Articles tagged with Ligands
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have shed light on the structure and functioning mechanism of CysLT receptors, regulating inflammatory responses associated with allergic disorders. The study identified critical ligand-binding determinants, enabling better understanding of receptor-ligand complexes and potential drug targets.
Recent methodologies for generating hierarchical porous metal-organic frameworks (MOFs) have been reviewed. Techniques such as template, etching, and construction of composites enable the creation of multi-level pore structures. These advancements facilitate improved mass transfer and guest diffusion in MOF-based applications.
Scientists have successfully prepared high-quality ZnO quantum dots using a novel one-pot self-supporting organometallic procedure, offering promising prospects for biological applications. The new method yields stable and uniformly sized particles with unique physicochemical properties.
Researchers from the University of Copenhagen have identified five new GPCRs activated by 17 peptide ligands, expanding the known peptide-GPCR network. This discovery has high translational potential as therapeutic targets for various diseases, including genetic, nervous system, and neoplastic disorders.
A team of researchers has fabricated silver nanoparticles that can rapidly change color in response to moisture, enabling fast and reversible switching of plasmonic color in solids. This technology holds promise for applications in product authentication, information encryption, and sensing.
A team of researchers at HZB has investigated the fundamental photochemical processes around metal atoms and its ligands in transition-metal dyes. They found that charge carriers are not spatially separated as previously assumed, but rather undergo a rapid recombination process.
Scientists have discovered semiconducting nanotubes with precise cylindrical structures, which can be used as fluorescent markers in medical research or catalysts in photoreduction reactions. The researchers' accidental discovery reveals the spontaneous formation of these nanostructures using metallic nanocrystals and certain ligands.
Scientists have successfully synthesized a 32-gold atom nanocluster with a core of 12 atoms surrounded by a shell of 20 atoms, demonstrating unusual stability. The cluster's geometry and electronic structure rely heavily on interactions with ligands, particularly amido and phosphine groups.
Researchers found that stem cells are sensitive to the speed of signaling molecule delivery, not just its concentration. This discovery highlights the dynamic interactions between morphogens and cells during embryonic development, allowing for more precise control over cell fates and potentially leading to new ways to drive cellular di...
Researchers at Kanazawa University develop a synthetic ligand that mimics the action of hepatocyte growth factor (HGF), inducing comparable biological responses. The macrocyclic peptide molecule activates the MET receptor, leading to tissue regeneration and gene expression profiles similar to HGF.
A study focusing on iron in the North Pacific reveals its role in controlling primary productivity, carbon cycle, and marine ecosystem. The distribution of biologically available iron is influenced by factors like mixing, upwelling, and ocean acidification.
Researchers at Tokyo University of Agriculture and Technology have discovered that a catalyst poison can be transformed into an efficient ligand by introducing a substituent. This finding has significant implications for the design of ligands for homogeneous catalysts, enabling the acceleration of catalytic reactions.
Researchers at Tohoku University have developed a novel small ligand, ATMND-C2-NH2, with the tightest binding affinity for the bacterial A-site among non-aminoglycoside ligands. The discovery has significant implications for the development of new antibiotics with reduced toxicity and resistance
Researchers use computer models to predict how molecules will behave in certain reactions, controlling the emergence of specific products with desired stereochemical structures. This breakthrough enables chemists to design additives that can select the right product outcomes, revealing new insights into chemical processes.
Researchers at Brown University have successfully assembled complex macroscale superstructures from pyramid-shaped nanoparticle building blocks. The 3D supercrystals demonstrated in the study possess aligned atomic structures, which may lead to interesting optical properties.
A team of neuroscientists at Columbia University has figured out how to tease apart the many roles EGFR plays in the body. They report their findings in PLOS Genetics, solving a long-standing question about EGFR signaling and development. The study sheds light on the link between EGFR and disease, offering clues for diseases like cancer.
Researchers at Université libre de Bruxelles have discovered a decoding mechanism for Wnt7 ligands, enabling precise interpretation of cell signals. This breakthrough has significant implications for understanding Wnt signaling and its regulation, potentially leading to new treatments for diseases like cancers and neurovascular disorders.
Researchers at MIT have designed a polymer material that can change its structure in response to different wavelengths of light, converting from rigid to softer and self-healing states. The material, composed of polymers attached to a light-sensitive molecule, can reversibly switch between two different topological states.
Researchers from Ruhr-University Bochum have developed new phosphine ligands that enhance gold catalysts' activity and stability. These findings allow for more efficient reactions at lower temperatures with reduced catalyst quantities, promising economic benefits in industries.
