Articles tagged with Molecular Chemistry
A team of chemists has found a simple way to attach the highly sought-after dichloromethyl group onto complex compounds using proline. This method enables the precise assembly of molecules with unparalleled purity and selectivity, simplifying the synthesis of complex drug compounds.
Researchers at Insilico Medicine have developed novel small molecular inhibitors and extremely selective PROTACs targeting the serine/threonine kinase PKMYT1. The discovery utilizes noncovalent interactions to achieve selectivity, masking hydrogen-bond donors that negatively affect permeability and solubility.
ISM6200 is a potent, potentially best-in-class preclinical candidate targeting NR3C1 for the treatment of ovarian cancer, Hypercortisolism (Cushing’s Syndrome), and other disorders related to excess cortisol. The molecule demonstrates low DDI risks and higher in vivo efficacy across multiple animal models.
Researchers created a new type of microporous aerogel that overcomes limitations of conventional materials, enabling flexible and highly processable shapes. The material's flexibility arises from reversible van der Waals interactions between metal–organic polyhedra molecules.
Researchers redesigned a key component of lipid nanoparticles to steer particles toward lymph nodes, reducing off-target delivery. This advancement could make mRNA vaccines more efficient, potentially achieving strong immune protection at lower doses.
A new commentary suggests that P3 peptide, a 'neglected cousin' of amyloid beta, may be a potential contributor to neurodegeneration and play a role in Alzheimer's disease progression. Research has shown that P3 can form amyloid deposits and interact with Aβ, potentially leading to increased toxicity and disease progression.
Researchers develop a multifunctional hydrogel system with broadband electromagnetic interference shielding and infrared stealth performance, exceeding that of commercial-grade materials under various harsh conditions. The gel's mechanical robustness and environmental stability are enhanced by a synergistic MXene treatment strategy.
Researchers at Flinders University have developed a new method to remove toxic PFAS chemicals from water using nano-sized molecular cages. The study successfully captures short-chain variants of the pollutants, which are notoriously difficult to isolate.
Researchers at Goethe University used X-ray radiation to determine the spatial structure of formic acid, finding that its atoms oscillate slightly back and forth. This 'quantum trembling' causes the molecule to lose its symmetry and become effectively three-dimensional at almost every moment.
The B-STING silica nanocomposite acts as a nanofactory of reactive oxygen species, activating itself in response to changes in the chemical environment. This material can be used to create biocidal coatings that are safe, durable, and resistant to dirt, with potential applications in medicine and other industries.
A team of researchers studied the effect of antisolvent addition rate and initial solute concentration on localized liquid-liquid phase separation in a ternary water/ethanol/butylparaben system. Their findings show that high antisolvent addition rates and high initial solute concentrations enhance the likelihood of LLPS, highlighting t...
Scientists at Northwestern University have determined the three-dimensional structures of rye pollen's cancer-fighting molecules, secalosides A and B. This breakthrough opens the door to exploring how these molecules interact with the immune system and could inspire new approaches to cancer therapy.
Researchers discovered that a significant drop in calcium levels in the ocean led to a massive decrease in carbon dioxide, driving global cooling and ending the planet's greenhouse era. The study suggests that changes in seawater chemistry played a key role in shaping climate history.
A new Junior Research Group at the University of Oldenburg aims to create fully biodegradable plastics from organic waste. The team will investigate various processes, including fermentation and downstreaming, to produce polybutylene succinate (PBS) based on polybutylene succinate.
The Nanalysis Edition of KnowItAll combines Wiley's analytical software platform with Nanalysis' specialized NMR database, streamlining spectral interpretation workflows for users. The tailored solution provides immediate access to reference spectra optimized for benchtop NMR instruments, expanding compound identification coverage.
Scientists have synthesised a new class of materials called state-independent electrolytes that allow negatively charged ions to move freely in solid and liquid states. This discovery opens possibilities for safer, lightweight solid-state devices with potential applications in batteries, sensors, and electrochromic devices.
A University of Houston chemist has received a nearly $2M grant to develop molecular blueprints for controlling how molecules change shape and reactivity upon absorbing light. This research could lead to breakthroughs in storing and using chemical energy, as well as designing materials that change when exposed to light.
Scientists have discovered a shape-shifting molecular valve in PANX1, a cellular gate that controls the flow of chemical messages. Researchers found that a common antimalarial drug can enhance or inhibit this gate's activity, paving the way for precision therapies.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
Researchers at Hokkaido University developed an environmentally friendly method to synthesize organosodium reagents using ball-milling mechanochemistry. This approach replaces traditional methods using highly reactive and toxic materials, offering a sustainable alternative in organic synthesis.
