A high-fructose diet has been shown to slow down the brain's ability to recover from head trauma, according to a new US study published in the Journal of Cerebral Blood Flow and Metabolism. The research found that rats fed a fructose-infused diet took 30% longer to solve a maze after being subjected to a simulated traumatic brain injury.
SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of Cerebral Blood Flow & Metabolism·DateOct 2, 2015
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Drinking sugar-sweetened beverages can lead to excess weight gain, a higher risk of developing type 2 diabetes, and cardiovascular disease. Fructose's unique role in metabolism contributes to these conditions.
SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·DateSep 28, 2015
A recent study published in PLOS ONE found that a high-soybean-oil diet caused significant weight gain, diabetes, and insulin resistance in mice compared to diets high in coconut oil or fructose. The researchers used mice fed different diets containing various types of fats to investigate the effects on obesity and metabolic syndrome.
SourceUniversity of California - Riverside·JournalPLOS ONE·DateJul 22, 2015
A study by University of Basel researchers found that fructose stimulates the reward system in the brain to a lesser degree than glucose, leading to increased satiety hormone levels and reduced feelings of fullness. This may contribute to the development of various disorders such as obesity, diabetes, and fatty liver disease.
Researchers discover fructose's role in heart failure, finding it efficiently converts to fat and stimulates glycolysis. Fructose also activates HIF, leading to increased KHK-C production and a vicious cycle of growth and damage.
A recent study at Beckman Institute for Advanced Science and Technology found that fructose causes significant weight gain, physical inactivity and body fat deposition when matched calorie for calorie with glucose. Fructose-fed mice displayed increased body weight, liver mass and fat mass compared to glucose-fed mice.
SourceBeckman Institute for Advanced Science and Technology·JournalScientific Reports·DateJun 1, 2015
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Recent studies suggest that added sugars, particularly fructose, are a principal driver of type 2 diabetes. Clinical experts recommend drastic reductions in added sugar and especially fructose consumption to combat the growing epidemic.
SourceElsevier Health Sciences·JournalMayo Clinic Proceedings·DateJan 29, 2015
A new study reveals that fructose-glucose mixtures in high-fructose corn syrup are more toxic to female mice than sucrose, reducing reproduction and lifespan. In contrast, male mice showed no significant differences between the two diets.
SourceUniversity of Utah·JournalJournal of Nutrition·DateJan 4, 2015
A study using fMRI found that fructose triggers greater activation in the nucleus accumbens and higher ratings of hunger compared to glucose, suggesting it may promote overeating. The findings have important public health implications for a society with high-sugar foods and tempting stimuli.
SourceAmerican College of Neuropsychopharmacology·JournalNeuropsychopharmacology·DateDec 10, 2014
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Added sugars, especially fructose, are likely to have a greater impact on high blood pressure and heart disease than salt. Reducing processed food intake containing added sugars can help mitigate cardiovascular risk. The authors argue that dietary guidelines should be more stringent in limiting sugar consumption, particularly among teens.
A new study led by Beth Israel Deaconess Medical Center found that fructose ingestion increases blood levels of the hormone FGF21, providing a reliable predictor for altered fructose metabolism. This discovery offers an avenue for further investigation into genetic and environmental determinants of metabolic response to fructose.
SourceBeth Israel Deaconess Medical Center·JournalMolecular Metabolism·DateOct 13, 2014
Researchers found that excess uric acid can disrupt normal metabolism, leading to the development of metabolic syndrome. A new study suggests that diet and fructose consumption may contribute to high uric acid levels, which can cause inflammation and oxidative stress in the body.
SourceWashU Medicine·JournalNature Communications·DateAug 8, 2014
A recent study published in Nutrition found that popular beverages like Coca-Cola and Pepsi contain higher ratios of fructose to glucose than claimed on labels. This high fructose content may increase the risk of diabetes, cardiovascular disease, and liver disease.
SourceUniversity of Southern California - Health Sciences·JournalNutrition Journal·DateJun 4, 2014
Scientists discovered that blocking GLUT8, a molecule carrying large amounts of fructose into liver cells, prevents fatty livers in mice. The study suggests the liver acts as a sink for processing fructose, potentially harming overall metabolic syndrome.
