Articles tagged with Molecular Chemistry
A UNIGE team has developed a rapid and efficient method for identifying proteins molecule by molecule using nanopore technology and AI. The researchers used artificial intelligence to interpret the electrical signals produced by the nanopore, breaking them down into measurable characteristics that can be associated with specific proteins.
Researchers found that ROS-producing enzymes coordinate cell proliferation, tissue integrity, and differentiation in plants. The study used a liverwort model to examine the role of RBOHs in plant development, revealing their importance in maintaining normal cell shape and tissue organization.
Mayo Clinic researchers have discovered the molecular structure of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. The findings provide a promising target for developing more precise therapies for these conditions, including breast cancer and Alzheimer's disease.
Researchers at The University of Hong Kong have developed a way to design polymers with precise molecular structures, allowing them to control material properties such as stiffness, strength, and elasticity. By introducing copper ions, the team can dynamically alter the rigidity of these materials.
Professor Tony James has been awarded Honorary Fellow of the Chinese Chemical Society in recognition of his significant contributions to fluorescence chemical sensing, molecular identification, and diagnostic chemistry. He is a renowned expert in supramolecular chemistry and chemical sensing with broad international influence.
By adding weak cross-linkers to polystyrene and a type of rubber used in shoe soles, MIT chemists have improved the ballistic impact resistance of these materials. The researchers found that these weak bonds selectively break at the site of impact, allowing the material to dissipate energy more effectively.
Scientists create a moiré metasurface to map right- and left-handed regions in materials, visualizing chirality as two-dimensional images. The new approach resolves chirality distributions with a resolution of approximately 100 μm.
Researchers developed a single-molecule platform to monitor asymmetric evolution in Diels-Alder reactions, revealing the molecular origin of reaction chirality. They proposed an excess-compensation mechanism for chiral amplification and achieved precise control over stereoselectivity and regioselectivity.
Researchers from OIST have reported the first full structural characterization of a doubly ring-slipped reaction intermediate in metallocene formation. This discovery provides new evidence on how metallocenes form and react, presenting opportunities for designing tunable structures for applications such as drug delivery systems, cataly...
Researchers at Kyoto University developed a porous polymer gel that selectively recognizes specific molecules through coordination chemistry, triggering visible color change and deformation. The gel's mechanical properties also strengthened upon recognition of guest molecules.
Researchers have developed a new synthesis method that enables precise control over chemical reactions at previously inaccessible sites on molecules. This breakthrough enables targeted modifications to carbon-hydrogen bonds, playing a key role in developing new drugs, functional materials, and more efficient chemical processes.
Complex systems exhibit emergent properties due to water's unique polarity, enabling DNA to store information and proteins to adopt specific structures. This order forms the basis for complex molecules to develop unpredictable properties, driving the evolution of life.
The partnership aims to generate evidence on the potential of MitoQ to slow or improve markers of biological ageing and support longevity. Mitochondria-targeted antioxidants like MitoQ are crucial in producing energy while reducing oxidative stress, a key contributor to ageing.
Researchers fine-tune a new type of glass made from metal-organic frameworks (MOFs) that efficiently trap gases like CO2 and hydrogen. The discovery provides a new design framework for making customized MOF glasses with tailored properties, enabling applications in gas separation, chemical storage, and advanced coatings.
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
Researchers identify previously unknown 'in-between' materials that can be used to design better solar fuels, batteries, and catalysis materials. The study reveals a series of hidden intermediate stages during heating, opening up new opportunities for material discovery and development.
Researchers develop substrate design strategy to selectively promote benzidine-type sigmatropic rearrangement of nitroarenes, enabling efficient synthesis of polyfunctionalized biaryls. The method achieves high yields without expensive transition-metal catalysts or complex prefunctionalization.
Researchers have developed a new methodology for selective molecular transformations of polycyclic aromatic hydrocarbons (PAHs), targeting the challenging L-region. This enables the creation of larger PAH structures and new nanographenes, increasing versatility in technological applications.
Researchers create molecular crystal with reversible color changes spanning from green to orange-red upon mechanical stress or pressure. The material exhibits adaptive intermolecular interactions and structural flexibility, enabling stimulus-responsive luminescence.
A team of chemists has found a simple way to attach the highly sought-after dichloromethyl group onto complex compounds using proline. This method enables the precise assembly of molecules with unparalleled purity and selectivity, simplifying the synthesis of complex drug compounds.