Extracellular vesicles can mediate communication between cells and tissues, influencing processes like immune signaling and cancer progression. Researchers have developed a practical, scalable EV-isolation platform that operates without preprocessing steps or specialized equipment.
Researchers have developed a new approach to overcome limitations in single-atom catalysts by creating one-dimensional organic polymers capable of selectively binding metal atoms. The platform marks a major advance in single atom catalysis, enabling stronger gas binding compared to other structures.
Researchers at Duke University traced PFAS contamination to a local textile manufacturing plant in Burlington, NC. The facility was releasing solid nanoparticle PFAS precursors into the sewer system, which were then transformed into regulated forms of PFAS that current tests can detect.
Researchers used quantum mechanical simulations to study the interaction of light with ice, revealing new insights into its chemical properties. The findings have implications for understanding the release of greenhouse gases from thawing permafrost and improving predictions of climate change.
A new type of DNA damage, glutathionylated DNA adducts, accumulates at high levels in mitochondrial DNA, affecting energy production and stress response. The discovery sheds light on how cells sense and respond to stress, with potential implications for diseases like cancer and diabetes.
A South Korean research team has discovered a molecular-level mechanism to switch the charge polarity of organic polymer semiconductors by adjusting the concentration of a single dopant. This enables polymers to exhibit both p-type and n-type characteristics, eliminating the need for separate materials or complex device architectures.
Scientists at the University of Groningen have developed a polymer that changes its shape with temperature and can break down into smaller molecules. The innovative material, inspired by the Shanghai Tower's unique design, has potential applications in biomaterials and may be recyclable into its chemical building blocks.
Researchers developed voltage-matrix nanopore profiling to accurately classify proteins in complex mixtures based on their electrical signatures. The method reveals molecular individuality and compositional differences without labeling or modifications, holding promise for disease diagnosis and real-world bioanalytical applications.
Researchers found that methane, ethane, and hydrogen cyanide can interact in ways previously thought impossible, expanding our understanding of chemistry before life emerged. This discovery has implications for the origin of life on Earth and may shed light on similar conditions in other cold environments in space.
A team of researchers at the University of Malaga develops a new family of fluorescent molecules that glow brighter in water, allowing for precise imaging of cells without damaging them. This breakthrough enables clearer images of cellular processes and improves early disease detection.
Researchers have developed an efficient way to synthesize valuable compounds using alcohol dehydrogenase enzymes. The enzymes catalyze the formation of amides and thioesters from alcohols and amines or thiols, offering a clean alternative to traditional methods.
KnowItAll users can now incorporate low-field NMR data analysis into their workflows, while Nanalysis users can integrate KnowItAll's complete suite of NMR analysis tools. The software's NMR database collection contains over 1.28 million spectra for database searching.
Researchers at ISTA have discovered a way to tune singlet oxygen, a highly reactive ROS that causes cell damage and degrades batteries. By controlling the pH inside mitochondria, they can produce more 'good' triplet oxygen and reduce the production of 'bad' singlet oxygen.
A study by University at Buffalo researchers reveals that some elements' semicore electrons can participate in bonding under just a few gigapascals of pressure, far lower than previously thought. This finding challenges traditional notions of core electron behavior and may have implications for our understanding of planetary evolution.
A team of researchers developed a simulation model to clarify the influence of 4-position substitution in cyclic ketene acetals on radical ring-opening polymerization. The study found that certain monomers can produce degradable polymers, which may be used for environmentally friendly packaging and biomedical applications.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
Researchers developed a new origami-inspired folding strategy for reversible actuation of hydrogel pores, integrating facet-driven folding into polygonal pores to enable programmable and predictable actuation. This strategy retained 90% of its original shape after repeated swelling-shrinking cycles, demonstrating excellent reliability.
Researchers at The University of Osaka have discovered a new type of chiral symmetry breaking involving a solid-state structural transition from achiral to chiral crystal. This phenomenon activates circularly polarized luminescence, enabling the development of novel optical materials with tunable light properties.
Scientists at La Trobe University have developed a powerful new material that can conduct electricity as well as metals, making it ideal for wearable technologies like medical devices. The new technique uses hyaluronic acid to create a thin, durable film that is flexible and scalable.
