Articles tagged with Molecular Imaging
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The UCLA-led team has developed a solution to improve cryo-electron microscopy's imaging capabilities for smaller protein molecules, enabling higher-resolution images. This advance is expected to help researchers identify specific locations on proteins that can be targeted for therapeutic purposes.
A study comparing PI-RADS 2.0 and 2.1 found no significant differences in upgrade (29% vs. 22%) or downgrade (19% vs. 21%) rates from targeted biopsy to radical prostatectomy, suggesting no improvement in prostate cancer grade assessment with the latest PI-RADS update.
Micro4PAP, a fast-scan Brillouin Microscope, allows for non-destructive, label- and contact-free imaging of biological samples. The device enables sub-millisecond acquisition time, suitable for in-vivo measurements in living cells, promoting early disease detection and diagnosis.
Researchers developed a new diffraction-gated real-time ultrahigh-speed mapping (DRUM) camera that captures dynamic events in a single exposure at 4.8 million frames per second. The camera uses off-the-shelf components and is fast enough to capture highly dynamic biomedical processes or enable high-speed lidar systems.
Researchers developed a new imaging technique using Bessel beam two-photon microscopy to detect stalling in brain capillaries, which can indicate acute neurological issues. The approach generates clear images of all capillaries every two seconds, providing better temporal resolution and enabling the detection of short stalling events.
The Society of Nuclear Medicine and Molecular Imaging has issued a new consensus statement to standardize the selection and management of patients with metastatic castrate-resistant prostate cancer (mCRPC) treated with Lu-177 PSMA radionuclide therapy. The statement recommends performing PSMA PET within three months of treatment or sin...
The research team created a multi-spectral, super-low-dose photoacoustic microscopy system with improved sensitivity, enabling new applications and clinical translation. The system achieved up to capillary-level or sub-cellular resolution at greater depths than traditional optical microscopy methods.
Imaging mass cytometry showcases odd numbers of proteins in kidneys of lupus patients, identifying novel markers for disease. The study found decreased and increased disease markers pointing to renal disease, with potential enlargement of glomeruli in some patients.
Researchers at UBC Okanagan's Integrated Optics Laboratory develop imaging systems that apply terahertz radiation, enabling fast and accurate characterization of biological specimens. This technology holds promise for improving diagnostic imaging and detecting carcinogenesis.
A study found that PSMA PET/CT can accurately diagnose advanced prostate cancer in elderly patients without the need for a biopsy. The procedure reduced the number of biopsies and associated complications, while providing clinical suspicion-based staging data.
A new imaging technique, tau PET, has been shown to predict cognitive decline in Alzheimer's patients with greater accuracy than current methods. This breakthrough could lead to earlier diagnosis and treatment, improving patient outcomes.
A new complex-domain neural network enhances large-scale coherent imaging by exploiting latent coupling information between amplitude and phase components. The technique reduces exposure time and data volume significantly while maintaining high-quality reconstructions.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
Metalenses have been developed with differentiated design principles to eliminate chromatic aberration. By merging bright spots into a single focusing spot, researchers achieved an efficiency of up to 43% and demonstrated the versatility of their approach for various optical applications.
PSMA PET imaging provides prognostic information on cancer recurrence risk before treatment, improving personalized treatments and guiding surgical plans. The tool outperforms current standard tests in predicting biochemical recurrence, a critical factor in determining cancer-specific mortality.
A study using molecular imaging found that individuals with obesity respond differently to food cues than normal-weight individuals, with altered connectivity between brain networks. The research offers valuable insights into potential medical interventions for obesity, including novel drug treatments and behavioral therapies.
A newly discovered radionuclide-based agent (CB-2PA-NT) has shown high tumor uptake, sustained retention, and contrast in preclinical models. Targeting neurotensin receptors, CB-2PA-NT expands precision medicine for cancer diagnosis and treatment.
A novel PET perfusion radiotracer, 18F-flurpiridaz, demonstrates high diagnostic efficacy for obese patients with coronary artery disease, outperforming traditional imaging methods. The study showed improved sensitivity and specificity in diagnosing significant CAD, even at lower radiation doses.
SNMMI has elected Jean-Luc C. Urbain as Vice President-Elect, who will focus on bringing new precision oncology nuclear therapies to the clinic. He aims to implement SNMMI's strategic plan, promoting its brand globally and increasing membership and financial support.
Researchers developed a computational technique combining genomic and tau PET imaging data to identify four subtypes of Alzheimer's disease. The integrated approach also revealed top genes associated with each subtype. This personalized diagnostic technique has potential for broad utility across various diseases.
