Articles tagged with Molecular Imaging
A novel PET imaging technique can detect active inflammation in the body before clinical symptoms arise, using a PET tracer that binds to proteins present on activated immune cells. This makes it easier for physicians to correctly diagnose and treat patients with rheumatoid arthritis.
Researchers developed a compact microscope using a single photon avalanche diode array detector, enabling super-resolution imaging with improved signal-to-noise ratio and spatial resolution. The system also combines fluorescence lifetime measurements for enhanced structural specificity.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
A novel imaging approach has been shown to accurately identify sub-types of primary aldosteronism, an adrenal gland disorder. The technique provides a clearer picture of the adrenal glands, helping doctors decide whether surgery is necessary.
A novel PET imaging agent has been found to effectively identify medullary thyroid cancer (MTC) in preclinical and clinical studies. The compound demonstrates favorable tumor uptake and improved activity clearance from off-target tissues, potentially enhancing lesion detection and enabling targeted MTC radioligand therapy.
MIT researchers have developed a new method to track cell differentiation and study long-term processes like cancer progression or embryonic development. They used noninvasive Raman spectroscopy to monitor embryonic stem cells as they differentiated into multiple cell types over several days.
Researchers developed a method to observe single protein vibrational spectra using near-field optical microscopy, enabling detailed analysis of extremely small samples. The technique represents a major breakthrough for ultra-high sensitivity and super-resolution infrared imaging, as well as single-molecule vibrational spectroscopy.
A new study introduces a machine learning-aided non-invasive imaging technique that can rapidly visualize liver fat distribution, enabling early diagnosis and treatment of liver diseases. The method uses near-infrared hyperspectral imaging and machine learning to differentiate between types of lipids in the liver.
The Society of Nuclear Medicine and Molecular Imaging has published a new procedure standard/practice guideline for estrogen receptor imaging of breast cancer patients using FES PET. The guideline aims to promote the appropriate use of FES PET and enhance research, providing advantages in assessing tumor ER expression and predicting re...
A new study found that Ga-68 FAPI PET imaging can effectively detect and stage pancreatic cancer, outperforming existing methods. The imaging modality also showed potential for future targeted radiopharmaceutical therapies.
A new PET imaging tracer has been developed to detect a common cancer gene mutation with high accuracy. The tracer targets the KRAS G12C protein, allowing for early identification of patients who can benefit from targeted therapy.
The Janelia Fluor dyes have become a staple in biology labs worldwide, and the team has now expanded their spectrum with a new set of far-red shifted dyes that can penetrate deeper into tissue. The researchers developed a novel chemistry to synthesize these dyes, enabling them to create dozens of functional versions relatively quickly.
Researchers at Purdue University developed a novel AI engine to control and optimize optical microscopes, enabling 3D ultrastructure visualization of the brain circuitry with nanometer resolution. This technology has the potential to shed light on human development and disease, particularly autism and Alzheimer's disease.
Researchers create new methods to visualize and understand samples with increased accuracy and sensitivity. The development of photothermal microscopy, also known as VIP microscopy, enables scientists to probe specific chemical bonds in a specimen, allowing them to map molecules at low concentrations without dye labeling.
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
Researchers have developed a novel PET radiotracer that enables early detection of inflammatory bowel disease (IBD) with high spatial and molecular specificity. The imaging tool targets the IBD biomarker IL12/23p40, providing detailed information for accurate diagnosis and treatment.
Scientists develop antiaromatic molecules that exhibit absorption and fluorescence bands in the near-infrared region, enabling deep biological imaging and photothermal therapy. This breakthrough holds potential for diverse NIR luminescent materials and applications in fields like healthcare, optoelectronics, and materials science.
A study found that bone scans overstage prostate cancer at initial staging, leading to potential withholding of definitive therapy from patients. PSMA PET is more accurate than CT and bone scans for staging patients with prostate cancer.
A team of researchers has developed a novel experimental system to simultaneously measure the mechanical properties and internal structure of rubber-like materials. The study found that strain within these materials is non-uniform, depending on the shape and size of composite particles.
Regular cannabis users show a greater understanding of others' emotions, while their brains exhibit stronger connections between regions related to emotional sensing. This study suggests potential therapeutic applications for conditions involving social interaction deficits.
