Articles tagged with Proteins
Researchers at ETH Zurich created an atlas of protein interactions in different tissues, revealing that every fourth interaction is tissue-specific. This knowledge helps identify disease genes and develop targeted drugs with increased specificity.
Researchers successfully constructed a large molecular spherical shell structure with the geometric topology of a regular dodecahedron through entanglement of peptides with metal ions. The resulting M60L60 metal-peptide shell exhibits remarkable stability against heat, dilution, and oxidative conditions, making it a promising platform ...
Researchers at Northwestern University discovered that DNA's behavior changes in a crowded environment, affecting the amount of stress required for strand separation. The study used microscopic magnetic tweezers to investigate interactions between DNA and various molecules.
Increasing Klotho protein levels in mice extends lifespan and improves both physical and cognitive health when aging. The treatment also enhances muscle, bone, and cognitive health, with potential benefits for osteoporosis prevention and brain function.
Research at the University of Bristol has linked mental health conditions like depression and schizophrenia to immune response, suggesting a fundamental change in understanding causal mechanisms. The study identified 29 potential biomarkers that could be used for novel therapeutics in mental health conditions.
A new study reveals that protein sources in an animal's diet significantly alter the gut microbiome, with some having extreme effects. The researchers found that diets high in brown rice, yeast, or egg whites led to changes in amino acid metabolism and complex sugar degradation.
Researchers discovered a protein associated with Parkinson's disease causes the transition from liquid to solid in microscopic blobs of protein found in human cells. The study's findings provide new insights into the development and progression of neurodegenerative diseases.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
Scientists have created a detailed map of U2OS cells, revealing previously unknown protein functions and assemblies. The study will help researchers understand how mutated proteins contribute to childhood cancers and provide a blueprint for mapping other cell types.
A new study by Johns Hopkins Medicine researchers has identified a protein called QRICH1 as a potential target for fine-tuning treatments for cancer and autoimmune diseases. The protein regulates T-cell response, and drugs could be designed to control its activity.
The Protein Society recognizes five award winners in 2025 for their groundbreaking research in protein science and technology. Professor Jan Steyaert receives the Christian B. Anfinsen Award for pioneering nanobody technology, while Dr. Brian Kuhlman wins the Emil Thomas Kaiser Award for novel protein design and structural modeling.
Jessica Lusty Beech wins award for understanding plastic-degrading Rieske iron oxidoreductase system, while Matteo Cagiada predicts absolute protein folding stability using generative models. The Protein Society recognizes their contributions to protein science.
Researchers have developed a new strategy to target hard-to-target proteins in human cells by reprogramming proteases to selectively degrade disease-causing proteins. The study demonstrates proof of concept for developing novel therapies for Parkinson's disease, cancers, and other illnesses, using α-Synuclein as a model protein.
Researchers have identified distinct protein degradation patterns in key brain regions for individuals who witnessed trauma, differing from those who experienced it firsthand. Sex-specific differences also emerge, with implications for targeted treatments and a better understanding of PTSD development.
Researchers developed synbiotic chocolates fortified with probiotics and prebiotics, showing improved gut microbiome balance and probiotic survival rates. The study found that the orange-flavored chocolates had a softer texture and more luxurious bite experience.
Researchers at Purdue University have developed AI-powered software, Molecular Intelligence, to structure biomolecules from cryo-EM image data. The tool uses deep learning to analyze low-resolution image data and construct accurate 3D structures of proteins and other biomolecules.
Researchers at Kyushu University have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs. By analyzing cerebrospinal fluid, they identified specific proteins associated with an immune response that can affect the central nervous system after therapy.
Researchers at Scripps Research have captured the first detailed images of polymerase theta (Pol-theta) in action, revealing its molecular processes responsible for a range of cancers. The study provides a blueprint for designing more effective cancer drugs by understanding how Pol-theta repairs DNA using a two-step process.
Researchers at UNIGE have developed a system that uses light to activate targeted molecules, enabling spatial and temporal control over the activity of a molecule in a living organism. This technology has vast potential applications in both basic research and improving existing medical treatments, such as those for skin cancer.
Researchers at the University of Sydney are using Zwitterions to create materials that can prevent blood clots from forming in medical devices and implants. They have successfully created a zwitterionic coating that repels water beyond the material's boundaries.
