Articles tagged with Molecular Imaging
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have successfully imaged ultrafast unidirectionally rotating molecules at 100 billion per second, revealing a quantum wave-like nature. The high-resolution imaging reveals rotational wave packets with distinct angular velocities, showcasing the transition from quantum to classical behavior.
Researchers used PET/CT with Ga-68 DOTATOC to detect primary tumors in patients with metastatic neuroendocrine cancer. The study found that 28% of patients underwent a major change in cancer management due to the imaging technique.
A novel PET technique tracks microglial activation in response to endotoxin, shedding light on neuroinflammatory diseases like Alzheimer's and depression. The study's findings could lead to new drug treatments by targeting immune dysfunction.
A novel radionuclide drug, PSMA-617, has been developed to target prostate-specific membrane antigen (PSMA) on prostate cancer cells, allowing for personalized diagnosis and therapy. The drug showed promising results in a human clinical trial, with effective imaging and therapeutic effects.
A specialized PET tracer has been developed to visualize the function of nerve cells that lead to neuronal loss and cognitive decline in neurodegenerative diseases. The tracer binds to a transporter of the neurotransmitter acetylcholine, allowing for the quantification of cholinergic neuron loss and its effects on cognition.
Researchers have developed a cloud-based software that analyzes and standardizes PET imaging data, allowing for earlier and more accurate diagnoses of Alzheimer's disease. The program uses machine learning to compare patients' scans with normal and abnormal scans, providing consistent results and quantifying PET data accurately.
Researchers developed PSMA-617, a theranostic drug that detects prostate cancer and targets enzyme on cancer cells. The technology shows substantial reduction in radiotracer uptake and significant decrease in PSMA in blood after therapy, indicating positive response.
A new study found that PET/CT scans are highly sensitive for detecting relapsed non-Hodgkin lymphoma, with a sensitivity rate of 95.1%. This breakthrough has significant implications for patient care, as early diagnosis can lead to improved treatment outcomes and longer survival rates.
Scientists have developed a novel PET tracer that can pinpoint thrombi throughout the body with over 97% accuracy. The tracer, Cu-64 FBP8, targets fibrin in blood clots and reflects thrombus age, enabling clinicians to choose more effective treatments.
Researchers have developed three new MRI agents that successfully target the prostate-specific membrane antigen (PSMA) biomarker in multiple cancers. PSMA is found in both primary and metastatic prostate tumors, as well as in newly developing blood vessels of many non-prostate cancers.
A new technique combines dynamic PET imaging with parametric tumor mapping to detect tumors and metastases throughout the body, providing quantitative evaluation and improved contrast. This method has the potential to be used for early diagnosis and more accurate prognosis of various cancers.
A new theranostic agent, I-124 PEG-AVP0458, has shown promise in targeting both ovarian and prostate cancer cells for imaging and treatment. The drug compound attaches itself to the targeted tumor sites via positron emission tomography (PET) scanners, enabling personalized cancer therapy.
A new molecular imaging scan detects dangerous protein deposits in the heart, significantly increasing cardiac risk. The scan uses a widely available agent to assess amyloid buildup and predict future heart attacks.
A new molecular imaging agent has been developed to detect prostate cancer that has spread to other tissues. The agent targets the PSMA enzyme, which is associated with prostate cancer, and has shown high accuracy in detecting disease sites, including those not identified by conventional methods.
The hybrid scanner combines conventional MRI, hyperpolarized MRI, positron imaging, luminescence imaging, and fluorescence microscopy to provide high-resolution multimodal intra-vital imaging. This allows researchers to study tumor biology and develop targeted therapies by analyzing the co-registration of multiple imaging data lines.
Phelps was recognized for his contributions to nuclear medicine and molecular imaging, including the invention of PET scanners. His work has improved outcomes for patients with cancer, neurological disorders, and cardiovascular disease.
Townsend's contributions to nuclear medicine have been transformative, introducing 3D PET imaging and the combined PET/CT scanner. His work has improved the signal-to-noise of reconstructed images without increasing detector material cost.
A new non-invasive PET scan with C-11-vorozole detects aromatase in all body organs, potentially identifying cancer patients who may benefit from aromatase inhibitor treatment. The study also finds sex-dependent differences in radiation exposure and hormonal status.
A recent study found that the Ga-68-PSMA-ligand PET/CT detected a large number of positive findings in patients with biochemical recurrence after radical prostatectomy, particularly at low PSA-values. The tracer's higher detection rates compared to other imaging methods suggest an early detection advantage for further clinical management.
François Légaré, an INRS researcher, has been awarded the 2015 Herzberg Medal for his work in ultrafast molecular imaging. His research team made significant breakthroughs in dynamic imaging, capturing images of molecular reactions at unprecedented resolution.
