Tissue Cultures
Articles tagged with Tissue Cultures
University of Toronto researchers improve maturity of lab-grown heart cells for disease modelling
Researchers at the University of Toronto have developed a new method to mature lab-grown heart cells, which exhibits greater structural organization and improved ability to contract. This advance could help create more reliable models for studying heart disease and testing new drugs.
Brain tumors: 3D experimental system to evaluate candidate drugs against glioma
Researchers have created a 3D experimental system to study the response of low-grade gliomas to drugs, providing a more realistic environment for testing treatments. The system uses organoids from pluripotent stem cells to replicate glioma development and characteristics.
A long-term and scalable system to record from neural organoids
Researchers at King's College London have developed a new brain organoid system that reduces variability and allows for longer-term recordings of neural activity. The approach enables the simultaneous study of multiple parallel cultures, providing a better understanding of how drugs or gene variants affect neural networks.
Brain organoids can be trained to solve a goal-directed task
Researchers at UC Santa Cruz successfully train brain organoids to balance a virtual pole, demonstrating adaptive learning capabilities. This breakthrough has implications for understanding neurological conditions and developing new tools for studying brain function.
Evidence suggests early developing human brains are preconfigured with instructions for understanding the world
Researchers found that early brain firings occur in structured patterns without external experiences, suggesting a genetically encoded blueprint. This discovery can help better understand neurodevelopmental disorders and the impact of toxins on the developing brain.
acCELLerate facilitates custom cell banking solutions for pharmaceutical and biotechnology research with ATCC authenticated cell lines
AcCELLerate has partnered with ATCC to provide customized Master, Working, and assay-ready instaCELL banks for research clients. Researchers will gain access to high-quality, authenticated cell lines with increased assay reproducibility.
MIT invents human brain model with six major cell types to enable personalized disease research, drug discovery
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
From passive to intelligent: Bioengineered organs meet electronics
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
Scientists propose rigorous validity framework for brain organoid disease models
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Toward recreating the brain’s immune system in a dish
Researchers at Harvard University's Wyss Institute have successfully created human microglia cells in a dish, using induced pluripotent stem cells, within four days. This breakthrough enables new avenues for brain disease-focused research and potential therapeutic perspectives.
World’s largest bat organoid platform paves the way for pandemic preparedness
Scientists have created a comprehensive bat organoid model to study zoonotic viruses, enabling early detection and drug testing for future outbreaks. The platform, comprising diverse bat species and organs, has led to breakthroughs in understanding virus behavior, isolation, and treatment.
Chimpanzee stem cells offer new insights into early embryonic development
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
Bioengineered blood vessels show promise in trauma care
A new type of bioengineered blood vessel demonstrated superior infection resistance and better limb preservation compared to conventional synthetic grafts. The technology has the potential to reduce amputation numbers significantly, as it can be implanted immediately and is more resistant to infection than traditional options.
Antidepressant shows promise for treating brain tumors
Researchers at ETH Zurich have found an antidepressant, vortioxetine, effective against glioblastomas, a particularly aggressive brain tumor with no cure. The drug's ability to cross the blood-brain barrier and trigger a signalling cascade makes it promising for treating this deadly tumour.
Color-adjusting technique for histopathology image datasets of stained tissue
Researchers developed Stain SAN, a novel domain adaptation technique to correct color differences in stained histopathology images. The method improves consistency and comparability of data, leading to better performance in machine-learning-based classifiers.
Novel 3D hydrogel culture to study TB infection and treatment
Researchers have designed a novel 3D hydrogel culture system that accurately mimics the mammalian lung environment, allowing for the study of tuberculosis bacteria infection and therapeutics. The system successfully tracks infection progression and demonstrates the efficacy of pyrazinamide in clearing out TB bacteria.
Degree of cell crowding in the early human embryo influences cell identity decision, new culture system finds
Researchers have developed a cell culture system that differentiates human pluripotent stem cells to amniotic and surface ectoderm, which are essential for human embryo development. The study found that the degree of cell crowding influences cell identity decision.
Effects of resveratrol on circadian clock gene expression in young and older human cells
Researchers studied the effects of resveratrol on circadian clock gene expression in young and older human adipose-derived progenitor cells. They found increased levels of some components in older-APCs compared to young-APCs, but also observed gained rhythmicity of some components after resveratrol treatment.
