Articles tagged with Biomaterials
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
Alvaro Della Bona, University of Passo Fundo Professor, received the 2021 Wilmer Souder Award for his contributions to dental biomaterials research. He is recognized internationally for his publications and invited presentations on the topic.
The IADR/AADR presented awards to researchers in three categories: Biological Research, Biomaterials & Bioengineering Research, and Clinical Research. The winners were recognized for their contributions to advancing dental health and well-being worldwide.
Scientists at the University of Leeds have developed an approach to control the structure and mechanics of synthetic biomaterials made from proteins. By removing specific chemical bonds, known as 'protein staples,' they altered the structure of a protein network, resulting in different mechanical properties.
Researchers develop a de novo peptide Y15 that readily forms secondary structures to enable bottom-up synthesis of functional protein assemblies in live cells. The peptide enables the formation of fibrous structures and clusters in test tubes and live cells, facilitating protein assembly and reconstitution of natural complexes.
Researchers at NYU Tandon School of Engineering developed stimuli-responsive coiled-coil fibrous hydrogels that can be triggered by temperature, pH, or light. These smart biomaterials have potential for tissue engineering, drug delivery, and wound healing applications.
A team of researchers from Japan discovered that high COOH concentration facilitates internal proton transport while lower concentrations favor interfacial transport. The study may contribute to developing bio-conductive materials for biological devices and eco-friendly fuel cells.
A research team has developed an in vitro diseased skin model that displays the pathophysiological hallmarks of type 2 diabetes using 3D cell printing technology. The model exhibits slow re-epithelialization, insulin resistance, and pro-inflammatory response, similar to diabetic skin.
Scientists have developed a new biomaterial that regrows both blood vessels and bone, potentially providing an alternative to current systems. The biomaterial was inspired by the natural way in which bone defects regenerate and uses a mechanobiology-informed approach to promote both angiogenesis and osteogenesis.
Researchers develop a 3D biomaterial scaffold that slowly releases stem cells, reducing dosages and improving therapeutic effects in mice with osteoarthritis. The cryogel 'sponge' ensures implanted stem cells stay in the knee joint area longer, allowing for more effective treatment.
A new biomaterial, a boron-loaded alginate hydrogel, has been designed to accelerate muscle regeneration after injury. The hydrogel stimulates integrins, which promotes tissue formation and reduces recovery time by half.
Scientists have identified a polymer with fine-tuned mobility properties that alter the immune activity of specific liver cells, offering potential for regenerative medicine. The study found that surface mobility significantly affects the movement and gene expression profile of Kupffer cells.
Northwestern University researchers create novel biomaterial that enhances neuron growth, a crucial finding for regenerative medicine. The material's bioactive properties allow cells to penetrate and interact with bioactive signals, potentially treating neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
Researchers have developed a thermoplastic biomaterial that can be controlled to degrade at varying rates and maintain mechanical properties. The material is suitable for soft tissue repair or flexible bioelectronics and has been shown to promote healthy tissue growth.
A team of scientists has developed objects made with living materials, using fungi as a key component. The research demonstrates that fungi can sense and process various external stimuli, including light, temperature, and electrical signals, making them suitable for creating sustainable smart wearables.
Researchers have identified a rare genetic bone disorder by using precision medicine strategies, uncovering mutations in the LAMA5 gene that cause extreme bone fragility and skeletal deformity. The study also revealed a new signaling pathway governing skeleton formation, which could be used for common bone conditions.
Researchers develop a biomaterial that enhances adult stem cell regenerative ability, repairing large bone defects and reducing inflammation. The material incorporates nanoparticles that activate JNK3, a key driver of children's stem cells' regenerative capacity.
Scientists at the University of Nottingham have developed a new protein imaging method that allows for the accurate analysis of biomaterials and tissue. This breakthrough technology has the potential to lead to the development of more effective drug delivery systems and medical devices.
A new species of spider, Ocrepeira klamt, has been discovered by a University of Bayreuth researcher in the highlands of Colombia. The spider differs from related species in its reproductive organs and is native to an altitude of over 3,500 meters above sea-level.