Fourth and subsequent PET/CT scans improved clinical assessment and management change in lung cancer patients, with 52.28% positive and 47.7% negative results for recurrence or metastasis. The scans resulted in treatment changes in 28.1% of cases, with new treatments initiated in 20.4%.
Researchers from Berkeley Lab presented on severe weather events in a changing climate, novel technologies for exploring uncultivated microorganisms, and future of accelerators. They also discussed battery innovations and what to expect from the LHC's second run.
A novel radioguided surgery technique using Y-90 DOTATOC can effectively identify residual cancer cells during brain tumor surgery, reducing healthy tissue removal. The study's findings suggest the potential for improved resection margins and enhanced patient outcomes.
Researchers develop a new approach to customize nuclear medicine treatment for cancer, using targeted alpha therapy with customized radiolabeled antibody cocktails. This method has great potential for treating various diseases, including those with disseminated tumor cells.
A new study shows a novel molecular imaging drug is effective in detecting early prostate cancer in soft tissue, lymph nodes, and bone. The drug, Tc-99m MIP-1404, has favorable pharmacokinetics and biodistribution, representing a breakthrough in prostate cancer imaging.
Researchers found that PET/CT imaging can help diagnose more aggressive tumors in young breast cancer patients, upstaging 21% of initial diagnoses. The study suggests considering patient age as a factor in staging decisions.
Scientists have developed a new generation of hyperpolarizing agents that can be used to dramatically enhance the signal intensity of imaged body tissues without presenting any danger to the patient. The HYPSOs are made from a fine, white, porous powder containing tracking molecules, which act as markers for imaging.
The Society of Nuclear Medicine and Molecular Imaging has announced the 2014-2016 Wagner-Torizuka Fellowship recipients, which provide two-year fellowships to support Japanese physicians in early stages of their careers. The fellows focus on functional imaging using modalities such as PET/CT and SPECT/CT to elucidate pathophysiology of...
A new study using PET/CT with FDG-labeled leucocytes has detected infection in acute pancreatitis patients, distinguishing between infected and non-infected fluid collections. This non-invasive method may quickly rule out active infection and guide treatment decisions.
The 2014 SNMMI Annual Meeting showcased over 100 scientific sessions, 750 oral presentations, and 1,155 posters on molecular imaging technologies, clinical applications, and translational research. The meeting also featured notable lectures and awards, including the Henry N. Wagner Jr. Lectureship and the Benedict Cassen Prize.
The Journal of Medical Imaging has launched with freely accessible articles on new research in cancer diagnosis, image quality assessment, and other topics. The journal covers fundamental and translational research in medical imaging, spanning physics, tomographic reconstruction algorithms, computer-aided diagnosis, and more.
Researchers developed a new concept to improve molecular imaging by co-injecting an NEP inhibitor, resulting in up to 40 times increased circulating radiopeptides and improved tumor uptake. This approach could lead to higher diagnostic sensitivity and therapeutic efficacy for cancer patients.
A new study reveals that combining SPECT/CT with conventional bone scans can provide accurate information about the source of low back pain, leading to more effective treatment. The results show that patients who underwent this imaging approach experienced significantly better pain relief outcomes compared to those who did not.
A new antibody-based molecular imaging agent has been developed to target the HER3 receptor in breast cancer, which may lead to better diagnosis and treatment of high-risk cases. This approach could also help identify patients who would benefit from additional therapies.
Researchers used novel molecular imaging techniques to identify outlier cancer cells in the blood, which may indicate increased risk of metastases. The study found that less than 3% of circulating tumor cells showed abnormal glucose metabolism, suggesting potential aggressiveness.
A new study reveals that PET/MR imaging is highly effective in detecting coronary artery disease, outperforming traditional SPECT methods. The hybrid technique provides a comprehensive view of the heart, combining anatomical and functional information for more accurate diagnoses.
Researchers can conduct five different imaging studies in one scan with the Opti-SPECT/PET/CT system, providing comprehensive data on anatomy and physiological processes. The device allows for minimally invasive studies with a single dose of anesthesia, enabling scientists to develop new drug discovery methods.
A comprehensive clinical trial found that SPECT/CT imaging detected significantly more sentinel lymph node involvement with various types of cancers, including melanoma, breast carcinoma, and pelvic malignancies. This improved imaging technique has the potential to alter surgical planning and improve patient outcomes.
Researchers used a novel radioluminescence microscope to study single cells and found unexpected variation. The tool helps personalize radionuclide imaging by characterizing how radiotracers interact with cells.
A new study shows that administering G-CSF, a stem cell-stimulating therapy, early in the treatment of heart attack patients can improve their chances of survival and cardiac function. The therapy was found to increase blood flow, access to energy, and overall cardiac health.
