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Small messengers called extracellular vesicles deliver molecules between cells using protein signal

Researchers discovered a new process by which cancer cells use small extracellular vesicles to spread to healthy tissue. The study found that these vesicles are primarily internalized by clathrin-independent endocytosis via galectin-3, which is facilitated by an increase in intracellular calcium concentration.

AI transforms label-free photoacoustic microscopy into confocal microscopy: A new frontiers in cell imaging technology

Researchers developed an AI-powered technology that transforms low-resolution, label-free images into high-resolution, virtually stained ones without fluorescent dyes. This innovation delivers stable and accurate cell visualization, overcoming limitations of traditional imaging methods.

SourcePohang University of Science & Technology (POSTECH)·JournalNature Communications·DateJan 16, 2025

Optical imaging technique offers more precise diagnosis of sleep apnea

A recent study has explored a new imaging approach that uses swept-source optical coherence tomography to visualize the upper airway with high precision. By integrating computational fluid dynamics, researchers were able to identify areas of turbulence and pinpoint obstruction sites, leading to more accurate diagnoses and treatment pla...

SourceSPIE--International Society for Optics and Photonics·JournalBiophotonics Discovery·DateJan 7, 2025

Highly sensitive transparent ultrasound transducer for photoacoustic and ultrasound endoscopy in live pigs

Researchers developed an ultra-compact transparent ultrasonic transducer for simultaneous high-resolution ultrasound and photoacoustic imaging. This technology improves diagnostic sensitivity by providing detailed information about tissue vasculature, thereby enhancing early cancer detection.

3D snapshots unveil the intricate dance of RNA folding

Scientists have captured 3D snapshots of individual RNA nanoparticles in motion, showcasing the dynamic and intricate folding process. This breakthrough uses advanced electron microscopy to study RNA's flexibility, enabling new insights into its structure and potential applications in molecular medicine.

SourceAarhus University·JournalNature Communications·TypeExperimental study·DateNov 25, 2024

Novel artificial intelligence-based method for pathological diagnosis of hereditary kidney diseases

Researchers developed an AI-based method to analyze kidney lesions in female patients with Alport syndrome, predicting renal prognosis and guiding treatment interventions. The approach uses a modified stain and deep learning to detect basement membrane lesions, showing a positive correlation with proteinuria concentration.

SourceUniversity of Tsukuba·JournalAmerican Journal Of Pathology·DateOct 30, 2024

New microscope offers faster, high-resolution brain imaging

Researchers developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution, providing insights into brain function and neurological diseases. The microscope uses an adaptive sampling scheme to image neurons in real time, reducing damage to brain tissue.

SourceOptica·JournalOptica·DateAug 15, 2024

Toward a quantum electron microscope: a compact pulse hollow cone hybrid TEM/SEM by CityUHK to revolutionize electron microscopy

A team from City University of Hong Kong has designed a compact hybrid transmission and scanning electron microscope that can operate at room temperature, offering high-resolution imaging capabilities without cryogenic temperatures. The new system reduces radiation damage to samples and provides improved image contrast using pulse elec...

Pioneering the cellular frontier

Researchers from Brookhaven National Laboratory have developed an effective way to image a single cell using multiple techniques, providing significant implications in medicine and agriculture. The team used advanced X-ray imaging technologies to capture high-resolution images of the cellular structure and chemical processes within cells.

SourceDOE/Brookhaven National Laboratory·JournalNature Communications·TypeImaging analysis·DateJul 23, 2024

Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation

Researchers have developed a novel time-of-flight resolved stimulated Raman scattering microscopy that uses counter-propagating ultraslow Bessel light bullets for deeper tissue imaging. The technique offers high spatial resolution and improved penetration depth without the need for mechanical z-scanning.

New computational microscopy technique provides more direct route to crisp images

Researchers at Caltech have developed a new microscopy technique called APIC that can produce clear, high-resolution images covering large fields of view without the need for iterative trial-and-error methods. This breakthrough eliminates guesswork and allows for faster, more accurate image acquisition.

SourceCalifornia Institute of Technology·JournalNature Communications·TypeExperimental study·DateJun 28, 2024

New all-optical approach to revolutionize night vision technology

Researchers at TMOS have developed a new infrared filter thinner than cling wrap, which can be integrated into everyday eyewear, allowing users to view both visible and infrared light spectra. This breakthrough miniaturizes night vision technology, opening up new applications in safety, surveillance, and biology.

