Articles tagged with Organic Synthesis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team of researchers developed a new strategy to functionalize the 'meta-position' of pyridines, which is extremely challenging and rare. They achieved high selectivity in introducing various functional groups into this position using temporary de-aromatization and radical/polar chemistry.
Researchers at UNIST have developed a method to synthesize single-crystalline graphite films of up to inch scale, overcoming the critical issue of small size due to weak interaction between layers. The resulting films exhibit exceptional thermal conductivity and uniform quality.
Researchers from Gwangju Institute of Science and Technology have developed a method to eliminate residual organic metal-binding ligands from transition metal oxide thin films, resulting in improved device stability and performance. The technique achieved a 20-fold enhancement in electrical conductivity and a 17.6% increase in efficiency.
A search of the Cambridge Structural Database found nearly 1,800 conglomerate crystal structures with spontaneous enriched chirality, augmenting synthetic building blocks for medicinal chemists. This discovery introduces a new pool of chiral molecules outside of natural sources, potentially leading to more effective treatments.
Researchers at Kobe University have developed a new method to synthesize fluoroalkyl carbonates, which are environmentally friendly alternatives to toxic precursors. These carbonates exhibit high reactivity and can be used to create pharmaceutical intermediates and other substances.
The new approach enables chemists to synthesize novel, potentially pharmaceutically relevant structures that were previously difficult to synthesize. The techniques employ directing templates that efficiently direct CH functionalization at desired sites.
Researchers at Hokkaido University used computer simulations to discover a reaction that selectively adds two fluorine atoms to a difficult-to-access position on an N-heterocycle. The successful synthesis of 48 new compounds with unique alpha position fluorine substitutions has significant potential for novel drug development.
Chemists at the University of Münster developed a novel method for synthesizing complex organic molecules using visible light. The method produces biologically valuable β-amino acids, including a bifunctional oxime oxalate ester with both amine and ester functionalities.
The Electrifying Technical Organic Syntheses (ETOS) research network, coordinated by JGU, will be funded from BMBF to support the development of new techniques for organic chemical synthesis using electrolysis. The cluster aims to promote forward-looking innovations and secure technological sovereignty.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
Researchers developed a sustainable method of synthesizing diphenylmethanol derivatives using Chinese alumina, reducing waste and costs. The new method recycles alumina by washing it with water and drying between usages, making it an environmentally friendly alternative.
Researchers from Prof. Martin's group at ICIQ develop a new strategy to create organic molecules of pharmacological interest using ketones as alkyl cross-coupling synthons. The method provides flexibility and mild reaction conditions, making it suitable for the synthesis of various organic molecules.
Researchers successfully synthesized a Möbius carbon nanobelt with a twisted Möbius band topology, revealing unique properties and molecular motions. The breakthrough paves the way for developing nanocarbon materials with complex topological structures.
Researchers have successfully synthesized a new type of carbon allotrope called holey graphyne, which has semiconductor properties and can be used in various applications. The material was created using a bottom-up approach and consists of alternately linked benzene rings and C≡C bonds.
The researchers successfully synthesized π-extended nanographene carbon nanosolenoid (CNS) material with continuous spiral graphene planes, matching the structure of Riemann surface. CNS exhibited special photoluminescence and magnetic properties, including red-shifted emission band and large thermal hysteresis.
Researchers have developed a new method to synthesize large defectless graphene crystals using carbon monoxide under ambient pressure. The process benefits from self-limiting conditions, resulting in purer graphene with faster growth rates and better crystal formation.
Researchers at Okayama University have developed a novel 'green' synthesis technique for the production of NEt-3IB, a promising small-molecule oral drug candidate for inflammatory bowel disease (IBD). The new method produces large quantities of NEt-3IB with high purity and a total yield of over 30%, using only recoverable organic solve...
A team of researchers has found that plastic waste-derived porous materials can adsorb CO2 from flue gas, reducing plastic pollution and emissions. The study suggests that these materials could be used in industrial-scale applications, making them a promising alternative to conventional CO2 capture technologies.
A team of researchers developed a novel method for producing optically active hydroxy β-lactam derivatives using baker's yeast and microwave irradiation. The process yielded 3:1 ratio of two hydroxyl compounds in 65% yield, with the resulting compounds showing high optical purity.
A zirconium oxide-supported platinum-molybdenum catalyst enables the selective conversion of esters into valuable unsymmetrical ethers under mild conditions. This process offers a sustainable solution for producing these compounds from renewable biomass-derived materials, reducing waste and energy consumption.
