Articles tagged with Molecular Imaging
Researchers have pinpointed the cellular machinery behind zebrafish's ability to rapidly change the color of their characteristic stripes from blue to yellow when distressed. By precisely altering the orientation of light-reflecting crystals, the fish can change the color of their stripes across the entire length of their body in seconds.
A study found that measuring liver attenuation at a depth of 6 cm from the skin yields better results for diagnosing hepatic steatosis. Technical factors like reverberation, blank color regions, and acoustic shadowing can affect imaging accuracy.
A team of visionaries at the Carney Institute developed 3D-printed brain and spinal cord implants, revolutionizing surgical implantations and optical access. Bioluminescence imaging overcomes limitations of traditional fluorescent microscopy, providing unprecedented observation of neural and vascular activity.
A new PET imaging biomarker, Gal-1, has been identified to predict the tumor responses before starting immune checkpoint blockade therapy. This enables targeted interventions and improves patient outcomes by facilitating patient stratification and optimizing immunotherapy.
MIT engineers create technique to image bioluminescent molecules in deep tissue with high resolution, enabling detailed studies of brain cell development and communication. The method uses engineered blood vessels that dilate in response to light, allowing researchers to pinpoint the source of light.
Scientists have developed strong-field photoelectron holography to visualize electron dynamics within molecules, revealing details of internuclear separation and atomic behavior.
A team of Harvard researchers, led by Jeff Lichtman, has created the largest synaptic-resolution, 3D reconstruction of a piece of human brain to date. The dataset contains 1,400 terabytes of data on neural connections in a tiny piece of human temporal cortex.
A new supplement to The Journal of Nuclear Medicine highlights China's significant advances in research and development, including long-field PET scanners and innovative theranostic concepts. The supplement aims to inform international collaborations and multicenter studies, featuring top experts in molecular imaging and theranostics.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
A novel investigational PET imaging agent, <sup> 68 </sup> Ga-DPI-4452 (Debio 0328), has been shown to provide rapid and accurate visualization of lesions in clear cell renal cell cancer patients. The agent offers a superior alternative to standard CT imaging and could potentially be used as part of a theranostic pair.
Researchers have developed a novel rigid endoscope system for visible-to-OTN hyperspectral imaging, enabling non-destructive imaging and visualization of lesions in normal tissues. The system demonstrated high accuracy in classifying molecular vibration information of various targets with an OTN wavelength range.
The IRIS beamline at BESSY II has been extended with a nanoscope, enabling the imaging and spectroscopy of structures smaller than a thousandth of a human hair. This upgrade allows researchers to study biological systems, catalysts, polymers, and quantum materials with unprecedented resolution.
A novel SPECT/CT acquisition method utilizing lead-212 (212Pb) can accurately detect radiopharmaceutical biodistribution in a convenient manner. This technique has the potential to change practice and increase access for patients around the world by providing more precise treatment options.
A team at the University of Tokyo has constructed an improved mid-infrared microscope that enables them to see the structures inside living bacteria at the nanometer scale with a resolution of 120 nanometers. This breakthrough can aid multiple fields of research, including into infectious diseases.
A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
A new 'rechargeable nanotorch' allows researchers to track the movement of cell-based microrobots in real-time, using afterglow luminescence imaging. The nanotorches can be recharged non-invasively with near-infrared light, enabling long-term tracking and potential applications in cancer treatment.
A new study found that PET/MRI can accurately classify prostate cancer patients and help avoid unnecessary biopsies. The PRIMARY scoring system showed that over 80% of unnecessary biopsies could be avoided while missing only 12.5% of clinically significant prostate cancer cases.
Researchers developed a novel theranostic platform that combines PET imaging and therapeutic radionuclides to detect and treat ovarian cancer. The system uses the huAR9.6 antibody to target the MUC16 protein, showing promise for improved patient survival rates.
Researchers at MIT have discovered a new way that neutrons can interact with materials, potentially providing insights into material properties and quantum effects. The discovery involves the binding of neutrons to nanoscale atomic clusters called quantum dots.
