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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Getting to the root of enamel evolution

A new study published in the Journal of Human Evolution identifies two genes that show evidence of positive selection in humans, contributing to the thickening of enamel. The research suggests that natural selection played a key role in shaping human teeth, with specific genetic changes linked to diet and environmental pressures.

Early exposure to bisphenol A might damage the enamel of teeth

Research suggests that early exposure to bisphenol A can damage the enamel of teeth in children, similar to a previously identified pathology known as MIH. The study found that low doses of BPA can cause mineral depletion and lead to hypomineralisation, making teeth more fragile and prone to cavities.

New evidence on how fluoride fights tooth decay

Researchers have found new evidence on how fluoride compounds reduce tooth decay risk by hardening enamel and reducing bacteria adhesion. This discovery lends credence to alternative theories on fluoride's mechanism of action.

Particles of crystalline quartz wear away teeth

The study found that quartz particles can remove pieces of tooth enamel at extremely low forces, making them a significant contributor to dental microwear. In contrast, fossilized plant remains had a minor effect on tooth surfaces, leaving only cosmetic rubbing marks.

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Nature-inspired advance for treating sensitive teeth

Researchers have developed a new substance inspired by mussels' adhesive, which can rebuild both enamel and dentin on teeth. Laboratory tests show that the gooey material promotes simultaneous remineralization of enamel and dentin, offering a potential solution for millions suffering from tooth sensitivity.

Early human ancestors had more variable diet

Researchers analyzed fossil teeth to determine the dietary preferences of three groups of hominins in South Africa. The study found that Australopithecus had a more varied diet than early Homo, while Paranthropus had a primarily herbivorous-like diet

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A thermometer for dinosaurs

Researchers from the University of Bonn analyzed fossil teeth from two giant herbivorous dinosaurs, Camarasaurus and Brachiosaurus, using a chemical thermometer to determine their body temperatures. The analysis revealed that both dinosaurs had a body temperature between 36 and 38 degrees Celsius.

Substantial consumption of fluoride increases chance of mild fluorosis

Research suggests that substantial amounts of fluoride through infant formula and toothpaste may cause mild fluorosis in young children. However, the American Dental Association recommends continued use of fluoridated water and toothpaste due to their proven effectiveness in preventing tooth decay.

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Leaded gasoline predominant source of lead exposure in latter 20th century

A new study by Case Western Reserve University researchers found that leaded gasoline was the predominant source of lead exposure for African-American children in Cleveland during the latter half of the 20th century. The study used dental records and other data to show that lead levels in teeth increased dramatically during this period...

Ancient remains put teeth into Barker hypothesis

The study found that tooth enamel defects in ancient humans were associated with shortened lifespans, suggesting a link between early life stress and adult diseases. The research supports the Barker hypothesis, which proposes that many adult diseases originate during fetal development and early childhood.

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Among apes, teeth are made for the toughest times

Ape teeth are shaped to handle scarce food resources during stressful times. The study found that gorillas have broader back teeth for chewing leaves and orangutans have thicker enamel for cracking seeds. Conservation efforts must also protect fallback foods sources, such as forest areas where fruits grow.

Look ma, no mercury in fillings!

Researchers at Southwest Research Institute have created a new proof-of-concept dental restorative material made with zirconia nanoplatelets, which are super hard due to the arrangement of atoms in the material. The new fillings aim to replace amalgam, containing mercury, and offer improved durability and ease of use.

Exposure to alkaline substances can result in damaged teeth

A new Swedish study reveals that exposure to alkaline substances can damage teeth by destroying organic content and leaving enamel more vulnerable. The study found that high pH values can cause flaked enamel, markedly increasing the risk of caries and other dental issues.

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Flying by the skin of our teeth

A study by Prof. Herzl Chai and colleagues reveals that teeth's wavy hierarchy and micro-cracking mechanism can inspire stronger composites for planes and aerospace engineering. Dental specialists can also use the research to create smarter crowns with improved durability.

Open wide and say 'zap'

Researchers developed a non-destructive way to measure the elasticity of human teeth using lasers, enabling early detection of oral health issues. The new method can help predict emerging dental problems like tooth decay and cavities.

OJ worse for teeth than whitening says Eastman Institute researchers

Researchers at the Eastman Institute found that acidic fruit juices like orange juice decrease tooth enamel hardness by up to 84%. Whitening products have no significant effect on enamel hardness. Poor oral hygiene and frequent consumption of acidic drinks can lead to severe tooth erosion.