Exploring the effects of vascularization strategies on brain organoids
A study by Waseda University explores the effects of different vascularization strategies on brain organoids, improving cell differentiation and transcriptome profiles. Vascularized cerebral organoids exhibit a gene expression profile closer to fetal human brains than non-vascularized ones.
Aging modulates extracellular vesicles of epidermal keratinocytes
Researchers found a significant increase in extracellular vesicles released by aged keratinocytes, which were also enriched with specific microRNAs. These EVs impaired young keratinocyte proliferation and organogenesis, mimicking aged skin defects.
Unlocking the secrets of cell behavior on soft substrates: A paradigm shift in mechanobiology
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
Potential target for reversing drug resistance in ovarian cancer identified
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers generate human embryo-like structures that include extraembryonic tissue
Scientists have developed an innovative method to create 'peri-gastruloids,' human embryo-like structures with extraembryonic tissues, including yolk sac and placenta. This breakthrough allows researchers to study early human development stages, mimicking the formation of vital organs.
Creating artificially engineered organs could become quicker and easier
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
Researchers create engineered human tissue to study mosquito bites, disease
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.
Innovative 3D drug screening system
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
How cells are influenced by their environment as tissues grow
Vogel and Benn's study replicates tissue growth in vitro, revealing the importance of ECM interactions. Myofibroblasts play a key role in wound healing and cancer progression, but their transformation into fibroblasts is influenced by ECM composition and structure.
Lab-grown fat could give cultured meat real flavor and texture
Researchers at Tufts University have successfully produced bulk fat tissue in a lab that has a similar texture and makeup to natural animal fat. The aggregated fat cells can be fine-tuned to resemble real-life fat within meat, offering a key step towards mass production of cultured meat.
Lab-grown fat could give cultured meat real flavor and texture
Researchers have successfully produced lab-grown fat tissue with a similar texture and make-up to naturally occurring fats from animals. The breakthrough could enable large-scale production of cultured meat with a more realistic texture and flavor.
Creating 3D objects with sound
Researchers at Max Planck Institute and Heidelberg University have developed a technology to assemble matter in 3D using sound waves. They successfully printed microparticles, gel beads, and biological cells into three-dimensional shapes, paving the way for novel 3D cell culture techniques.
Aging | Organotypic cultures as aging associated disease models
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
The future of replacement organs is (quite possibly) here: robust human intestinal organoids created in a lab
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
Research to mend broken bones, test implantable devices, and inspire future explorers on next mission to international space station
The SpaceX Dragon spacecraft will launch onboard a Falcon 9 rocket with critical research and supplies for the International Space Station. ISS National Laboratory-sponsored projects aim to bring value through space-based research and technology development.
Profiling of fatty sweet molecules on cell surfaces
A new method developed by the University of Vienna has provided deeper insights into glycolipids located on stem cell surfaces. The approach enables comprehensive analysis of gangliosides, a class of fatty sweet molecules whose composition changes during stem cell differentiation.
‘Love hormone’ revealed to have heart healing properties
Researchers discover that oxytocin stimulates stem cells to migrate and develop into cardiomyocytes in zebrafish and human cell cultures. This could lead to the regeneration of damaged hearts after a heart attack. The study found that oxytocin also activates EpiPCs, which can replenish lost cardiomyocytes.
Modeling a devastating childhood disease on a chip
A team of researchers created an in vitro human model of environmental enteric dysfunction (EED) using the Human Organ Chip technology. The EED Chips recapitulate features of EED found in biopsies from human patients, including inflammation and intestinal barrier dysfunction. The study sheds light on the complex interplay between malnu...
Robot skin heals
Researchers from the University of Tokyo have created a controllable robotic finger covered with living skin tissue that can heal itself. The development could lead to new possibilities in advanced manufacturing industries, such as automation and cosmetics, reducing costs, time, and complexity of research.
Repurposing cancer drug to treat neuroinflammation
Researchers at Karolinska Institutet have successfully repurposed a cancer drug to target neuroinflammatory diseases like multiple sclerosis. A novel drug carrier was developed to deliver the treatment specifically to microglia, reducing inflammation and disease progression.