SourceWashU Medicine·JournalJournal of Biological Chemistry·DateJun 3, 2014
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Researchers have found that agavins, a natural sweetener from the tequila plant, can lower blood glucose levels and aid in weight loss. By acting as a dietary fiber, agavins are non-digestible and won't raise blood glucose, making them an attractive alternative to artificial sweeteners.
A meta-analysis published in the European Journal of Clinical Nutrition found that fructose is not responsible for the increase in non-alcoholic fatty liver disease. The study suggests that excess calorie consumption, regardless of source, contributes to the development of the disease. Dr. John Sievenpiper, lead author of the study, em...
SourceSt. Michael's Hospital·JournalEuropean Journal of Clinical Nutrition·DateFeb 26, 2014
Researchers at St. Michael's Hospital found that consuming fructose may increase total cholesterol and postprandial triglycerides, but not affect insulin production or markers of fatty liver disease more than glucose. Fructose showed potential benefits over glucose in some key risk factor categories.
SourceSt. Michael's Hospital·JournalCurrent Opinion in Lipidology·DateJan 31, 2014
Researchers at University of Nottingham develop novel MRI method for diagnosing and treating Irritable Bowel Syndrome (IBS), allowing continuous bowel imaging with no risk to patients. The technique enables measurement of colon volumes, transit times, and effects of FODMAPs on gut health.
SourceUniversity of Nottingham·JournalNeurogastroenterology & Motility·DateJan 9, 2014
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Researchers found no link between fructose and postprandial triglycerides, a marker for cardiovascular risk. However, excessive calorie intake from fructose contributes to negative health outcomes.
SourceSt. Michael's Hospital·JournalAtherosclerosis·DateDec 30, 2013
Researchers found hummingbirds can switch between burning glucose and fructose equally well, unlike humans who struggle with fructose metabolism. This efficient sugar-burning strategy enables hummingbirds to maintain hovering flight while minimizing unnecessary weight gain.
SourceUniversity of Toronto·JournalFunctional Ecology·DateDec 5, 2013
A recent study published in Nature Communications suggests that the body's production of fructose from non-fructose containing carbohydrates may be a key factor in obesity and insulin resistance. Researchers found that mice converted glucose to fructose in the liver, leading to the development of fatty liver and insulin resistance.
SourceUniversity of Colorado Anschutz Medical Campus·JournalNature Communications·DateSep 10, 2013
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A study published in the American Journal of Clinical Nutrition found that dietary fructose rapidly caused liver damage in an animal model, with damage more than doubling over six weeks. The researchers found that high-fructose diets led to increased intestinal bacteria migration and liver damage, even without weight gain.
SourceAtrium Health Wake Forest Baptist·JournalAmerican Journal of Clinical Nutrition·DateJun 19, 2013
A new study published in the Journal of Applied Physiology, Nutrition, and Metabolism found that consuming high fructose corn syrup (HFCS) and sucrose at average daily levels does not increase liver fat. The findings add to scientific evidence that HFCS and table sugar are metabolically equivalent.
A recent study published in JAMA Network found that glucose ingestion reduces cerebral blood flow and increases feelings of fullness in the brain regions that regulate appetite. In contrast, fructose ingestion had no significant effect on these regions, suggesting that fructose may actually promote food-seeking behavior.
A new study by USC and University of Oxford researchers indicates that large amounts of high fructose corn syrup (HFCS) in food supplies worldwide may contribute to the rising global epidemic of type 2 diabetes. Countries using HFCS had a 20% higher prevalence of diabetes than those not using it.
SourceUniversity of Southern California - Health Sciences·JournalGlobal Public Health·DateNov 27, 2012
A new study published in International Journal of Obesity concludes that high fructose corn syrup is not a unique cause of obesity and is nutritionally equivalent to sugar. The research found no short-term health differences between the use of HFCS or sugar.
SourceFleishman-Hillard, Inc.·JournalInternational Journal of Obesity·DateSep 18, 2012
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Researchers found that high fructose intake is associated with more severe depletion of liver ATP, a compound involved in energy transfer between cells. Elevated uric acid levels may serve as a marker for increased fructose consumption and hepatic ATP depletion.
A new study published in Nutrition Journal found that reducing calorie intake, regardless of whether it comes from table sugar or high fructose corn syrup, leads to similar weight loss outcomes. The research debunks the notion that one type of added sugar is more detrimental to weight loss than others.
