Research suggests visfatin stimulates membrane raft clustering, leading to NLRP3 inflammasome activation and podocyte injury. The study highlights the role of membrane raft redox signaling in visfatin-induced inflammation and kidney damage.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateDec 5, 2023
Researchers developed a quantitative pharmacodynamic assay for detecting apoptosis in fixed tumor tissue, resolving limitations of existing methods. The assay uses colocalization of γH2AX and cleaved caspase-3 markers to identify apoptotic cells with high accuracy.
SourceImpact Journals LLC·JournalOncotarget·DateApr 18, 2018
Scientists at the University of Warwick have discovered a thermodynamic switch that enables the pairing of X chromosomes in female cells during embryo development. The discovery sheds light on the complex mechanism behind X-chromosome inactivation and its role in preventing medical conditions such as Down's Syndrome and Turner's Syndrome.
SourceUniversity of Warwick·JournalPLOS Computational Biology·DateDec 26, 2008