Articles tagged with Molecular Imaging
A literature review published by the Society of Nuclear Medicine and Molecular Imaging reveals how nuclear medicine brain imaging can help evaluate biological changes causing chemotherapy-related cognitive impairment. The findings confirmed the impact of chemotherapy drugs on cognitive function and highlighted the utility of various SP...
A new article in The Journal of Nuclear Medicine explores the potential for using ChatGPT, an artificial intelligence chatbot, in nuclear medicine and molecular imaging. The authors discuss the strengths and weaknesses of current AI bots and highlight the benefits of collaborating with AI allies to cope with increasing workloads.
Current radiotherapy contouring guidelines often miss lesions in the prostate bed, leading to unnecessary tissue irradiation. PSMA PET mapping reveals that nearly a third of patients experience disease progression within 10 years after radical prostatectomy.
A novel lensless radiomicroscope has been developed for nuclear medicine imaging, offering high-resolution images of cells with a field of view over 500 times larger than current technology. The instrument is made from off-the-shelf parts and costs less than $100, making it accessible to more labs.
A new radiotracer successfully detected 100% of primary tumors across multiple cancer types, outperforming the current standard. It also showed promise in detecting lymph node and distant metastases, offering a promising alternative for diagnosis and treatment.
The NCCN Annual Conference will debut a new hybrid format featuring in-person events at a new venue, allowing for hallway conversations and networking opportunities. The conference will also showcase more than 100 abstract poster presentations on various oncology-related categories.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) have published a new procedure standard/practice guideline for somatostatin receptor (SSTR) PET imaging in patients with neuroendocrine tumors. The guideline focuses on improved sensitivity, lower radiation dose, and sh...
Researchers at Ruhr University Bochum developed a new digital imaging method using artificial intelligence and infrared imaging to determine microsatellite status in colon cancer. This approach enables fast, label-free, and automated detection of the biomarker, which is crucial for personalized medicine.
A novel nuclear medicine imaging protocol, dual-phase amyloid PET, can assess both amyloid deposition and neurodegeneration with a single tracer injection, cutting costs and radiation exposure. The protocol was shown to be comparable in distinguishing patients with neurodegenerative diseases from controls.
Researchers developed high-throughput Raman microscope for rapid large-area imaging hundreds of times faster than traditional approach. The new technique enables label-free molecular analysis and multiplex chemical imaging, holding promise for efficient medical diagnoses and drug development.
A new study published in The Journal of Nuclear Medicine found that e-cigarette users have greater lung inflammation than cigarette smokers and non-smokers. The study used PET imaging to compare lung inflammation between e-cigarette users and cigarette smokers, revealing a unique inflammatory response in the lungs.
Scientists used multi-isotope imaging mass spectrometry to identify key contributors to blood vessel obstruction in PAH. The study reveals proline and glucose play a crucial role in forming excess scar tissue, which obstructs blood flow.
Researchers at Beckman Institute for Advanced Science and Technology will use a unique combination of MRI and mass spectrometry imaging techniques to study Alzheimer's disease on an unprecedented scale. By capturing detailed chemical information, they aim to understand the molecular-level changes that occur in aging brains and develop ...
A team at Harvard Medical School has created large-scale 2D and 3D spatial maps of colorectal cancer, layering molecular information on top of histological features. The maps reveal the interconnectedness of traditional isolated structures in colorectal cancer, allowing researchers to explore differences within individual tumors.
A study found that nearly half of Medicare patients with non-small cell lung cancer do not receive the recommended FDG PET/CT imaging prior to radiation therapy, leading to decreased overall and cancer-specific survival rates. This lack of adherence is linked to greater mortality rates.
A novel imaging agent, 68Ga-FAPI, has been shown to reduce the number of false-positive PET/CT findings among cancer patients recently vaccinated for COVID-19. This can help prevent costly follow-up and false management decisions for cancer patients.
PSMA PET/MRI successfully determines prostate cancer likelihood of return within two years after prostatectomy, aiding treatment decisions. High uptake in primary lesion and metastasis are associated with rapid recurrence.
A new study found that approximately three percent of all bone scan patients have markers of cardiac amyloidosis, which can lead to heart failure and increased mortality. The research highlights the importance of early diagnosis and treatment, as well as potential automated detection methods using machine-learning algorithms.
Researchers developed a new spatial-omics technology called DISCO-MS to detect early molecular changes in diseases. This approach allows for the characterization of diseased cells in intact tissues, revealing new biomarkers and therapeutic targets for conditions like Alzheimer's disease and atherosclerosis.