Researchers at Northwestern University have synthesized a new form of melanin enriched with selenium, called selenomelanin, which shows promise as a shield for human tissue against harmful radiation. The new biomaterial offers better protection than traditional forms of melanin and has potential applications in space travel
Researchers are developing biomaterials to boost the body's natural healing process, with two approaches: incorporating cells or designing materials to stimulate cellular response. This can lead to improved success rates in tissue regeneration, reducing regulatory barriers and increasing available options.
Researchers at the University of Birmingham have created a new thermoplastic biomaterial with shape memory properties, enabling it to be stretched and molded but reforming into its original shape when heated. The material offers a stable, long-lasting option for medical devices such as bone replacements.
Scientists at RCSI University of Medicine and Health Sciences have developed a biomaterial that promotes an immune response to encourage repair and lowers the risk of inflammation in damaged bone tissue. The technology is designed to deliver microRNA silencers, increasing cells responsible for bone repair.
A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...
A new bone-graft biomaterial supercooled before application could eliminate pain and improve smile outcomes for dental patients. The material, combining octacalcium phosphate with collagen, has shown superior bone regenerative properties compared to earlier substitutes.
A team of microbiologists at the University of Bayreuth created a modular system for genetic reprogramming of bacteria, turning them into cell factories for multifunctional magnetic nanoparticles. These nanoparticles combine various useful functions and properties, offering a promising new material in biomedicine and biotechnology.
Researchers at Wyss Institute and collaborating institutions aim to develop biomaterials-based approaches to enable anti-cancer immuno-therapies. The center will focus on boosting tumor-specific activities of cytotoxic T cells using innovative biomaterials and DNA origami.
A team of scientists has created a new class of 3D-printed biomaterials that can direct the regeneration of functional tissue in damaged cartilage. The materials are designed to provide cells with the exact cues they need to form tissue organized in the same way as natural cartilage.
Scientists create a bilayer platform that can alter surface topographies using shape-memory polymers and gold nanorods to promote cell polarization and collective migration of vascular endothelial cells. This approach enables dynamic manipulation of cell functions, mimicking the native ECM-mediated effects in the human body.
Biomaterials Science and Engineering Fellow Anson Ong recognized for outstanding contributions to biomaterials research, education, and service. His primary focus areas include implant surface modifications and tissue-engineered bioceramic scaffolds.
Researchers at NAU are developing a polypropylene glycol-based biomaterial to treat cerebral aneurysms, aiming to improve outcomes and reduce recurrence rates. The material, PPODA-QT, is designed to fill the aneurysm space effectively, leaving a smooth surface for healing.
Scientists at the Universitat Autonoma de Barcelona have developed artificial protein granules that can sustainably release therapeutic proteins in lab animals. These 'artificial inclusion bodies' mimic natural bacterial structures and hold great potential for vaccines and controlled-release drug delivery systems.
Engineers at Duke University create a bandage that traps and holds the pro-healing molecule adenosine, accelerating callus formation and vascularization to improve bone repair. The results show better bone formation, higher bone volume, and better vascularization in mice treated with adenosine-laced bandages.
Researchers developed a remote-controlled 'smart' platform to mimic natural extracellular matrix-mediated endothelialization. The platform uses shape-memory polymers and gold nanorods to direct programmed vascular endothelium remodeling in a temporally controllable manner, offering new possibilities for treating cardiovascular disease.
Colorado State University scientists create a novel chemical catalysis pathway for producing PHAs with enhanced mechanical and physical properties. This breakthrough offers a scalable solution to the plastics crisis, enabling faster production and tunability of biodegradable materials.
Researchers at the University of Birmingham have developed a new 3D printing technique called Suspended Layer Additive Manufacturing (SLAM) that can create soft biomaterials for repairing body defects. The technique uses a polymer-based hydrogel with self-healing properties, allowing for precise detail and support without sagging.
Researchers at the University of Maryland Baltimore County have successfully sequenced two genes that allow spiders to produce their sticky glue. This achievement could lead to new applications in organic pest control and biomaterials, building on previous discoveries about spider silk genes.
A new biosensor developed by DGIST's Professor Jae Eun Jang's team can detect biomaterials in real-time without secondary processing or an analyzer. The technology uses plasmonic nanostructures and image signal processing to reveal the colors of colorless biomaterials.