Umar Mahmood, a prominent researcher and leader in the field of nuclear medicine and molecular imaging, has been awarded the first annual SNMMI Minoshima-Pappas Transformational Leadership Award. His work focuses on developing new imaging methods for disease process examination and early therapeutic response assessment.
A study found that monitoring early-response biomarkers enables personalized dosing in prostate cancer treatment, improving patient outcomes. The approach allowed patients to take
Helen Nadel, MD, FRCPC, has been named SNMMI President, aiming to raise awareness of and access to nuclear medicine, molecular imaging, and theranostics. She will focus on precision health, standardization, diversity, and increasing qualified professionals in the field.
Cathy Sue Cutler is elected SNMMI president-elect to tackle talent shortages, funding issues and education gaps in the field. She aims to attract talent, enhance training opportunities and educate practitioners on theranostics for personalized medicine.
The Society of Nuclear Medicine and Molecular Imaging has recognized ten new SNMMI Fellows, including Virginia Pappas as an honorary Fellow, for their excellence in volunteer service and scientific discovery. The SNMMI Fellowship is among the most prestigious formal recognitions available to long-time members.
Dr. Peter J. H. Scott has made significant contributions to radiopharmaceutical sciences through his development of new methods and technologies. He has also received numerous awards for his research, including the Sam Gambhir Trailblazer Award.
Mullani, a pioneer in positron emission tomography (PET) prototype development, has been recognized for his significant contributions to the field. He developed new innovations in PET designs and published the first validation of time-of-flight information in PET to improve image quality.
Dmitry Beyder has been elected as the president of the SNMMI-TS for 2023-24, aiming to increase technologists' roles in providing theranostics and nuclear medicine therapy. He brings extensive experience from various positions in the field.
Henry VanBrocklin, a professor at the University of California, San Francisco, has been recognized for his decades-long research on novel radiopharmaceuticals and their applications in medical imaging. He is being honored with the prestigious Paul C. Aebersold Award for his contributions to nuclear medicine.
SNMMI-TS elects Julie Dawn Bolin as president-elect, focusing on educating students about nuclear medicine careers and improving professional development. Bolin brings extensive experience in nuclear medicine technology and education.
A new PET radiotracer called <sup> 18 </sup> F-Cholestify has been developed to visualize metabolic cholesterol clearance in the brain. The tracer successfully visualized brain cholesterol metabolism in rats, non-human primates, and humans, showing promising results for studying neurodegenerative diseases.
Researchers have developed a new PET model to quantify cardiac amyloidosis, allowing for more accurate diagnoses and monitoring. The study found that a two-tissue reversible compartment model is the best method for quantifying 18F-flutemetamol myocardial uptake.
The global nuclear medicine initiative addresses the need for standardized educational curriculums to train physicians in nuclear theranostics procedures. The report highlights the rapid evolution of theranostic radiopharmaceuticals and emphasizes the importance of continuing medical education to maintain expertise.
A new approach uses pretherapy imaging and dosimetry to personalize radioactive iodine treatment for refractory differentiated thyroid cancer patients. The method allows researchers to calculate personalized dosage of treatment, resulting in improved outcomes.
A novel imaging agent has been developed to non-invasively detect pulmonary fibrosis in its early stages. The agent targets extracellular matrix fibers and has shown significant uptake in lungs with pulmonary fibrosis, matching histological results. This breakthrough could lead to earlier detection and better monitoring of the disease.
Researchers developed a novel endoscopic imaging system with a bioinspired sensor that can detect multiple fluorescent probes, enabling more accurate fluorescence-guided cancer surgery. The system showed improved spatial resolution and sensitivity in detecting tumors, paving the way for the adoption of multi-tracer FGS.
Researchers at the Beckman Institute for Advanced Science and Technology have developed a new framework for super-resolution ultrasound using deep learning, reducing processing speeds from minutes to seconds. The new technology enables real-time blood flow visualization, overcoming challenges faced by conventional methods.
A recent meta-analysis shows that amino acid PET can accurately differentiate between recurrent brain metastases and treatment-related changes. This technology has the potential to reduce unnecessary invasive procedures and overtreatment in patients with cancer.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new study has shown that FAPI PET imaging is superior to standard FDG PET in evaluating multiple types of cancer. A newly designed FAP-targeted treatment also suppressed tumor growth in several common cancers, suggesting a powerful tool for the field of clinical nuclear medicine.
A new Raman probe, 9CN-JCR, has been developed for detecting multiple enzyme activities in heterogeneous biological tissues. The probe exhibits high sensitivity and multiplexing ability, making it a promising tool for cancer diagnosis and research.
