Articles tagged with Molecules
Scientists systematically map the Biginelli reaction to uncover a previously unknown branch that produces complex bicyclic structures and molecules with unusual supramolecular behavior
Researchers developed a flexible metal–organic framework, APF-40, to analyze large pharmaceutical molecules with complex structures. The framework enables the determination of structures from microgram-scale samples, aiding drug discovery and natural products research.
Scientists create new two-step annulative p-extension method for synthesizing structurally diverse nanographenes, including curved and non-planar structures. The research expands the toolbox for chemists to access rare molecular fragments with unique properties.
Researchers designed bacteria that function as transistors, allowing for the creation of living circuit boards that can perform complicated calculations. The transistors can be combined to create a variety of circuits, including those that add two or three inputs or send one input to a specific location.
Researchers at Kaunas University of Technology have developed hybrid compounds that simultaneously reduce cancer cell viability and inhibit bacterial and fungal growth. The compounds showed strong activity against aggressive cancer cells and certain bacteria and fungi, outperforming currently used drugs.
Researchers developed a new molecular editing strategy that relocates the nitrogen atom within the pyridine ring, creating positional isomers. This approach preserves substituents while altering properties such as solubility and interactions with biological targets.
Researchers at KAIST create microscale chiral pinwheel arrays through self-assembly of achiral liquid-crystal molecules, enabling circularly polarized light with a desired rotation direction. This breakthrough simplifies the production of chiral optical materials, paving the way for next-generation displays and optical communications.
Researchers from the University of Waterloo developed a new quantum sensing technique using a molecule as a sensor, enabling precise imaging of single molecules. This technique has potential applications in drug discovery and structural biology.
Researchers at Tohoku University developed a method to restore the mechanical strength of degraded polybutylene terephthalate by repairing molecular chains with a chain extender. The technique recovers plastic tensile strength to nearly that of virgin material, enabling high-performance plastics to be reused instead of discarded.
A new bio-based conductive hydrogel platform is presented to preserve biomembrane activity and enable sensitive detection of organophosphate pesticides. The developed biosensor demonstrated stable operation, retaining 85.8% of its original electrochemical response after seven days.
The study introduces a graph-attention deep learning model, CBPFNet, to predict mechanochemical site selectivity and bond-resolved peak force in complex molecules. This method enables rapid screening of sustainable polymer design and biomaterials, accelerating the targeted engineering of sacrificial-bond networks.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
A University of Houston chemist is uncovering how copper imbalances in neurons contribute to neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. The new imaging technique provides a closer look at individual protein behaviors inside living cells, giving researchers insight into the cellular pathways that fail.
A new study published in Nature links casdatifan, an investigational HIF-2a inhibitor, to improved clinical outcomes in metastatic clear cell renal cell carcinoma (ccRCC) patients. Deep suppression of serum EPO correlated with higher response rates and longer progression-free survival.
Researchers found that ROS-producing enzymes coordinate cell proliferation, tissue integrity, and differentiation in plants. The study used a liverwort model to examine the role of RBOHs in plant development, revealing their importance in maintaining normal cell shape and tissue organization.
Researchers have identified several groups of metabolites involved in embryo implantation, including glucose, lactate, lipid-derived molecules, amino acids, and neurotransmitters. These metabolites help create a local environment that supports embryo invasion into the uterine lining and promotes tissue remodeling and immune tolerance.
A new anti-inflammatory molecule has shown promising results in protecting neurons and delaying disease progression in mice with Parkinson's disease. The study, published in Neuropharmacology, found that the Ac2-26 peptide mitigated neuroinflammation and protected against cell death.
Scientists create a moiré metasurface to map right- and left-handed regions in materials, visualizing chirality as two-dimensional images. The new approach resolves chirality distributions with a resolution of approximately 100 μm.
A new study by the University of Ottawa suggests that a tiny molecule, methylglyoxal, plays a major role in triggering neurological disorders after a heart attack. The molecule accumulates in the brain following a heart attack and is linked to depression, anxiety, and cognitive decline.
Researchers from Nagoya University developed a two-step synthetic method for dihydrodinapthopentalenes, conductive organic molecules with complex synthesis. The new mechanochemical method synthesizes DHDPs in 15 minutes with minimal solvent waste and structural constraints.
Researchers develop substrate design strategy to selectively promote benzidine-type sigmatropic rearrangement of nitroarenes, enabling efficient synthesis of polyfunctionalized biaryls. The method achieves high yields without expensive transition-metal catalysts or complex prefunctionalization.