Researchers at Penn State have discovered that citrate, a natural product found in bones and citrus fruit, can fuel bone healing by providing extra energy for stem cells. This understanding will help develop slow-release biomaterials to speed up bone repair and reduce inflammation.
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
Researchers created a biomaterial that can be seeded with insulin-producing beta cells, reversing diabetes in a mouse model. The study found normalized glucose levels and increased survival in treated mice, without triggering an immune response.
Biomaterials with precisely ordered structures could be used for various biomedical applications due to their precise control of self-assembly. The hybrid approach allows researchers to expand the chemical diversity of protein-based materials by combining different alphabets, such as amino acids and lipids.
A $3.4 million grant will help researchers study endocrine-disrupting chemicals in medical devices, with a focus on improving transfusion safety and understanding the impact on cardiovascular health.
Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Researchers explore the use of nanoparticles, microneedle patches, and polymer particles to enhance vaccine effectiveness and delivery. These innovative biomaterials may improve responses in HIV, cancer, and autoimmune disorders, reducing medical waste and expanding vaccine accessibility.
Researchers at Penn State have developed a new biomaterial that can replace plastic barrier coatings in packaging and other applications, offering strong oil and water barrier properties. The material, comprised of treated cellulose pulp and chitosan, is compostable and has the potential to greatly reduce pollution if widely adopted.
Researchers at Kazan Federal University (KFU) have won a Russian Science Foundation grant to develop dry storage technology for biomaterials. They are studying the anhydrobiosis mechanism of mosquitoes, which can survive without water, and plan to apply it to store oocytes, proteins, or vaccines.
Researchers are exploring the potential of mollusc shells to restore damaged oyster reefs and cultivate new oysters. The shells contain over 95% calcium carbonate, a valuable biomaterial used in various applications, offering a sustainable alternative to mined limestone.
TU Dresden will establish two new Collaborative Research Centres (CRCs) and continue a third CRC, receiving significant funding from the German Research Foundation (DFG). The new CRCs focus on interdisciplinary research topics such as vituperations and insults, and the adrenal's role in stress and disease.
UCR researchers developed an inexpensive sensor that can weigh microgram-sized biological samples in fluids, expanding applications in toxicity research, plant sciences, and biomaterials engineering. The sensor uses a simple glass tube and off-the-shelf electronics to measure mass, volume, and density of tiny samples.
Twelve University of Delaware students and alumni have won National Science Foundation Graduate Research Fellowships, with a total award value of $1.4 million. The fellowships provide three years of funding and cost-of-education allowances for study leading to a master's or doctoral degree in science and engineering.
A researcher is studying how early immune system responses can predict the long-term success of biomedical implants. The study aims to develop methods for modulating macrophage activity to encourage positive outcomes.
Researchers developed a mouse model to assess early tissue responses to biomaterials, including bioactive glass. The model's feasibility and reliability have been demonstrated using various biomaterials, enabling the design of novel biomaterials for regenerative medicine.
Researchers at Columbia University have developed a method to manufacture microscale-sized machines from biomaterials that can safely be implanted in the body. The technique uses hydrogels and stacks them in layers to create devices with three-dimensional, freely moving parts.
Researchers at Mayo Clinic are developing a universal shear-thinning biomaterial that can be injected through an endovascular catheter, creating an impenetrable cast of the vessel and preventing further bleeding. This alternative to metallic coils may improve treatment outcomes for patients undergoing coil embolization.
Researchers developed a new biomaterial to examine how stem cells perceive their environment's mechanical properties. The study found that manipulating this perception could control stem cell differentiation and promote regenerative therapies for musculoskeletal disorders.
A team of researchers found that squid suckerin proteins are composed of beta-sheet polymer networks, giving them strength and stretchiness. These thermoplastic proteins could be used to create biomaterials for tissue growth and artificial ligaments, offering a sustainable alternative.
Researchers created a mechanically durable hydrogel using an elastic silk-like protein called aneroin, which has improved mechanical properties compared to collagen and silkworm silk. The aneroin hydrogel provided an adequate environment for cell growth, proliferating mammalian cells with healthy morphology.
The University of Nottingham leads a £6.5m research project to create bespoke biomaterials for specific applications in regenerative medicine, drug delivery, and medical devices. The team aims to identify new materials that can control cell response and address unmet clinical needs.