Researchers at Insilico Medicine have developed novel small molecular inhibitors and extremely selective PROTACs targeting the serine/threonine kinase PKMYT1. The discovery utilizes noncovalent interactions to achieve selectivity, masking hydrogen-bond donors that negatively affect permeability and solubility.
ISM6200 is a potent, potentially best-in-class preclinical candidate targeting NR3C1 for the treatment of ovarian cancer, Hypercortisolism (Cushing’s Syndrome), and other disorders related to excess cortisol. The molecule demonstrates low DDI risks and higher in vivo efficacy across multiple animal models.
Researchers created a new type of microporous aerogel that overcomes limitations of conventional materials, enabling flexible and highly processable shapes. The material's flexibility arises from reversible van der Waals interactions between metal–organic polyhedra molecules.
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
A new commentary suggests that P3 peptide, a 'neglected cousin' of amyloid beta, may be a potential contributor to neurodegeneration and play a role in Alzheimer's disease progression. Research has shown that P3 can form amyloid deposits and interact with Aβ, potentially leading to increased toxicity and disease progression.
Researchers develop a multifunctional hydrogel system with broadband electromagnetic interference shielding and infrared stealth performance, exceeding that of commercial-grade materials under various harsh conditions. The gel's mechanical robustness and environmental stability are enhanced by a synergistic MXene treatment strategy.
Researchers at Flinders University have developed a new method to remove toxic PFAS chemicals from water using nano-sized molecular cages. The study successfully captures short-chain variants of the pollutants, which are notoriously difficult to isolate.
Researchers at Goethe University used X-ray radiation to determine the spatial structure of formic acid, finding that its atoms oscillate slightly back and forth. This 'quantum trembling' causes the molecule to lose its symmetry and become effectively three-dimensional at almost every moment.
The B-STING silica nanocomposite acts as a nanofactory of reactive oxygen species, activating itself in response to changes in the chemical environment. This material can be used to create biocidal coatings that are safe, durable, and resistant to dirt, with potential applications in medicine and other industries.
A team of researchers studied the effect of antisolvent addition rate and initial solute concentration on localized liquid-liquid phase separation in a ternary water/ethanol/butylparaben system. Their findings show that high antisolvent addition rates and high initial solute concentrations enhance the likelihood of LLPS, highlighting t...
Researchers discovered that a significant drop in calcium levels in the ocean led to a massive decrease in carbon dioxide, driving global cooling and ending the planet's greenhouse era. The study suggests that changes in seawater chemistry played a key role in shaping climate history.
Scientists at Northwestern University have determined the three-dimensional structures of rye pollen's cancer-fighting molecules, secalosides A and B. This breakthrough opens the door to exploring how these molecules interact with the immune system and could inspire new approaches to cancer therapy.
A new Junior Research Group at the University of Oldenburg aims to create fully biodegradable plastics from organic waste. The team will investigate various processes, including fermentation and downstreaming, to produce polybutylene succinate (PBS) based on polybutylene succinate.
The Nanalysis Edition of KnowItAll combines Wiley's analytical software platform with Nanalysis' specialized NMR database, streamlining spectral interpretation workflows for users. The tailored solution provides immediate access to reference spectra optimized for benchtop NMR instruments, expanding compound identification coverage.
Scientists have synthesised a new class of materials called state-independent electrolytes that allow negatively charged ions to move freely in solid and liquid states. This discovery opens possibilities for safer, lightweight solid-state devices with potential applications in batteries, sensors, and electrochromic devices.
A University of Houston chemist has received a nearly $2M grant to develop molecular blueprints for controlling how molecules change shape and reactivity upon absorbing light. This research could lead to breakthroughs in storing and using chemical energy, as well as designing materials that change when exposed to light.
Scientists have discovered a shape-shifting molecular valve in PANX1, a cellular gate that controls the flow of chemical messages. Researchers found that a common antimalarial drug can enhance or inhibit this gate's activity, paving the way for precision therapies.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers at Hokkaido University developed an environmentally friendly method to synthesize organosodium reagents using ball-milling mechanochemistry. This approach replaces traditional methods using highly reactive and toxic materials, offering a sustainable alternative in organic synthesis.
Extracellular vesicles can mediate communication between cells and tissues, influencing processes like immune signaling and cancer progression. Researchers have developed a practical, scalable EV-isolation platform that operates without preprocessing steps or specialized equipment.