Recent study reveals supports in atomically dispersed catalysts play a significant role in catalysis, not just as ligands. The findings suggest that metal atoms on the support can directly participate in the activation of reactants.
Researchers develop a method to prepare aggregated, highly luminescent nanostructures from copper-iodine cluster molecules. These nanoaggregates can be used as luminescent inks for invisible paintings and color coatings for LEDs, emitting light in various colors.
Scientists create nanoparticles that can change their surface topography under light control, enabling precise control over chemical reactions. This breakthrough allows for more efficient and selective catalysis, with potential applications in multistage reactions and simplified post-reaction processing.
Researchers created a biomimetic surface that simulates antigen-presenting cell features and found that precise ligand spacing is crucial for T-cell triggering. The study sheds light on the role of CD45 exclusion in receptor activation, offering new insights into T-cell stimulation.
Researchers from Dalian University of Technology have developed a new material that can exhibit switchable functions through successive solid transformations and electron transfer. The material's properties, including magnetic, electric, and optical behavior, can be controlled using external stimuli such as light or temperature.
A new compound, AH10-7, has been identified as a powerful activator of human invariant natural killer T (iNKT) cells, a key player in the immune system's fight against cancer. The compound is highly effective and selective, encouraging iNKT cells to release specific proteins that stimulate anti-tumor immunity.
Researchers create reconfigurable material using liquid tubes, which can be customized into reaction vessels for various uses. The material can conform to surroundings and repeatedly change shape, opening doors for new chemical synthesis and electronic applications.
Researchers have developed a method to create large amounts of fillable and targeted nanovesicles using immune cells. These nanovesicles can be customized with specific ligands to target different types of tumors, enabling more effective cancer treatment.
Caltech scientists have discovered that cells can transmit multiple messages through the Notch signaling pathway by encoding them rhythmically over time. This discovery reveals that cellular messaging is closer to sending smoke signals than texting, and cells use temporal patterns to differentiate between similar ligands.
Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Researchers at OIST have developed a simple way to create copper molecular wires of different lengths by adding or removing copper atoms one by a time. This breakthrough could lead to the creation of miniature computing devices and practical applications in microelectronics.
A new MOF has been created with a responsivity rate of 2.5 x 10^5 amperes per watt, making it suitable for use in solar cells and other photoactive materials.
A new technique, ligand-accelerated non-directed C-H functionalization, enables the late-stage modification of complex drug molecules to improve therapeutic properties. Researchers used a special ligand molecule called 2-pyridone to enhance palladium's reactivity with targeted C-H bonds.
Researchers at Georgia Institute of Technology have demonstrated that certain ligands can create signals similar to those of molecular oxygen, potentially masking true discoveries. The study highlights the tool's limitations and emphasizes the need for careful interpretation in specific cases.
Researchers have developed a new approach to precisely identify and localize prostate cancer tumors while protecting healthy tissue. The double targeting ligand RPS-027 binds to both PSMA and albumin, reducing kidney uptake and increasing tumor-to-tissue ratios for improved therapeutic profile.
Researchers have engineered gut bacteria to produce molecules that mimic human ligands, binding to receptors involved in glucose and appetite regulation. This breakthrough may lead to novel therapeutic approaches for diseases such as diabetes and obesity.
Scientists at EPFL have developed a new ligand that can extend the half-life of peptide drugs from minutes to several days. The ligand, which is easy to synthesize and has high affinity for human albumin, can be appended to peptides using standard synthesizing techniques.
Researchers have developed a copper-catalyzed double hydroboration method to synthesize internal gem-diborylalkanes. The approach restricts regioselectivity with carbonyl groups, overcoming previous challenges with internal alkynes.
Okinawa Institute of Science and Technology researchers created efficient catalysts based on inexpensive and abundant manganese to convert carbon dioxide into formic acid and formamide, widely used in industry. The new catalyst can perform over 6,000 turnovers and is stable in air, opening possibilities for other CO2 conversions.
Scientists at the University of Konstanz and Umea University have successfully generated a structural model of the adenylate kinase enzyme in its closed state. This breakthrough allows researchers to analyze the precise moment when the enzyme is biochemically active, shedding light on its biochemical mechanisms.
A study by Osaka University reveals that a single heterodimer of two T1r members can detect a wide range of sweet and savory flavors in humans. The researchers found that the structure of the heterodimer is similar regardless of the amino acid bound, but with varying affinity for each ligand.