Researchers at Duke University have developed a novel imaging platform to visualize the growth of the placenta throughout pregnancy. The approach provides detailed images of blood flow and oxygen metabolism, shedding light on how lifestyle factors and health complications affect placental development.
Researchers have identified a crucial interface in a mutated protein that drives lung cancer growth, which could act as a target for more effective treatments. The study used advanced laser imaging techniques to provide unprecedented details of the protein's structure and interactions.
Researchers have developed a new method to trigger and image seizures in epilepsy patients, allowing for real-time data collection to tailor epilepsy surgery. This method is clinically feasible, convenient, and spares resources, providing valuable information for successful surgeries.
A novel transparent ultrasonic transducer (TUT) developed by POSTECH researchers offers exceptional optical transparency and maintains acoustic performance, surpassing conventional limitations. This breakthrough enables high-depth-to-resolution ratios for ultrasound imaging, with applications in various medical devices and fields.
A recent study using cutting-edge super-resolution microscopy has shed light on the role of cohesin in cell division. The research revealed multiple populations of cohesin complexes, each playing a specific role in faithful genetic material segregation during cell division.
Researchers developed a novel PET tracer that can map fructose metabolism, differentiating diseased tissues from healthy ones. This non-invasive technique has the potential to detect diseases such as stroke, brain metastases, and heart attacks more sensitively.
Researchers used mass spectrometry imaging and single-cell metabolomics with deep learning to create 3D molecular maps of the brain, enabling a better understanding of chemical interactions within brain tissue. This breakthrough could help address currently intractable neurological diseases.
New research reveals that radioguided surgery can effectively detect and remove metastatic pelvic lymph nodes in newly diagnosed prostate cancer patients. The procedure targets the prostate-specific membrane antigen, improving nodal staging to guide treatment recommendations.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Researchers have published novel spatial omics algorithms and tools in GigaScience and GigaByte journals to analyze biological data-based spatial information. These new methods enable the discovery of spatial domains, improvement of data quality, and better clustering of cells.
Researchers have created fluorescent, colour-changing dyes that can visualise multiple distinct biological environments using only one dye. These dyes enable 'time travel' within cells by allowing scientists to distinguish between cellular and delivery vessel environments in real-time. The breakthrough has significant implications for ...
A novel imaging technique, low-dose positron emission mammography (PEM), shows promise in transforming breast cancer detection by providing high sensitivity and low false positive rates. PEM could potentially decrease healthcare costs and reduce unnecessary procedures for patients with dense breasts.
A novel PET imaging technique can detect active inflammation in the body before clinical symptoms arise, using a PET tracer that binds to proteins present on activated immune cells. This makes it easier for physicians to correctly diagnose and treat patients with rheumatoid arthritis.
Researchers developed a compact microscope using a single photon avalanche diode array detector, enabling super-resolution imaging with improved signal-to-noise ratio and spatial resolution. The system also combines fluorescence lifetime measurements for enhanced structural specificity.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
A novel imaging approach has been shown to accurately identify sub-types of primary aldosteronism, an adrenal gland disorder. The technique provides a clearer picture of the adrenal glands, helping doctors decide whether surgery is necessary.
A novel PET imaging agent has been found to effectively identify medullary thyroid cancer (MTC) in preclinical and clinical studies. The compound demonstrates favorable tumor uptake and improved activity clearance from off-target tissues, potentially enhancing lesion detection and enabling targeted MTC radioligand therapy.
MIT researchers have developed a new method to track cell differentiation and study long-term processes like cancer progression or embryonic development. They used noninvasive Raman spectroscopy to monitor embryonic stem cells as they differentiated into multiple cell types over several days.
Researchers developed a method to observe single protein vibrational spectra using near-field optical microscopy, enabling detailed analysis of extremely small samples. The technique represents a major breakthrough for ultra-high sensitivity and super-resolution infrared imaging, as well as single-molecule vibrational spectroscopy.
A new study introduces a machine learning-aided non-invasive imaging technique that can rapidly visualize liver fat distribution, enabling early diagnosis and treatment of liver diseases. The method uses near-infrared hyperspectral imaging and machine learning to differentiate between types of lipids in the liver.
