Articles tagged with Molecular Imaging
A first-in-human study found that naloxone reduces opioid receptor availability by 40-50 percent in brain regions, but shows a greater reduction in women compared to men. This suggests sex-based differences in how men and women respond to opioid overdose treatments.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
Researchers at Vanderbilt University have generated a high-resolution metabolic map of how cells process glucose, revealing a hidden world where organelles and molecular complexes collaborate. The study provides insights into an organizational framework that can be used to study disruptions in diseases like diabetes, obesity, and cancer.
A new study found that long COVID patients with abnormal cardiopulmonary PET/MR findings are at a higher risk of developing heart and lung diseases. The study included 98 patients with persistent cardiopulmonary symptoms after initial COVID infection and showed significant abnormalities in both PET/MRI and dual-energy CT scans.
The Society of Nuclear Medicine and Molecular Imaging's Annual Meeting featured over 120 continuing education sessions on innovations in oncology, neurology, and cardiology. The meeting also showcased cutting-edge technology, including AI, theranostics, and novel imaging probes.
Heather Jacene, MD, has been elected as the new president-elect of SNMMI, with a focus on strengthening the organization and promoting nuclear medicine. She aims to create opportunities for member participation and multidisciplinary collaborations, while raising awareness of nuclear medicine's value to clinical colleagues and patients.
Dr. Gary Ulaner has been elected vice president-elect of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), committed to advancing nuclear medicine research and expanding educational activities for professionals. As part of his role, he aims to drive growth and funding for training new radiochemistry and physics professionals.
A novel PET imaging approach can accurately detect and monitor Mycobacteroides abscessus lung infections. The technique uses 11C-PABA PET to differentiate between bacterial infection and inflammatory diseases.
A new PET/CT imaging technique visualizes activated fibroblasts in the heart muscle, detecting multiple forms of cardiomyopathy. The method provides valuable insights into disease progression and helps improve risk stratification for patients with non-ischemic cardiomyopathy.
Jean-Luc C. Urbain has been named president of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), aiming to integrate radiopharmaceutical theranostics into clinical practice. As president, he plans to prioritize research, education, and patient safety to benefit patients worldwide.
A study found that modifiable risk factors like education, BMI, and hypertension can slow down the spread of Alzheimer's tau tangles. The research suggests that modifying these risk factors can help delay disease progression.
A new peptide-based PET tracer outperforms FDG PET in measuring PD-L1 expression in head and neck cancers. The tracer's uptake strongly correlates with PD-L1 levels, suggesting its potential for personalized treatment strategies.
Researchers developed a novel PET tracer targeting phosphodiesterase 4B to visualize real-time brain inflammation. The tracer showed superior image quality and greater brain distribution compared to existing tracers, highlighting its potential for early diagnosis and personalized therapy in neurodegenerative diseases.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has selected 7 new Fellows for their exceptional achievements in the field. The SNMMI Fellowship is a prestigious recognition of outstanding service to the society and excellence in scientific discovery, educational efforts, or clinical practice.
A novel molecular imaging agent targeting glypican-3 has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter. The agent provides high-contrast images of GPC3-positive liver tumors, offering a promising new tool for early diagnosis and staging of HCC.
Researchers used PET imaging to map brain inflammation in PAOS patients, finding distinct patterns that correlate with tau pathology and Parkinson-plus syndrome. The study provides new insights into neuroinflammation's role in disease progression and may lead to earlier diagnosis and targeted treatments.
A new PET radiotracer can detect a wide range of mold species linked to life-threatening infections in cancer and transplant patients. The imaging agent, 18F-FDS, has the potential to dramatically enhance diagnosis and monitoring of invasive mold infections.
Cybil Nielsen has been elected as the new president of the SNMMI Technologist Section, with a focus on expanding educational programs, mentorship opportunities, and networking events. She aims to promote the recognition and advancement of nuclear medicine technologists within the healthcare landscape.
Wynn Volkert, a renowned expert in nuclear medicine, has been awarded the 2025 SNMMI Georg Charles de Hevesy Nuclear Pioneer Award. He made significant contributions to radiopharmaceutical development, including FDA-approved agents for brain and bone imaging.
A newly developed cardiac PET imaging technique offers a simpler way to detect significant coronary artery disease by eliminating the need for complex scanning protocols. The technique has been shown to accurately estimate myocardial flow reserve during both exercise and pharmacologic stress, making advanced heart imaging more accessible.