Researchers have developed a new approach to overcome limitations in single-atom catalysts by creating one-dimensional organic polymers capable of selectively binding metal atoms. The platform marks a major advance in single atom catalysis, enabling stronger gas binding compared to other structures.
Researchers at Duke University traced PFAS contamination to a local textile manufacturing plant in Burlington, NC. The facility was releasing solid nanoparticle PFAS precursors into the sewer system, which were then transformed into regulated forms of PFAS that current tests can detect.
Researchers used quantum mechanical simulations to study the interaction of light with ice, revealing new insights into its chemical properties. The findings have implications for understanding the release of greenhouse gases from thawing permafrost and improving predictions of climate change.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
A South Korean research team has discovered a molecular-level mechanism to switch the charge polarity of organic polymer semiconductors by adjusting the concentration of a single dopant. This enables polymers to exhibit both p-type and n-type characteristics, eliminating the need for separate materials or complex device architectures.
Scientists at the University of Groningen have developed a polymer that changes its shape with temperature and can break down into smaller molecules. The innovative material, inspired by the Shanghai Tower's unique design, has potential applications in biomaterials and may be recyclable into its chemical building blocks.
Researchers developed voltage-matrix nanopore profiling to accurately classify proteins in complex mixtures based on their electrical signatures. The method reveals molecular individuality and compositional differences without labeling or modifications, holding promise for disease diagnosis and real-world bioanalytical applications.
Researchers found that methane, ethane, and hydrogen cyanide can interact in ways previously thought impossible, expanding our understanding of chemistry before life emerged. This discovery has implications for the origin of life on Earth and may shed light on similar conditions in other cold environments in space.
A team of researchers at the University of Malaga develops a new family of fluorescent molecules that glow brighter in water, allowing for precise imaging of cells without damaging them. This breakthrough enables clearer images of cellular processes and improves early disease detection.
Researchers have developed an efficient way to synthesize valuable compounds using alcohol dehydrogenase enzymes. The enzymes catalyze the formation of amides and thioesters from alcohols and amines or thiols, offering a clean alternative to traditional methods.
KnowItAll users can now incorporate low-field NMR data analysis into their workflows, while Nanalysis users can integrate KnowItAll's complete suite of NMR analysis tools. The software's NMR database collection contains over 1.28 million spectra for database searching.
Researchers at ISTA have discovered a way to tune singlet oxygen, a highly reactive ROS that causes cell damage and degrades batteries. By controlling the pH inside mitochondria, they can produce more 'good' triplet oxygen and reduce the production of 'bad' singlet oxygen.
A study by University at Buffalo researchers reveals that some elements' semicore electrons can participate in bonding under just a few gigapascals of pressure, far lower than previously thought. This finding challenges traditional notions of core electron behavior and may have implications for our understanding of planetary evolution.
A team of researchers developed a simulation model to clarify the influence of 4-position substitution in cyclic ketene acetals on radical ring-opening polymerization. The study found that certain monomers can produce degradable polymers, which may be used for environmentally friendly packaging and biomedical applications.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
Researchers developed a new origami-inspired folding strategy for reversible actuation of hydrogel pores, integrating facet-driven folding into polygonal pores to enable programmable and predictable actuation. This strategy retained 90% of its original shape after repeated swelling-shrinking cycles, demonstrating excellent reliability.
Researchers at The University of Osaka have discovered a new type of chiral symmetry breaking involving a solid-state structural transition from achiral to chiral crystal. This phenomenon activates circularly polarized luminescence, enabling the development of novel optical materials with tunable light properties.
Scientists at La Trobe University have developed a powerful new material that can conduct electricity as well as metals, making it ideal for wearable technologies like medical devices. The new technique uses hyaluronic acid to create a thin, durable film that is flexible and scalable.
Researchers developed molecular capsules that can impart strong chiral properties to inherently non-chiral metal-containing dyes. The capsules create flexible, adaptable chiral cavities that induce chirality without requiring chemical modifications.
Researchers at the University of Basel have developed an engineered enzyme to precisely build complex molecules, such as pharmaceuticals and fine chemicals. The new approach uses metal hydride hydrogen atom transfer (MHAT) chemistry with enzymatic catalysis to produce three-dimensional molecules with single-handed configuration.