Articles tagged with Single Molecules
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new research provides a mechanism to detect and correct systematic errors in data and image analysis used in many areas of science and engineering. The single-pixel interior filling function (SPIFF) method can improve the accuracy of imaging systems for tracking objects on scales ranging from nanometers to astrophysical scales.
The Biophysical Society has announced the winners of its Education Committee Travel Awards, recognizing students and postdoctoral fellows for their scientific merit. The recipients will present their research during the meeting, receive a travel grant, and be recognized at a reception.
Researchers propose a graphene-based spaser that can detect small amounts of explosives and toxic chemicals using surface plasmons. The device's construction involves a graphene layer, enabling subwavelength light focusing and increasing sensitivity beyond conventional optical devices.
Researchers at Vienna University of Technology have developed a new method to distinguish real protein clusters from single blinking molecules in superresolution microscopy. The study reveals that many studied proteins do not form clusters as previously assumed, challenging the theory on protein distribution on cell membranes.
Researchers have developed a technology allowing them to visualize single molecules of messenger RNA as they are translated into proteins in living mammalian cells. Initial findings suggest that this may shed light on neurological diseases such as Fragile X Syndrome and Alzheimer's, as well as cancer.
Researchers have demonstrated that nanoscale electronic components can be made from single DNA molecules, representing a promising advance in the search for a replacement for silicon chips. The discovery may lead to smaller, more powerful and more advanced electronic devices.
Researchers develop a universal theory to describe single-molecule temporal resolution, enabling real-time observation of macromolecules in live cells. This breakthrough allows for the study of chemistry and biochemistry at a single-molecule level.
Researchers have developed a technique that enables the detection of single molecules of contaminants, explosives, or diseases using a combination of surface-enhanced Raman scattering (SERS) and a slippery surface. This innovation has vast applications in analytical chemistry, molecular diagnostics, environmental monitoring, and nation...
Scientists at EPFL show how a light-induced force can push the capabilities of surface-enhanced Raman scattering (SERS) even further. They overcame limitations by amplifying molecular vibrations with light, increasing sensitivity and resolution.
Researchers have developed a new method to calibrate high-tech microscopes, enabling the tracking of single molecules in 3D at the nanoscale. This breakthrough has exciting implications for understanding key biological processes such as signaling, cell division, and neuron communication.
Researchers have successfully trapped single atoms or molecules using a laser light in a doughnut-shaped metal cage. This breakthrough could lead to the development of advanced storage devices, computers, and high-resolution instruments. The technique uses scanning probe microscopy techniques to access individual nano-traps.
A new technology, SR-STORM, enables high-resolution imaging of multiple components and local chemical environments inside a cell. It allows scientists to examine cell structures and study diseases using unprecedented spectral and spatial resolution.
Researchers discovered a toxin that turns a common protein into poison, disabling the immune cell's ability to neutralize bacteria. The toxin targets a protein called formin, which is essential for assembling actin filaments, ultimately crippling the cell.
Researchers have created a method that can identify the mass and shape of individual molecules, opening up new possibilities for biologists and biomedical applications. The technique uses vibrations in a tiny device to measure the mass-to-charge ratio and then analyzes the resulting frequencies to determine the molecule's shape.
Researchers at HZDR and University of Konstanz successfully switch on a single molecule using light, enabling the creation of smallest possible components. The diarylethene compound exhibits unique physical behavior, rotating minimally when open and becoming conductive when closed.
Scientists from TUM and LIU create technology to cage molecules in 2D nanopores, allowing them to investigate thermal behavior of individual species. They successfully track molecule motions at sub-nanometer resolution using scanning tunneling microscopy.
Researchers at UC Davis have developed a method to measure the conformation of single molecule 'wiring', resolving a gap between theoretical predictions and experiments. This technique provides important information for theoretical modeling, enabling better design and prediction of molecule-scale circuits.
Jülich researchers create a word using 47 molecules by manipulating them with a novel control system. The technique allows for the first time to remove large organic molecules from associated structures and place them elsewhere in a controlled manner.
Researchers from UCI capture moving images of a single molecule as it vibrates and shifts between quantum states, opening a window into the realm of quantum mechanics. This breakthrough could lead to applications such as lightning-fast quantum computers and uncrackable encryption.
Researchers successfully measured the vibrational motion of a single molecule for the first time, showing distinct behavior from larger molecular groups. This achievement demonstrates ultrafast spectroscopy at the single-molecule level, enabling new possibilities for quantum computing and single-molecule photonics.
