Articles tagged with Molecular Imaging
A newly developed granzyme B PET imaging method can non-invasively detect IBD and provide a real-time picture of active inflammation. This technology could guide personalized patient management strategies and monitor treatment efficacy.
A team from City University of Hong Kong has designed a compact hybrid transmission and scanning electron microscope that can operate at room temperature, offering high-resolution imaging capabilities without cryogenic temperatures. The new system reduces radiation damage to samples and provides improved image contrast using pulse elec...
Researchers at Rice University have developed ultrasmall gas-filled protein nanostructures that can penetrate tissue and reach immune cells, opening up new possibilities for ultrasound imaging and drug delivery. The breakthrough could revolutionize treatment for cancers and infectious diseases.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
Researchers at St. Jude Children's Research Hospital have developed a way to mitigate long-lived triplet dark states in smFRET, significantly increasing the method's resolution for molecular imaging. This advancement enables direct visualization of biomolecules' functions and dynamics, crucial for understanding biological processes and...
The 2024 SNMMI Annual Meeting showcased the latest advancements in theranostics, artificial intelligence, and other fields, with over 130 continuing education sessions and 1,000 posters. The meeting also featured unique opportunities for attendee engagement and connection.
A comparative study between FAPI and 18F-FDG PET/CT shows that FAPI PET/CT is more accurate in staging newly diagnosed breast cancer patients, with 19.8% being restaged due to its high sensitivity. This could lead to optimized management plans and improved patient outcomes.
A new ultra-low dose imaging method with long axial field-of-view PET scanners can generate quantitative PET images without the need for accompanying CT scans, reducing radiation exposure to patients. The technique reduces the total effective dose by approximately 50 times lower than the standard PET dose.
Dr. David M. Goldenberg, MD, has received the 2024 Benedict Cassen Prize for his pioneering work in monoclonal antibodies and immunotherapy, leading to significant advances in nuclear medicine science. His contributions have resulted in personalized therapy for cancer patients with a new generation of agents.
Jean-Luc C. Urbain, MD, PhD, FASNC, has been named president-elect of SNMMI, focusing on radiopharmaceutical theranostics integration into clinics to benefit patients. He aims to increase the society's visibility, membership, and financial support through outreach to underrepresented professionals.
Cathy Sue Cutler, Ph.D., FSNMMI, was elected SNMMI President to continue supporting the Facilitating Innovative Nuclear Diagnostics (FIND) Act. She aims to improve workforce development, create training opportunities, and educate the public on nuclear medicine.
The NeuroEXPLORER PET scanner offers exceptional brain PET images with ultra-high sensitivity and resolution, showcasing focal uptake in specific brain nuclei. This technology has the potential to spur advances in treating conditions like Alzheimer's disease, Parkinson's disease, and mental illnesses.
A novel AI approach can accurately detect six different types of cancer on whole-body PET/CT scans, automatically quantifying tumor burden. The tool provides a framework for identifying robust predictive biomarkers and enabling early detection and treatment of cancer.
Researchers developed a novel radiotracer that generates high-quality images of cardiac amyloidosis, a condition referred to as the Alzheimer's disease of the heart. The technetium-99m labeled variant of the pan-amyloid reactive peptide p5+14 showed significant uptake in patients with amyloid cardiomyopathy.
SNMMI has elected Heather Jacene, MD, as Vice President-Elect, aiming to strengthen the organization through active listening and collaborations. Jacene's research focuses on cancer therapy response monitoring using novel tracers, and she aims to break down barriers in radiopharmaceutical availability.
Dr. Michael J. Evans has been named the 2024 recipient of the prestigious Sam Gambhir Trailblazer Award, recognizing his exceptional contributions to nuclear medicine and molecular imaging. He is honored for his groundbreaking work in biomarker discovery and radiopharmaceutical development.
[177Lu]Lu-PSMA-617 significantly improves radiographic progression-free survival and overall quality of life for patients with taxane-naive mCRPC, while minimizing adverse events. The study's findings suggest that [177Lu]Lu-PSMA-617 may change the treatment paradigm for pre-taxane advanced prostate cancer patients.
A novel imaging approach, Ga-DOTATATE PET/CT, offers enhanced sensitivity and specificity for detecting residual/recurrent tumors in patients with head and neck paragangliomas. This method improves the differentiation between tumor and scar tissue post-surgery.
