The article includes an introduction to the significance of breast cancer, particularly TNBC, and the role of post-translational modifications such as arginine methylation. The study details the expression and functional analysis of CARM1 in breast cancer, its interaction with HIF1A, and its impact on TNBC progression. Experimental data demonstrate that CARM1 promotes proliferation, invasion, EMT, and stemness in TNBC cells. Genome-wide analysis identifies CARM1's transcriptional targets, emphasizing its role in various signaling pathways. The study concludes with findings on the potential therapeutic effects of ellagic acid as a CARM1 inhibitor.
Key findings from the study include:
The study concludes that CARM1 plays a significant role in the progression of triple-negative breast cancer by interacting with HIF1A and regulating genes involved in cell cycle and signaling pathways. The upregulation of CARM1 in breast cancer tissues, especially in more aggressive subtypes like TNBC, highlights its potential as a biomarker for cancer progression. Experimental evidence demonstrates that CARM1 enhances proliferation, invasion, EMT, and stemness in TNBC cells, indicating its pivotal role in cancer metastasis and resistance to treatment. The identification of ellagic acid as a potent inhibitor of CARM1 opens new avenues for therapeutic intervention. By suppressing CDK4 expression, ellagic acid shows promise in reducing TNBC proliferation and invasion, providing a potential natural compound for cancer therapy. This research underscores the importance of targeting CARM1 in developing effective treatments for TNBC and possibly other cancers with elevated CARM1 expression. The work entitled “ CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A ” was published on Protein & Cell (published on Mar. 13, 2024).
Protein & Cell
Experimental study
Animals
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A
13-Mar-2024