Articles tagged with Ligands
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from Gwangju Institute of Science and Technology have developed a method to eliminate residual organic metal-binding ligands from transition metal oxide thin films, resulting in improved device stability and performance. The technique achieved a 20-fold enhancement in electrical conductivity and a 17.6% increase in efficiency.
A Japanese team has introduced a molecular cage with 'caps' that can confine certain rare-earth-metal ions, including lanthanum and europium, for isolation or recycling. The critical feature of the cage is its two 'caps' that cover the openings and bind to the ions through hydrogen bridges and electrostatic interactions.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
Researchers at IBS and Xiamen University reported the synthesis of Cd14Se13 cluster, the smallest nanocluster synthesized as of today. The cluster has a core-cage arrangement with an adamantane-like CdSe structure, enabling the growth of nanocrystals with unusual structures.
Researchers from Tokyo University of Science create new method for producing heterolayer coordination nanosheets with improved properties and controllability. The study expands the diversity of 2D materials, enabling potential applications in optoelectronics and renewable energy.
A team of scientists from the University of Bristol has identified a host cell pathway hijacked by SARS-CoV-2, allowing it to penetrate human cells. The study found that removing a protein complex called ESCPE-1 blocks COVID-19 infection by around 50%.
A research team from Tokyo University of Science has developed a new method to create copolymers with different metal species, which have potential uses in catalysis and drug discovery. The technique allows for controlling the composition of metal species in the resulting polymer.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
A study found that high fat diets and synthetic substances in unregulated athletic performance enhancers can activate a receptor accelerating the progression of pre-cancerous lesions to pancreatic cancer in mice. Limiting exposure to these substances may help prevent pancreatic cancer development.
Researchers have developed a new ligand that promotes a direct nickel-photocatalyzed cross-coupling reaction. This novel tridentate pyridinophane ligand enables the discovery of key reaction steps and intermediate species in the catalytic cycle.
Scientists at UC San Diego develop a method to bind unstable diphosphorus to a single metal ion, creating a relatively stable and selectively reactive form. This breakthrough could enable the development of selective phosphorus-atom transfer reactions and open up new areas of discovery in synthetic chemistry.
A new virtual ligand-assisted screening method enables efficient searching of ligands for optimal catalysis, accelerating reaction design. By simplifying ligand description with two metrics, researchers identify promising ligands and focus on real testing.
Scientists develop a new framework for creating versatile quantum devices by fine-tuning molecular qubits. This breakthrough enables tailored quantum systems with improved control over spin and photon properties.
Researchers at Tokyo University of Science have discovered a method to improve the crystallinity of coordination nanosheets by mixing two metal ion solutions. This approach results in higher crystallinity and improved performance in devices such as electronics and batteries. The findings open a new pathway for tuning the functional pro...
Researchers developed an injectable, adhesive surgical gel that prevents postoperative adhesions and improves wound healing. The gel, dubbed HAD, was tested in rats and rabbits with promising results, showing a significant reduction in inflammation and mortality rates.
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
Research identifies way of using nanoparticles to target and disrupt bacterial cells, making them more susceptible to standard antibiotic treatments. Laboratory studies show a strong effect in killing a range of bacteria, including some linked to hospital-acquired infections.
Researchers aim to make drug purification more efficient and scalable by understanding unwanted element interactions. They explored ligand-surface interactions using NMR spectroscopy and simulations.
Researchers at IOCB Prague have created a glowing DNA enzyme called Supernova, which catalyzes a chemiluminescent reaction. This breakthrough uses artificial evolution to identify light-producing deoxyribozymes in a vast library of DNA molecules, opening up new possibilities for point-of-care assays and high-throughput screens.
Researchers developed a predictive tool using %V bur (min) to categorize phosphine structures as active or inactive in many experimental datasets. This advancement will facilitate organometallic chemistry and catalysis, enabling easier computation and prediction of phosphine reactivity.
Researchers reveal stable phosphatidylglycerol-DNA complex formation with strong van der Waals and hydrophobic interactions. The complex's structural parameters are determined, providing insight into the differences between DNA-phospholipid interaction and fatty acid binding.