A new PSMA PET scoring system, the tumor-to-salivary gland ratio (PSG score), can predict patient response to <sup> 177 </sup> Lu-PSMA therapy. Patients with high PSG scores had longer PSA progression-free survival and overall survival rates.
The Society of Nuclear Medicine and Molecular Imaging has issued new appropriate use criteria (AUC) for lymphoscintigraphy in sentinel node mapping and lymphedema/lipedema. The AUC covers four clinical categories of cancer, including breast cancer, skin cancer, and others, and addresses pediatric considerations.
A new nuclear medicine therapy has been shown to cure human non-Hodgkin lymphoma in an animal model, achieving a median survival of over 221 days. The treatment, [177Lu]Lu-ofatumumab, was found to quickly eliminate tumor cells and showed favorable in vitro characteristics.
A blood draw can provide valuable information on the effectiveness of peptide receptor radionuclide therapy for neuroendocrine cancer patients. Blood-based biomarkers PPQ and NETest were found to predict PRRT response with 96% and 90% accuracy, respectively. The study opens possibilities for tailoring treatment to individual patients.
A new imaging technique using a novel nuclear medicine tracer has been developed to improve the treatment of intestinal strictures in Crohn's disease patients. The technique allows for precise differentiation between inflammation and fibrosis, enabling targeted therapy.
A literature review published by the Society of Nuclear Medicine and Molecular Imaging reveals how nuclear medicine brain imaging can help evaluate biological changes causing chemotherapy-related cognitive impairment. The findings confirmed the impact of chemotherapy drugs on cognitive function and highlighted the utility of various SP...
A new article in The Journal of Nuclear Medicine explores the potential for using ChatGPT, an artificial intelligence chatbot, in nuclear medicine and molecular imaging. The authors discuss the strengths and weaknesses of current AI bots and highlight the benefits of collaborating with AI allies to cope with increasing workloads.
Current radiotherapy contouring guidelines often miss lesions in the prostate bed, leading to unnecessary tissue irradiation. PSMA PET mapping reveals that nearly a third of patients experience disease progression within 10 years after radical prostatectomy.
A novel lensless radiomicroscope has been developed for nuclear medicine imaging, offering high-resolution images of cells with a field of view over 500 times larger than current technology. The instrument is made from off-the-shelf parts and costs less than $100, making it accessible to more labs.
A new radiotracer successfully detected 100% of primary tumors across multiple cancer types, outperforming the current standard. It also showed promise in detecting lymph node and distant metastases, offering a promising alternative for diagnosis and treatment.
The NCCN Annual Conference will debut a new hybrid format featuring in-person events at a new venue, allowing for hallway conversations and networking opportunities. The conference will also showcase more than 100 abstract poster presentations on various oncology-related categories.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) have published a new procedure standard/practice guideline for somatostatin receptor (SSTR) PET imaging in patients with neuroendocrine tumors. The guideline focuses on improved sensitivity, lower radiation dose, and sh...
Researchers at Ruhr University Bochum developed a new digital imaging method using artificial intelligence and infrared imaging to determine microsatellite status in colon cancer. This approach enables fast, label-free, and automated detection of the biomarker, which is crucial for personalized medicine.
A novel nuclear medicine imaging protocol, dual-phase amyloid PET, can assess both amyloid deposition and neurodegeneration with a single tracer injection, cutting costs and radiation exposure. The protocol was shown to be comparable in distinguishing patients with neurodegenerative diseases from controls.
Researchers developed high-throughput Raman microscope for rapid large-area imaging hundreds of times faster than traditional approach. The new technique enables label-free molecular analysis and multiplex chemical imaging, holding promise for efficient medical diagnoses and drug development.
A new study published in The Journal of Nuclear Medicine found that e-cigarette users have greater lung inflammation than cigarette smokers and non-smokers. The study used PET imaging to compare lung inflammation between e-cigarette users and cigarette smokers, revealing a unique inflammatory response in the lungs.
Scientists used multi-isotope imaging mass spectrometry to identify key contributors to blood vessel obstruction in PAH. The study reveals proline and glucose play a crucial role in forming excess scar tissue, which obstructs blood flow.
Researchers at Beckman Institute for Advanced Science and Technology will use a unique combination of MRI and mass spectrometry imaging techniques to study Alzheimer's disease on an unprecedented scale. By capturing detailed chemical information, they aim to understand the molecular-level changes that occur in aging brains and develop ...
A team at Harvard Medical School has created large-scale 2D and 3D spatial maps of colorectal cancer, layering molecular information on top of histological features. The maps reveal the interconnectedness of traditional isolated structures in colorectal cancer, allowing researchers to explore differences within individual tumors.