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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

A new look at wetting models: Continuum analysis

Researchers propose a continuum-based model that illustrates contact line pinning at phase interfaces between materials, differing from traditional Wenzel and Cassie models. The study shows the macroscopic contact angle depends solely on the triple contact line's properties.

How do protein binding sites stay dry in water?

Researchers studied model cavity and tunnel structures resembling protein binding sites to understand their ability to stay dry. Geometric shields prevent water molecules from penetrating at the nanoscale.

In the pursuit of dangerous clumps

Researchers at Helmholtz-Zentrum Dresden-Rossendorf develop a system to recreate amyloid formation on artificial surfaces, providing insights into disease mechanisms. The customized mica surface exhibits hydrophobic properties, facilitating the formation of oligomers and fibrils that can destroy cell surfaces.

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New lab-on-chip advance uses low-cost, disposable paper strips

Researchers at Purdue University have developed a technique to create microfluidic devices on paper strips, enabling more complex chemical assays and applications in medicine and research. The approach uses a laser to modify paper with patterns, allowing for the detection of specific chemicals and biological molecules.

Triblock spheres provide a simple path to complex structures

University of Illinois researchers developed a simple method to create intricate lattice structures using triblock Janus spheres. The innovative material exhibits self-assembly capabilities, enabling the creation of porous sheets with tailored properties for specialized filtering applications.

Nanoparticle gives antimicrobial ability to fight Listeria longer

A Purdue University research team developed a nanoparticle that can hold and release an antimicrobial agent, preserving its effectiveness against Listeria monocytogenes for up to three weeks. The nanoparticle attracts and stabilizes nisin, a food-based antimicrobial peptide, allowing for extended use in foods susceptible to Listeria.

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Mimicking nature, scientists can now extend redox potentials

Researchers at the University of Illinois have discovered a way to fine-tune the reduction potential of copper-containing proteins, enabling the creation of efficient water-soluble redox agents. This breakthrough allows for greater control over electron-transfer properties and extends the range of redox potentials.

Boron-based compounds trick a biomedical protein

Researchers at the University of Oregon have successfully demonstrated that specially synthesized boron compounds can be accepted by biologically active enzymes. This breakthrough could lead to new drug design strategies and boost boron's expanding use in medicine.

MIT: Extending the shelf life of antibody drugs

A new computer model developed at MIT allows researchers to design more stable antibodies, reducing clumping and aggregation issues. The model identifies regions responsible for aggregation and enables mutation of amino acids to increase stability without affecting function.

Research gives clues for self-cleaning materials, water-striding robots

Scientists at the University of Nebraska-Lincoln and RIKEN institute developed a computer simulation to design nanostructured surfaces with superhydrophobic properties. This technology can help create self-cleaning materials and water-striding robots, which are inspired by nature's ability to repel water.

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Bristly spheres as capsules

Scientists have produced amphiphilic hybrid particles consisting of water-insoluble inorganic nanoparticles at the core surrounded by bristle-like layers of hydrophilic polymer chains. The nature of these aggregates depends on the density of polymer

Cellular construction methods emulated

The Dutch team used two types of self-aggregating compounds: surfactants and gelators. They formed aggregates that coexisted without interfering with each other, resulting in complex structures with separate compartments. This orthogonal self-aggregation enables the creation of versatile compartmentalized systems.

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UT-ORNL governor's chair unlocks secrets of protein folding

Researchers reveal driving force behind protein folding involving water interactions and hydrophobic areas of peptides. This insight builds on previous theories, allowing for the determination of a peptide's structure from its amino acid sequence.

Emulsion with a round-trip ticket

Researchers successfully create a double inversion of an emulsion by adding surfactant to a nanoparticle-containing mixture. The process, which uses silica nanoparticles and a specific type of surfactant, allows for the conversion between oil-in-water and water-in-oil emulsions.

Water theory is watertight, researchers say

A team of researchers from the University of Illinois and Argonne National Laboratory has confirmed a long-standing theoretical prediction about water's behavior on hydrophobic surfaces. They found a thin layer of depleted water at the interface, contradicting previous findings of nanobubbles.

Bio-inspired assembly of nanoparticle building blocks

Researchers at Rice University have discovered a novel method for assembling gold and silver nanoparticle building blocks into larger structures, inspired by the self-assembly of lipid membranes that surround every living cell. The new technique allows for the creation of ultra-potent cancer drugs and efficient catalysts.

Mind the gap

A team of scientists used high-energy X-rays to study the hydrophobic water gap, revealing its size and characteristics. The study provides new insights into protein folding and stability, which are crucial in biological systems.

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CU, Scripps researchers provide evidence of how proteins fold

A study by CU, Scripps researchers provides evidence of how proteins fold to create their characteristic shapes and biological functions. They propose that nonpolar groups in a polypeptide chain are responsible for initial folding, which then propagates to form the final folded structure.

Sandia researchers solve mystery of attractive surfaces

Sandia researchers found that rough hydrophobic surfaces exhibit longer-range attractive forces, which may help explain protein folding and the self-cleaning 'Lotus effect'. By inserting rough surfaces into experiments, they slowed down the reaction to measure the attraction and observe its origin, a cavitation bridge between the subme...

UCSD chemists develop self-assembling silicon particles

Researchers at UCSD create tiny silicon chips, 'smart dust,' that can detect chemical or biological compounds and report information to the outside world. The dual-sided particles can collect at a target and self-assemble into a larger reflector for remote sensing applications.

Non-toxic anti-fouling coating for ships

Researchers at Cornell University have developed a non-toxic paint that effectively prevents marine fouling by creating a self-cleaning surface. The hydrophilic and hydrophobic materials, tested by the ONR and other collaborators, deny bacteria a compatible surface to grow on, reducing fouling.

Reversible switch presages new paradigm for surface design

The UCSB team has developed a reversible switch for surface design, allowing for dynamic regulation of macroscopic properties. The technology uses alkanethiolates to create nanometer-thin interfaces that can be controlled as a function of space and time.

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