Researchers at MIT have synthesized himastatin, a natural compound with antimicrobial properties. The team discovered that the compound kills bacteria by disrupting their cell membranes.
Researchers successfully synthesized nitrogen-substituted undecacenes using on-surface chemistry, retaining their electronic properties with modified orbital energies. The study offers a new method for investigating complex electronic correlation effects in acenes and developing organic electronics and spintronics.
Scientists at Hokkaido University have developed an electrochemical method to recycle waste CO2 while producing molecules useful for drug development. The method utilizes an electron added to either the CO2 molecule or another molecule in the solution, making it easier to react with each other.
A team of researchers from Skoltech and universities developed a neural network-based solution for automated recognition of chemical formulas on research paper scans. The algorithm combines molecules, functional groups, fonts, styles, and printing defects to mimic existing molecular template depiction styles.
Researchers at Hokkaido University have developed a new method for creating chemical subunits using blue LEDs and copper, reducing the need for precious metals. This breakthrough has potential applications in pharmaceutical and photoelectronic development.
A research team has developed a new strategy to create molecular compounds without multi-step syntheses, using a system of three catalysts. The catalysts work together to selectively insert an aryl group into unactivated alkenes, offering a sustainable and efficient solution for organic synthesis.
Researchers at RIKEN successfully treated cancer in mice using metal catalysts that assemble anticancer drugs inside the body. The technique avoids indiscriminate tissue damage and increases cancer-inhibiting activity by 1000 times.
Researchers from Japan have developed a new method to synthesize a pure Si-CHA membrane showing much higher CO2 separation performance than existing membranes. The key to this achievement is using a porous silica substrate instead of alumina, eliminating problems with pore size reduction and improving efficiency.
Researchers developed a simpler, greener method for producing Grignard reagents using environment-friendly paste-based technology. This new process drastically cuts down on the use of hazardous organic solvents and could lead to reduced production costs and environmental benefits.
The study investigates the effect of solvent on liquid-phase synthesis of lithium solid electrolytes. The research team found that solvents with high dielectric constants enhance reactivity and lead to crystalline Li7P3S11 with high conductivity. Acetonitrile emerges as the best solvent for mass production of sulfide solid electrolytes.
Researchers found that borosilicate glass was crucial for synthesizing amino acids and other prebiotic organic compounds. The study suggests that the emergence of life on Earth may be more abiotic than previously thought.
Researchers at Ural Federal University developed an ultra-sensitive sensor to analyze honey for nitrobenzene, a toxic compound. The sensor's exceptional accuracy and low sample requirements make it suitable for on-site analysis.
Researchers from Shibaura Institute of Technology synthesized atropisomeric N-aryl quinazoline-4-thiones, showing unprecedented isotopic atropisomerism due to rotational restriction around an N-Ar bond. The findings support the formation of diastereomers and have potential applications in pharmaceuticals.
A novel manganese-based catalyst has been developed to efficiently deconstruct commercial and end-of-life polyurethane (PU) materials into monomeric building blocks. This process enables the creation of virgin polymeric material with the same characteristics as the original material, promoting a circular plastic economy.
Researchers have successfully formed rings made of three pyrroles for the first time, which could be used to produce compounds with unique properties. The discovery explains why tripyrrolic macrocycles were not observed before due to strain issues.
A team of four scientists from Hokkaido University developed a rapid and efficient protocol for cross-coupling reactions using ball milling, expanding the pool of chemicals usable in organic synthesis. They successfully applied this method to mostly-insoluble aryl halides, yielding desired products.
Scientists at Japan's National Institutes of Natural Sciences have successfully synthesized zigzag nanotubes using a novel method. This breakthrough enables the controlled production of all three types of nanotubes: armchair, chiral, and zigzag.
Researchers at Skoltech have discovered a way to increase the productivity of carbon nanotube synthesis by adjusting catalyst injection rates, leading to a 9-fold increase in yield while preserving key properties. This breakthrough has the potential to pave the way for cheaper and more accessible nanotube-based technology.
Scientists at the Institute for Basic Science successfully synthesized a large organic cage composed of multi-porphyrin units without using templates. The P12L24 cage has a truncated cuboctahedral structure and an inner cavity diameter of 4 nm, making it suitable for encapsulating large guest molecules.
A team of chemists from Scripps Research developed a theoretical approach that can ease the process of making highly complex, compact molecules. They used information theory and computer modeling to analyze the synthesis of bilobalide, a molecule with strong promise as a potential neurological or psychiatric drug.