Researchers developed molecular capsules that can impart strong chiral properties to inherently non-chiral metal-containing dyes. The capsules create flexible, adaptable chiral cavities that induce chirality without requiring chemical modifications.
Researchers at the University of Basel have developed an engineered enzyme to precisely build complex molecules, such as pharmaceuticals and fine chemicals. The new approach uses metal hydride hydrogen atom transfer (MHAT) chemistry with enzymatic catalysis to produce three-dimensional molecules with single-handed configuration.
Researchers develop efficient template-guided method for synthesizing endo-functionalized oligophenylene cages with yields up to 68%. The approach enables precise control over internal environments, leading to selective molecular encapsulation and recognition capabilities.
Researchers from UNIGE and the University of Pisa have developed a new family of remarkably stable chiral molecules, paving the way for new drug constructs. The stability of these molecules is crucial to drug design and storage.
Researchers emphasize the need to distinguish between harmful PFAS and essential fluoropolymers used in medical devices, which have not been linked to health issues. Experts advocate for a balanced approach to protect both human health and environmental concerns.
Researchers at Pusan National University have created novel materials called disulfide-based covalent adaptable networks (DS-CAN) that can change, fix, and retain their shape reversibly using magnetic fields and ultraviolet light. These materials enable UV- or heat-assisted shape fixation after deformation, which is also reversible.
UVA engineer Nick Vecchiarello is using a $600,000 grant to develop customized molecularly engineered surfaces for purifying protein-based drugs. The technology has the potential to reduce waste and failed batches, saving manufacturers millions of dollars while making treatments more affordable.
Researchers have observed the luminescence of an excited complex formed by two donor molecules, opening possibilities for developing simpler, more efficient OLED devices. The discovery also enables the creation of sensitive sensors capable of detecting low concentrations of explosive substances.
Researchers at OIST have synthesized a stable 20-electron ferrocene derivative, defying the traditional 18-electron rule. This breakthrough could lead to new applications in energy storage, chemical manufacturing, and sustainable chemistry.
A new study by Colorado State University outlines a path to creating advanced, recyclable plastics using natural poly(3-hydroxybutyrate) (P3HB). The breakthrough method involves stereodivergent catalysis, which enables the production of enantiopure PHAs with improved properties for various applications.
Researchers have engineered a new type of molecule that can store information at extremely low temperatures, potentially leading to ultra-high data densities and smaller storage devices. The discovery could enable the development of stamp-sized hard drives capable of storing 100 times more data than current technologies.
The DFG is establishing 13 new Collaborative Research Centres (CRC) to tackle innovative, challenging and long-term research projects. The CRCs will focus on circadian medicine, metabolic dysfunction-associated steatotic liver disease, heterostructures of molecules and 2D materials, and criticality.
A team of Cambridge chemists has developed a powerful new method for adding single carbon atoms to molecules more easily, offering a simple one-step approach. This technique targets alkenes, common in everyday products, and allows for the introduction of functional groups, enabling further versatility in molecule design.
Scientists have designed human-made molecules that self-assemble into stacked rings, allowing charge and energy to circulate freely, echoing photosynthesis. This breakthrough could lead to improved energy generation and advanced electronics.
Scientists have created a new way to store and decode data using synthetic molecules, which can be used to unlock computers with encoded passwords. The method involves designing molecules that contain electrochemical information, allowing messages to be decoded using electrical signals.
A new study from Uppsala University investigates how sleep deprivation affects biomarkers associated with cardiovascular disease. Researchers found that chronic lack of sleep increases the risk of heart problems by promoting inflammatory proteins.
Rasika Dias, a renowned chemist at UTA, has been named a 2025 fellow of the Royal Society of Chemistry for his groundbreaking contributions to chemical sciences. He is the second chemistry faculty member to receive this honor.
A new approach, GlycoCaging, delivers medicine directly to the lower gut at significantly lower doses than current treatments, potentially helping people with inflammatory bowel disease. The technique has been shown to be effective in mice and has potential for treatment in humans, as most people have the ability to activate the drugs.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
A recent study reveals that tropical forests are home to an incredible diversity of chemical compounds, including terpenoids and alkaloids, which could have practical implications for human health. The researchers found that tree species in higher elevations tend to use similar chemicals to protect themselves from enemies.
A new web platform, AutoSolvateWeb, developed at Emory University enables chemists of all levels to configure and execute complex quantum mechanical simulations through chatting. The free platform uses cloud infrastructure and automates software processes on the backend.