Articles tagged with Organic Reactions
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Kyoto University successfully synthesized the structure of Lancilactone C, a rare anti-HIV compound. The team's method revealed an incorrect initial structure and showed that electrocyclization occurs in both synthesis and biosynthesis, leading to potential development of novel antivirals.
Researchers discovered bimetallic tartrate complexes with unique structures, formed by insufficient ligand, leading to improved sensor characteristics for microbiosensors. The study showcases the potential of laser-induced chemical liquid phase deposition for creating nanostructures with various applications.
A team of researchers from China and the UK has developed new ways to optimise the production of solar fuels by creating novel photocatalysts. These photocatalysts, such as titanium dioxide with boron nitride, can absorb more wavelengths of light and produce more hydrogen compared to traditional methods.
Researchers at Brookhaven Lab used pulse radiolysis to study a key class of water-splitting catalysts, revealing the direct involvement of ligands in the reaction mechanism. The team discovered that a hydride group jumped onto the Cp* ligand, proving its active role in the process.
Researchers at Hokkaido University have developed a simplified Birch reduction method that avoids liquid ammonia and can be carried out in ambient air, making it faster and more eco-friendly. The mechanochemical approach uses a ball mill to break through the surface layer on lithium metal, enabling the Birch reduction to proceed.
Researchers at Hokkaido University have developed a new method using cooperating catalysts to perform challenging dearomative carboxylation reactions. This process enables the production of α-amino acids, which are potentially useful for drug development, and offers greater freedom in designing and synthesizing molecules with carboxyl ...
Researchers from Osaka University have stabilized atomic carbon for common reaction conditions in organic chemistry, enabling the synthesis of complex drugs in one step. This breakthrough simplifies and lowers the cost of pharmaceutical synthesis.
Researchers at MIT have observed a rare resonance in colliding ultracold molecules for the first time, shedding light on the forces that drive molecules to chemically react. The discovery could lead to new ways to steer and control certain chemical reactions using magnetic fields.
Researchers have developed a new method to synthesize functionalized dibenzoazacyclooctynes, expanding the possibilities for strain-promoted azide–alkyne cycloaddition reactions in biomolecular analysis. This work enables precise modification of cellular components without affecting overall cell physiology.
Researchers at Linköping University used computer simulations to show that stable aromatic molecules can become reactive after absorbing light. This could enable new ways to control photochemical reactions using the aromaticity of molecules.
Researchers from Tokyo University of Science create a metal–organic framework-based magnesium ion conductor showing superionic conductivity at room temperature, overcoming the limitations of magnesium ion-based energy devices. The novel Mg2+ electrolyte exhibits a high conductivity of 10−3 S cm−1, making it suitable for battery applica...
A research team from Tokyo University of Science has developed a new method to create copolymers with different metal species, which have potential uses in catalysis and drug discovery. The technique allows for controlling the composition of metal species in the resulting polymer.
Researchers have discovered a novel chemical reaction that allows for the efficient migration of molecular fragments, enabling the production of health-promoting ingredients in food. This groundbreaking discovery has the potential to revolutionize the field of chemistry.
Scientists at the University of Copenhagen have discovered a new class of highly reactive chemical compounds called hydrotrioxides. Formed during atmospheric decomposition of substances like isoprene and dimethyl sulfide, these compounds are stable enough to react with other atmospheric compounds.
Researchers at Waseda University demonstrate a novel zirconocene-catalyzed epoxide ring-opening reaction under visible light, expanding the reaction scope and regioselectivity. The approach enables accessible synthesis of elusive alcohol products with improved efficiency and environmental sustainability.
Researchers at Swiss Federal Laboratories for Materials Science and Technology have discovered a new chemical synthesis method that forms stable benzene rings on a gold surface. This method, called the 'dry' method, avoids toxic byproducts and allows for the observation of molecular reactions in real-time.
Researchers from the University of Münster have successfully performed an unconventional cycloaddition, reacting a carbon-carbon double bond with a strained single bond. This method has significant synthetic benefits, allowing for the creation of polycyclic, three-dimensional carbon scaffolds.
Researchers at Okayama University have developed a novel 'green' synthesis technique for the production of NEt-3IB, a promising small-molecule oral drug candidate for inflammatory bowel disease (IBD). The new method produces large quantities of NEt-3IB with high purity and a total yield of over 30%, using only recoverable organic solve...
Researchers have identified a novel enzyme that catalyzes the formation of glycosidic bonds in complex sugar moieties. The discovery provides fresh insights into carbohydrate metabolism and offers a breakthrough for the synthesis of sugar chains, which play key roles in various biological processes.
Chemists at Scripps Research have found that cyanide can drive metabolic reactions to create carbon-based compounds from carbon dioxide, expanding our understanding of the origins of life on Earth and its potential for existing elsewhere. This discovery opens up new avenues for searching for extraterrestrial life.