Shannon Youngblood, a seasoned nuclear medicine professional, has been elected as President-Elect of the SNMMI Technologist Section. She aims to elevate visibility and recognition for nuclear medicine professionals through advocacy, promote diversity and inclusion in the workforce, and advance education and professional development. Wi...
Julie C. Price has been recognized for her groundbreaking work on PET imaging techniques and multimodal imaging for translational neuroscience. She aims to advance early detection of Alzheimer's disease-related tau protein deposition.
A novel integrated molecular imaging approach using dual PET/MR and PET/CMR techniques enables precise localization of heart damage and accurate identification of disease subtypes. This method also provides direct evidence supporting surgery as a cardio-protective intervention in patients with primary aldosteronism.
A new brain imaging platform combining upright PET scanning, AR eye tracking, and motion tracking enables researchers to study brain function in a more natural and dynamic way. This approach offers a more realistic view of brain activity, holding promise for earlier detection of cognitive disorders.
Advanced software is used to measure radiation dose distribution throughout the body, ensuring patient safety and tailoring treatments. Post-therapy imaging helps identify complications and guide clinical decisions, ultimately optimizing treatment outcomes and protecting patients.
Two new PET imaging agents have been developed to identify the histamine H3 receptor, which regulates learning, memory, and sleep. These novel tracers show high brain uptake, excellent specificity, and improved in vivo stability.
A new PET imaging technique has successfully visualized three radiotracers in a single scan, enabling a more comprehensive molecular profile of disease. This innovation offers the potential to deliver greater precision in both diagnosis and therapeutic assessment, particularly for complex diseases like cancer.
Researchers found that low blood flow at rest may predict heart failure or death, while low stress flow may indicate heart attack risk. A new PET scan method also showed promise for Alzheimer's detection with high accuracy and minimal discomfort.
A novel immuno-PET/CT imaging technique has identified a potent biomarker for nasopharyngeal cancer (NPC), CD70, which is highly expressed in NPCs. The technique showed 100% detection rate of primary tumors and 93% detection rate of local lymph node metastasis in patients with early-stage disease.
New radioimmunotherapy approaches show promise against advanced breast cancer and prostate cancer. Additionally, new imaging tools enhance cancer detection and diagnosis, while a proposed standard improves lesion interpretation. Cost-effectiveness studies also support novel therapies for rare digestive cancers.
A newly developed molecular imaging technique can identify multiple subtypes of triple-negative breast cancer, improving diagnostic capacity. The approach targets extra domain A of fibronectin, a stable protein in the tumor stromal environment abundantly expressed in breast cancer.
Researchers studied obesity's impact on breast cancer, linked imaging patterns to lung disease survival, and tracked hidden inflammation in COVID-19 patients using advanced PET imaging techniques.
New studies explore peptide receptor radionuclide therapy, targeted radiation for prostate cancer, and neuroendocrine tumor treatment. Targeted radiation boosts survival in colorectal liver cancer and bone metastases, while a new PET imaging tracer shows promise for detection.
Scientists have developed a novel pretargeting system to boost cancer imaging using DARPin G3, which achieves specific tumor targeting with reduced kidney and liver uptake. GRPR is emerging as a powerful tool for both imaging and treatment in various cancers, offering personalized cancer care across multiple tumor types.
Scientists have developed a new PET imaging compound to visualize key enzymes in mental health, enabling multiple same-day scans. Additionally, researchers have discovered that PET scans can detect not only HER2-positive but also HER2-low breast cancer lesions.
Researchers have developed new imaging tools to visualize protein changes in Alzheimer's, heart and lung issues in long COVID patients, and a common marker in nasopharyngeal cancer. A first-in-human trial tests a next-generation radiopharmaceutical for advanced prostate cancer.
Researchers developed a new method for imaging enzyme activity in whole organs with high-resolution 3D mapping. This allowed them to visualize differences in aminopeptidase N activity and the effects of inhibitors in mouse kidneys. The study opens up an unbiased evaluation method for drug development.
A Phase II trial found durable antitumor activity in patients with BRCA1/2 mutations treated with olaparib and pembrolizumab, with 8.3% complete response rate
Researchers have discovered important differences in how a targeted therapy behaves in the body over time, allowing for more tailored treatment strategies. A new PET/CT scanner also shows promise for accurate imaging with dramatically reduced exposure, especially for sensitive patients like children or those needing repeated scans.
The breakthrough allows researchers to non-invasively assess BBB permeability using a wide range of radiotracers, enabling early detection of altered permeability and potential markers for neurodegenerative diseases. The scanner can also measure the effects of aging and liver inflammation on BBB health.
