Articles tagged with Biomaterials
Researchers at Wyss Institute and collaborating institutions aim to develop biomaterials-based approaches to enable anti-cancer immuno-therapies. The center will focus on boosting tumor-specific activities of cytotoxic T cells using innovative biomaterials and DNA origami.
A team of scientists has created a new class of 3D-printed biomaterials that can direct the regeneration of functional tissue in damaged cartilage. The materials are designed to provide cells with the exact cues they need to form tissue organized in the same way as natural cartilage.
Scientists create a bilayer platform that can alter surface topographies using shape-memory polymers and gold nanorods to promote cell polarization and collective migration of vascular endothelial cells. This approach enables dynamic manipulation of cell functions, mimicking the native ECM-mediated effects in the human body.
Biomaterials Science and Engineering Fellow Anson Ong recognized for outstanding contributions to biomaterials research, education, and service. His primary focus areas include implant surface modifications and tissue-engineered bioceramic scaffolds.
Researchers at NAU are developing a polypropylene glycol-based biomaterial to treat cerebral aneurysms, aiming to improve outcomes and reduce recurrence rates. The material, PPODA-QT, is designed to fill the aneurysm space effectively, leaving a smooth surface for healing.
Scientists at the Universitat Autonoma de Barcelona have developed artificial protein granules that can sustainably release therapeutic proteins in lab animals. These 'artificial inclusion bodies' mimic natural bacterial structures and hold great potential for vaccines and controlled-release drug delivery systems.
Engineers at Duke University create a bandage that traps and holds the pro-healing molecule adenosine, accelerating callus formation and vascularization to improve bone repair. The results show better bone formation, higher bone volume, and better vascularization in mice treated with adenosine-laced bandages.
Researchers developed a remote-controlled 'smart' platform to mimic natural extracellular matrix-mediated endothelialization. The platform uses shape-memory polymers and gold nanorods to direct programmed vascular endothelium remodeling in a temporally controllable manner, offering new possibilities for treating cardiovascular disease.
Colorado State University scientists create a novel chemical catalysis pathway for producing PHAs with enhanced mechanical and physical properties. This breakthrough offers a scalable solution to the plastics crisis, enabling faster production and tunability of biodegradable materials.
Researchers at the University of Birmingham have developed a new 3D printing technique called Suspended Layer Additive Manufacturing (SLAM) that can create soft biomaterials for repairing body defects. The technique uses a polymer-based hydrogel with self-healing properties, allowing for precise detail and support without sagging.
Researchers at the University of Maryland Baltimore County have successfully sequenced two genes that allow spiders to produce their sticky glue. This achievement could lead to new applications in organic pest control and biomaterials, building on previous discoveries about spider silk genes.
A new biosensor developed by DGIST's Professor Jae Eun Jang's team can detect biomaterials in real-time without secondary processing or an analyzer. The technology uses plasmonic nanostructures and image signal processing to reveal the colors of colorless biomaterials.
Researchers at Penn State have discovered that citrate, a natural product found in bones and citrus fruit, can fuel bone healing by providing extra energy for stem cells. This understanding will help develop slow-release biomaterials to speed up bone repair and reduce inflammation.
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
Biomaterials with precisely ordered structures could be used for various biomedical applications due to their precise control of self-assembly. The hybrid approach allows researchers to expand the chemical diversity of protein-based materials by combining different alphabets, such as amino acids and lipids.
Researchers created a biomaterial that can be seeded with insulin-producing beta cells, reversing diabetes in a mouse model. The study found normalized glucose levels and increased survival in treated mice, without triggering an immune response.
A $3.4 million grant will help researchers study endocrine-disrupting chemicals in medical devices, with a focus on improving transfusion safety and understanding the impact on cardiovascular health.
Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Researchers explore the use of nanoparticles, microneedle patches, and polymer particles to enhance vaccine effectiveness and delivery. These innovative biomaterials may improve responses in HIV, cancer, and autoimmune disorders, reducing medical waste and expanding vaccine accessibility.
Researchers at Penn State have developed a new biomaterial that can replace plastic barrier coatings in packaging and other applications, offering strong oil and water barrier properties. The material, comprised of treated cellulose pulp and chitosan, is compostable and has the potential to greatly reduce pollution if widely adopted.
Researchers at Kazan Federal University (KFU) have won a Russian Science Foundation grant to develop dry storage technology for biomaterials. They are studying the anhydrobiosis mechanism of mosquitoes, which can survive without water, and plan to apply it to store oocytes, proteins, or vaccines.