Home tooth bleaching slightly reduces enamel strength

A new study from Ohio State University found that home tooth bleaching products reduce enamel hardness by 1.2-2 nanometers, affecting its ability to bounce back after force. Researchers suggest reformulating products to minimize side effects.

Study: Sports drink consumption can cause tooth erosion

A recent study by NYU researchers found that sports drinks can cause tooth erosion and hypersensitivity due to high levels of citric acid. The condition affects one in 15 Americans and can lead to severe tooth damage if left untreated.

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Genetic discovery could lead to advances in dental treatment

Researchers at Oregon State University have identified the gene Ctip2 as controlling tooth enamel production, a significant step towards repairing damaged enamel and preventing cavities. This discovery could lead to new approaches in dental health, including using tooth stem cells to stimulate enamel growth.

Piecing together an extinct lemur, large as a big baboon

Researchers have digitally reconstructed a nearly complete skull of the extinct lemur species Hadropithecus stenognathus, providing new insights into its diet and body size. The study reveals that the lemur was as large as a male baboon and had a brain size comparable to some large monkeys.

Mobile Neanderthals

A 40,000-year-old tooth reveals direct evidence of Neanderthal movement over lifetimes. The analysis of strontium isotope ratios in the enamel indicates that the individual lived in a different location than where the tooth was found.

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Improper consumption of acidic foods could lead to destroyed enamel

Consuming acidic foods and beverages can lead to tooth erosion, causing decay and damage to dental enamel. Dr. Bartlett advises patients to wait at least 20 minutes before brushing after eating or drinking an acidic food or beverage, and to minimize snacking throughout the day.

Scientists re-grow dental enamel from cultured cells

Researchers have developed a method to produce enamel-like tissue in culture, using epithelial cells extracted from developing teeth and seeded onto collagen scaffolds. This breakthrough could lead to the regeneration of whole teeth and treatment of damaged or missing enamel, revolutionizing dental care.

Simmer to receive research in Biological Mineralization Award

Dr. Simmer's laboratory made significant observations on the alternative splicing of amelogenin RNA transcripts, leading to improvements in understanding genetic etiologies of inherited enamel defects like amelogenesis imperfecta. His work also focused on tooth dentin and the isolation of dentin sialophosphoprotein-derived proteins.

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A buffet for early human relatives

Researchers analyzed tooth enamel to determine early human relatives' diet, finding seasonal variations in leaves, fruit, seeds, roots, and possibly grazing animals. This study sheds light on the variability of human diets over time, suggesting that it has been a key factor in modern humans' ability to adapt to different environments.

Amoxicillin use during infancy may be linked to tooth enamel defects

A study suggests a possible link between amoxicillin use in early infancy and an increased risk of dental fluorosis, a condition caused by excessive fluoride exposure. The research found that the duration of amoxicillin use was related to the severity of fluorosis on permanent teeth.

New tooth enamel dating technique could help identify disaster victims

Researchers have developed a new dating technique using radioactive carbon-14 in tooth enamel, which can accurately determine a person's age at the time of death within 1.6 years. This method can help forensic scientists identify victims of disasters like Hurricane Katrina and narrow down search efforts.

Competing proteins influence strength of tooth enamel

A study by USC researchers has identified two competing proteins, DSP and DPP, that influence the strength of tooth enamel. Over-expression of DSP increases enamel hardness, while over-expression of DPP creates pitted and chalky enamel prone to fracture and wear.

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Dental researchers answer key enamel question

Dental researchers successfully grown natural tooth enamel using a protein scaffold, solving a long-standing puzzle. The discovery unlocks one mystery of enamel formation and may have long-term applications in dental science and medical-device development.

Scientists uncover secret to sharp teeth

A new research study reveals that follistatin, a gene playing a critical role in organ patterning, regulates enamel formation on mouse incisors. The asymmetric expression of follistatin accounts for the distinct patterning of enamel formation and is required for the formation of enamel-free tooth regions.

Spun from bone

A team from PNNL and USC has identified the region of a protein that interacts with crystals to form enamel, a material with entirely different properties from bone. The discovery explains how proteins can control crystal structure, enabling nano-patterning and nano-building.

Bone, enamel, dentine, milk & saliva share gene family

Researchers identified a shared gene family responsible for calcium binding in bones, enamel, dentine, milk, and saliva. The genes, including SPARC and SPARCL1, evolved from a common ancestral gene and reside on the same chromosome in most vertebrates.

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Shedding some light on teeth whiteners

The main cause of tooth discoloration lies at the surface of enamel, where red wine, coffee and tea stain teeth. Hydrogen peroxide-based whitening agents target deeper discoloration by forming radical intermediates that break down into water and oxygen.