Microgravity analog culture profoundly affects microbial infection process in 3-D human tissue models, a new study finds
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
Cardiac progenitor cells generate healthy tissue after a heart attack
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Researchers share insights about the mechanisms of human embryo and create method to develop transcriptionally similar cells in tissue culture
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
Turmeric compound helps grow engineered blood vessels and tissues
Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
Multi-omics analyses help to analyze the variation produced by in vitro culture
A recent study analyzed the genomes, methylomes, and transcriptomes of calli and sweet orange calli cultured in vitro for 30 years. The results show dynamic somaclonal variation patterns during dedifferentiation and reprogramming, affecting somatic embryogenesis. The findings offer a deeper understanding of in vitro variation and its a...
3D model of living brain cancer points to possible future for drug screening
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Getting the most therapeutic potential out of cells
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells. The finding offers new avenues for research around cellular therapies, where transplanted cells are used to help the body heal or work better.
Deleting dysfunctional cells alleviates diabetes
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
The signatures of peritoneal metastases
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
Researchers shed new light on the inner workings of stem cells
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
When organoids meet coronaviruses
Researchers have established an organoid biobank to search for genes essential for SARS-CoV-2 replication and spread. The study identified TMPRSS2 as a potential therapeutic target for the coronavirus, with specific inhibitors recently developed.
Exploring the genetic ma(i)ze: Functional genomics can help molecular breeding of maize
Researchers used functional genomics to identify key genes involved in inducing callus from immature maize embryos, overcoming a major roadblock in plant breeding. The study found that nearly 30% of predicted A188 genes were structurally different from other maize lines, accounting for high protein divergence and phenotypic variations.
Martha Somerman named 2021 Recipient of the AADR Jack Hein Public Service Award
Martha Somerman received the AADR Jack Hein Public Service Award for her exemplary work promoting oral health research to a wide constituency. She has over 150 peer-review publications and contributed to 20 books or book chapters.
Resetting the biological clock by flipping a switch
Researchers from the University of Groningen and Nagoya University developed a compound that can elongate the 24-hour cycle and be activated or deactivated using light. The study shows that it is possible to change the 24-hour cycle in cells or tissues to a 28-hour cycle, providing a new approach to analyzing the circadian clock system.
One step closer to efficient cannabis production
UConn researchers have successfully developed a micropropagation technique for cannabis, which can produce large quantities of healthy clones with predictable qualities. The method has the potential to meet the growing demand for medical cannabis by providing consistency and reliability in crops.
Biological artificial organs like skin, vessels...now produced more easily
A Korean research group has developed a new cell co-culture platform that enables the differentiation of stem cells into desired cell types without special pretreatment. The platform displays surface traits similar to those of the extracellular matrix, providing cells with an environment similar to that of the body.
Decoy receptor neutralizes coronavirus in cell cultures
A team of scientists has engineered a decoy receptor protein that binds to the SARS-CoV-2 virus and blocks infection in human cells. The research found that this decoy receptor is attractive to the virus due to subtle mutations, making it an ideal candidate for neutralizing the virus.
Mix and match: New 3D cell culture model replicates fibrotic elements of pancreatic cancer
Researchers at Okayama University developed a novel 3D cell culture model that accurately replicates the fibrotic components of pancreatic cancer. The model allows for the tuning of fibrosis levels, enabling a better understanding of how it hinders cancer treatment and its therapeutic ramifications.
Scientists find optimal age of stem cells
Researchers have found that reprogrammed stem cells between days 15 and 28 of maturation can successfully restore heart tissue. This 'window of opportunity' makes it possible to use stem cells that the body recognizes as its own, allowing for more effective regenerative medicine.
Developing human corneal tissue
Scientists at Osaka University have developed a new method to isolate and generate human corneal tissue from induced pluripotent stem cells. By using specific proteins and magnetic-activated cell sorting technology, researchers were able to purify corneal epithelial cells and produce highly pure corneal sheets for therapeutic purposes.
Little tissue, big mission: Beating heart tissues to ride aboard the ISS
Researchers at Johns Hopkins University launch a project to study the effects of microgravity on human heart tissues. The team sends heart muscle tissues on tissue chips to the ISS for observation, with the goal of understanding aging and developing treatments for heart disease.