A novel F-18 labeled tracer, F-18 THK5117, selectively binds to tau/neurofibrillary tangles in Alzheimer's brains. This study demonstrates the potential for F-18 THK5117 to develop new anti-dementia drugs.
Researchers link late-life depression to accelerated Alzheimer's disease development through beta-amyloid accumulation. Mild cognitive impairment patients with depressive symptoms showed higher amyloid deposition than non-depressed controls.
Siegel's work on PET has led to a major advance in nuclear medicine science, with a focus on evidence-based clinical trials and widespread acceptance of imaging studies. He is recognized for his visionary leadership in developing scientific methodology.
Researchers used SPECT and PET systems to detect inflammation involved in osteoarthritis, giving doctors a clear read on chronic pain and possible joint destruction. Radiolabeled anti-FAP antibodies showed significantly increased imaging agent uptake in inflamed joints.
A new molecular breast imaging protocol using a higher dose of Tc-99m filtered sulfur colloid has been shown to improve the detection of advanced breast cancer. Imaging performed the day prior to surgery was more sensitive than imaging on the day of surgery, detecting 76% versus 49% of cases with metastasized lymph nodes.
Researchers have developed a novel imaging agent, Tc-99m MIP-1404, which binds to PSMA enzyme in prostate cancer cells, enabling detection of metastases. The agent shows promise in detecting lesions more accurately than standard bone imaging.
Researchers developed a new dual agent scan that can differentiate between diabetic foot infection and a non-infectious complication in nerve-damaged joints. The technique combines agents targeting bone cell activity and immune response, allowing doctors to accurately diagnose and rule out unnecessary scans.
The new SPECT/MR system offers exceptional molecular imaging capabilities, reducing patient exposure to ionizing radiation and offering customized multifunctional imaging. It has the potential to diversify options for clinicians and biomedical investigators, with possible human trials in the near future.
A new method of dose calculation estimates radiation absorbed dose in radioimmunotherapy, predicting progression-free survival and enabling personalized treatment. Patients receiving higher doses (>200 centigray) had significantly longer progression-free survival.
Researchers at RIKEN have developed a new molecular imaging technology that visualizes both bio-metals and molecules simultaneously in a live mouse. This breakthrough technology is expected to provide insights into the complex interactions between metal elements and associated bio-molecules in diseases such as diabetes and cancer.
Two novel radiolabeled small molecules targeting PSMA have excellent potential for diagnosing and staging prostate cancer. The imaging agents showed a high sensitivity of lesion detection in bone, soft tissue, and the prostate gland.
Researchers found that the lateral and orbital regions of the frontal cortex interact during drug-related cues, suggesting that addiction may result from abnormal brain circuitry. The study's findings suggest that a therapeutic approach for addiction could be developed by targeting this neural circuit.
Researchers have achieved two significant 'firsts' in studying the human cardiac protein alpha-tropomyosin, which controls heart contraction on every beat. By direct imaging, they found individual molecules to be roughly 40 nanometers long and demonstrated their flexibility, establishing a baseline for normal protein function.
A new molecular imaging method using PET/CT with Gallium-68 DOTATATE identifies hormonally active tissues, allowing clinicians to re-evaluate patient management. This technique changes treatment plans in over 35% of patients, saving them from unnecessary surgeries.
Research finds that combining molecular imaging with computed tomography (CT) can reduce patient radiation dose. By using just one CT scan for multiple PET studies, researchers lower radiation exposure and improve image quality.
Researchers develop a molecular imaging tool to detect coronary artery disease, which is caused by atherosclerosis. The technique measures the coronary flow reserve, or CFR, and calculates precise dilation of blood vessels at rest and under stress.
Piramal Imaging will present data from five florbetaben studies, including a pivotal Phase III trial that will provide the basis for regulatory submission later this year. The company is developing an innovative and proprietary tracer portfolio to address major clinical needs in Alzheimer's disease and other conditions.
Researchers at Berkeley Lab have provided the first experimental determination of the pathways by which electrical charge is transported in organic thin films. By chemically modifying these films, they show improved conductance and pave the way for future organic electronic devices with better performance.
A new review of imaging studies confirms that positron emission tomography (PET) safely and accurately detects dementia, including the most common form among the elderly, Alzheimer's disease. The study found that combining PET with a biomarker called 18F-FDG can pinpoint key areas of metabolic decline in the brain indicating dementia.
A new PET technique using FLT-PET has shown highly sensitive imaging for patients with mantle cell lymphoma, a relatively rare and devastating blood cancer. The study found that all cancerous lesions were very highly visible using FLT-PET, providing a powerful biomarker for MCL.