Articles tagged with Tissue Cultures
Researchers have developed new methods that leverage growth regulators and gene editing reagents to trigger seedlings with edited genes. These approaches significantly reduce the time needed for gene-edited plant production from months to weeks, making it easier for small labs and companies to utilize.
Recent advancements in 3D bioprinting have the potential to revolutionize organ transplantation by enabling customized organs for patients. However, significant technical challenges need to be overcome, including biomimicry, vascularization, and tissue maturation.
Researchers developed a microfluidic device to keep brain tissue viable for months using a semi-permeable membrane, allowing gas exchange while preventing dehydration or drowning. This breakthrough enables long-term study of biological development and organogenesis, facilitating drug discovery and tissue research.
The researchers developed a 3D organ-on-chip platform using bioelectrical sensors to measure the electrophysiology of heart cells in three dimensions. This platform enables studying cell communication in multicellular systems, potentially screening drugs on human-like tissue.
Researchers developed sensors to map cell-generated forces in 3D tissues, finding that small tensions can balance large compressive loads. This insight could help understand developmental processes and develop novel tissue-engineering strategies.
A team at Kyoto University has discovered that individual cells sense and modulate themselves to form the spherical shape of the eye through a process called self-bending. This phenomenon generates a hinge that pushes cells into the cup-like structure, resulting in the formation of an optic cup.
Researchers at University of Colorado Boulder found that amyloid-like structures play a beneficial role in the development of healthy muscle tissue during regeneration. The discovery sheds new light on potential origins of diseases such as ALS, inclusion body myopathy, and muscular dystrophy.
Researchers in Switzerland have developed a novel screening platform using automated 3D bioprinting to fabricate muscle- and tendon-like tissues. The platform demonstrates high viability and good tissue differentiation, functionality of the muscle tissue models is also shown.
Scientists successfully merged heart tissues from different species and ages, demonstrating the potential for artificial heart patches to function with host cardiac tissue. The study overcomes a major hurdle in regenerative medicine by proving electrical coupling between cells of different origins.
A major conservation effort is underway to conserve the last remaining paintbrush lilies in Stellenbosch University Botanical Garden. The species, Haemanthus pumilio, has declined drastically due to habitat destruction and invasive species. The garden aims to increase the population through micropropagation and control burns.
Scientists have developed a bioorthogonal labeling approach to identify sialylated glycoproteins in prostate cancer tissue, which could serve as tumor markers. The method allows for direct assessment of tumor metabolism in its natural environment, providing insights into cancer biology.
Advances in lab-on-a-chip technology allow for more accurate analysis and translation of research to the clinic. Organ-on-a-chip (OOAC) technology has great potential in helping screen drugs in a more cost-effective manner, reducing failures and costs.
Researchers have created a new culture model of the human intestine where living tissue from a patient biopsy can be preserved and studied for days. The model enables studies of complex interactions between host cells, mucus production, and gut microbes.
Researchers found that Zika virus productively infects primary human placenta-specific macrophages, with 10-15% of placental macrophages infected. The study suggests that placental macrophages may play a role in maternal-fetal Zika transmission and warrants further investigation.
Researchers developed bioengineered blood vessels that appear safe and functional after implantation in dialysis patients. The vessels showed no signs of rejection and maintained their mechanical integrity, with a 90% durability rate compared to traditional synthetic grafts.
Researchers at Boyce Thompson Institute developed a tissue culture procedure to propagate the rare and threatened woodland agrimony, multiplying its numbers by 1013. The study aimed to understand why this species is in decline, with results suggesting grazing deer as an important factor.
A team of researchers at Massachusetts General Hospital has successfully regenerated functional heart muscle in decellularized human hearts using stem-cell derived cells. The study involved the use of induced pluripotent stem cells (iPSCs) reprogrammed from skin cells, which were then differentiated into cardiac muscle cells and reseed...