Researchers have developed a new methodology for selective molecular transformations of polycyclic aromatic hydrocarbons (PAHs), targeting the challenging L-region. This enables the creation of larger PAH structures and new nanographenes, increasing versatility in technological applications.
The North Carolina State University researchers successfully synthesized bacteriochlorophyll a , a photosynthetic pigment found in bacteria which absorbs infrared light. The strategy could be used to synthesize other photosynthetic macrocycles of interest, leading to increased exploration in energy sciences.
A team of chemists has found a simple way to attach the highly sought-after dichloromethyl group onto complex compounds using proline. This method enables the precise assembly of molecules with unparalleled purity and selectivity, simplifying the synthesis of complex drug compounds.
Researchers have discovered that native soil bacteria can degrade persistent pollutants like dioxins without genetic engineering. Using decoy molecules, the bacteria's natural enzymes are tricked into breaking down these toxic compounds.
A team of researchers from Pohang University of Science & Technology has identified the underlying cause of water's unique properties, solving a fundamental mystery in science. They have observed water's liquid-liquid critical point, which marks the transition from two distinct liquid states into a single supercritical liquid state.
Researchers developed a solvent-free method to transform biochar into a hydrophobic material that repels water and absorbs oil. The material, created through mechanochemical functionalization, was applied to hemp fibers, providing strong water repellent properties while allowing oil absorption.
A research team at Kumamoto University identified a plant-derived molecule, PGG, that breaks down transthyretin (TTR) amyloid linked to heart and nerve disorders. The study found PGG effectively disassembled amyloid fibrils without disrupting other types of protein aggregates.
Researchers at Goethe University used X-ray radiation to determine the spatial structure of formic acid, finding that its atoms oscillate slightly back and forth. This 'quantum trembling' causes the molecule to lose its symmetry and become effectively three-dimensional at almost every moment.
Researchers develop a synthetic compound that acts on all three stages of the disease cycle, eliminating parasites from human blood and liver, and preventing transmission to mosquitoes. The molecule has shown effectiveness against P. vivax and P. falciparum species.
Scientists at Northwestern University have determined the three-dimensional structures of rye pollen's cancer-fighting molecules, secalosides A and B. This breakthrough opens the door to exploring how these molecules interact with the immune system and could inspire new approaches to cancer therapy.
Researchers have developed a method called PropMolFlow that can generate molecular candidates roughly 10 times faster than existing methods while maintaining accuracy. The breakthrough could lead to faster creation of pharmaceuticals, materials, and new technologies by specifying properties first and then finding structures.
Researchers have combined molecular imprinting technology with biochar to create materials that can selectively target specific molecules, achieving high adsorption capacity and selectivity. These smart sorbents show promise for efficient pollution control in complex mixtures and at low concentrations.
A University of Houston chemist has received a nearly $2M grant to develop molecular blueprints for controlling how molecules change shape and reactivity upon absorbing light. This research could lead to breakthroughs in storing and using chemical energy, as well as designing materials that change when exposed to light.
A UCO study verifies acorns' high starch content, fatty acid profile similar to olive oil, and nutrient-rich compounds with antioxidant and anti-inflammatory activity. The research identifies diverse microbiomes associated with seeds influencing bitterness levels and paves the way for future domestication programs.
Researchers have developed a chemical compound that degrades beta-amyloid plaques, reducing symptoms of Alzheimer's disease. The compound was tested on rats and showed promising results, including reduced memory loss and improved spatial awareness.
Researchers developed a composite hydrogel that integrates antibacterial, immunomodulatory, and regenerative functions to promote faster wound closure. The hydrogel demonstrated over 98% antibacterial efficacy and improved fibroblast and endothelial cell growth.
Researchers developed a new method to probe an atom's nucleus using its own electrons as messengers within a molecule. They measured the energy of electrons whizzing around a radium atom in a molecule, detecting a slight energy shift and analyzing it to sense the internal structure of the nucleus.
Researchers developed voltage-matrix nanopore profiling to accurately classify proteins in complex mixtures based on their electrical signatures. The method reveals molecular individuality and compositional differences without labeling or modifications, holding promise for disease diagnosis and real-world bioanalytical applications.
Researchers found that methane, ethane, and hydrogen cyanide can interact in ways previously thought impossible, expanding our understanding of chemistry before life emerged. This discovery has implications for the origin of life on Earth and may shed light on similar conditions in other cold environments in space.