Researchers created single-chain nanoparticles with thermoresponsive properties, which can be used to produce high-resolution internal images of the human body. These particles create a rich optical contrast that can be used to examine tumors more closely.
A new AI tool provides fully automated, easy-to-use evaluation of brain tumors using amino acid PET scans. The deep learning-based segmentation algorithm assesses treatment response with quality comparable to that of an experienced physician.
Cells employ a protective mechanism to preserve orphan ribosomal proteins during heat shock, allowing for rapid recovery once the stress subsides. This study uses lattice light sheet 4D imaging and pulse labeling with HaloTag dye to visualize these processes in real-time.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
Researchers found a single dose of ADC therapy combined with lovastatin reduced tumor volume rates similar to multiple doses in preclinical settings. Immuno-PET scans also monitored HER2 tumor levels after treatment, offering real-time insights into therapy response and potential personalized cancer treatments.
A phase 2 clinical trial found that serial blood tests can identify patients who benefit from additional immunotherapies, suggesting a potential early marker of treatment response. The study also showed that ctDNA analyses correlated with tumor size and survival, making it a promising strategy for guiding therapy.
The study developed a highly accurate AI model for fully automated cancer detection, including small and difficult-to-detect tumors. The model could detect visually imperceptible cancer from normal-appearing pancreases substantially early before clinical diagnosis, with a median of 438 days.
A new tau PET radiotracer, 18F-SNFT-1, demonstrates high sensitivity and specificity in identifying Alzheimer's disease. This improved tracer enables earlier diagnosis and potential therapeutic interventions.
A new study explores how alpha-synuclein disrupts metabolic processes in neurons. Researchers used NanoSIMS imaging techniques to visualize isotopic variations and found changes in carbon turnover, suggesting increased metabolic demands on affected cells.
The UCLA-led team has developed a solution to improve cryo-electron microscopy's imaging capabilities for smaller protein molecules, enabling higher-resolution images. This advance is expected to help researchers identify specific locations on proteins that can be targeted for therapeutic purposes.
A new imaging agent, 68Ga-ABY-025, can predict early metabolic response to HER2-targeted treatment in HER2-positive metastatic breast cancer patients. Whole-body PET/CT enables quantification of HER2 expression and predicts metabolic response, potentially sparing patients from unnecessary side effects.
A study comparing PI-RADS 2.0 and 2.1 found no significant differences in upgrade (29% vs. 22%) or downgrade (19% vs. 21%) rates from targeted biopsy to radical prostatectomy, suggesting no improvement in prostate cancer grade assessment with the latest PI-RADS update.
Researchers developed a new diffraction-gated real-time ultrahigh-speed mapping (DRUM) camera that captures dynamic events in a single exposure at 4.8 million frames per second. The camera uses off-the-shelf components and is fast enough to capture highly dynamic biomedical processes or enable high-speed lidar systems.
Micro4PAP, a fast-scan Brillouin Microscope, allows for non-destructive, label- and contact-free imaging of biological samples. The device enables sub-millisecond acquisition time, suitable for in-vivo measurements in living cells, promoting early disease detection and diagnosis.
Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.
The Society of Nuclear Medicine and Molecular Imaging has issued a new consensus statement to standardize the selection and management of patients with metastatic castrate-resistant prostate cancer (mCRPC) treated with Lu-177 PSMA radionuclide therapy. The statement recommends performing PSMA PET within three months of treatment or sin...
The research team created a multi-spectral, super-low-dose photoacoustic microscopy system with improved sensitivity, enabling new applications and clinical translation. The system achieved up to capillary-level or sub-cellular resolution at greater depths than traditional optical microscopy methods.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
A study found that PSMA PET/CT can accurately diagnose advanced prostate cancer in elderly patients without the need for a biopsy. The procedure reduced the number of biopsies and associated complications, while providing clinical suspicion-based staging data.
Researchers at UBC Okanagan's Integrated Optics Laboratory develop imaging systems that apply terahertz radiation, enabling fast and accurate characterization of biological specimens. This technology holds promise for improving diagnostic imaging and detecting carcinogenesis.
