Articles tagged with Reagents
Researchers at RUDN University synthesized isoquinoline derivatives with potential biological activity, including bactericidal and antileukemic properties. The team developed a new method for isolating the compounds, which may be effective in treating Alzheimer's disease by inhibiting certain enzymes.
Researchers developed a novel sensor array that can detect and differentiate among a diverse range of aldehydes and ketones, providing a sensitive, fast, and inexpensive method for identifying volatile compounds. The array allows for the detection of chemical toxins, safety inspections, and preventative screening in various fields.
Researchers have developed a copper-catalyzed double hydroboration method to synthesize internal gem-diborylalkanes. The approach restricts regioselectivity with carbonyl groups, overcoming previous challenges with internal alkynes.
Chemical engineers and chemists at Pitt and Penn State create a system that utilizes chemical reactions to drive fluid flow, enabling controllable transport of particles and cells. This breakthrough could lead to rapid and efficient chemical assays.
Researchers at ICIQ have designed a new strategy for stereoconvergent preparation of trans-cyclopropanes from E/Z alkene mixtures. The 'radical carbenoid' method uses diiodomethane as a commercially available and easy-to-handle reagent.
Researchers at Rice University have created a multifunctional reagent from pine tree terpenoids, enabling the rapid synthesis of nitrogen- and oxygen-containing molecules in one step. This process cuts waste and saves money for manufacturers by using biorenewable and cost-effective methods.
Two researchers have discovered a single-step chemical process that creates both alcohols and esters without generating any waste or using harmful reagents. The process is more straightforward and simpler than existing methods, offering an economical and sustainable alternative for industrial applications.
Researchers create efficient way to form carbon-carbon bonds with high chiral selectivity for nitrogen-containing heterocyclic molecules. The breakthrough uses century-old techniques and a copper catalyst, offering a more efficient process for drug discovery and development.
Scientists at Scripps Research Institute have developed a new electrochemistry-based method for allylic oxidation reactions, which are used in pharmaceuticals, flavor, and fragrance industries. The new method uses inexpensive, safe chemicals and is scalable, producing better yields and reducing toxic waste.
Researchers at MIT have developed paraffin-based capsules that can enclose multiple reagents and catalysts, simplifying chemical synthesis. The capsules can protect water-sensitive compounds for extended periods, extending the shelf life of common commodity chemicals.
A new handheld device replaces traditional methods with a safer, more accurate, and affordable testing procedure. It is adaptable for different chemical measurements and can be used by schools and individuals to gather real data in their communities.
A new technique for detecting proteins in tissues has been developed at Uppsala University, enabling robust and inexpensive analysis. The method uses antibodies linked to DNA strands and emits light when attached, making it suitable for point-of-care devices and clinical applications.
A team of researchers has developed a virtual archive of building blocks to create nano-knots of all shapes and forms. By studying the shape of fragments, they found that complex knots can be assembled efficiently from just four helical fragments.
Researchers aim to standardize antibody identification by defining them by their sequences, like genes. This would enable consistent results across experiments and reduce waste in the research pipeline.
Millions of antibodies used in research often have unclear specificity due to lack of quality control and standardization. Experts advocate for recombinant antibodies with defined sequences, enabling worldwide reproducibility of experiments.
Commercial antibodies used in research often fail to function properly, but DNA technology can solve this problem by producing high-quality antibodies. The authors advocate for the use of recombinant DNA technology to improve reproducibility and reduce waste in biological science.
ASU researchers are developing artificial genetic polymers composed of threose nucleic acid (TNA) to address emerging health and defense threats. The team plans to search large combinatorial pools for TNA molecules with desired functional properties.
Researchers at the University of Vienna developed a new, atom-economical chemical synthesis for α-arylated Carbonyl derivatives. The method eliminates the need for additional reagents, reducing product contamination and labor-intensive reaction conditions.
A study published in PeerJ found that nearly 50% of scientific resources are unidentifiable due to a lack of detail in journal articles. Researchers developed guidelines for reporting research resources to aid reproducibility, but these did not improve identification rates.
Scientists have developed a new method for chemical reduction using a biomimetic catalyst that mimics naturally occurring enzymes. The catalyst-based approach uses cheap, replenishable reagents and works well at room temperature and in air, even allowing for safe use in a teacup. With high efficiency rates, the research has wide applic...
A team of chemists at USC developed a method to convert fluoroform, an ozone-destroying chemical waste product, into useful reagents for producing pharmaceuticals. The discovery is based on the precise conditions needed to coax fluoroform into useful compounds, including trifluoromethanesulfonic acid.