SourceARC Centre of Excellence for Transformative Meta-Optical Systems·JournalAdvanced Materials·TypeExperimental study·DateJun 3, 2024

Wake Forest University School of Medicine awarded $1.5 million from NIH to use advanced imaging to assess bone loss after bariatric surgery

Wake Forest University School of Medicine has received a $1.5 million grant to study bone microarchitecture in patients following bariatric surgery. The researchers will use high-resolution peripheral quantitative computed tomography (HR-pQCT) imaging to assess bone loss and muscle changes after weight-loss surgery.

USC researchers pioneer new brain imaging technique through clear “window” in patient’s skull

In a proof-of-concept study, USC researchers used functional ultrasound imaging to collect high-resolution brain imaging data through a transparent skull implant in a patient. The results suggest that this approach could open new avenues for patient monitoring and clinical research.

SourceKeck School of Medicine of USC·JournalScience Translational Medicine·TypeExperimental study·DateMay 29, 2024

How did the zebrafish get its stripes? Researchers are one step closer to finding out

Researchers have pinpointed the cellular machinery behind zebrafish's ability to rapidly change the color of their characteristic stripes from blue to yellow when distressed. By precisely altering the orientation of light-reflecting crystals, the fish can change the color of their stripes across the entire length of their body in seconds.

SourceHoward Hughes Medical Institute·JournalProceedings of the National Academy of Sciences·DateMay 29, 2024

UArizona Health Sciences professor uses CT network to promote public access to open science

Researchers are working to make publicly funded data collection in computed tomography widely available and understandable by diverse communities. The Non-Clinical Tomography Users Research Network aims to improve data handling across scientific disciplines and standardize data acquisition, handling, and sharing.

SourceUniversity of Arizona Health Sciences·JournalTomography of Materials and Structures·TypeComputational simulation/modeling·DateMay 22, 2024

A fragment of human brain, mapped

A team of Harvard researchers, led by Jeff Lichtman, has created the largest synaptic-resolution, 3D reconstruction of a piece of human brain to date. The dataset contains 1,400 terabytes of data on neural connections in a tiny piece of human temporal cortex.

SourceHarvard University·JournalScience·TypeData/statistical analysis·DateMay 9, 2024

Switching off the light to see better

Researchers from Osaka University have developed a new approach for super-resolution microscopy that can observe dense microstructures inside cells with excellent sharpness. By selecting only a desired plane to image using thin 'light sheet' illumination, they were able to achieve background-free super-resolution imaging.

SourceOsaka University·JournalNature Methods·TypeImaging analysis·DateApr 22, 2024

High resolution imagery advances the ability to monitor decadal changes in emperor penguin populations

Researchers used VHR satellite imagery to monitor emperor penguin global population trends, finding nearly 10% fewer birds in 2018 compared to 2009. This new monitoring methodology could help with adaptive conservation management efforts and provide insights into the causal factors behind the population trend.

SourceWoods Hole Oceanographic Institution·JournalProceedings of the Royal Society B Biological Sciences·TypeObservational study·DateMar 13, 2024

Would the highly sensitive transparent ultrasound transducer revolutionize biomedical imaging technology?

A novel transparent ultrasonic transducer (TUT) developed by POSTECH researchers offers exceptional optical transparency and maintains acoustic performance, surpassing conventional limitations. This breakthrough enables high-depth-to-resolution ratios for ultrasound imaging, with applications in various medical devices and fields.

SourcePohang University of Science & Technology (POSTECH)·JournalNature Communications·DateMar 10, 2024

Intravascular imaging significantly improves survival, safety, and outcomes in cardiovascular stenting procedures over conventional angiography

Using intravascular imaging to guide stent implantation significantly improves survival and reduces adverse cardiovascular events compared to angiography-guided PCI. The study found a 25% reduction in all-cause death, 45% reduction in cardiac death, and improved outcomes for patients with coronary artery disease.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalThe Lancet·TypeMeta-analysis·DateFeb 21, 2024

Mount Sinai ophthalmologists develop novel protocol to rapidly diagnose and treat eye stroke

Researchers at Mount Sinai Health System developed a novel protocol for rapid diagnosis of eye stroke, improving outcomes and preserving vision. The protocol uses high-resolution retinal imaging in emergency rooms, along with remote consultation, to confirm diagnosis and expedite care.

SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalOphthalmology·TypeRandomized controlled/clinical trial·DateFeb 13, 2024