Articles tagged with Molecular Imaging
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The Society of Nuclear Medicine and Molecular Imaging has issued a new procedure standard/practice guideline for the use of fibroblast activation protein (FAP) PET, outlining indications, imaging procedures, and quality control/quality assurance procedures. The guideline aims to deliver diagnostic efficacy and study quality for patients.
A new PET approach has detected early signs of tissue remodeling in patients with pulmonary arterial hypertension, providing an early marker for disease progression. This could pave the way for more personalized management and timely interventions to improve patient prognosis.
Researchers developed a supramolecular probe with enhanced phosphorescence properties for biological imaging and sensing. The probe demonstrated outstanding stability, biocompatibility, and specificity in viscosity response, enabling real-time visualization of critical physiological processes in cells and in vivo biosensing.
A new study found that nearly half of high-risk prostate cancer patients have metastatic disease when evaluated with advanced PSMA-PET imaging, suggesting traditional imaging may underestimate cancer spread. This challenge the interpretation of previous studies like EMBARK trial, and support the inclusion of PSMA-PET for patient select...
A novel radiotracer has accurately identified a crucial cancer biomarker, Trop2, found in various types of cancer. The radiotracer, <sup>18</sup> F-AlF-RESCA-T4, enables precise visualization of Trop2 expression and can differentiate lung inflammation from cancer.
A new technique for detecting long wave infrared photons of different wavelengths has been developed by UCF researchers. This method, based on a nanopatterned graphene, offers dynamic spectral tunability and ultrafast response times, surpassing existing cooled and uncooled detectors.
Researchers developed a deep learning model that classifies pancreatic cancer into molecular subtypes using histopathology images, achieving high accuracy and rapid turnaround time. The AI tool has the potential to improve patient outcomes by enabling timely and tailored treatment strategies.
A new noninvasive imaging method developed by MIT researchers can penetrate deeper into living tissue than previous techniques, producing richer and more detailed images. This breakthrough enhances biological research capabilities, enabling scientists to study immune responses and develop new medicines with greater accuracy.
A team led by Eric Stach at Penn Engineering has developed a new approach to visualize and understand molecular catalysts on semiconductor surfaces. By combining atomic-resolution imaging with machine learning analysis, they created detailed maps of the distribution and behavior of these microscopic structures.
A new MRI-based imaging technique can rapidly assess ovarian cancer subtypes and their response to treatment, allowing for personalized treatment planning. The technique, called hyperpolarised carbon-13 imaging, distinguishes between two different subtypes of ovarian cancer and reveals their sensitivities to treatment.
Max Delbrück Center researchers have uncovered new features of the molecular architecture of synaptic vesicles using cryo-electron tomography. The study reveals a persistent association between V-ATPase and synaptophysin, suggesting an important function in neurotransmission.
Researchers at Rice University developed soTILT3D, an innovative imaging platform that enables fast and precise 3D imaging of multiple cellular structures while controlling the extracellular environment. The platform improves upon conventional fluorescence microscopy by reducing background fluorescence and increasing imaging speed.
Scientists have captured 3D snapshots of individual RNA nanoparticles in motion, showcasing the dynamic and intricate folding process. This breakthrough uses advanced electron microscopy to study RNA's flexibility, enabling new insights into its structure and potential applications in molecular medicine.
Researchers found that individuals with depression who engage in reflexive emotion regulation experience increased suicidal thoughts during daily stressful events. In contrast, adaptive responses to stress were observed when participants used reappraisal strategy.
A new PACT system offers rapid imaging of living organisms, enabling the tracking of whole-body dynamics and disease progression. The system achieves spatial resolution of approximately 212 micrometers and enables the visualization of oxygen saturation across complex biological systems.
Researchers at the University of Texas at Dallas are using a 7-Tesla MRI machine to study brain structure, function, and cognition across time. The team aims to identify biomarkers for healthy or pathological aging, shedding light on individual differences in brain aging.
Research reveals the structural features of beta cell primary cilia, including microtubule organization and interactions with neighboring cells. The findings suggest that primary cilia play a crucial role in signal transmission and networking of beta cells with other islet cells, potentially linking to type 2 diabetes pathogenesis.
A recent study published in Cell reveals that nearly one in six disease-causing mutations leads to proteins mislocalizing within the cell. The research team developed a high-throughput imaging platform to assess protein location and found that breakdowns in protein stability are a major driver of misplaced proteins.
Researchers have developed a 'mini-protein' that targets cancer cells expressing Nectin-4, allowing for direct delivery of radiation to tumours. The treatment shows promise in targeting multiple types of cancers and has the potential to be safe for repeated administrations.
Researchers at ETH Zurich have discovered a new predatory bacterium, Aureispira, that uses grappling hooks and cannons to capture prey. The bacterium's molecular structures resemble those of pirate tools, allowing it to entangle and kill its victims quickly.