Scientists at Brown University have successfully cultured cells to produce extracellular matrix with strength comparable to natural tissues. By using specialized molds to guide cell growth and alignment, the researchers created ECMs with specific mechanical properties, such as collagen fibers aligned along a tendon-like structure.
The researchers created mini-brains using living tissue from a single rodent, which can form complex neural connections and produce electrical signals within two weeks. The approach is expected to reduce animal use in neuroscience research and make it more accessible to labs without advanced equipment.
Researchers have created a human heart-on-a-chip that models the structure and function of human heart tissue, enabling accurate testing of cardiovascular medications. The system successfully replicated the effects of four well-known drugs on heart cells.
Researchers discovered that lab-grown cells undergo rapid changes within three days of adaptation to their new environment. This finding affects the interpretation of past studies and provides clues for improving cell cultures.
Researchers at Brown University have developed a method to clear 3-D cell cultures, allowing for clearer imaging and analysis of neural tissues. The ClearT2 method works within 1.5 hours and preserves the size of the tissue, making it ideal for studying neural growth and development.
The Tufts team created a modular design that replicated fundamental features relevant to the brain's tissue-level physiological functions. The model exhibits biochemical and electrophysiological responses, offering new options for studying brain function, disease, and trauma, and treatment.
Scientists use magnetic levitation to create laboratory techniques for growing tissues virtually identical to those found in people's bodies. Researchers combined four cell types to replicate bronchiole deep inside the lung, creating realistic lung tissue.
Researchers have developed a safe co-culture system using human umbilical cord blood cells to support the expansion of human embryonic stem cells. This method eliminates the risk of tumor formation associated with traditional feeder cultures, making it a more feasible option for cell transplantation.
A new model explains dopamine's direct and indirect role in modulating the immune system. Recent research has opened up possibilities for treating diseases such as Parkinson's and Alzheimer's disease, schizophrenia, multiple sclerosis, or autoimmune disorders.
Researchers at Purdue University have developed a new imaging technique to detect subtle changes in breast tissue, which may help determine a woman's risk of developing breast cancer. The technology uses vibrational spectral microscopy to identify early precancerous stages and study the impact of fatty acids on breast tissue.
Researchers at UC San Diego developed a new method for culturing complex tissue in three-dimensional arrangements. The approach allows for the production of tissue culture scaffolds with multiple structurally and chemically distinct layers, enabling broader accessibility and potential applications in tissue engineering.
The seven winning Celldance 2011 videos demonstrate the structure and function of living organisms at a microscopic scale. The award-winning entries feature various cell types, including fibroblasts and tumor cells, showcasing their behavior and interactions.
The USDA has safeguarded a diverse collection of blueberries, including wild relatives and lesser-known species, to ensure their preservation for future generations. The genebank will provide plant breeders with access to these plants as parents for new and improved blueberry varieties.
Scientists at the University of Nottingham's Malaysia campus are working on a new method to improve the commercial production of vanilla plants through tissue culture. The research aims to overcome issues with genetic instability in micropropagated sub-clones, which can lead to reduced quality and yield.
Research reveals distinct exocytosis regulation mechanisms between living organisms and laboratory tissue cultures. The study used intravital microscopy to examine exocytosis in live mice, finding that secretory vesicles fuse with the plasma membrane one by one under beta-adrenergic receptor stimulation.
Researchers at Arizona State University have developed a new 3D cell culture method that better mimics the in vivo environment, allowing for more accurate study of infectious diseases. This innovation has the potential to expand our understanding of disease onset and progression, and could lead to the development of novel therapeutics.
Researchers found that the subaleurone layer of brown rice inhibits angiotensin II, a protein linked to high blood pressure and atherosclerosis. This discovery suggests that consuming half-milled or brown rice may offer cardiovascular protection.
Researchers at Harvard's Wyss Institute have developed a method to grow cells in three dimensions using paper stacks, mimicking real tissues. This technique allows for uniform oxygen and nutrient delivery, making it easier to study cancer and other diseases.