Researchers are exploring the potential of mollusc shells to restore damaged oyster reefs and cultivate new oysters. The shells contain over 95% calcium carbonate, a valuable biomaterial used in various applications, offering a sustainable alternative to mined limestone.
TU Dresden will establish two new Collaborative Research Centres (CRCs) and continue a third CRC, receiving significant funding from the German Research Foundation (DFG). The new CRCs focus on interdisciplinary research topics such as vituperations and insults, and the adrenal's role in stress and disease.
UCR researchers developed an inexpensive sensor that can weigh microgram-sized biological samples in fluids, expanding applications in toxicity research, plant sciences, and biomaterials engineering. The sensor uses a simple glass tube and off-the-shelf electronics to measure mass, volume, and density of tiny samples.
Twelve University of Delaware students and alumni have won National Science Foundation Graduate Research Fellowships, with a total award value of $1.4 million. The fellowships provide three years of funding and cost-of-education allowances for study leading to a master's or doctoral degree in science and engineering.
A researcher is studying how early immune system responses can predict the long-term success of biomedical implants. The study aims to develop methods for modulating macrophage activity to encourage positive outcomes.
Researchers developed a mouse model to assess early tissue responses to biomaterials, including bioactive glass. The model's feasibility and reliability have been demonstrated using various biomaterials, enabling the design of novel biomaterials for regenerative medicine.
Researchers at Columbia University have developed a method to manufacture microscale-sized machines from biomaterials that can safely be implanted in the body. The technique uses hydrogels and stacks them in layers to create devices with three-dimensional, freely moving parts.
Researchers at Mayo Clinic are developing a universal shear-thinning biomaterial that can be injected through an endovascular catheter, creating an impenetrable cast of the vessel and preventing further bleeding. This alternative to metallic coils may improve treatment outcomes for patients undergoing coil embolization.
Researchers developed a new biomaterial to examine how stem cells perceive their environment's mechanical properties. The study found that manipulating this perception could control stem cell differentiation and promote regenerative therapies for musculoskeletal disorders.
A team of researchers found that squid suckerin proteins are composed of beta-sheet polymer networks, giving them strength and stretchiness. These thermoplastic proteins could be used to create biomaterials for tissue growth and artificial ligaments, offering a sustainable alternative.
Researchers created a mechanically durable hydrogel using an elastic silk-like protein called aneroin, which has improved mechanical properties compared to collagen and silkworm silk. The aneroin hydrogel provided an adequate environment for cell growth, proliferating mammalian cells with healthy morphology.
The University of Nottingham leads a £6.5m research project to create bespoke biomaterials for specific applications in regenerative medicine, drug delivery, and medical devices. The team aims to identify new materials that can control cell response and address unmet clinical needs.
A new vaccine patch made of dissolvable material has been shown to be effective in protecting against flu infection, with an immune reaction equal to or stronger than traditional needle-delivered vaccines. The patch is easy to use without medical personnel, making it ideal for developing countries.
Researchers at the University of Illinois developed a novel single-step process to create three-dimensional (3D) texturing of graphene, increasing surface area. The 3D texturing enables expanded capabilities for electronics and biomaterials, including battery and supercapacitor applications.
The book explores the potential of 3D printing with biomaterials to minimize our carbon footprint and create sustainable products. A remarkable example is the printing of an entire town house from bio-based plastics, which reduces the material's carbon footprint by more than 60%.
Researchers have created DNA-coated nanoparticles that can hold together 3D-printed materials, forming gel-like substances suitable for human cell growth. This breakthrough could lead to the development of scaffolds for growing tissues and organs.
In a breakthrough study, researchers at Georgia Institute of Technology have developed a technique to activate biomaterials containing peptide signaling molecules using ultraviolet light. By designing molecular 'hats' that shield the peptides from recognition by cells, they can deliver drugs or particles with their signal in the 'off' ...
A special themed issue of the Journal of Dental Research covers recent developments in novel dental biomaterials and technologies, aiming to improve oral health outcomes. The issue highlights significant advances in materials engineering and their clinical applications.
Researchers leverage magnetically heated nanoparticles to overcome heat transfer limitations in cryopreservation, enabling rapid thawing of large biomaterials. The technology offers tunable heating rates and can accommodate unloaded sections up to several millimeters in dimension.