Researchers at MIT have developed a new expansion technique to image nanoscale structures inside cells using conventional light microscopes. The method, which expands tissue 20-fold in a single step, allows for high-resolution imaging of organelles and protein clusters.
A new non-invasive imaging technique has been shown to accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer. The technique uses a monoclonal antibody drug that targets the protein CA9, highly expressed in up to 95% of clear cell kidney cancers.
Researchers comprehensively reviewed cerebellar involvement in Parkinson's disease, highlighting the pathophysiological role of the cerebellum in motor and non-motor symptoms. Studies showed abnormal α-synuclein aggregation, neurodegeneration, and altered functional connectivity between the cerebellum and other brain regions.
A team led by Weiying Lin created a molecular probe that selectively detects serotonin, a key player in depression. The study suggests that the ability of neurons to release serotonin is more critical than serotonin levels themselves.
Researchers have developed novel photoacoustic probes for neuroscience applications, enabling visualization of neurons in specific brain regions. The probes use a combination of protein and synthetic dye to bind to chemicals and emit sound waves that can be detected by imaging equipment.
A novel PET/CT technique has been developed to detect neuroblastoma in children with high sensitivity and short scan time, eliminating the need for sedation or anesthesia. The new technique uses a novel tracer and next-generation scanner, resulting in improved diagnostic accuracy and reduced radiation exposure.
A new fluorescent imaging probe can non-invasively measure loss of smell, potentially eliminating biopsies used to diagnose anosmia. The tool targets the olfactory nerve, showing promise for diagnosing and treating smell disorders in patients.
Researchers have identified a metal deficiency in SOD1 protein associated with motor neurone disease using native ambient mass spectrometry imaging. This breakthrough could lead to new insights and treatments for the disease, which affects around 5,000 people in the UK.
Researchers at the University of Göttingen developed a new approach to analyze cell properties, using random fluctuating movement of microscopic particles. The method, called mean back relaxation (MBR), can distinguish between active processes and temperature-dependent processes.
A new hybrid contrast agent has been developed to combine the benefits of MRI and PET imaging techniques, offering improved accuracy and opening new diagnostic applications. The agent has shown potential in detecting kidney problems and other conditions, paving the way for personalized diagnostics and precise imaging.
A newly developed granzyme B PET imaging method can non-invasively detect IBD and provide a real-time picture of active inflammation. This technology could guide personalized patient management strategies and monitor treatment efficacy.
A team from City University of Hong Kong has designed a compact hybrid transmission and scanning electron microscope that can operate at room temperature, offering high-resolution imaging capabilities without cryogenic temperatures. The new system reduces radiation damage to samples and provides improved image contrast using pulse elec...
Researchers at Rice University have developed ultrasmall gas-filled protein nanostructures that can penetrate tissue and reach immune cells, opening up new possibilities for ultrasound imaging and drug delivery. The breakthrough could revolutionize treatment for cancers and infectious diseases.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
Researchers at St. Jude Children's Research Hospital have developed a way to mitigate long-lived triplet dark states in smFRET, significantly increasing the method's resolution for molecular imaging. This advancement enables direct visualization of biomolecules' functions and dynamics, crucial for understanding biological processes and...
The 2024 SNMMI Annual Meeting showcased the latest advancements in theranostics, artificial intelligence, and other fields, with over 130 continuing education sessions and 1,000 posters. The meeting also featured unique opportunities for attendee engagement and connection.
A comparative study between FAPI and 18F-FDG PET/CT shows that FAPI PET/CT is more accurate in staging newly diagnosed breast cancer patients, with 19.8% being restaged due to its high sensitivity. This could lead to optimized management plans and improved patient outcomes.
A new ultra-low dose imaging method with long axial field-of-view PET scanners can generate quantitative PET images without the need for accompanying CT scans, reducing radiation exposure to patients. The technique reduces the total effective dose by approximately 50 times lower than the standard PET dose.
SNMMI has elected Heather Jacene, MD, as Vice President-Elect, aiming to strengthen the organization through active listening and collaborations. Jacene's research focuses on cancer therapy response monitoring using novel tracers, and she aims to break down barriers in radiopharmaceutical availability.
Dr. Michael J. Evans has been named the 2024 recipient of the prestigious Sam Gambhir Trailblazer Award, recognizing his exceptional contributions to nuclear medicine and molecular imaging. He is honored for his groundbreaking work in biomarker discovery and radiopharmaceutical development.
Dr. David M. Goldenberg, MD, has received the 2024 Benedict Cassen Prize for his pioneering work in monoclonal antibodies and immunotherapy, leading to significant advances in nuclear medicine science. His contributions have resulted in personalized therapy for cancer patients with a new generation of agents.