Researchers propose a new neural network-based method to visualize chemical reactions in a 2D plane, grouping similar reactions together. The visualization helps chemists understand the global chemical reaction space and identify underused or unused reaction types.
University of Warwick scientists developed a new method to produce indolic amides, carboxylic acids, and auxins using enzymes that mimic plant production. The process is reusable, produces minimal waste products, and could help make pharmaceutical and agrochemical manufacturing more environmentally friendly.
Researchers from Waseda University have developed an alternative technique, sampled current voltammetry (SCV), to accurately determine the activity of electrocatalysts used in water-splitting reactions. The study shows that SCV can provide reliable measurements of electrocatalytic performance at constant steady-state applied voltages.
Osaka University researchers have successfully synthesized a stable, crystalline nanographene with predicted magnetic properties, opening the door to revolutionary advances in electronics and magnets. The breakthrough uses a simplified model system called triangulene, which has long been elusive due to polymerization issues.
KAUST researchers propose a radical new mechanism for polycyclic aromatic hydrocarbon (PAH) formation, which consumes fewer radicals than current hypotheses. The mechanism involves resonance-stabilized radicals, allowing successive addition reactions to occur without activation.
Researchers from Shibaura Institute of Technology synthesized atropisomeric N-aryl quinazoline-4-thiones, showing unprecedented isotopic atropisomerism due to rotational restriction around an N-Ar bond. The findings support the formation of diastereomers and have potential applications in pharmaceuticals.
Researchers at RMIT University have developed a clean and cost-effective way to upcycle used plastic into high-value products such as carbon nanotubes and clean liquid fuel. The two-step process converts organic waste into charcoal, which is then used as a catalyst to upcycle the plastic.
Michigan Tech researchers developed a model to calculate how particular chemicals break down in surface water using singlet oxygen, which degrades contaminants and helps protect our waterways. The study's findings can aid environmental engineers and scientists in estimating half-lives of chemicals and predicting their degradation rates.
Researchers at RUDN University have discovered a new three-component reaction that results in the synthesis of acetimidamides, heterocyclic compounds with biological activity. The reaction reaches an efficiency of up to 96% and can be used for the synthesis of hormones, anti-inflammatory drugs, and other medical substances.
Researchers challenge the notion that organic compounds like amino acids were formed from isotopically enriched substrates in the early solar system. They found that formose-type reactions create differences in carbon isotope concentrations between small and large organic molecules.
Scientists at Tokyo Institute of Technology developed a new strategy for producing organotin compounds by photoexciting stannyl anions. This approach increases selectivity and reactivity, enabling the efficient synthesis of bioactive products, novel drugs, and functional materials.
Chemists have developed a simplified three-step process for synthesizing spirocyclic tetrahydroisoquinolines, a key organic molecule in drug discovery. The new method significantly reduces the time and complexity of existing approaches, enabling more efficient creation of pharmaceutical compounds.
Researchers have developed a new reaction, called ASHA ligation, for efficiently forming amide bonds under mild aqueous conditions. This method is fast, chemoselective, and broadly applicable, opening pathways to new approaches in medicinal chemistry and chemical biology.
Researchers synthesized indolizines with green fluorescence using pyridinium salts and enamiones. The resulting substances have potential applications in medical fields, including cancer treatment and diabetes management.
Researchers at Purdue University have developed a machine learning model that can predict reaction outcomes and test new reactions in a blind prospective manner. The model uses statistical robust machine learning models trained on a small number of reactions to provide interpretable chemical reactivity flowcharts.
Researchers at Hokkaido University have successfully synthesized a non-natural fluorinated amino acid using a novel computer-assisted method. The Artificial Force Induced Reaction (AFIR) method predicts feasible reaction pathways, significantly reducing synthesis time and cost, with yields of up to 99.99%.
Researchers at Nara Institute of Science and Technology developed a new reaction system that detects X-rays at the highest sensitivity ever recorded using organic molecules. The system can detect even the faintest X-ray levels considered dangerous, making it safer for workers exposed to radiation.
Researchers found that nitrogen heterocycles, common in young Earth and solar system, formed similar genetic precursors under varied atmospheric conditions. These modified heterocycles may have served as subunits of peptide nucleic acids (PNAs), a proposed precursor to RNA.
A new software library CGRtools has been developed to improve chemical reaction processing by predicting reaction characteristics, finding optimal conditions, and detecting errors. The library is rich in functionality, supporting molecules and reactions as objects and offering transparent class inheritance.