Researchers from The University of Osaka develop a groundbreaking synthetic method to incorporate boron-rich carboranes into aromatic compounds, eliminating complex steps and hazardous conditions. This 'dump-and-stir' technique enables large-scale production using inexpensive aryl bromides and chlorides.
Researchers have created a novel strategy using a polycationic long-chain molecule to develop stable and efficient zinc-iodine batteries. This breakthrough addresses challenges including zinc dendrite formation and corrosion, paving the way for next-generation energy storage technologies.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
The global market for AI in pharmaceuticals is projected to reach $13.4 billion by 2035, driven by Insilico Medicine's innovative use of generative AI. The company will share its achievements at a satellite forum during BIOHK2025, showcasing significant efficiency boosts compared to traditional methods.
Researchers at Max Planck Institute successfully couple spatially separated molecules via a modified vacuum field in an optical microresonator. This breakthrough enables the creation of synthetic states of coupled molecules, with potential applications in quantum technology and information processing.
Researchers have found a way to rearrange atoms in a new generation of malaria drugs to make them more soluble, maintaining their effectiveness against drug-resistant parasites. This breakthrough could lead to an effective successor to artemisinin-based combination therapy.
Scientists at UC Riverside successfully measured the electric dipole moment of aluminum monochloride, a crucial diatomic molecule. The precise measurement will aid in quantum technologies, astrophysics, and planetary science.
A team of Cambridge chemists has developed a powerful new method for adding single carbon atoms to molecules more easily, offering a simple one-step approach. This technique targets alkenes, common in everyday products, and allows for the introduction of functional groups, enabling further versatility in molecule design.
The new device, nicknamed ABLE, uses a natural process to condense airborne biomarkers into water droplets, allowing for accurate detection at low concentrations. This technology has immediate applications in hospitals and neonatal units, offering a less invasive alternative to blood draws.
Scientists have designed human-made molecules that self-assemble into stacked rings, allowing charge and energy to circulate freely, echoing photosynthesis. This breakthrough could lead to improved energy generation and advanced electronics.
Researchers at UCSF have successfully engineered a shapeshifting protein that can change shape in response to signals, potentially leading to breakthroughs in medicine, agriculture, and environmental applications. This achievement marks the first step towards creating stable yet dynamic proteins using AI-augmented protein engineering.
Dr Constantine Evans, a Maynooth University researcher, has won the Robert Dirks Molecular Programming Prize for his work on molecular self-assembly and its applications in biological systems. His research continues to make important strides in the scientific community.
A study found that spending on GLP-1 RAs increased from 2018 to 2023, with the largest growth rate between 2022 and 2023. The total spending on these medications exceeded $71 billion.
Researchers at Durham University have successfully demonstrated long-lasting quantum entanglement between molecules, a key capability for next-generation quantum technology. The team achieved exceptionally high entanglement fidelity, reaching levels over 92%, enabling precision measurements in quantum sensing and simulating complex qua...
Researchers reaffirm collective bond theory, demonstrating its stability through computational tools. The LiCF3 molecule's unique arrangement challenges traditional understanding of chemical bonds.
Recent research at Shinshu University explores how molecular structure and geometry influence light emission in aggregation-induced emission molecules. The study reveals that changes in molecular shape affect emission behavior in both solution and solid states, enabling innovations in material design and energy interactions.
Researchers from Bar-Ilan University have uncovered a previously unknown phenomenon that enables precise control over molecular patterns on liquid droplet surfaces. The discovery, which involves a transformation between two types of structural defects, has broad implications for technologies such as vaccine design and nanoengineering.
A new AI method developed by Swedish researchers can identify toxic substances based on their chemical structure, potentially replacing animal testing. The method has been shown to be more accurate and broadly applicable than existing computational tools, offering a promising alternative for environmental research and authorities.
Researchers have identified a novel protein FOXF1 that stabilizes blood vessels inside lung tumors, decreasing intertumoral hypoxia and preventing lung cancer metastases. Increasing levels of FOXF1 or FZD4 shows promise to improve therapeutic outcomes in lung cancer patients.
Chemists develop new reactions using model systems and substrates to demonstrate versatility. A new computer-aided method reduces subjective bias by analyzing real pharmaceutical compounds' complexity and structural properties. This improves data quality and facilitates machine learning applications.