Articles tagged with Chemical Biology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A mathematical model shows that injections of peptide CK2.3 can increase bone formation and decrease bone degradation, potentially treating osteoporosis. The researchers used a combination of biological and mathematical models to calculate ideal dosages for humans and mice, aiming to develop a promising remedy for the condition.
A team of chemists from Konstanz University has made a significant discovery about the effects of selective mutations on the alpha-synuclein protein. By applying magnetic probes to the protein, they found that these changes disturb the binding of alpha-synuclein to membranes.
Researchers identified 49 persistent haze events in China's capital region, with a significant increase in events since the 2000s. The scientists found that specific circulation patterns can trap pollutants close to the Earth, leading to prolonged haze events.
Researchers have developed a brighter and more biocompatible chemiluminescent probe that can be used in water and detect various cell activities. The new probe enables the detection of several biologically relevant chemicals, enzyme activity, and imaging cells using microscopy.
Researchers at Queen Mary University of London trained bumblebees to roll a mini-ball into a goal, demonstrating unprecedented learning abilities. The study found that bees learned more efficiently when observing a skilled demonstrator, suggesting complex cognitive flexibility.
Researchers from Queen Mary University of London found that a chromosome responsible for the social organization of colonies is likely to have evolved through a single genetic event. The study reveals that a 'supergene' region containing over 500 genes plays a crucial role in determining colony type and social organization.
A European Commission proposal to define and identify endocrine-disrupting chemicals has been widely criticized by experts, who argue it sets an unrealistic burden of proof and limits regulatory action. The Endocrine Society, led by UMass Amherst biologist Thomas Zoeller, claims the proposal will create gaps in identification criteria,...
Researchers at Max Planck Institute for Chemical Ecology have developed a new technique to visualize molecular distributions on rippled, hairy, or bulgy surfaces. The 'corrective glass' method uses laser ablation electrospray ionization (LAESI) to correct for surface topography and provide accurate chemical imaging.
Researchers at Tufts University have developed a method to embed functional elements in silk-based materials, creating mechanical components that can change color with strain or respond to light. These materials have potential applications in orthopedics, surgery, and household goods.
A hormone-disrupting compound could provide a new strategy for controlling the spread of malaria by preventing transmission of malaria parasites in female mosquitoes. The study found that DBH-treated mosquitoes were less likely to be infected and produced fewer eggs, making it an effective alternative to insecticides.
The discovery by University of Konstanz researchers reveals two regions within Ssb that mediate direct contact with the ribosome, supporting its function. The findings suggest a unique feature of Ssb that enables it to position itself optimally at the ribosome.
Researchers have identified a novel microprotein called NoBody, which is involved in sweeping out unneeded genetic material inside cells. This discovery may signal the existence of additional microproteins involved in key biological mechanisms and diseases.
An international team has made a breakthrough by trapping an intermediate in the mechanism of heme peroxidase enzymes and determining its structure using neutron beams. This finding could change our understanding of how these enzymes work, shedding new light on their role in biochemical processes.
A recent study published in Journal of Vision found that women and men process facial information differently, with women exhibiting a stronger left eye bias and exploring faces more thoroughly. The researchers used eye-tracking technology on almost 500 participants to analyze their scanning patterns.
Scientists have developed multicolor electron microscopy, enabling up to three colors (green, red, yellow) to be used in an image. The new method has potential applications in biology, distinguishing cellular compartments and tracking proteins.
Researchers develop genetically engineered peptides to transmit information between biological systems and synthetic materials, enabling a coherent bioelectronic interface. The discovery enables the creation of biomolecular solid-state devices with potential applications in biomedical and electro-optical devices.
Researchers have created a fabric material capable of degrading chemical warfare agents (CWAs), rendering them harmless. The unique 'nano-kebab' structure, formed by metal-organic frameworks (MOFs) on nanofibers, breaks down CWAs with half-lives as brief as 2.3 minutes.
Scientists at KU Leuven have developed a new cocktail of biological pesticides and synthetic predator cues that kills mosquitoes more efficiently and sustainably. The combination triggers a stress response in mosquitoes, impairing their immune system and reducing the spread of diseases.
Researchers found that rats rely heavily on their whiskers to locate airflow sources, even when other sensory cues are available. The discovery could lead to the development of artificial flow sensors for robots.
Lawrence Livermore National Laboratory scientists have created a breathable material that provides protection from biological agents due to its small pore size. The material also responds to chemical hazards with dynamic functional groups, mimicking the adaptive response of human skin.