Researchers discovered that cytokine APRIL protects against atherosclerosis by binding to proteoglycans in arteries, reducing plaque formation. High levels of non-canonical APRIL (nc-APRIL) in human blood predict risk of cardiovascular death.
Researchers have determined the structure of human leukotriene B4 receptor 1 (hBLT1), a protein involved in inflammation and disease. The analysis reveals how the receptor recognizes its binding partners and interacts with them, opening up avenues for designing better drugs.
A team of researchers at Tokyo University of Science has developed a stable and highly active photocatalyst from gold nanoclusters. By removing the protective molecules around the nanoclusters, they were able to increase their catalytic activity and stability, opening up new possibilities for hydrogen generation and other applications.
Scientists have created the first chromium complex that emits light in the longer wavelength NIR-II range, a significant breakthrough for biomedical imaging. This achievement is expected to lead to cheaper alternatives for luminescence-based applications.
Researchers developed a new imaging technique to study ligand interactions with nanoparticles, discovering that varying ligand concentration can control particle shape. This approach could lead to the creation of chemical sensors and methods for removing micropollutants from the environment.
Researchers at Cornell University have developed a method to control the shape of nanoparticles using small molecule adsorption. By varying the concentration of an individual ligand, they can change the particle's shape, opening up new possibilities for applications such as removing micropollutants from the environment.
Researchers from Oak Ridge National Laboratory used Stampede2 to refine the screening of potential drug molecules targeting COVID-19's spike protein. The method, developed by Stephan Irle and Van Quan Vuong, uses quantum mechanics-based ranking refinement and binding analysis to identify top candidates for further testing.
Researchers found that LSL60101 improved cognitive deficit and biomarkers related to Alzheimer's disease in animal models. The compound acts on I2 imidazoline receptors, which are altered in neurodegenerative diseases like Alzheimer's.
Chemists at Scripps Research have developed a new method for adding hydroxyl groups to organic molecules using a shape-shifting catalyst. The breakthrough eases the process of modifying existing molecules for valuable applications such as improving drug potency and duration. The new method has been demonstrated on various existing drug...
A study published in the Proceedings of the National Academy of Sciences has identified a synergy between ICOS ligand and interleukin-10 that promotes mutualism with the gut microbiota. The research found that mice deficient in ICOSL had increased frequencies of IL-10-producing CD4+ T cells, which were crucial for preventing severe inf...
Researchers at RUDN University found that fluorine-containing compounds can simplify the purification of catalysts from reaction products, making them reusable. This technology could improve ruthenium-based catalysts for pharmaceutical and industrial applications.
UT Southwestern researchers have identified the structure of nicotinic acetylcholine receptor a7 in three different shapes. This breakthrough could lead to new pharmaceutical treatments for schizophrenia, lung cancer, and COVID-19.
Researchers propose a new strategy to obtain size-controlled Eu3+-complex nanoparticles with self-assembly induced luminescence characteristics. The amphiphilic Eu3+-complex possessing carbazole derivative ligands can self-assemble into Eu-NPs with excellent water dispersibility and controllable particle size in aqueous solution.
Research reveals molybdenum-nitrogen complexes as effective catalysts for disproportionation of cyclohexadienes, with the Mo-N=N unit playing a key role in the reaction. High catalytic activity suggests new approaches to participate in catalytic systems for nitrogen ligands.
A new pillar[5]arene-based hybrid material has been fabricated with enhanced emission in both solid state and solution phases. The material exhibits stimuli-responsive luminescent properties, including tunable multicolor luminescence and ion sensing ability.
The molecules generated at the University of Bonn have a trapezoidal arrangement of bonding partners around the silicon atom, which is energetically unfavorable. Despite this, they are found to be extremely stable and can be stored for weeks without degradation.
Researchers engineered β-Ni(OH)2 catalysts with different alkoxyl ligands, achieving high-efficiency oxygen evolution reactions. The ethoxyl-substituted β-Ni(OH)2 shows great potential as an efficient OER catalyst.
Research suggests that impaired tryptophan metabolism may contribute to celiac disease inflammation. A high-tryptophan diet and specific bacteria or drugs can alleviate symptoms in mice with the disease.