A new chip-based platform combines electrical and optical measurements to study single molecules and nanoparticles. The device allows for the discrimination of particles with different sizes and optical properties, enabling reliable counts of virus particles.
Researchers have developed a highly sensitive system to detect individual molecules using a 'golden trap' technique. By creating a customized environment with gold nanoparticles and DNA, they can capture and identify single molecules, opening up possibilities for early disease detection in medical diagnostics.
Researchers at Columbia University have won a $5.25 million NIH grant to develop a new single molecule electronic DNA sequencing platform that could reduce genome sequencing costs to $100. The platform uses nucleic acid chemistry, electronics, and protein engineering to sequence DNA in real-time.
A team of physicists has successfully demonstrated magnetism within a single molecule. By applying voltage, researchers were able to switch the magnetic state on and off, reproducing elementary physics in a single molecule. This discovery provides new insights into magnetism as an elementary phenomenon of physics.
Researchers design and fabricate a tiny optical device called an 'antenna-in-box' that can detect and sense individual biomolecules at concentrations similar to those found in the cellular context. The device allows for enhanced single-molecule analysis and has potential applications in early disease diagnosis and molecular visualization.
Researchers have developed temperature-controlled nanopores that can detect and identify a wide range of molecules in the bloodstream, including proteins and DNA. This innovation may enable doctors to diagnose diseases more effectively by quickly identifying indicators of disease in the blood.
Researchers share code for Amazon Cloud that significantly reduces time necessary to process super-resolution images, enabling biologists to study molecular machines like proteins and enzymes in greater detail. The method saves over a week's worth of time, making it possible to analyze data within hours instead of days.
Researchers have successfully created single-molecule 'intelligent' motors powered by common enzymes, catalase and urease. These motors can generate force and move in specific directions, even at the nanoscale, with implications for applications in medicine, engineering, and more.
Researchers successfully integrated a single functionalized photosynthetic protein system into an artificial photovoltaic device, retaining its biomolecular properties. This breakthrough demonstrates the potential for light-driven, highly efficient single-molecule electron pumps to act as current generators in nanoscale electric circuits.
Researchers at Columbia University have developed a novel approach for single molecule electronic DNA sequencing that can accurately distinguish four DNA bases using nanopores. The technique, called Nano-SBS, uses distinct chemical tags to label DNA building blocks, overcoming the challenge of small differences among the four nucleotides.
Stephen Quake's work has revolutionized biophysics, biological automation, genome analysis, and personalized medicine with innovative physical techniques. His pioneering efforts have enabled answers to previously impossible questions and had profound impact on nearly every area of biology.
Researchers at Kiel University have successfully switched the magnetism of individual molecules using electrons, paving the way for molecular data storage. The study, published in Angewandte Chemie, demonstrates the technical feasibility of storing information in a single molecule.
Researchers at Columbia Engineering and the University of Pennsylvania have created a new integrated circuit design that enables faster single-molecule measurements, including DNA sequencing. This breakthrough could lead to cheaper and more accurate diagnostic tests for diseases, as well as insights into inherited traits.
A team of scientists at EMBL found that oskar RNA requires both tags to reach its correct destination, suggesting a 'ticket' that also affects its speed of transport. The study provides clues on how a single molecule could receive tickets for different destinations depending on the type of cell.
The new sensor uses nanometer-scale pores to selectively screen single molecules passing through a semiconductor membrane. The technology has the potential to detect and identify specific proteins in a single cell, with applications in medical research, pharmaceuticals, and fundamental biological studies.
Researchers at RIKEN developed an automated sample preparation system for the HeliScope single molecule sequencer, reducing preparation time from 42 days to 8 days. The new system uses Cap Analysis of Gene Expression (CAGE) and yields reproducible results comparable to manual prep.
Scientists have found that stretching single molecules can increase their electrical conductivity, contradicting the common assumption that longer wires are less conductive. The discovery uses force-induced resonant tunneling and has significant implications for microelectronics and biological sensing.
The Biophysical Society has announced the winners of its 2012 Education Committee travel awards, selected based on scientific merit and conference presentation. The awardees will receive travel grants and be recognized at a reception.
Researchers at the University of Pittsburgh have invented a new type of electronic switch that performs logic functions within a single molecule. The discovery could enable smaller, faster and more energy-efficient electronics.
Chemists at Tufts University have developed a single molecule electric motor, measuring 1 nanometer across and controlled by electricity. The motor's operation depends on temperatures around 5 Kelvin, which could lead to real-world applications in sensing devices and medical equipment.