Researchers developed self-healing polyelectrolyte coatings that can repair themselves and neutralize chemicals, protecting users from toxic substances and hazardous environments. The coatings are thin, micron-sized and can increase material strength while being reusable and rewearable after laundering.
A team of Cornell University researchers has devised a method for isolating one specific enzyme activity of SIRT6, a protein with multiple biological functions. The study used a mutant form of SIRT6 to determine its contribution to various functions, including genome stability and metabolism.
Researchers discovered a lost hormone in starfish that is linked to human sexual maturity and evolution. The study found that the evolutionary history of the hormone gonadotropin-releasing hormone (GnRH) is written in the genes of the starfish, with two GnRH-like hormones found in both humans and fruit flies.
A London bee tracking project has begun, releasing 500 tagged bees to study their behavior and interactions with flowers in urban gardens. The project aims to understand the bees' preferred patches and favourite flowers, rewarding participants with prizes for identifying the most flowers visited by individual bees.
Researchers reconstructed ancient bacterial enzymes and found that they were sophisticated and functional, contrary to the widely-held theory. This discovery suggests that biological evolution progressed rapidly in its early stages, with enzymes becoming fully developed within a 500-million-year period.
Researchers have developed an inexpensive and flexible micro-Raman system for non-destructive analysis of biological samples, offering a fraction of the cost and capability of commercial tools. This system allows for label-free detection of variations in biomolecular composition and correlates it with corresponding biological changes.
Scientists develop new method to control magnetic particles of two distinct sizes suspended in liquid, forming channels that drive small particles along, improving sorting and lab-on-a-chip device functionality.
A new project aims to mobilize the public to help local urban bees by planting bee-friendly flowers and tracking their movements. The London Pollinator Project encourages Londoners to plant flowers that are rich in nectar and pollen, such as English lavender and spiked speedwell, to support the ailing urban bee population.
Researchers developed steric trapping method to analyze membrane proteins' folding, showing promise for treating diseases at early stages. The study's findings could lead to medicinal advances in understanding protein structure and function.
Researchers at Pitt and Penn State found that simple physical and chemical processes directed the self-assembly of microcapsules into colonies. The study suggests a plausible mechanism for protocell organization, potentially leading to the formation of larger biological structures.
Researchers developed a new method that uses plasma to deposit nanomaterials onto flexible surfaces and 3-D objects. The technique can produce wearable chemical and biological sensors, flexible memory devices, batteries, and integrated circuits with improved efficiency and reduced costs.
The 2016 Protein Society Awards recognized Dr. Gary Pielak, Dr. Rachel Klevit, Dr. H. Eric Xu, and Dr. Andreas Plückthun for their groundbreaking contributions to protein science. The winners received prestigious awards sponsored by Rigaku Corporation, Genentech, The Neurath Foundation, and The Protein Society.
A novel small-molecule antiviral compound, GS-5734, has been shown to protect rhesus monkeys from Ebola virus infection when administered three days post-infection. This preclinical result demonstrates the compound's ability to block viral replication and reduce disease severity.
Researchers successfully control ultrafast electron motion using FERMI's light, achieving a time resolution of 3 attoseconds. This breakthrough enables the study of fast chemical reactions on the scale of attoseconds, shedding new light on processes like photosynthesis and combustion.
A new non-destructive technique using EPR oximetry measures oxygen levels in smaller 3D cell cultures, reducing oxygen concentration loss and enabling comparable results to native tissues.
Genetically encoded fluorescent biosensors allow researchers to visualize the formation of valuable products in real-time and test billions of candidates at a time. This breakthrough enables efficient identification of the most productive microbes for fine chemicals, therapeutics, and biofuels production.
Researchers at Iowa State University have successfully developed a hybrid technology that combines genetic engineering and electrocatalysis to convert sugar into biobased, unsaturated nylon-6,6. This process offers several advantages, including low operating temperatures, the use of cheap metals, and production from water.
A new synthetic biopathway enables efficient conversion of agricultural waste into various useful products, including spandex and chicken feed. The process results in a 70% higher yield and is better for the environment than previous methods.
The 2016 ASBMB meeting featured scientific symposia on various topics including bioinorganic catalysis, cell signaling, chemical biology, chromatin organization, DNA replication, education, and glycoscience. Key researchers like Aziz Sancar will present their work on DNA repair and precision medicine.
Researchers have made significant progress in developing fluorescent chemical probes that can target specific cancer cells, allowing for more accurate tumor removal. These probes have the potential to improve patient outcomes and reduce the need for repeat surgeries.
Volatile organic compounds protect plants from stress, attract insects for pollination and seed dispersal, and send warning signs to neighbor plants and animals. Plant VOC emissions contribute significantly to the atmosphere, emitting approximately 600 million tons of carbon annually.