A team led by Arun Sharma has developed a system to protect against inflammatory reactions that can hinder tissue growth and function. Using self-assembling peptide amphiphiles, they demonstrated superior bladder function in a urinary bladder augmentation model.
Northwestern University professor Guillermo Ameer's team created a biodegradable, antioxidant biomaterial that reduces scarring and heals diabetic ulcers. The material is made from citric acid and vitamin C, and has potential applications in tissue engineering, medical device coating, and regenerative medicine.
Researchers at the University of Toronto have developed a tool that allows for cost-efficient, three-dimensional microgels to study cells in a naturalistic manner. The digital microfluidics platform enables flexible incorporation of different cell types and shapes, with potential applications in personalized medicine.
A research team at the University of California, San Diego has discovered how calcium phosphate-based materials encourage stem cells to differentiate into bone-forming cells. The findings could lead to the development of new biomaterials that can be used to treat bone defects and diseases.
Researchers have discovered cellulose nanocrystals with remarkable mechanical properties, including stiffness comparable to steel. These tiny structures, abundant in nature, offer a potential green alternative to carbon nanotubes for reinforcing materials.
Researchers have developed a new biomaterial that can deliver reparative cells to the nucleus pulposus, or jelly-like cushion found between spinal discs. The gel mix holds cells in place upon injection and provides environmental cues to promote their persistence and biosynthesis.
Researchers discovered that low levels of a toxic protein may cause more harm than high levels in neurodegenerative diseases such as Alzheimer's. Short protein threads formed at low levels can lead to disease progression, whereas longer filaments are thought to be protective.
Researchers developed a biomaterial that successfully engrafted insulin-producing cells into diabetic mice, reversing symptoms in just 10 days. The material promotes blood vessel formation and allows cells to survive and function within the body.
Researchers have developed a new solid form of bioactive plasma-based biomaterials that can promote healing at sites of tissue injury. These materials, known as PBMs, are easier to work with, inexpensive to produce, and safe to use.
A diagnostic 'cocktail' containing a single drop of blood, a dribble of water, and a dose of DNA powder with gold particles can mean rapid diagnosis and treatment of the world's leading diseases. The technology uses nanoparticles to target and illuminate cancer cells and tumours.
University of Toronto researchers dominated eight prize categories in this year's Natural Sciences and Engineering Research Council of Canada (NSERC) awards. A total of nine U of T researchers won honours, including Stephen Cook receiving the Gerhard Herzberg Canada Gold Medal for Science and Engineering.
The REBORNE project aims to develop new biomaterials that stimulate bone tissue formation with the use of mesenchymal stem cells. Clinical trials will be conducted in France, Spain, Germany, and Italy to evaluate the safety and efficacy of this treatment for delayed union fractures.
University of Toronto researchers have developed a device that can create three-dimensional, functional tissues through a precise and controlled process. The technology uses biomaterials to form a 'mosaic hydrogel' sheet, onto which cells are seeded in specific placements, mimicking natural cell placement in living tissues.
Ryan Gilbert, assistant professor at Rensselaer Polytechnic Institute, receives a $500,000 NSF CAREER Award to create novel biomaterials that can reduce astrocyte reactivity and aid nerve regeneration after spinal cord injuries. The project aims to deliver therapies directly to the injury site to promote axon growth.
Researchers at Georgia Tech and Emory University will develop biomaterials to capture molecules from embryonic stem cells for enhanced tissue regeneration in adults. The goal is to harness regenerative power of stem cells without tumor formation or immune system compatibility issues.
Professor Ali Khademhosseini, a leading expert in biomedical microdevices and biomaterials, will join the University of Texas at Austin's Department of Biomedical Engineering as a Donald D. Harrington Fellow. He aims to develop tissue-engineered organs and control cell behavior using novel, modular approaches.
New research provides evidence for the significant differences between new and old red blood cells used for transfusions. The study found that older red blood cells have undergone 'significant changes and damage', compromising their cell membrane integrity, making them not useful for transfusions.
Researchers at Cornell University have developed dermal templates made of type 1 collagen that promote vascular growth and encourage healthy skin to invade wounded areas. The templates are designed to improve healing outcomes and reduce the need for invasive surgeries.
Researchers at the University of Bristol are developing biologically-engineered synthetic liquid polymers to create a permanent solution for cartilage defects. The injectable gel can form three-dimensional scaffolds that encourage healthy cell growth and tissue repair.