Articles tagged with Chemical Biology
Scientists at Max Delbrück Center discovered two lead compounds that inhibit activation of IKK/NF-κB pathway only when triggered by DNA double-strand breaks. These substances make cancer cells more sensitive to chemotherapy, potentially increasing the success rate of genotoxic cancer therapies.
A new study uses machine learning to analyze data from DrugAge, a database of chemical compounds modulating lifespan in model organisms. The researchers create four types of datasets to predict whether or not a compound extends the lifespan of C. elegans, using features such as compound-protein interactions and Gene Ontology terms.
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
The study evaluates recent research on artificial intelligence-generated molecular structures from the perspective of medicinal chemists, recommending guidelines for assessing novelty and validity. Insilico Medicine's recommendations aim to improve the process of generating and evaluating novel AI-generated drugs.
A team of scientists at Harvard Medical School has identified six chemical cocktails that can restore cellular aging and rejuvenate human cells. The study builds upon the discovery of Yamanaka factors, which can convert adult cells into induced pluripotent stem cells, raising hopes for treating age-related diseases and injuries. The im...
Researchers found that bitter taste receptors can detect and respond to bile acids, which are produced in the liver and play a crucial role in fat digestion. The discovery suggests that bitter taste receptors may have evolved not only to detect food toxins but also to sense endogenous substances.
The new VOLT Center aims to understand the interactions between organisms, environment, and atmosphere regarding volatile organic compounds (VOCs), which influence global climate. Researchers will study the production, consumption, and effects of VOCs from various organisms, including bacteria, plankton, and plants.
Kolomeisky aims to develop analytical models that quantify the role of heterogeneity in chemical and biological processes. He plans to explore its impact on catalytic reactions, antimicrobial peptides and early cancer development.
Researchers at MIT have created a metal-free, Jell-O-like material that can conduct electricity similarly to conventional metals. The material is made into a printable ink, which the researchers patterned into flexible, rubbery electrodes.
A novel framework guides informed and effective soil management as carbon sinks, considering context-dependent environmental conditions. Management targeting 'labile' carbon is more effective in increasing carbon sequestration than focusing on 'stabilized' carbon.
Researchers at Cold Spring Harbor Laboratory have devised a chemical transformation called phosphorus fluoride exchange (PFEx), which efficiently assembles complex molecules. This click chemistry method uses phosphorous as a connector, inspired by biology's use of phosphorus in DNA and energy-storing molecules.
Researchers at the University of Helsinki discovered a small molecule that inhibits cytokine protein formation, alleviating rheumatoid arthritis symptoms in mice. This breakthrough enables the rational design of novel molecules for disease prevention and treatment.
Researchers at UC San Diego and Stanford University have developed a roadmap of root chemicals that are critical to plant growth, providing new insights into plant development. The study reveals that key small molecules are clustered in patches across the root, suggesting a purposeful distribution for optimal growth.
A new study finds that popular compostable plastics like PLA don't biodegrade in marine environments, instead persisting unchanged. The research highlights the need for standardizing tests to see if materials promoted as compostable or biodegradable actually break down in natural environments.
Researchers have successfully created bacteria that can produce an unnatural amino acid, para-nitro-L-phenylalanine (pN-Phe), which has potential applications in vaccine development. The discovery was made using genetic code expansion methods and metabolic engineering techniques.
Researchers develop a new method for fixing carbon dioxide using formic acid, which can replace conventional chemical manufacturing processes with carbon-neutral biological methods. The process produces formaldehyde, a non-toxic substance that can be fed into metabolic pathways to create valuable substances.
Scientists have developed a gene-editing technique that allows them to easily engineer specific cancer-linked mutations into mouse models. This new method, based on CRISPR genome-editing technology, enables researchers to explore many unknown mutations and develop new drugs targeting those mutations.
Scientists at Duke University found electric fields within biological condensates, which could change the way researchers think about biological chemistry. The discovery suggests that these structures may have played a crucial role in the first life on Earth, providing energy for essential reactions.
Scripps Research scientists develop a new strategy to identify small molecules that can alter protein function, offering a promising path for discovering targeted cancer drugs. By comparing how mirror image versions of small molecules impact clusters of proteins, they identified potential new drug targets such as MY-1B and EV-96.
A new discovery by researchers at the University of Warwick has found a simple material that can prevent bacterial viruses from contaminating laboratories and microbial factories. This breakthrough aims to develop next-generation industrial biotechnologies and remove a bottleneck in fundamental research.