Researchers from Osaka University found that peristaltic pump action promotes amyloid nucleation in supersaturated fluids, including blood and cerebrospinal fluid. High shear stress caused by the pumping motion mechanically breaks supersaturation to induce amyloid formation.
A team of researchers from Japan directly visualized protein translocation across membranes for the first time, providing insights into the SecYEG-SecA complex dynamics and its role in facilitating protein movement. The study estimated a protein translocation rate of 2.2 amino acid residues per second.
A recent gene therapy study for advanced metachromatic leukodystrophy (MLD) showed stabilization or improvement in two patients, but lacks critical clinical assessments. The research highlights the need for comprehensive evaluations of cognition, motor, and speech function to substantiate claims.
Researchers develop new method to study glycosylation in proteins, discovering that gut bacteria can alter molecular signatures in the brain. The study found over 150,000 glycosylated protein forms in brain tissue samples from mice.
ApoB100 protein structure revealed for the first time, allowing for more precise testing and treatment of high cholesterol and heart disease. The discovery may lead to new drugs targeting LDL particles, reducing side effects of statin drugs.
The Bennu samples contain amino acids and nucleobases, building blocks for proteins, as well as ammonia, which can react to form complex molecules under the right conditions. These findings suggest that the conditions necessary for life were widespread across the early solar system, increasing the odds of life existing elsewhere.
The study reveals that the transthyretin protein forms asymmetric structures with two differently shaped binding pockets, which may contribute to its instability. The researchers' novel graphene grid method allows them to capture the protein's natural conformations, providing new insights into its structure and potential for targeted t...
Intrinsically disordered proteins make up 30% of all proteins and are linked to various diseases. By combining two methods in a single sample, researchers have improved the accuracy of measuring protein size and its impact on disease development.
A cross-sectional study found that maternal use of certain antidepressants and anti-inflammatory medications can lower protein and fat levels in breast milk. This may impose health risks on infants who are breastfed by mothers taking these medications, highlighting the need for further research to clarify the clinical implications.
Gene and cellular therapeutic approaches aim to enhance treatment outcomes for Huntington's disease by targeting different cellular, epigenetic, and genetic factors. Preclinical studies show promising results, paving the way for future clinical trials.
A new method captures RNA from diverse microbes, revealing distinct adaptive states in Prevotella and Roseburia genera. The study identifies novel host-phage transcriptional activity associations, providing insights into the complex relationships within the human gut microbiome.
This study maps aberrant cerebellar nuclei outputs in an autism mouse model, highlighting their link to social deficits. Targeted rescue of these deficits through chemogenetic inhibition suggests a promising new therapeutic strategy.
Alzheimer's disease is characterized by amyloid plaques and neurofibrillary tangles, with genetic predispositions and aging contributing to its development. Early intervention and biomarkers are crucial for diagnosis and treatment.
Researchers developed AI-driven therapeutic platform mimicking viral structures to deliver therapeutic genes to target cells. The innovative approach achieved precise symmetrical structures and effectively delivered payloads, paving the way for breakthroughs in gene therapies and next-generation vaccines.
A study using multi-omics analysis identified SP1 and EGR1 as key drivers of pathological remodeling in hypertrophic cardiomyopathy. Inhibition of these transcription factors alleviated left ventricular hypertrophy and fibrosis in an animal model.
Dr. Michael Courtney's team will use advanced phenotyping techniques to assess how SYNGAP1 missense variants impact protein function, focusing on pathogenic or uncertain variants. The project aims to inform therapeutic strategies for patients with SYNGAP1-related disorders through drug repurposing and functional assays.
A study by Tulane University researchers found that tumors in female fruit flies grew 2.5 times larger than those in male fruit flies due to sex-based differences in immune response. The stronger innate immune response in females accelerated tumor growth.
A study by Chiba University researchers has identified 106 compounds in pregnant women's serum samples, including phthalates, nitrogenous compounds, and parabens, which may impact biological pathways. The study proposes a non-targeted approach for detecting foreign chemicals and evaluating their potential health effects.
Researchers create novel protein-based gel, Q5, for high-performance skincare products with improved pH stability and sustainability. The protein-based material enables more stable and responsive formulations under acidic skin conditions.