Jean-Luc C. Urbain, MD, PhD, FASNC, has been named president-elect of SNMMI, focusing on radiopharmaceutical theranostics integration into clinics to benefit patients. He aims to increase the society's visibility, membership, and financial support through outreach to underrepresented professionals.
Cathy Sue Cutler, Ph.D., FSNMMI, was elected SNMMI President to continue supporting the Facilitating Innovative Nuclear Diagnostics (FIND) Act. She aims to improve workforce development, create training opportunities, and educate the public on nuclear medicine.
The NeuroEXPLORER PET scanner offers exceptional brain PET images with ultra-high sensitivity and resolution, showcasing focal uptake in specific brain nuclei. This technology has the potential to spur advances in treating conditions like Alzheimer's disease, Parkinson's disease, and mental illnesses.
A novel AI approach can accurately detect six different types of cancer on whole-body PET/CT scans, automatically quantifying tumor burden. The tool provides a framework for identifying robust predictive biomarkers and enabling early detection and treatment of cancer.
Researchers developed a novel radiotracer that generates high-quality images of cardiac amyloidosis, a condition referred to as the Alzheimer's disease of the heart. The technetium-99m labeled variant of the pan-amyloid reactive peptide p5+14 showed significant uptake in patients with amyloid cardiomyopathy.
Research suggests that using hearing aids can help mitigate the acceleration of brain metabolism decline in individuals with mild cognitive impairment. The study found significant annual metabolic decline in frontal cortical regions among those with untreated hearing loss, whereas those with treated hearing aids experienced no such dec...
A multi-center study found that healthy older adults with beta-amyloid deposits showed significantly less training improvement in cognitive tasks. However, individuals without amyloid deposits demonstrated better cognitive plasticity and training effectiveness.
Julie Dawn Bolin, a seasoned nuclear medicine technologist and educator, has been elected as the new president of the SNMMI Technologist Section for 2024-25. Bolin aims to advance the field by bolstering educational initiatives, championing advocacy efforts, and promoting access to education and healthcare in marginalized communities.
[177Lu]Lu-PSMA-617 significantly improves radiographic progression-free survival and overall quality of life for patients with taxane-naive mCRPC, while minimizing adverse events. The study's findings suggest that [177Lu]Lu-PSMA-617 may change the treatment paradigm for pre-taxane advanced prostate cancer patients.
A novel imaging approach, Ga-DOTATATE PET/CT, offers enhanced sensitivity and specificity for detecting residual/recurrent tumors in patients with head and neck paragangliomas. This method improves the differentiation between tumor and scar tissue post-surgery.
Carolyn J. Anderson has made significant contributions to the development of radiometal-based agents for diagnostic imaging and targeted radionuclide therapy of cancer, a field known as 'theranostics.' Her work led to the FDA approval of Lu-177 DOTATATE for treating neuroendocrine tumors.
Cybil Nielsen has been elected as the 2024-25 president-elect of the Society of Nuclear Medicine and Molecular Imaging Technologist Section. She aims to expand educational programs, mentorship opportunities, and networking events to facilitate continuous learning and career advancement among members.
A new study has found that FAPI PET/CT is more effective than FDG in predicting progressive pulmonary fibrosis in ILD patients. The study's results suggest that FAPI PET/CT can identify high-risk patients who require closer monitoring or preventive treatment.
Researchers found that FAP-targeted radioligand therapy controlled disease progression in nearly half of patients with advanced sarcoma, and was well-tolerated without critical organ radiation dose levels being reached. The study's results indicate a promising approach for this patient group with limited treatment options.
Researchers developed a novel radiotracer to detect Claudin18.2 in gastrointestinal cancers, allowing for early diagnosis and targeted therapy optimization. The radiotracer enables whole-body PET imaging within one day, increasing compliance and reducing radiation exposure.
The SNMMI Annual Meeting will showcase new radiopharmaceuticals, instrumentation, and techniques for managing various diseases. Over 6,500 attendees from around the globe will participate in more than 100 scientific and CE sessions.
Researchers developed an optical module with cascaded momentum-space polarization filters, enabling high SNR imaging of individual nano-objects. The technology improves conventional label-free optical microscopy sensitivity for single nanoparticles analysis.
Researchers have pinpointed the cellular machinery behind zebrafish's ability to rapidly change the color of their characteristic stripes from blue to yellow when distressed. By precisely altering the orientation of light-reflecting crystals, the fish can change the color of their stripes across the entire length of their body in seconds.
A study found that measuring liver attenuation at a depth of 6 cm from the skin yields better results for diagnosing hepatic steatosis. Technical factors like reverberation, blank color regions, and acoustic shadowing can affect imaging accuracy.