SourceFleishman-Hillard, Inc.·JournalNutrition Journal·DateAug 9, 2012
A new study by St. Michael's Hospital researchers found that fructose significantly improved blood sugar control in participants with Type 1 and 2 diabetes, comparable to oral antidiabetic drugs. The study also showed no negative effects on body weight, blood pressure, or cholesterol levels.
SourceSt. Michael's Hospital·JournalDiabetes Care·DateJun 21, 2012
A new UCLA study reveals that a high-fructose diet can slow the brain and impair memory and learning. However, adding omega-3 fatty acids to the diet may help minimize this damage.
SourceUniversity of California - Los Angeles Health Sciences·JournalThe Journal of Physiology·DateMay 15, 2012
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Researchers found that increased fructose consumption depletes cellular energy in obese and diabetic individuals, leading to decreased ATP stores and increased risk of nonalcoholic fatty liver disease. Measuring uric acid levels may help doctors predict the presence and monitor the severity of this condition.
SourceDuke University Medical Center·JournalHepatology·DateMay 2, 2012
Researchers found two forms of an enzyme in fructose metabolism, one causing fatty liver and obesity, the other protecting against these conditions. The study provides new insights into the cause of metabolic syndrome, a condition affecting over 25% of adults in the US.
SourceUniversity of Colorado Anschutz Medical Campus·JournalProceedings of the National Academy of Sciences·DateFeb 27, 2012
A recent study by researchers at St. Michael's Hospital reviewed over 40 published studies on fructose and its link to obesity. The findings suggest that it may not be the fructose molecule itself causing weight gain, but rather consuming too many calories from any food source.
SourceSt. Michael's Hospital·JournalAnnals of Internal Medicine·DateFeb 21, 2012
Annual deaths from hepatitis B and C now exceed those from HIV, concentrated among middle-aged persons. Researchers found that birth-cohort testing and treatment for HCV is cost-effective, saving thousands of lives each year.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateFeb 20, 2012
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A new study found that fructose intake over seven days does not increase blood pressure, but rather leads to a decrease in diastolic blood pressure in some individuals. Researchers aimed to determine whether fructose itself raises blood pressure or if the apparent harm is due to excessive calorie consumption.
SourceSt. Michael's Hospital·JournalHYPERTENSION·DateFeb 13, 2012
Researchers at Sanford-Burnham Medical Research Institute discovered that beta cells in the pancreas use taste receptors to sense fructose, a type of sugar. This finding suggests that fructose plays a role in insulin release, amplifying the effect of glucose and potentially impacting metabolic diseases like obesity and diabetes.
SourceSanford Burnham Prebys·JournalProceedings of the National Academy of Sciences·DateFeb 6, 2012
Adolescents who consume high amounts of fructose are at increased risk for cardiovascular disease and diabetes, according to a recent study. The researchers found that heavy consumers of fructose had lower levels of protective fats like HDL cholesterol and adiponectin.
SourceMedical College of Georgia at Augusta University·JournalJournal of Nutrition·DateJan 24, 2012
A new study using Saccharomyces cerevisiae found that yeast cells grow and reproduce better in multicellular clumps than singly, especially in dilute sugar solutions. This cooperative behavior increases the chances of each cell taking in enough nutrients to grow and divide.
A recent study found that consuming high fructose corn syrup increases cholesterol and triglycerides, key indicators of heart disease risk. The study suggests the current upper limit of sugar consumption may need re-evaluation.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateJul 28, 2011
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Recent research review finds no difference in metabolic impact between HFCS and sucrose, contradicting previous media claims. Despite declining HFCS consumption, US obesity and diabetes rates continue to rise.
Researchers found a significant association between sugar-sweetened drink consumption and increased systolic and diastolic blood pressure levels. Higher glucose and fructose intake also contributed to higher blood pressure levels, particularly when combined with sodium.
A recent study found that maternal fructose consumption during pregnancy results in sex-specific changes in fetal and neonatal endocrinology, with female fetuses showing higher leptin and blood glucose levels. Male offspring also exhibit increased plasma fructose levels and hypoinisulinemia.
SourceThe Endocrine Society·JournalEndocrinology·DateFeb 24, 2011
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A comprehensive review of fructose consumption found no association between fructose and increased food intake or body weight. The study concluded that normal amounts of fructose do not contribute to hyperlipidemia or obesity in either healthy or overweight individuals.