Origin-of-life chemists suggest glyoxylate reaction scenario could have yielded simple sugars without drawbacks of formaldehyde-based reactions. The researchers aim to demonstrate this hypothesis in the laboratory and explore potential commercial applications.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
A team of researchers has discovered that chromium(III) supplementation can regulate glucose metabolism in type 2 diabetic mice by targeting ATP synthase activity. This process improves mitochondrial deformation caused by high glucose levels and boosts glucose metabolism.
Researchers at Cold Spring Harbor Laboratory have created a method to safely synthesize the cancer-fighting molecule JA, which has shown promise in treating triple-negative breast cancer. The team found that JA inhibits metabolic activity in cancer cells, starves them of energy and building blocks, leading to cell death.
Researchers at UC San Francisco have created the first molecular-level picture of how an odor molecule activates a human odorant receptor, opening doors to creating novel smells. This achievement paves the way for new insights into biological processes, including fragrances and food science.
Researchers at the University of Nebraska-Lincoln have discovered that the orientation of a single amino acid in peptides can direct activation to specific neurons, influencing communication among brain cells. This finding has far-reaching implications for understanding and regulating signaling processes in the brain.
A new device developed by quantum engineers can measure the spins in materials with high precision, breaking the current record of thousands of spins. This breakthrough enables researchers to study systems that were previously inaccessible, such as microscopic samples and two-dimensional materials.
Scientists studied F1-ATPase function in bacteria to clarify the angle of rotation during ATP hydrolysis. The study revealed three sets of short and long dwells associated with different intervals per revolution, resolving a long-term debate over the ATP-cleavage shaft angle.
Scientists at St. Jude Children's Research Hospital demonstrate a framework to develop solutions to evade detoxification networks in drug development, potentially reducing side effects. By altering the structure of a small molecule, they found a way to stretch out binding regions, making it energetically unfavorable for drugs to bind a...
A Keck School of Medicine study found exposure to PFAS, known as 'forever chemicals,' disrupts key biological processes in children and young adults, increasing risk of diseases such as developmental disorders, cardiovascular disease, and cancer. The study highlights the importance of regulating PFAS as a class of chemicals.
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
The team developed a technology to globally assess Fe-S cluster binding in an entire proteome without laborious protein purification or radioisotopes. The study found differential sensitivity of iron-sulfur clusters to iron limitation and pathway impairment, prioritizing iron-sulfur cluster delivery in E. coli.
Researchers at Nagoya University have identified 2,6-dihalopurines as a new class of stomatal opening inhibitors, potentially involving LRX3-5 and RALF peptide. This discovery may lead to the development of new agrochemicals and chemical biology research applications.
Researchers developed a new method for measuring indoor air quality using transgenic nematode strains that produce fluorescence when exposed to harmful pollutants. The amount of fluorescence can be measured and used to detect various impurities in the air, including fungal samples, surfactants, and volatile compounds.
Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.
A research team led by Professor Xiang David LI has developed a novel chemical tool called photo-ANA to investigate bacterial interactions with the host in real-time. This approach enables scientists to comprehensively profile host–bacteria protein interactions during infection, revealing known and newly discovered interactions.
A new electrochemical sensor has been developed to detect dopamine levels in biological fluids, potentially leading to earlier disease detection for conditions like Parkinson's disease and depression. The method uses carbon quantum dots and ionic liquids, offering a quick and sensitive test.
Researchers identified hundreds of microorganisms associated with plant roots and soil, showing potential for developing biological substitutes for phosphorus-based fertilizers. The discovery highlights the importance of microbial communities in supplying essential nutrients like nitrogen.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers have discovered that ancient crocodilian hemoglobin required 21 interconnected mutations to develop its hyper-efficient oxygen-binding properties. This complexity, not found in other vertebrates, enabled crocodilians to exploit their onboard oxygen stores for extended periods underwater.
Researchers at Kyoto University have discovered a vital role of two proteins, ABCA1 and Aster-A, in maintaining the asymmetric distribution of cholesterol within cells. This process allows for selective control over substances entering and leaving cells.
Researchers have created a chemical compound, Pillar[6]MaxQ (P6AS), which can counteract the effects of fentanyl and methamphetamine in lab experiments. The compound works as a molecular container, binding to drugs and reversing their biological properties.