Researchers have developed a new method that uses expansion microscopy to overcome the spatial resolution problem in mass spectrometry imaging. This allows scientists to detect hundreds of biomolecules at the single cell level in their native locations, enabling better understanding of their functions and interactions.
A novel radiolabeled antibody targeting the cancer antigen IL13Rα2 has been developed with high specificity for diagnosing and treating solid tumors. The antibody was effective in delineating malignancies at a low injected mass dose, making it a potential candidate for radioimmunotherapy applications.
Researchers have developed novel imaging agents targeting shared proteins in triple-negative breast cancer tumors, successfully highlighting various tumor types using PET/CT scans. Additionally, a new brain imaging technique shows promise in identifying complex brain diseases like progressive supranuclear palsy and corticobasal degener...
A new microscopy technique, SIMIP, combines structured illumination with mid-infrared photothermal detection to achieve high-speed chemical imaging with superior resolution. The method outperforms conventional methods in terms of spatial resolution and chemical contrast.
Researchers discovered rare cases of prostate cancer spreading to the testicles using advanced PSMA PET/CT scans, changing how doctors monitor recurring prostate cancer. A new ultra-low-dose PET scanning method reduced radiation exposure without compromising diagnostic image quality in cancer and metabolic imaging.
A study using cryo-electron microscopy revealed that autoantibodies in myasthenia gravis disrupt acetylcholine receptor function by blocking or activating the immune system's complement pathway. This knowledge helps explain treatment variability and offers a foundation for personalized therapies targeting specific antibody interactions.
Two new studies published in The Journal of Nuclear Medicine explore innovative approaches to treating melanoma with radiation therapy and enhancing brain PET imaging. A third study validates an AI network for brain tumor imaging, demonstrating promising results.
A team of chemists from Virginia Tech found a way to visualize the intricate structure and chemical reactions of battery interfaces using an X-ray beam line. This breakthrough enables researchers to gain better control over these critical surfaces, potentially leading to cheaper, higher performance batteries.
Researchers have developed a new way to map how individual connections between neurons change across the entire brain during learning. The method, DELTA, provides a brain-wide map of how individual synaptic proteins change over time, allowing scientists to understand how synaptic connections change and pinpoint areas of the brain impor...
A novel PET imaging approach has effectively quantified the COX-2 enzyme in human brains, opening doors for its use in clinical settings for various brain disorders. This breakthrough could lead to earlier disease detection and monitor disease progression with anti-inflammatory treatments.
New research published in The Journal of Nuclear Medicine explores ways to improve the diagnosis and treatment of metastatic breast cancer using Ga-NeoB PET/CT. Additionally, studies examine the potential of paraaminohippurate to reduce kidney toxicity during radiopharmaceutical therapy.
Researchers have confirmed a neurobiochemical link between dopamine and cognitive flexibility through PET imaging, showing increased dopamine production with cognitively demanding tasks. This finding may lead to the development of more precise treatment strategies for neurological and psychiatric disorders.
The device enables precise control over terahertz wave polarization, revolutionizing applications such as data transmission, imaging, and sensing. This innovation promises to transform fields like wireless communication and biomedical imaging.
Researchers use advanced imaging to study molecular movement through NPCs, finding that molecules move through narrow conduits and avoid congestion despite slow movement. This discovery could lead to new insights into conditions like neurodegenerative diseases and cancers.
Conjugated small molecular nanoparticles (CSMNs) have shown promise in near-infrared phototheranostics (NIR PTs) for imaging, therapy, and synergistic treatment. Strategies to improve performances and extend absorption wavelengths are crucial for their clinical translations.
Researchers explore new techniques to improve prostate cancer diagnosis and treatment, including dual-target PET/CT for enhanced lymph node staging and novel PSMA-targeted radioligands for more precise tumor targeting.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
Researchers used novel fluorogen imaging techniques to visualize biomolecular condensates, revealing distinct environmental and structural features. The study provides insights into the dynamic behavior of these condensates, which play a crucial role in various diseases.
A new PET radiotracer effectively visualizes Nectin-4, a biomarker found in triple-negative breast cancer (TNBC), with the potential to improve clinical outcomes. Researchers developed a series of Nectin-4-targeted radiotracers and evaluated their efficacy in detecting TNBC.
A new technique called cycleHCR uses DNA barcodes to track hundreds of RNA and protein molecules in single cells within thick biological samples. This allows researchers to decipher how genes function in different parts of an organism, how they enable development, and how they might be altered in diseases.