A set of chemical tools simplifies the creation of potential new drug compounds, enabling previously time- and cost-prohibitive chemical modifications. The toolkit works in a variety of conditions, including water and biological media.
Researchers at Arizona State University have developed a new method using plants to produce biological reagents for detecting and diagnosing West Nile Virus. The technique, which relies on plant viral-based vectors, allows for rapid, high-accuracy testing with lower costs and scalability compared to existing methods.
Researchers from SomaLogic and the University of Washington identified 36 proteins with significant expression changes in lung cancer tissue samples, including 13 new biomarkers. This study provides new insights into NSCLC biology and suggests potential therapeutic targets.
The SOMAscan assay identifies and measures thousands of proteins, unlocking protein biomarker discovery for therapeutic and diagnostic applications. This technology empowers personalized medicine by detecting early disease onset in real-time.
Biodesign researchers are developing a state-of-the-art pipeline to generate synthetic affinity reagents called 'DNA synbodies' to study protein function and disease. The goal is to create low-cost, high-quality reagents for the entire human proteome, revolutionizing molecular medicine.
Researchers at RIKEN have developed a new aqueous reagent, Scale, which renders biological tissue transparent, allowing for vivid 3D images of neurons and blood vessels deep inside the mouse brain. The reagent's unique properties enable visualization of fluorescently-labeled samples at unprecedented depths and levels of spatial detail.
Researchers at LMU München have developed a facile route to versatile organozinc compounds by synthesizing them as salt-stabilized solids. This allows for easier storage and transportation compared to traditional liquid forms, making them more suitable for industrial applications.
Researchers at Arizona State University have developed a new method for producing antibody-like binding agents, called DNA synbodies, which can be rapidly optimized for high affinity. The technique uses pre-existing ligands to create artificial antibodies capable of detecting diseases, offering a promising alternative to traditional mo...
Researchers have devised a new technique that simplifies the improvement of drugs and other products by adding a CF3 molecule. This method reduces the need for high-heat equipment and metal catalysts, making it safer and more accessible to chemists.
Researchers have created the first class of reagents to potently and selectively inhibit miRNAs in C. elegans, a widely used model organism. The new reagents efficiently and specifically inhibited targeted miRNA in different tissues, including the hypodermis, vulva, and nervous system.
A new microfluidic sorting device rapidly analyzes millions of biological reactions, allowing researchers to identify potent drugs and cleaner sources of energy. The device uses drop-based microfluidics to sort compounds in parallel at high speed.
Researchers have created a new technology that allows for the localization of nanoliter droplets of reagents over cells in high-density arrays without physical walls or dry substrates. This enables the use of hundreds of times less reagent and maintains cell viability in wet environments, revolutionizing gene expression studies.
A new method of synthesizing peptides using simple reagents has been discovered by McGill University researchers. The technique allows for the creation of multiple peptides with minimal equipment and expense, revolutionizing biological research.
The International Rice Research Institute has received a $500,000 donation from 5 PRIME to support research on developing drought-tolerant rice varieties. This donation will strengthen IRRI's capabilities for efficient and cost-effective rice production.
A chemist at Washington University in St. Louis has developed a technique that allows for the simultaneous monitoring of up to 12,000 molecules on an electrochemically addressable computer chip. The method uses a polymer substrate and confining agents to selectively initiate chemical reactions on individual electrodes.
The National Cancer Institute has established a collaborative network of five Clinical Proteomic Technology Assessment for Cancer teams to evaluate and compare different proteomic platforms. The network aims to improve diagnostics, therapies, and prevention by standardizing technologies and methodologies.
A new RNAi toolset enables researchers to systematically study thousands of genes, revealing previously unknown growth regulators and confirming the library's sensitivity. The toolset, developed by a public-private partnership, is now available to all genetic researchers.
Researchers at Illinois and Rice University developed a new process to chemically select and separate carbon nanotubes based on their electronic properties. The process uses reaction chemistry to create handles that can selectively manipulate metallic and semiconducting nanotubes.
Researchers at Rice University have developed a technique to sort single-walled carbon nanotubes based on their electronic properties. This allows for the separation of metallic and non-metallic nanotubes, which could lead to significant advances in molecular electronics and device development.
Researchers at Lehigh University are developing a tiny generating plant, housed on a silicon chip, that can produce enough hydrogen to run power-consuming portable devices. The chip-based micro-chemical plant demonstrates feasibility in producing small amounts of hydrogen.
Researchers at the University of Illinois Chicago have developed a fluorous chemistry-based method to convert alcohols into aldehydes and ketones, retaining the convenience of the Swern reaction. The new reagents eliminate the byproduct dimethyl sulfide, producing an odorless and easily recyclable alternative.