The Society of Nuclear Medicine and Molecular Imaging has published a new procedure standard/practice guideline for estrogen receptor imaging of breast cancer patients using FES PET. The guideline aims to promote the appropriate use of FES PET and enhance research, providing advantages in assessing tumor ER expression and predicting re...
A new study found that Ga-68 FAPI PET imaging can effectively detect and stage pancreatic cancer, outperforming existing methods. The imaging modality also showed potential for future targeted radiopharmaceutical therapies.
A new PET imaging tracer has been developed to detect a common cancer gene mutation with high accuracy. The tracer targets the KRAS G12C protein, allowing for early identification of patients who can benefit from targeted therapy.
The Janelia Fluor dyes have become a staple in biology labs worldwide, and the team has now expanded their spectrum with a new set of far-red shifted dyes that can penetrate deeper into tissue. The researchers developed a novel chemistry to synthesize these dyes, enabling them to create dozens of functional versions relatively quickly.
Researchers at Purdue University developed a novel AI engine to control and optimize optical microscopes, enabling 3D ultrastructure visualization of the brain circuitry with nanometer resolution. This technology has the potential to shed light on human development and disease, particularly autism and Alzheimer's disease.
Researchers create new methods to visualize and understand samples with increased accuracy and sensitivity. The development of photothermal microscopy, also known as VIP microscopy, enables scientists to probe specific chemical bonds in a specimen, allowing them to map molecules at low concentrations without dye labeling.
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
Researchers have developed a novel PET radiotracer that enables early detection of inflammatory bowel disease (IBD) with high spatial and molecular specificity. The imaging tool targets the IBD biomarker IL12/23p40, providing detailed information for accurate diagnosis and treatment.
Scientists develop antiaromatic molecules that exhibit absorption and fluorescence bands in the near-infrared region, enabling deep biological imaging and photothermal therapy. This breakthrough holds potential for diverse NIR luminescent materials and applications in fields like healthcare, optoelectronics, and materials science.
A study found that bone scans overstage prostate cancer at initial staging, leading to potential withholding of definitive therapy from patients. PSMA PET is more accurate than CT and bone scans for staging patients with prostate cancer.
A team of researchers has developed a novel experimental system to simultaneously measure the mechanical properties and internal structure of rubber-like materials. The study found that strain within these materials is non-uniform, depending on the shape and size of composite particles.
Regular cannabis users show a greater understanding of others' emotions, while their brains exhibit stronger connections between regions related to emotional sensing. This study suggests potential therapeutic applications for conditions involving social interaction deficits.
Researchers created single-chain nanoparticles with thermoresponsive properties, which can be used to produce high-resolution internal images of the human body. These particles create a rich optical contrast that can be used to examine tumors more closely.
A new AI tool provides fully automated, easy-to-use evaluation of brain tumors using amino acid PET scans. The deep learning-based segmentation algorithm assesses treatment response with quality comparable to that of an experienced physician.
Cells employ a protective mechanism to preserve orphan ribosomal proteins during heat shock, allowing for rapid recovery once the stress subsides. This study uses lattice light sheet 4D imaging and pulse labeling with HaloTag dye to visualize these processes in real-time.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
Researchers found a single dose of ADC therapy combined with lovastatin reduced tumor volume rates similar to multiple doses in preclinical settings. Immuno-PET scans also monitored HER2 tumor levels after treatment, offering real-time insights into therapy response and potential personalized cancer treatments.
A phase 2 clinical trial found that serial blood tests can identify patients who benefit from additional immunotherapies, suggesting a potential early marker of treatment response. The study also showed that ctDNA analyses correlated with tumor size and survival, making it a promising strategy for guiding therapy.
The study developed a highly accurate AI model for fully automated cancer detection, including small and difficult-to-detect tumors. The model could detect visually imperceptible cancer from normal-appearing pancreases substantially early before clinical diagnosis, with a median of 438 days.
A new tau PET radiotracer, 18F-SNFT-1, demonstrates high sensitivity and specificity in identifying Alzheimer's disease. This improved tracer enables earlier diagnosis and potential therapeutic interventions.