Researchers combined ultrafast imaging with 3D atomistic simulation to study femtosecond laser ablation. The technique revealed the ablation mechanism of bulky gold at different excitation energy flow densities, providing guidance for material fabrication.
Researchers discovered that toxins produced by Vibrio bacteria hijack cell processes, redirecting key proteins into "roads to nowhere". This abnormal filament formation wastes cell resources and raises questions about its potential role or necessity.
A new molecular imaging radiotracer, <sup> 68 </sup> Ga-PentixaFor, demonstrates high image contrast in various cancers, including hematologic malignancies and small cell lung cancer. This agent targets the C-X-C motif chemokine receptor 4 (CXCR4), which is a predictor of poor prognosis in cancer patients.
A new study published in The Journal of Nuclear Medicine found that a PET/MRI machine learning model can reliably distinguish between patients with and without lymph node metastases. This breakthrough technology has the potential to eliminate sentinel lymph node biopsy, a common procedure for breast cancer treatment.
Researchers are developing a comprehensive cell atlas for the human brain, which would cover billions of cells and provide a holistic description of its properties. Advanced visualization techniques have been developed to catalog brain regions and cell types, enabling better resolution and accuracy in studying neural circuits.
A team of researchers has developed a prototype of a quantum microscope that can see electric currents, detect fluctuating magnetic fields, and even see single molecules on a surface. The microscope uses atomic impurities and van der Waals materials to achieve high resolution sensitivity and simultaneous imaging of magnetic fields and ...
Scientists have successfully created two types of light-driven molecular motors that can both rotate and fluoresce in the same molecule. This achievement demonstrates that these motors can be designed to control various functions using light energy, paving the way for potential applications in biomedical imaging and cellular processes.
The Beckman Institute has established a new national collaborative Biomedical Technology Research Resource to develop label-free optical imaging technologies. The center aims to create optical and computational imaging technologies that can serve as a resource for clinicians and researchers.
Researchers at La Jolla Institute for Immunology have developed a new therapy for Lassa fever using a trio of rare human antibodies that can block viral infection. The therapy, called Arevirumab-3, was tested in non-human primates and proved 100% effective in treating the disease.
A study published in European Journal of Nuclear Medicine and Molecular Imaging identified specific genetic markers associated with high risk of head and neck cancer. The research used DNA sequencing, artificial intelligence, and positron emission tomography to analyze cellular characteristics of tumors. These markers can facilitate mo...
A new radiotracer, 18F-SMBT-1, detects overexpressed monoamine oxidase-B in cognitively unimpaired individuals with high beta amyloid levels, a key early sign of Alzheimer's disease. The agent shows increased binding to reactive astrocytes, suggesting its potential as a surrogate marker for detecting Alzheimer's disease.
Plant cells use a complex 'hub and spoke' system to recycle organelles, involving specialized vesicles and molecular mechanisms. The discovery sheds light on the role of autophagy in plant stress tolerance.
Researchers have discovered that zinc ions tune the ability of human serum albumin to prevent α-synuclein aggregation, a process linked to Parkinson's disease. Zinc binding alters HSA's chaperone function, blunting fibril formation and slowing down protein deposition that can lead to neurodegeneration.
Researchers successfully visualized systemic joint involvement in patients with autoimmune arthritis using ultra-low dose total body PET/CT scans. The scans showed high agreement with standard joint-by-joint rheumatological evaluations and a moderate to strong correlation with rheumatological outcome measures.
A new genetic test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, improving the accuracy of diagnoses compared to current guidelines. The test distinguishes between different types of cysts with higher accuracy than traditional forms of surveillance and current pancreatic cyst guidelines.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A novel PET radiotracer has been developed to assess tumor aggressiveness in neuroendocrine neoplasms, providing valuable information for personalized care. High uPAR expression was associated with a worse prognosis, making it a potential target for therapy.
A study conducted at the University of Zurich has identified a key gene network responsible for severe tooth enamel defects. The researchers found that mutations in the Adam10 molecule lead to disorganization of ameloblasts and severe defects in both structure and mineral composition of enamel.
Researchers developed a machine learning algorithm that can generate a continuous 3D model of cells from a partial set of 2D images. The neural field network learns a mapping from spatial coordinates to physical quantities, allowing for smooth zooming and no pixelation.
The Journal of Nuclear Medicine Technology special issue highlights the potential of theranostics to tailor cancer treatment to individual patients. The innovation uses targeted radiopharmaceuticals for both diagnosis and treatment of tumors.
A new study shows that PSMA PET/CT imaging can change treatment plans for nearly 50% of patients with prostate cancer recurrence after radical prostatectomy. The imaging technique detected disease in 46.9% of patients, leading to major changes in treatment plans, including recommendations for additional treatments.