Carolyn J. Anderson has made significant contributions to the development of radiometal-based agents for diagnostic imaging and targeted radionuclide therapy of cancer, a field known as 'theranostics.' Her work led to the FDA approval of Lu-177 DOTATATE for treating neuroendocrine tumors.
Cybil Nielsen has been elected as the 2024-25 president-elect of the Society of Nuclear Medicine and Molecular Imaging Technologist Section. She aims to expand educational programs, mentorship opportunities, and networking events to facilitate continuous learning and career advancement among members.
Research suggests that using hearing aids can help mitigate the acceleration of brain metabolism decline in individuals with mild cognitive impairment. The study found significant annual metabolic decline in frontal cortical regions among those with untreated hearing loss, whereas those with treated hearing aids experienced no such dec...
A multi-center study found that healthy older adults with beta-amyloid deposits showed significantly less training improvement in cognitive tasks. However, individuals without amyloid deposits demonstrated better cognitive plasticity and training effectiveness.
Julie Dawn Bolin, a seasoned nuclear medicine technologist and educator, has been elected as the new president of the SNMMI Technologist Section for 2024-25. Bolin aims to advance the field by bolstering educational initiatives, championing advocacy efforts, and promoting access to education and healthcare in marginalized communities.
A new study has found that FAPI PET/CT is more effective than FDG in predicting progressive pulmonary fibrosis in ILD patients. The study's results suggest that FAPI PET/CT can identify high-risk patients who require closer monitoring or preventive treatment.
Researchers found that FAP-targeted radioligand therapy controlled disease progression in nearly half of patients with advanced sarcoma, and was well-tolerated without critical organ radiation dose levels being reached. The study's results indicate a promising approach for this patient group with limited treatment options.
Researchers developed a novel radiotracer to detect Claudin18.2 in gastrointestinal cancers, allowing for early diagnosis and targeted therapy optimization. The radiotracer enables whole-body PET imaging within one day, increasing compliance and reducing radiation exposure.
The SNMMI Annual Meeting will showcase new radiopharmaceuticals, instrumentation, and techniques for managing various diseases. Over 6,500 attendees from around the globe will participate in more than 100 scientific and CE sessions.
Researchers developed an optical module with cascaded momentum-space polarization filters, enabling high SNR imaging of individual nano-objects. The technology improves conventional label-free optical microscopy sensitivity for single nanoparticles analysis.
Researchers have pinpointed the cellular machinery behind zebrafish's ability to rapidly change the color of their characteristic stripes from blue to yellow when distressed. By precisely altering the orientation of light-reflecting crystals, the fish can change the color of their stripes across the entire length of their body in seconds.
A study found that measuring liver attenuation at a depth of 6 cm from the skin yields better results for diagnosing hepatic steatosis. Technical factors like reverberation, blank color regions, and acoustic shadowing can affect imaging accuracy.
A team of visionaries at the Carney Institute developed 3D-printed brain and spinal cord implants, revolutionizing surgical implantations and optical access. Bioluminescence imaging overcomes limitations of traditional fluorescent microscopy, providing unprecedented observation of neural and vascular activity.
A new PET imaging biomarker, Gal-1, has been identified to predict the tumor responses before starting immune checkpoint blockade therapy. This enables targeted interventions and improves patient outcomes by facilitating patient stratification and optimizing immunotherapy.
MIT engineers create technique to image bioluminescent molecules in deep tissue with high resolution, enabling detailed studies of brain cell development and communication. The method uses engineered blood vessels that dilate in response to light, allowing researchers to pinpoint the source of light.
Scientists have developed strong-field photoelectron holography to visualize electron dynamics within molecules, revealing details of internuclear separation and atomic behavior.
A team of Harvard researchers, led by Jeff Lichtman, has created the largest synaptic-resolution, 3D reconstruction of a piece of human brain to date. The dataset contains 1,400 terabytes of data on neural connections in a tiny piece of human temporal cortex.
A new supplement to The Journal of Nuclear Medicine highlights China's significant advances in research and development, including long-field PET scanners and innovative theranostic concepts. The supplement aims to inform international collaborations and multicenter studies, featuring top experts in molecular imaging and theranostics.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
A novel investigational PET imaging agent, <sup> 68 </sup> Ga-DPI-4452 (Debio 0328), has been shown to provide rapid and accurate visualization of lesions in clear cell renal cell cancer patients. The agent offers a superior alternative to standard CT imaging and could potentially be used as part of a theranostic pair.