Scientists have developed a fast and versatile two-in-one synthetic strategy to partition pores in metal-organic frameworks (MOFs), resulting in highly efficient adsorbents. The new pore-space-partitioned MOF shows better gas uptakes than unpartitioned materials, particularly for ammonia uptake with high packing density.
A team of researchers from Kanazawa University has developed a phototriggered modification reaction of a carboxylic acid using an aminocyclopropenone. The resulting ynamine works as a dehydration agent to connect the carboxylic acid and the amine. Under intense light conditions, another isomeric mixture of three ketones was produced.
Researchers at Kanazawa University developed a novel method for hydroboration of alkynes utilizing radical chemistry, resulting in the creation of previously inaccessible trans-hydroboration products. This breakthrough enables the synthesis of various bench-stable alkenyl borane compounds that can be converted into drug candidates.
Researchers have developed a new synthetic route to 1,4-dicarbonyls, a class of molecules found in natural products, drug targets, and pharmaceuticals. By using sulfoxides, a type of oxidized sulfur compound, they can create multiple isomers selectively.
Researchers at University of Innsbruck investigate proton exchange reaction using laser-induced vibration excitation. They find that the laser does not enhance the reaction, but rather amplifies a competing reaction process, highlighting the importance of controlling molecular interactions in chemical reactions.
Researchers at RUDN University synthesized isoquinoline derivatives with potential biological activity, including bactericidal and antileukemic properties. The team developed a new method for isolating the compounds, which may be effective in treating Alzheimer's disease by inhibiting certain enzymes.
Researchers from RUDN University have developed a novel three-component reaction to produce complex heterocyclic compounds with antitumor and anti-Alzheimer's properties. The approach enables the efficient synthesis of these compounds, reducing waste and labor costs, and opens up new possibilities for pharmaceutical applications.
Scientists from RUDN University have synthesized a range of cytotoxic substances with potential anticancer activity. The compounds were obtained through domino reactions, and their cytotoxic effects were confirmed in primary bioscreening.
A new synthetic method has been introduced to obtain novel triazole structures, used in drug production and high-molecule development. The method uses a nickel-catalyzed cycloaddition reaction that proceeds in water and air at room temperature.
Researchers at TSRI unveil a new technique for constructing chiral drug molecules using an α-chiral center, enabling the synthesis of valuable products. The method requires only inexpensive and widely available starting chemicals, mimicking enzymes in cells to create asymmetry.
Researchers have created a safer and more efficient water-based system for synthesizing organic compounds, reducing reliance on volatile organic solvents and improving environmental sustainability. The new process also produces higher yields of product and allows for easy separation and extraction of the final compound.
A team of Korean scientists has developed a new framework for understanding acid-base reactions in organic chemistry. The study revealed that hydrogen-bonded clustering plays a critical role in enhancing the reactivity of alcohols and promoting the formation of an effective Brønsted base.
Matthew Disney, a professor at Scripps Research Institute, has won the Tetrahedron Young Investigator Award for his exceptional creativity and dedication to organic synthesis and bioorganic and medicinal chemistry. The award recognizes his lab's work on tackling difficult problems in biomedical science.
A revolutionary new scientific method developed at the University of Leeds uses 'promiscuous reactions' to improve the diversity of biologically active molecules, such as antibiotics and anti-cancer agents. The approach has successfully identified three biologically active molecules with potential applications in cancer treatment.
Researchers connect 250 years of organic chemical knowledge into a giant computer network, optimizing syntheses of drug molecules and identifying suspicious chemical recipes. The Chematica system learns from experience and can test every possible synthesis, finding truly optimal ways to make desired chemicals.
The Scripps Research Institute has proven the plausibility of a new pathway to life's essential sugars called the glyoxylate scenario, potentially pushing past the formose reaction hurdle. This alternative pathway, led by Ramanarayanan Krishnamurthy, reveals efficient conversion of DHF and glyoxylate to ketoses.
Researchers developed a practical and general method to synthesize organoboron compounds for Suzuki reactions, improving yields and reducing waste. The new approach enables the creation of diverse organic molecules, including novel drugs and materials.
Researchers discovered Robert Burns Woodward's notes on organic superconductors, including original scans of his work, and successfully redrawn compounds using modern techniques. The study sheds light on Woodward's ideas for developing an organic superconductor that operates at room temperature.
Researchers at MIT have developed a new method for attaching phosphorus to organic compounds using ultraviolet light, eliminating the need for hazardous chlorine. The breakthrough could lead to more sustainable production of industrial chemicals and materials.
Deep biosphere microbes may hold the key to recovering petroleum through complex organic reactions. Researchers at Arizona State University are studying how hot water and pressure transform organic compounds in unexpected ways.
Researchers at the University of Southern California have observed a clean three-way split in a molecule for the first time. The study uses a sym-triazine molecule and energizes its electrons to create identical and equally energetic parts.