SourceKellen Communications·JournalCritical Reviews in Food Science and Nutrition·DateFeb 10, 2011
New research at OHSU finds that the brain responds differently to fructose and glucose, with fructose inhibiting activity in cortical brain control areas. This study supports animal research and links fructose to obesity, suggesting a potential explanation for the nation's growing obesity epidemic.
SourceOregon Health & Science University·DateFeb 9, 2011
A new review suggests that excessive amounts of fructose may play a role in high blood pressure, diabetes, obesity, and chronic kidney disease. The study recommends restricting added sugars containing fructose for patients with CKD to lower the risk of these health conditions.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateNov 22, 2010
A large cohort study found that consuming fructose-rich beverages like sugar-sweetened soda and orange juice increases the risk of gout among women. The study, which analyzed data from over 78,000 women, also found a significant association between increasing orange juice intake and gout risk.
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A new study found that fructose intolerance is common in children with recurrent or functional abdominal pain, affecting 53.9% of patients. A low-fructose diet was effective in resolving symptoms in 67.7% of patients, highlighting the importance of identifying and managing this condition.
A study by UCLA researchers found that pancreatic cancer cells can metabolize fructose to generate nucleic acids, driving cell division and proliferation. The study suggests that high fructose corn syrup consumption may be linked to increased cancer risk, highlighting the need for reduced refined sugar intake.
SourceUniversity of California - Los Angeles Health Sciences·JournalCancer Research·DateAug 2, 2010
A study by American Society of Nephrology suggests that consuming foods with high fructose levels can increase the risk of hypertension. Researchers analyzed data from over 4,500 US adults and found a significant association between fructose consumption and elevated blood pressure.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateJul 1, 2010
A new mouse model has revealed that a diet high in fructose and trans fats can lead to fatty liver disease with scar tissue. The study also identified potential biomarkers for early detection and suggests therapeutic interventions may reverse or protect against progressive liver damage.
SourceCincinnati Children's Hospital Medical Center·JournalHepatology·DateJun 23, 2010
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A laboratory study found that fructose makes fat cells in belly fat more mature and less responsive to insulin. The findings suggest a link between high fructose intake during childhood and increased visceral obesity, which raises cardiometabolic risk.
Recent studies suggest that cigarette smoking and high fructose corn syrup consumption exacerbate nonalcoholic fatty liver disease (NAFLD) in overweight individuals. Modifying these risk factors may improve patient outcomes for those with NAFLD, who are at risk of disease progression.
A diet high in fructose increases the risk of developing high blood pressure. Studies found that consuming more than 74 grams per day of fructose led to a higher risk of hypertension, with significant associations seen across various blood pressure levels.
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A high-fructose diet was found to raise blood pressure in men, while a gout drug helped protect against the increase. The study also showed that excessive fructose consumption is associated with metabolic syndrome and may contribute to obesity and diabetes.
Researchers correct inaccuracies surrounding high fructose corn syrup's role in obesity and nutrition. They argue that the sweetener is essentially identical to sugar in terms of metabolism and calories.
Research suggests that fructose metabolism in the brain plays a significant role in increasing food intake and obesity risk, particularly with high consumption of high fructose sweeteners. The study's findings raise health concerns for youth and adults consuming large amounts of these sweeteners.
SourceElsevier·JournalBiochemical and Biophysical Research Communications·DateMar 25, 2009
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Recent studies using pure fructose are misinterpreted due to its absence of glucose, a critical factor in human diet. High fructose corn syrup and sugar have equal sweetenss and calorie content, with no meaningful difference in metabolism.
A new study in mice reveals that a gene called PGC-1b plays a key role in the development of insulin resistance caused by high fructose intake. The researchers found that blocking PGC-1b activity improved metabolic profiles and reversed fructose-induced insulin resistance.
SourceCell Press·JournalCell Metabolism·DateMar 3, 2009
A study by Monell Center researchers found that fructose-sweetened beverages increased triglyceride levels in obese individuals, even when consumed with meals. This effect was most pronounced in insulin-resistant subjects, who already had high triglyceride levels.
SourceMonell Chemical Senses Center·JournalThe Journal of Clinical Endocrinology & Metabolism·DateFeb 12, 2009
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A recent study published in PLoS ONE found that women who drink two or more cans of soda per day are nearly twice as likely to show early signs of kidney disease. The study also did not find an elevated risk for men or diet soda consumption.