Quinoline and its derivatives have diverse chemical and pharmacological properties. The new water-mediated synthetic method offers environmentally friendly and regioselective transformations. This innovation provides an alternative route for the synthesis of quinolines, minimizing waste and improving efficiency.
Researchers successfully synthesized hetero-steroid-amino acid conjugates using microwave-assisted Ugi-4-CR reactions. This method improves yields and reaction rates, offering a promising approach for synthesizing novel hybrid molecules.
Researchers explore ascorbic acid's role in organic synthesis, revealing its potential as a catalyst for diverse reactions and its unique mechanistic pathways. This study contributes to green chemistry by demonstrating the versatility of ascorbic acid in environmentally benign processes.
Researchers developed a rapid synthesis method for useful organic fluorine compounds, including gem-difluoroalkenes. This method uses triflones and Grignard reagents to produce the compounds efficiently and safely.
Chemists at Scripps Research have created three families of complex, oxygen-containing molecules that are normally obtainable only from plants. The key to this new method is harnessing natural enzymes--from bacteria--to assist in complex chemical transformations.
A novel and extremely efficient synthesis method has been developed for bioactive natural compounds with potential anti-cancer properties. The new method allows easier access to these substances, enabling further investigations into their biological activity and potential therapeutic applications.
Researchers at Okayama University create novel electrochemical reaction to produce thienoacenes, key building blocks in organic semiconductors. The new method replaces expensive rare metal catalysts with an eco-friendly approach, reducing manufacturing costs and environmental impact.
Researchers at Kanazawa University have developed a novel method for generating alkyl radicals under mild conditions using organoboron compounds and visible-light. The new protocol enables the generation of bulky tertiary alkyl radicals and unstable methyl radicals, which are useful carbon sources for chemical reactions.
A team of scientists from Tokyo University of Science has developed a novel method to use protected boronic acids in the Suzuki-Miyaura reaction, reducing the number of steps and increasing atom economy. The new process enables the direct use of masked molecules, leading to faster and cheaper synthesis of complex molecules.
Researchers at Shinshu University successfully synthesized 2-arylazulene, a breakthrough that enables the production of azulene derivatives on a larger scale. The study also revealed unexpected fluorescence properties in acidic conditions, which the team is investigating to elucidate.
Researchers developed a method to retain boron units during C-C couplings, expanding the range of industrial boron compounds. The new process enables sequential incorporation of building blocks and potential future use in pharmaceutical production.
A team of researchers successfully synthesized organic UV filters from cashew nut shell liquid, reducing reliance on petroleum-based chemicals. The process showcases the potential of xylochemistry for sustainable chemical synthesis.
Researchers use carbon nanotube nanoreactors to produce and stabilize metastable silver iodide structures, including rock-salt and helix phases, at ambient conditions. The synthesis provides a new path to the creation of extreme structures.
Researchers at the University of Science and Technology of China have developed a simple, efficient, and non-metallic anionic composite photocatalytic system to free trapped radicals from carboxyl groups. This breakthrough simplifies photocatalytic systems, reduces costs, and promotes industrialization in organic synthesis.
Researchers used X-ray scattering to analyze nanoporous carbons produced under different synthesis conditions, revealing optimal pore size and shape requirements for electrochemical performance.
Researchers at EPFL developed a photoelectrocatalytic arene C-H amination method, producing pharmaceutical molecules like metaxalone and benzethonium chloride. Hematite semiconductor is used as a catalyst under visible light, offering a low-cost and energy-efficient alternative to traditional methods.
Researchers at Johannes Gutenberg University Mainz have developed an electrochemical synthesis method for thebaine, overcoming decades-long challenges in mimicking its natural formation. The new approach uses astute modification of starting materials to achieve high selectivity and efficiency in the reaction.
Researchers from Xiamen University have synthesized cyclic ruthenium carbyne complexes with an unusually low carbyne carbon angle, showcasing their good stability and unique ambiphilic reactivity. The discovery provides a valuable complement to the chemistry of metal carbynes.
A female graduate student at FEFU has developed a new synthesis method for marine organic substances related to fascaplysin. The method allows for the production of compounds with higher activity than natural fascaplisin, promising for medicinal applications.
Researchers have developed a new method for synthesizing insulin using self-assembly of polypeptide chains, achieving a 40% efficiency rate. This approach enables the production of customized insulin compounds without relying on genetic engineering, which could lead to the development of novel insulin preparations.