The report explores diffuse optical imaging methods applicable to noninvasive human studies, including near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). It introduces state-of-the-art technologies and software, exploring their impact on neuroscience and clinical applications.
Researchers at Texas A&M University created a device that harnesses quantum fluctuations to enhance spectroscopy results in Brillouin microscopy, increasing image clarity and accuracy. The new source significantly improves the signal-to-noise ratio, allowing for better visualization of biological structures and properties.
The IQ-Sense project brings together researchers from two German universities to develop and demonstrate integrated quantum sensors for spectroscopic and imaging applications. The project will enable precise measurements of temperature, pressure, magnetic or electric fields, crucial in various scientific and medical fields.
The Journal of Nuclear Medicine publishes a first-hand account of daily nuclear medicine practice in Kyiv, Ukraine, where physicians face constant bombing and shelling. Despite the challenges, Dr. Kmetyuk expresses gratitude for international support and hope for the future of Ukrainian medical professionals.
Researchers have created a photoacoustic imaging endoscope probe that can fit inside a medical needle, resolving subcellular-scale tissue structural and molecular information in 3D. The device has an ultra-thin design, allowing for real-time 3D characterization of tissue during minimally invasive procedures.
Researchers have developed novel 3D atomic force microscopy (AFM) probes with improved designs, materials, and production processes. The new probes enable high-resolution, high-speed AFM imaging under air and liquid environments, opening doors for advanced applications in fields like biomedical sciences.
A retrospective study of molecular breast imaging (MBI) findings suggests that the MBI lexicon's lesion descriptors can inform interpretation and guide the incorporation into the BI-RADS Atlas. The study found high positivity rates for malignancy among mass lesions, those with marked uptake intensity, and certain distribution patterns.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A University of Illinois research effort has accelerated imaging techniques to visualize small molecules clearly, enabling better understanding of their chemical processes and synthesis. The team's discovery unlocks potential in everyday life applications, from plastics to pharmaceuticals.
Researchers will develop and test new beacon molecules and imaging equipment to improve the detection and removal of non-small-cell lung cancers, aiming to reduce unnecessary tissue removal. The goal is to enhance surgical outcomes and improve patient care.
Current guidelines for salvage radiation treatments in patients with local recurrence of prostate cancer should be updated to consider information from PSMA PET imaging. PSMA PET is effective in identifying recurrences partially or fully outside the clinical target volume, suggesting its value for therapy planning.
A new PET imaging agent, <sup>68</sup> Ga-FAPI-46, has been shown to predict the severity of cardiac remodeling after a heart attack by identifying active fibrosis. This biomarker has potential to aid in diagnosis and treatment selection for patients with heart failure.
A new SPECT imaging system performs scans 10-100 times faster than current systems, offering better image quality and increased patient throughput. The self-collimation concept improves traditional SPECT imaging by reducing scan time and radiation exposure.
A newly developed small-molecular radiopharmaceutical pair has successfully visualized and treated melanoma in a preclinical study. The theranostic approach targets metabotropic glutamate receptor 1 (GRM1) found in many human solid tumors.
Andrei Iagaru has received the inaugural Sam Gambhir Trailblazer Award from the Society of Nuclear Medicine and Molecular Imaging (SNMMI) for his outstanding contributions to transformative research and exceptional mentorship. He is recognized for his work in PET/MRI, PET/CT, and targeted radionuclide therapy.
Cathy Sue Cutler, PhD, was elected vice president-elect of SNMMI, focusing on securing funding for nuclear medicine services. She aims to generate training opportunities for SNMMI members on theranostics and educate the public on the value of nuclear medicine.
Schwaiger received the SNMMI Georg Charles de Hevesy Nuclear Pioneer Award for his significant work in multimodal imaging and development of novel quantitative methods. His research interests included oncologic PET, thyroid endocrine, and neuroendocrine diseases.
Helen Nadel, MD, FRCPC, has been named president-elect of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). She plans to address issues such as global communication, government and industry relationships, and diversity initiatives. With over 30 years of SNMMI membership, Nadel brings extensive experience to her role.
The Society of Nuclear Medicine and Molecular Imaging has recognized 15 new SNMMI Fellows, including past president Richard Wahl, MD, for their excellence in volunteer service, scientific discovery, and clinical practice. The SNMMI Fellowship is one of the most prestigious formal recognitions available to long-time members.
Munir Ghesani, MD, has been elected as president of SNMMI for his commitment to improving patient access to nuclear medicine scans. He plans to address issues such as reimbursement and regulatory approvals to grow the field of nuclear medicine.