Researchers at Queen Mary University of London found that Protoceratops' large bony frill increased in size as the animal matured, suggesting it played a role in attracting mates. The study provides the first demonstration of sexual selection in dinosaurs and sheds light on the evolution of ornamental structures.
Researchers have developed a technique that enables the detection of single molecules of contaminants, explosives, or diseases using a combination of surface-enhanced Raman scattering (SERS) and a slippery surface. This innovation has vast applications in analytical chemistry, molecular diagnostics, environmental monitoring, and nation...
Researchers found schreibersite, an iron-nickel phosphide mineral, could provide phosphate essential for prebiotic molecules. The mineral's phosphorylation reaction with early Earth water likely played a role in the emergence of metabolic molecules.
A special issue of Future Medicinal Chemistry explores the diverse field of chemical biology, highlighting its expanding scope and sub-disciplines. The issue features reviews, opinion pieces, and primary research papers on topics such as protein-protein interactions, epigenetic modulators, and tissue regeneration.
A QMUL PhD student has found a simple way to produce two ancient chemical compounds, sultones and sultines, which have applications in antiviral agents and may lead to new treatments for diseases such as HIV and Herpes. The breakthrough reduces the production process from five to two steps, increasing yield by nearly 100%.
Researchers at University at Buffalo have developed a novel pre-purification system to enhance the production of yersiniabactin, a metal-binding compound with potential applications in wastewater treatment and physiological metal imbalance. The new method improves the recovered levels of the final compound, paving the way for its use i...
Synthetic biology holds promise for revolutionizing science and medicine, but its safe and stable application is crucial before being applied in real-world settings. Engineers are working on developing safety infrastructure, including kill switches and microbial sensors, to ensure the reliability and predictability of engineered microbes.
Scientists at Goethe University Frankfurt have developed SLAP technology, a small labeling pair that achieves high sensitivity and efficiency in single-molecule localization microscopy. The approach avoids mislocalization artifacts caused by large detection markers, enabling precise analysis of protein clusters and oligomeric states.
Researchers will investigate three projects: one on menopausal symptoms, another on biological activity of botanicals, and a third on interactions with prescription drugs. The goal is to determine the safety and efficacy of botanical dietary supplements as alternatives to hormone therapy.
Researchers at MIT have developed a family of materials that can emit light of precisely controlled colors and respond to external conditions. The materials, made from rare-earth elements and polymers, show promise for detecting chemical and biological compounds, mechanical changes, and thermal conditions.
The Hybrid Photonic Mode-Synthesizing Atomic Force Microscope combines nanospectroscopy and nanomechanical microscopy, allowing for rapid non-invasive exploration of materials' surface and subsurface. Researchers can study synthetic and biological samples with high resolution and spectroscopic capabilities.
Exposure to endocrine-disrupting chemicals, psychological stress and malnutrition may alter gene expression and lead to increased risk of cognitive disorders, obesity and metabolic diseases. The preconception period is a sensitive developmental window, emphasizing the need for universal healthy starts for children.
A novel approach using a motile bacteria and microbial lug-gage enhances cellulose degradation in solid-state conditions. This method overcomes limitations of current biocatalysts, offering a promising solution for efficient and cost-effective cellulose hydrolysis.
Researchers at Wayne State University aim to determine contaminant prevalence in urban agriculture soil, identify risk factors and develop guidance for safe and sustainable gardening. The project will provide urgently needed information on physical, chemical and biological contamination in urban agricultural environments.
The REDIchip can detect drugs in urinalyses, provide earlier detection of emerging health problems, enhance medical imaging, improve tumor margin determinations, and identify endocrine disruptors in the environment.
The university will create a new generation of tools to develop novel architectures combining hard and soft materials for electronics and biomedicine. The 4-D printer will use nanoscale technology to construct devices for research in chemistry, materials sciences, and U.S. defense-related areas.
Researchers have developed a nanotechnology that promises to make SERS simpler and more affordable, enabling the detection of trace amounts of molecules in various fields. The universal substrate can trap a wide range of wavelengths, reducing the need for different substrates and increasing the efficiency of sensing techniques.
Corleone Delaveris, a Boston College senior, has been awarded a National Science Foundation Graduate Research Fellowship to study chemical biology at Stanford University. The award will provide financial support for three years of graduate study, covering an annual stipend and tuition costs.
A large-scale study of Ebola survivors found persistent health effects, including vision loss, hearing impairment, and cognitive decline. The study highlights the need for strategies to address the long-term health needs of survivors.