Chemists from the Center for Multidimensional Carbon Materials discovered how oxygen affects the synthesis of a novel MOF; copper 1,3,5-triamino-2,4,6-benznetriol metal-organic framework. Oxygen prevents ligands from reducing Cu ions to Cu metal, facilitating MOF synthesis.
Researchers have found a way to directly couple aryl halides and alkyllithium compounds using palladium catalysts containing YPhos-type ligands. This breakthrough enables the efficient synthesis of complex chemical structures with minimal side products, reducing costs and environmental impact.
Researchers have developed a new cerium(III) complex that achieves 100% EUE in OLEDs, leading to improved device stability and efficiency. The device shows a maximum external quantum efficiency of 20.8%, smaller roll-off, higher maximum luminance, and longer operating lifetime compared to traditional iridium-based OLEDs.
Researchers have developed a novel cerium(III) complex that enables the creation of high-efficiency, deep-blue organic light-emitting diodes. The complex exhibits a high photoluminescence quantum yield and leads to an external quantum efficiency of up to 14% in prototype OLEDs.
Researchers at Eindhoven University of Technology prove the Velcro method enhances selectivity in drug particle binding based on receptor number and strength. This allows precise targeting of diseased cells while distinguishing them from healthy ones.
Researchers from Kazan Federal University developed a program to predict DSC curves from known binding constants and concentrations. This approach allows for the accurate measurement of high and weak binding constants, as well as stoichiometry of complexes, using albumin as a model protein.
Researchers at GIST designed new chiral ligands to generate useful compounds in a single step, achieving high enantioselectivity and efficiency. The novel catalytic reaction paves the way for synthesizing novel drugs and natural products with numerous bioactivities.
The researchers developed new synthesis methods for polyheterocyclic compounds containing triazolo and tetrazolo moieties. These compounds were found to act as inhibitors for the Tankyrase I enzyme, showing potential in cancer treatment
Researchers discovered how viruses exploit lipid rafts in the cell membrane to trick receptors into binding, allowing the virus to enter the cell. The study may suggest new strategies for preventing or combating diseases like SARS and Covid-19 by understanding the interactions between viruses and host cells.
Researchers engineered a single messenger protein to induce cellular responses targeting two distinct conditions: neuronal regeneration and lung tumor inhibition. The study demonstrates the potential of bioengineering ligands to treat neurodegenerative disease and cancer.
Researchers have discovered heteroligand complexes of copper with malonic or adipic acid dihydrazides and L-histidine, showcasing trans-influence. The study suggests that these complexes can serve as models for biological systems and potentially be used to enhance the biologically active properties of organic substances.
A new family of molecules with high affinity to join imidazoline I2 receptors has been discovered, improving cognitive skills and biomarkers in murine models. The study presents a novel structure-activity relation for these receptors.
Biophysicists analyzed the mechanical stability of a protein-ligand complex, finding that geometry affects stability and forces required to extract ligand vary by barrel structure. This discovery may improve experimental data analysis and understanding of mechanosensitive proteins.
Researchers have developed highly selective ligands to label opioid receptors, shedding light on their behavior in living cells. The study reveals that most opioid receptors exist as individual entities, but a small proportion forms pairs, which may contribute to the receptor's function.
Researchers created surface-clean noble metal aerogels with controlled ligand chemistry, revealing a new dimension for enhancing electrocatalysis performance. The intrinsic electrocatalytic properties of these clean gels were unveiled and found to be positively correlated with the oxidation state of metals.
A Clemson University team created a double-helical metal-organic framework with unique S-shaped charge transport pathways, enabling it to conduct electricity. The material shows promise as a next-generation semiconductor due to its energy efficiency and temperature tolerance.
Researchers have discovered a novel approach to selectively target and kill several types of cancer cells using nanoparticles that assemble into crystals. The crystals induce lysosomal swelling, loss of membrane integrity, and cell death in cancer cells but do not harm non-cancerous cells.
Researchers found that Earth's oceans already contain just the right amount of iron, making it unlikely to improve carbon dioxide absorption. Phytoplankton growth is more dependent on organic compounds called ligands, which regulate iron availability.
The study reveals that ligand distribution and angles influence the formation of 1D-CS, affecting electronic structure and conductivity. The findings provide guidelines for creating 1D-CS with desired connecting structures.