A new approach enables precise mass measurements of single molecules using molecular oscillators, overcoming limitations of conventional mass spectrometry. The technique allows for fast, miniaturized, and real-time analysis of molecular binding affinity, paving the way for versatile low-cost mass spectrometry measurements.
A team of MIT chemical engineers has created a new detector that can pick up a single molecule of an explosive such as TNT, surpassing the sensitivity of existing explosives detectors. The sensor uses protein fragments to recognize nitro-aromatic compounds and can identify unique 'fingerprints' for different explosives.
Scientists have successfully controlled the electrical conductance of a single molecule by manipulating its mechanical properties. The research uses a type of molecule called pentaphenylene and demonstrates that changing the tilt angle can increase conductance up to 10 times, thanks to lateral coupling effects.
Researchers have successfully used nanoscale transistors to detect the binding of DNA double helix halves, directly amplifying single biomolecule charge. This technique offers a powerful tool for studying single molecule interactions and has potential applications in protein assays, DNA sequencing and other areas.
Researchers have developed a single molecule imaging technology called BEAST to map the electromagnetic field inside nano-sized metal hotspots. The results show highly localized fields with exponential shapes that rise steeply to peaks and decay quickly.
Researchers at Delft University of Technology and Oxford University have developed a new, more robust type of nanopore device that combines biological and artificial building blocks. This technology has the potential to revolutionize DNA analysis by making it faster and cheaper.
A team led by Sanjeevi Sivasankar at Iowa State University has developed a new instrument that can study individual biological molecules, advancing biomedical research, drug discovery, and cancer diagnostics. The instrument combines technologies to observe single molecules with high resolution.
A team of researchers developed a dual scanning tunneling and microwave-frequency probe to study nanoscale interactions, enabling the measurement of physical, chemical, and electronic interactions between single molecules and substrates. The probe can locate and switch single molecule switches on substrates with high resolution.
A team of McGill University researchers has developed a method to study energy transport along individual conductive polymer molecules, enabling the development of new technologies. By visualizing energy transport in various conformations, they aim to improve sensors and hybrid organic-inorganic light harvesting materials for solar cells.
Researchers have developed a model that confirms correlation between on and off periods in blinking phenomena, providing insights into the physical mechanism behind the vast range of emission times. The finding has potential applications in quantum dot imaging, cancer cell detection, and display screen development.
JILA's technique uses infrared laser light to quickly and precisely heat 'nano bathtubs'—tiny sample containers—for microscopy studies of single molecules and nanoparticles. The new method enables fast, noncontact heating of very small samples, enabling new experiments with single molecules.
Researchers at Delft University of Technology have developed a novel technique to fabricate graphene nanopores that can detect individual DNA molecules as they pass through. This technology has the potential to significantly impact DNA sequencing by reading off the sequence base by base in real-time.
A new technique developed by Rice University researchers can detect the movement of single molecules over hours using plasmonic properties of nanoparticles. This method is label-free and permanent, enabling the tracking of molecular interactions at the single-molecule limit.
Researchers have developed a method to deterministically position silver nanoparticles onto self-assembling DNA scaffolds, paving the way for new biomedical applications and precise sensing operations. The study demonstrates the viability of using silver instead of gold nanoparticles in DNA-based architectures.
A new sensor array made of carbon nanotubes can detect single molecules of hydrogen peroxide emanating from a single living cell. The detection could lead to new targets for potential cancer drugs and diagnostic devices for some types of cancer.
A team of Marshall University researchers has successfully developed bionanomotors that can efficiently transport and manipulate single molecules at the nanoscale. Using myosin and actin proteins, they created a system that can move cargo with controlled movement and stop it at designated points.
A team of European researchers has achieved the first experiment to study the electrical behavior of only two C60 molecules touching each other. The investigation revealed that the conductance between the two molecules is significantly lower than expected, with a controlable leakage current between neighboring circuits.
Researchers at Arizona State University have successfully created a molecular diode, the smallest electrical component in electronics. The breakthrough uses a technique called AC modulation to apply a mechanical perturbation to a molecule, allowing it to form a closed circuit and control current flow.
Researchers have made significant advancements in imaging live neurons and developing hearts, with a new scope helping premature babies breathe easier. Optical coherence tomography has enabled the visualization of embryonic heart dynamics, paving the way for studies on developmental causes of birth defects.
A team of researchers used nanopores to investigate the movement of DNA in a gel, finding that larger pores reduce resistance and calculations based solely on electrostatic forces did not accurately predict results. The study's unique combination of techniques offers promising developments in single molecule techniques.