Researchers have developed a novel rigid endoscope system for visible-to-OTN hyperspectral imaging, enabling non-destructive imaging and visualization of lesions in normal tissues. The system demonstrated high accuracy in classifying molecular vibration information of various targets with an OTN wavelength range.
The IRIS beamline at BESSY II has been extended with a nanoscope, enabling the imaging and spectroscopy of structures smaller than a thousandth of a human hair. This upgrade allows researchers to study biological systems, catalysts, polymers, and quantum materials with unprecedented resolution.
A novel SPECT/CT acquisition method utilizing lead-212 (212Pb) can accurately detect radiopharmaceutical biodistribution in a convenient manner. This technique has the potential to change practice and increase access for patients around the world by providing more precise treatment options.
A team at the University of Tokyo has constructed an improved mid-infrared microscope that enables them to see the structures inside living bacteria at the nanometer scale with a resolution of 120 nanometers. This breakthrough can aid multiple fields of research, including into infectious diseases.
A new 'rechargeable nanotorch' allows researchers to track the movement of cell-based microrobots in real-time, using afterglow luminescence imaging. The nanotorches can be recharged non-invasively with near-infrared light, enabling long-term tracking and potential applications in cancer treatment.
A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
A new study found that PET/MRI can accurately classify prostate cancer patients and help avoid unnecessary biopsies. The PRIMARY scoring system showed that over 80% of unnecessary biopsies could be avoided while missing only 12.5% of clinically significant prostate cancer cases.
Researchers developed a novel theranostic platform that combines PET imaging and therapeutic radionuclides to detect and treat ovarian cancer. The system uses the huAR9.6 antibody to target the MUC16 protein, showing promise for improved patient survival rates.
Researchers at MIT have discovered a new way that neutrons can interact with materials, potentially providing insights into material properties and quantum effects. The discovery involves the binding of neutrons to nanoscale atomic clusters called quantum dots.
Researchers at Duke University have developed a novel imaging platform to visualize the growth of the placenta throughout pregnancy. The approach provides detailed images of blood flow and oxygen metabolism, shedding light on how lifestyle factors and health complications affect placental development.
Researchers have identified a crucial interface in a mutated protein that drives lung cancer growth, which could act as a target for more effective treatments. The study used advanced laser imaging techniques to provide unprecedented details of the protein's structure and interactions.
Researchers have developed a new method to trigger and image seizures in epilepsy patients, allowing for real-time data collection to tailor epilepsy surgery. This method is clinically feasible, convenient, and spares resources, providing valuable information for successful surgeries.
A novel transparent ultrasonic transducer (TUT) developed by POSTECH researchers offers exceptional optical transparency and maintains acoustic performance, surpassing conventional limitations. This breakthrough enables high-depth-to-resolution ratios for ultrasound imaging, with applications in various medical devices and fields.
Researchers developed a novel PET tracer that can map fructose metabolism, differentiating diseased tissues from healthy ones. This non-invasive technique has the potential to detect diseases such as stroke, brain metastases, and heart attacks more sensitively.
A recent study using cutting-edge super-resolution microscopy has shed light on the role of cohesin in cell division. The research revealed multiple populations of cohesin complexes, each playing a specific role in faithful genetic material segregation during cell division.
Researchers used mass spectrometry imaging and single-cell metabolomics with deep learning to create 3D molecular maps of the brain, enabling a better understanding of chemical interactions within brain tissue. This breakthrough could help address currently intractable neurological diseases.
New research reveals that radioguided surgery can effectively detect and remove metastatic pelvic lymph nodes in newly diagnosed prostate cancer patients. The procedure targets the prostate-specific membrane antigen, improving nodal staging to guide treatment recommendations.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Researchers have published novel spatial omics algorithms and tools in GigaScience and GigaByte journals to analyze biological data-based spatial information. These new methods enable the discovery of spatial domains, improvement of data quality, and better clustering of cells.
Researchers have created fluorescent, colour-changing dyes that can visualise multiple distinct biological environments using only one dye. These dyes enable 'time travel' within cells by allowing scientists to distinguish between cellular and delivery vessel environments in real-time. The breakthrough has significant implications for ...
A novel imaging technique, low-dose positron emission mammography (PEM), shows promise in transforming breast cancer detection by providing high sensitivity and low false positive rates. PEM could potentially decrease healthcare costs and reduce unnecessary procedures for patients with dense breasts.