Researchers from Japan have developed an RNA interference method using antisense oligonucleotides to correct a genetic defect in Fukuyama Muscular Dystrophy. This approach has shown promise in treating patients with the disease, which is characterized by generalized muscle weakness and intellectual disability.
Researchers at Johns Hopkins Medicine discovered that regulating the electrical charge on the inner side of the cell membrane can activate pathways responsible for cell movement. This finding has potential implications for understanding cancer cell migration and immune cell function.
Researchers at Scripps Research have developed a general synthesis method for 1,2,3,5-tetrazines, a family of compounds with great promise for making new pharmaceuticals and chemical products. The new method is more efficient than previous approaches, requiring just five reaction steps to produce myriad versions of these compounds.
Researchers modeled how genetic changes affecting protein synthesis speed can lead to misfolding and altered activity levels in proteins. This finding suggests the importance of kinetics alongside sequence for determining protein structure and function, with potential implications for fields such as biopharmaceutics and medicine.
Through its Integrated Pest Management program, WVU Extension educates growers on safe techniques, including barriers, insect traps, and predatory insects. The goal is to reduce pesticide use and promote environmentally friendly practices.
Researchers developed an integrated approach to accelerate drug discovery by combining complex datasets from two screening platforms and next-generation metabolomics analysis. The new framework identified known compounds, confirmed mechanisms of action, and discovered novel compounds with unique biological signatures.
Researchers at Texas A&M University engineered DARPins to block the interaction between the COVID-19 virus and host cells, significantly reducing disease progression. The nasal sprays showed effectiveness against various variants, including omicron, and could provide a lower-cost therapeutic option for those at high risk.
A new bioreactor system developed by KAUST scientists delivers gases to maintain physiological environments, reducing unpredictable shifts in cell growth. The system allows for more accurate and reproducible experiments in biomedical research.
Researchers used quantum chemical calculations to study DNA replication and found that enzyme helicase speeds up the process, stabilizing mutated forms of DNA. This discovery sheds new light on the role of quantum effects in genetic mutations.
Researchers at Princeton University have identified a multi-step biosynthetic pathway that transforms a biologically inert peptide into structurally complex antibiotics, called enteropeptins. Enteropeptins exhibit narrow-spectrum activity and inhibit the growth of specific bacteria, such as Enterococcus.
MU researchers, including Jay J. Thelen and Dong Xu, are exploring genetic modification to increase seed oil production in camelina and pennycress for biofuel use in the aviation industry. The team aims to create a sustainable 'green energy' source as an alternative to petroleum-based fossil fuels.
Researchers at Nagoya University identified the pheromone PGE2 involved in puffer fish spawning behavior, which is synchronized with the lunar cycle. The study found that applying PGE2 to puffer fish triggers their characteristic writhing motion during spawning.
Researchers have engineered a microbe to break down and upcycle mixed plastics into building blocks for next-generation materials. The process converts deconstructed plastic waste into polyhydroxyalkanoates or beta-ketoadipate, ideal for applications such as automotive parts.
Researchers have made a breakthrough in plastics recycling by developing a technology that can convert mixed plastics into biodegradable products, reducing the need for costly separations. The process uses chemical oxidation and biological processes to break down plastics into smaller building blocks that can be consumed by microorgani...
New research by Frank Schroeder's team reveals two parallel biosynthetic pathways for serotonin production in C. elegans, challenging the long-held assumption that serotonin is made and quickly broken down. The findings suggest new therapeutic targets for treating anxiety, depression, and eating disorders.
Researchers at Tokyo Institute of Technology have developed a novel method for detecting protein phosphorylation using phosphate's electrical signature. The technique boasts 95% accuracy and 91% specificity, offering new avenues for clinical diagnosis and pharmaceutical applications.
A new drug, NMT5, has shown promising results in blocking SARS-CoV-2 infection in animals. The drug coats the virus with chemicals that temporarily alter the human ACE2 receptor, preventing it from infecting cells. In cell culture experiments, the Omicron variant of SARS-CoV-2 was prevented from attaching to human ACE2 receptors by 95%.
Using biofertilizer on 80% of their planted area, Brazilian soybean growers enjoy environmental and economic benefits by employing the microbiome instead of chemical fertilizers. The use of biofertilizer saves farmers huge amounts of money, with costs significantly lower than chemical fertilizer.