A new imaging technique, tau PET, has been shown to predict cognitive decline in Alzheimer's patients with greater accuracy than current methods. This breakthrough could lead to earlier diagnosis and treatment, improving patient outcomes.
A new complex-domain neural network enhances large-scale coherent imaging by exploiting latent coupling information between amplitude and phase components. The technique reduces exposure time and data volume significantly while maintaining high-quality reconstructions.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
Metalenses have been developed with differentiated design principles to eliminate chromatic aberration. By merging bright spots into a single focusing spot, researchers achieved an efficiency of up to 43% and demonstrated the versatility of their approach for various optical applications.
PSMA PET imaging provides prognostic information on cancer recurrence risk before treatment, improving personalized treatments and guiding surgical plans. The tool outperforms current standard tests in predicting biochemical recurrence, a critical factor in determining cancer-specific mortality.
A newly discovered radionuclide-based agent (CB-2PA-NT) has shown high tumor uptake, sustained retention, and contrast in preclinical models. Targeting neurotensin receptors, CB-2PA-NT expands precision medicine for cancer diagnosis and treatment.
A novel PET perfusion radiotracer, 18F-flurpiridaz, demonstrates high diagnostic efficacy for obese patients with coronary artery disease, outperforming traditional imaging methods. The study showed improved sensitivity and specificity in diagnosing significant CAD, even at lower radiation doses.
A study using molecular imaging found that individuals with obesity respond differently to food cues than normal-weight individuals, with altered connectivity between brain networks. The research offers valuable insights into potential medical interventions for obesity, including novel drug treatments and behavioral therapies.
A study found that monitoring early-response biomarkers enables personalized dosing in prostate cancer treatment, improving patient outcomes. The approach allowed patients to take
Helen Nadel, MD, FRCPC, has been named SNMMI President, aiming to raise awareness of and access to nuclear medicine, molecular imaging, and theranostics. She will focus on precision health, standardization, diversity, and increasing qualified professionals in the field.
Cathy Sue Cutler is elected SNMMI president-elect to tackle talent shortages, funding issues and education gaps in the field. She aims to attract talent, enhance training opportunities and educate practitioners on theranostics for personalized medicine.
The Society of Nuclear Medicine and Molecular Imaging has recognized ten new SNMMI Fellows, including Virginia Pappas as an honorary Fellow, for their excellence in volunteer service and scientific discovery. The SNMMI Fellowship is among the most prestigious formal recognitions available to long-time members.
Dr. Peter J. H. Scott has made significant contributions to radiopharmaceutical sciences through his development of new methods and technologies. He has also received numerous awards for his research, including the Sam Gambhir Trailblazer Award.
SNMMI has elected Jean-Luc C. Urbain as Vice President-Elect, who will focus on bringing new precision oncology nuclear therapies to the clinic. He aims to implement SNMMI's strategic plan, promoting its brand globally and increasing membership and financial support.
Researchers developed a computational technique combining genomic and tau PET imaging data to identify four subtypes of Alzheimer's disease. The integrated approach also revealed top genes associated with each subtype. This personalized diagnostic technique has potential for broad utility across various diseases.
Umar Mahmood, a prominent researcher and leader in the field of nuclear medicine and molecular imaging, has been awarded the first annual SNMMI Minoshima-Pappas Transformational Leadership Award. His work focuses on developing new imaging methods for disease process examination and early therapeutic response assessment.
Dmitry Beyder has been elected as the president of the SNMMI-TS for 2023-24, aiming to increase technologists' roles in providing theranostics and nuclear medicine therapy. He brings extensive experience from various positions in the field.
Henry VanBrocklin, a professor at the University of California, San Francisco, has been recognized for his decades-long research on novel radiopharmaceuticals and their applications in medical imaging. He is being honored with the prestigious Paul C. Aebersold Award for his contributions to nuclear medicine.
SNMMI-TS elects Julie Dawn Bolin as president-elect, focusing on educating students about nuclear medicine careers and improving professional development. Bolin brings extensive experience in nuclear medicine technology and education.
A new PET radiotracer called <sup> 18 </sup> F-Cholestify has been developed to visualize metabolic cholesterol clearance in the brain. The tracer successfully visualized brain cholesterol metabolism in rats, non-human primates, and humans, showing promising results for studying neurodegenerative diseases.