Researchers evaluated over 400 patients with suspected Alzheimer's disease and found that CSF analysis was less reliable than PET imaging. The study suggests using amyloid PET scans as the diagnostic method of choice, especially for those with gray area results between 5.5-7.1 in their CSF.
Researchers have developed a simple model system to break down fibrils into their constituent single units or liquid droplets. This discovery has the potential to treat neurodegenerative diseases such as Alzheimer's and Parkinson's by targeting pathological fibrils.
A recent study published in JSFA Reports confirms that various pork cuts, Italian hams, and sausages offer excellent protein quality. The study found that all tested pork products achieved a Digestible Indispensable Amino Acid Score (DIAAS) greater than 100.
The new portal connects genetic variant data with protein sequence and structural information, enabling easy visualization of variants on protein 3D structures. This facilitates the analysis of genetic variants' impact on protein function and structure.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
Scripps Research scientists have identified a crucial binding site on the protein FOXA1 that could pave the way for future cancer treatments. The team's findings mapped out how tiny drug-like chemical compounds interact with the protein, revealing a hidden lock that small molecules can bind to.
Researchers at São Paulo State University used condensed matter physics concepts to describe protein compartmentalization in cells. The study proposes a cellular Griffiths-like phase that may be linked to the origin of life and the emergence of primordial organisms.
Scripps Research scientists develop a new approach to designing drugs that selectively bind to cancer-related proteins and their paralog counterparts. By identifying a druggable site on the paralog, they characterize drugs that only bind to the protein of interest, potentially leading to more effective treatments for certain cancers.
Researchers at Martin-Luther-Universität Halle-Wittenberg have observed proteins restructuring themselves to produce inositol, a key substance for metabolism. The study reveals that this process occurs in multiple similar proteins, shedding light on their functions.
Scientists at Stanford University have developed a new method to relocalize misplaced proteins in cells, which could lead to therapeutic treatments for diseases. The team created a class of molecules called TRAMs that convince natural shuttles to take cargo like proteins to different parts of the cell.
Researchers at Tel Aviv University discovered that aneuploid cells, which have an abnormal number of chromosomes, are more susceptible to certain types of anticancer drugs. The studies found that disrupting the MAPK pathway increases the sensitivity of these cancer cells to chemotherapy.
Researchers create a novel paradigm for adding non-canonical amino acids to proteins by using four RNA nucleotides instead of the traditional three. This approach allows for efficient and targeted incorporation of new building blocks into specific sites in target proteins, enabling the creation of tailored proteins with unique functions.
Researchers from Japan have discovered that Exportin-5 interacts with a broader spectrum of RNAs, including tRNAs, miRNAs, lncRNAs, and specific mRNAs. This study sheds light on the unique roles of Exp5 in RNA export within Drosophila cells.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
A team of chemists at Scripps Research has mapped over 300 small molecule-reactive cancer proteins and their binding sites, revealing key protein targets that can be disrupted with certain chemical compounds to halt cancer cell growth. The findings have the potential to lead to more effective and precise cancer treatments.
Terc-53 overexpression affects normal aging in mice, leading to cognitive decline and shortened lifespan. Hmmr levels decrease with age, but restoring them improves cognitive abilities and reduces neuroinflammation markers.
A Kobe University study establishes a new mouse model to study fetal abdominal inflammation caused by meconium peritonitis. The researchers found that heat-treated proteins in the meconium slurry disrupt digestive enzymes, leading to significant reduction in mortality rates.
Researchers have developed a new method to predict protein movements by teaching AI about energetic frustration. This improves the accuracy of tools like AlphaFold2 in predicting alternative structures and functional movements. The study has significant implications for drug design, enzyme engineering, and disease mechanisms.
Scientists studying environmental bacteria have determined a protein's essential role in maintaining the germ's shape. Loss of the protein OpgH disrupts the bubble-like cell envelope, resulting in the cell's death. This finding could lead to new drug targets and advance the search for better antibiotics.
Researchers at the University of Cambridge have developed an atlas of proteins that reveals how they behave inside human cells. The tool allows for the identification of new proteins involved in important bodily functions, including fat distribution and protein creation.
A new study by ACS Journal of Proteome Research identifies shifts in tear protein levels as predictors of long-lasting pain after LASIK surgery. The analysis suggests that specific patterns of protein changes could one day be used to evaluate patients' risk of post-surgical eye pain and find new treatments.