme in energy production, has been shown to build molecules one step at a time, shedding light on how organic chemistry matured on the planet.
Scientists have created new fluorescent chemical compounds for photodynamic therapy of cancerous tumors, which can stain affected tissues and destroy tumor cells without harm to healthy ones. The compound containing pyrene shows the highest fluorescent and anticancer activity.
Rensselaer researchers will use a five-year grant to develop novel inhibitors of the SARS-CoV-2 virus's CLpro and PLpro proteases. The team aims to create an orally bioavailable drug that can be administered at home, with the potential for improved antiviral activity when combined with other drugs like remdesivir.
Scientists have developed artificial photosynthesis to produce food in the dark, bypassing sunlight's need. This technology converts CO2, electricity, and water into acetate, a key component of vinegar, boosting food production's conversion efficiency up to 18 times.