Researchers at KAUST have identified the molecular liaison responsible for promoting inflammation in endothelial tissues. They found that CD44 and PSGL-1 are key E-selectin ligands involved in this process.
A new treatment strategy has been discovered for neuroinflammation related to severe type of stroke, involving the blockade of a protein called TSPO. Etifoxine, a TSPO ligand, reduced inflammation and brain edema in animal models of intracerebral hemorrhage.
Researchers at Princeton University have developed a predictive model for Ni cross-coupling success based on subtle steric differences in ligand parameters. The study found that remote steric hindrance enhances reaction yields, which could help explain why Pd-based ligands are less effective on the smaller Ni atom.
Researchers have developed a mathematical foundation to explain the role of small molecules in promoting proper protein folding. This understanding has important implications for developing future therapies based on pharmacological chaperones to treat misfolding diseases.
Researchers at OIST have developed a new strategy for producing photoluminescent compounds by combining the flexibility of weak aggregation-driven complexes with the controllability of conventional metal-ligand systems. This results in molecules that can be tuned to emit light of specific colors based on their structure.
Researchers have discovered that an important chemical bonding principle, inverse-trans-influence (ITI), operates in metal complexes across the periodic table, including lanthanides and actinides. The finding has potential implications for waste clean-up and treatment of cancerous tumors.
Researchers at Nagoya University identified two peptides, CIF1 and CIF2, that regulate Casparian strip assembly in response to developmental and environmental cues. The study found that these peptides are necessary for the formation and maintenance of the barrier, which helps maintain ion homeostasis and adapt to harsh soil conditions.
Researchers at TSRI develop a versatile method to quickly find small molecules that bind to hundreds of thousands of proteins in their native cellular environment. The method enables the discovery of new drugs and the study of proteins, with potential applications for understanding diseases such as type 2 diabetes.
Researchers at KAUST have developed a simpler way to assemble silver nanoclusters, opening up new opportunities for catalysis and opto-electronics. The clusters can be modified with atom-by-atom control, allowing their properties to be tailored for specific applications.
Researchers at Oregon State University have isolated metal-oxide clusters in water, allowing for precise control over atomic growth. This breakthrough enables the creation of high-performance materials for energy applications.
A new approach to solid-phase extraction of ibuprofen from pharmaceuticals has been successfully developed using zirconium dioxide as the extraction material. The procedure demonstrated efficient trapping of ibuprofen in hydrophobic suppository matrices, with recoveries of 95% and 94%, respectively.
Researchers are developing potent quorum sensing inhibitors using ligand and structure-based screening to combat antibiotic resistance-induced bacterial virulence. Key findings include the potential of synthetic AHL analogs, farnesol, and furanones as biofilm matrix inhibitors.
A team of chemists has developed a process to identify new catalysts for synthesizing drugs more efficiently and cheaply. By examining libraries of drugs, they found highly effective ligands that can improve reactions beyond those reported nearly four years ago.
Edward Nikonowicz will investigate a gene-regulating switch that could lead to the development of new antibiotics, targeting Bacillus anthracis bacteria.
Researchers explore cyclic opioid peptides with constrained topographical structure, offering improved affinities and selectivities at target receptors. The benefits of cyclization have been enhanced through the generation of polycyclic peptides, promoting increased stability and therapeutic potential for novel therapeutics.
Researchers at Texas A&M University have developed nanosystems that can cross the gastrointestinal tract and blood-brain barriers, enabling oral delivery of difficult-to-administer drugs. This approach uses non-competitive active transport to bind to cells, allowing the drug to be absorbed by the body.
Scientists at Scripps Research Institute developed a powerful new method to find drug candidates that bind to specific proteins. The technique can be applied to thousands of distinct proteins and has successfully identified selective inhibitors for two caspase enzymes, which play key roles in multiple diseases.
Researchers at UC Santa Cruz developed a new capping strategy to stabilize perovskite nanocrystals, overcoming instability issues with organometal-halide materials. The approach uses unique branched ligands to control particle size and improve photoluminescence quantum yield.
Researchers developed DNA-based tension sensors to study T cell interactions. They found that T cells use precise mechanical tugs to test whether a cell is a friend or foe, with stronger tugs indicating a foreign invader. This discovery could aid in the development of immune therapies for cancer and treatments for autoimmune diseases.
Researchers have identified 11 molecules capable of binding to the PSMA biomarker, making them potential treatments for prostate cancer. These ligands are suitable for synthesizing and have good pharmacokinetic parameters, increasing their effectiveness in clinical trials.