Researchers found that carnosine reduced cloudiness in lens tissue cultures by 50-60% and restored clarity to cloudy lenses. Carnosine's potential as a preventive and therapeutic agent for cataracts is demonstrated.
Researchers have developed an automatic slicing system to culture normal and cancerous pancreatic tissue from patient specimens, allowing for reproducible testing of novel treatment options, including gene therapy. This new ex-vivo model assesses cellular heterogeneity and extracellular matrix accumulation in human tumors.
A research team developed an autologous full-thickness oral substitute that mimics the characteristics of gingiva, providing a promising solution for oral cavity reconstruction. The study's results support the need for larger clinical trials to further evaluate the effectiveness of this new tissue-engineered product.
Scientists at Northwestern University found that HIV can penetrate female genital tissue by moving quickly between skin cells, allowing the virus to reach immune cells. This discovery challenges the long-held assumption that the female genital tract is an efficient barrier to viral penetration.
Researchers have created disease-specific stem cell lines for ten genetic disorders, including muscular dystrophy and Parkinson's disease. These lines will enable scientists to model human diseases in a laboratory setting, making it possible to study the development of various tissues relevant to these conditions.
Scientists have identified p16 as a gene that accelerates cellular aging, while p19 slows it down. The study sheds light on the development of aging-related characteristics such as loss of muscle mass and cataracts.
Cornell engineers develop gel scaffold that can nourish growing tissues, supplying oxygen and nutrients. The system mimics a vascular system at the cellular scale, allowing for fine-tuning of biochemical environments and desired tissue outcomes.
Recent study results show 75% of babies receiving thymus transplants survive after one year. The procedure has led to survival for most infants who would otherwise die from DiGeorge anomaly. Thymus transplantation is a treatment option that offers new hope to families affected by this rare condition.
Researchers at U-M's Life Sciences Institute discovered that the MT1-MMP gene regulates fat cell size and metabolic gene expression. In three-dimensional environments, the gene plays a critical role in adipocyte development, potentially leading to novel therapeutics for obesity prevention.
Researchers created a simplified version of cardiac tissue using cells from neonatal rats, mimicking normal heart tissue. The study found that pace-setting pulses successfully halted the abnormal rhythm 80% of the time, but in 20% of cases, it worsened the condition.
The study provides anatomical evidence of nanometer-sized particles in calcified human arterial and valvular tissue, which share characteristics with nanoparticles recovered from geological specimens. The cultured particles contain nucleic acids, suggesting ongoing synthesis and potential bacterial-like etiology of vascular calcification.
Researchers at University of Pittsburgh successfully used suspension culture systems to promote follicular growth in rats and mice, showing promise for preserving ovarian fertility after cancer treatment. The study's findings suggest a promising step towards conserving fertility for cancer patients.
A mild brain injury can make brain cells vulnerable to the immune system's attack, leading to worsening of Alzheimer's and other neurodegenerative diseases. Researchers discovered that drugs targeting specific immune proteins could reduce neural damage in these conditions.
A study published in the American Journal of Pathology found that uncircumcised men are more susceptible to HIV due to high concentrations of target cells in their foreskin tissue. This tissue contains higher densities of CD4+ T cells, macropahges and Langerhans' Cells than in circumcised individuals or cervical tissue.
Researchers have created a bioartificial trabeculum, or BAT, that exhibits rhythmic contraction at 100 beats per minute and functional cell-to-cell coupling. The model has potential applications in studying cardiac disease and developing new treatments for congestive heart failure.
A study published in The Lancet found that HIV-positive women can shed the virus in their genital tracts even when their blood levels are low, posing a risk of transmission to others. The researchers analyzed samples from 311 HIV-positive women and found that about a third had HIV-1 shedding in their genital region.
Researchers found that HHV-6 inhibits early-stage HIV variants by blocking CCR5 receptors, slowing their reproduction. The harmless herpesvirus may create favorable conditions for later-stage HIV variants that use CXCR4 receptors.